Protein: CBLC
E3 ubiquitin-protein ligase CBL-C (EC 2.3.2.27) (RING finger protein 57) (RING-type E3 ubiquitin transferase CBL-C) (SH3-binding protein CBL-3) (SH3-binding protein CBL-C) (Signal transduction protein CBL-C)

Gene: CBLC
Organism: Homo sapiens
Interactions: 74
UniProt ID: Q9ULV8

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0005154 - epidermal growth factor receptor binding
GO:0005509 - calcium ion binding
GO:0005886 - plasma membrane
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

896396

UBE2K
Ubiquitin-conjugating enzyme E2 K

2

20

High-throughput

0.783

High

919905

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

20

Small-scale

0.778

High

339127

EGFR
Epidermal growth factor receptor

5

20

Small-scale

0.721

High

159103

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

20

High-throughput

0.698

High

909319

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.698

High

930452

UBC9
SUMO-conjugating enzyme UBC9

1

20

High-throughput

0.698

High

932597

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

20

High-throughput

0.698

High

1036369

BIRC2
Baculoviral IAP repeat-containing protein 2

1

1

High-throughput

0.698

High

1174553

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

20

High-throughput

0.698

High

523198

SRC
Proto-oncogene tyrosine-protein kinase Src

3

20

Small-scale

0.676

High

802773

CRK
Adapter molecule crk

3

20

Small-scale

0.651

High

169313

MDM4
Protein Mdm4

1

1

High-throughput

0.647

High

476560

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

16

Small-scale

0.647

High

665361

EPHA2
Ephrin type-A receptor 2

1

16

High-throughput

0.647

High

849487

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

20

Small-scale

0.647

High

895953

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

Small-scale

0.647

High

1274178

LPP
Lipoma-preferred partner

2

10

High-throughput

0.628

High

1348428

ABI2
Abl interactor 2

2

20

High-throughput

0.628

High

1357076

WASF2
Actin-binding protein WASF2

2

1

High-throughput

0.628

High

433504

YES
Tyrosine-protein kinase Yes

2

20

High-throughput

0.606

High

1294885

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

7

Small-scale

0.586

High

434308

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

2

20

Small-scale

0.584

High

161736

GAK
Cyclin-G-associated kinase

2

1

High-throughput

0.574

High

1184672

CYFP1
Cytoplasmic FMR1-interacting protein 1

2

1

High-throughput

0.574

High

1267039

WASF1
Actin-binding protein WASF1

2

2

High-throughput

0.574

High

1290816

CYFP2
Cytoplasmic FMR1-interacting protein 2

2

1

High-throughput

0.574

High

200192

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

2

8

Small-scale

0.566

High

412405

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.561

High

1190463

TRI46
Tripartite motif-containing protein 46

1

5

High-throughput

0.541

High

1290126

CHFR
E3 ubiquitin-protein ligase CHFR

1

2

High-throughput

0.541

High

1313383

TRAF4
TNF receptor-associated factor 4

1

9

High-throughput

0.541

High

1267244

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.536

High

72170

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

666188

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.508

High

1307462

SH3G3
Endophilin-A3

1

20

High-throughput

0.508

High

1344054

PDLI7
PDZ and LIM domain protein 7

1

10

Small-scale

0.504

High

375080

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

12

High-throughput

0.501

High

384025

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.501

High

387726

P53
Cellular tumor antigen p53

1

2

High-throughput

0.501

High

434075

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.501

High

608187

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.501

High

682068

AKT1
RAC-alpha serine/threonine-protein kinase

1

5

High-throughput

0.501

High

719651

MERL
Merlin

1

2

High-throughput

0.501

High

805486

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

2

High-throughput

0.501

High

1224658

ABI1
Abl interactor 1

1

20

Small-scale

0.501

High

271219

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

5

High-throughput

0.481

High

1076569

TRIP6
Thyroid receptor-interacting protein 6

1

11

Small-scale

0.481

High

1356317

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

5

High-throughput

0.481

High

154064

TERT
Telomerase reverse transcriptase

1

0

High-throughput

0.480

High

960260

CDK6
Cyclin-dependent kinase 6

1

0

High-throughput

0.480

High

1079183

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.480

High

441583

MET
Hepatocyte growth factor receptor

1

14

Small-scale

0.479

High

1052348

SRC8
Src substrate cortactin

1

20

Small-scale

0.479

High

1357075

CD2AP
CD2-associated protein

1

20

Small-scale

0.479

High

868800

ATX1
Ataxin-1

1

1

High-throughput

0.470

High

1026010

TADBP
TAR DNA-binding protein 43

1

2

High-throughput

0.470

High

166515

NACAD
NAC-alpha domain-containing protein 1

1

1

High-throughput

0.464

High

348216

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.457

High

417103

KCRM
Creatine kinase M-type

1

1

Small-scale

0.457

High

790955

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

1

High-throughput

0.457

High

1344972

LATS2
Serine/threonine-protein kinase LATS2

1

3

High-throughput

0.457

High

160849

AURKA
Aurora kinase A

1

5

Small-scale

0.437

High

1292290

AURKB
Aurora kinase B

1

4

Small-scale

0.437

High

796488

ZAP70
Tyrosine-protein kinase ZAP-70

1

20

Small-scale

0.408

High

1260615

BRK1
Protein BRICK1

2

0

High-throughput

0.328

High

1309777

MGME1
Mitochondrial genome maintenance exonuclease 1

2

0

High-throughput

0.328

High

1355574

ZNHI2
Zinc finger HIT domain-containing protein 2

2

0

High-throughput

0.328

High

1357074

NCKP1
Nck-associated protein 1

2

0

High-throughput

0.328

High

1067374

OXA1L
Mitochondrial inner membrane protein OXA1L

1

0

High-throughput

0.282

High

443269

NFIC
Nuclear factor 1 C-type

1

0

High-throughput

0.261

Low

673114

CCND2
G1/S-specific cyclin-D2

1

0

High-throughput

0.261

Low

1317726

NSD3
Histone-lysine N-methyltransferase NSD3

1

0

High-throughput

0.261

Low

1317827

GLIS2
Zinc finger protein GLIS2

1

0

High-throughput

0.261

Low

1185442

OTU6A
OTU domain-containing protein 6A

1

0

High-throughput

0.251

Low


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Last updated: 15 Jul 2024