Protein: TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 (EC 4.1.3.44) (Radical S-adenosyl methionine and flavodoxin domain-containing protein 1) (tRNA wybutosine-synthesizing protein 1 homolog) (tRNA-yW-synthesizing protein)

Gene: TYW1
Organism: Homo sapiens
Interactions: 108
UniProt ID: Q9NV66

Gene Ontology (top 5):
GO:0010181 - FMN binding
GO:0031591 - wybutosine biosynthetic process
GO:0046872 - metal ion binding
GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0102521 - tRNA-4-demethylwyosine synthase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1262534

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

3

High-throughput

0.628

High

276277

CIB2
Calcium and integrin-binding family member 2

1

1

High-throughput

0.618

High

513763

CP19A
Aromatase

1

5

High-throughput

0.618

High

1016038

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

2

High-throughput

0.618

High

199966

SPIT2
Kunitz-type protease inhibitor 2

3

1

High-throughput

0.609

High

885956

EVA1C
Protein eva-1 homolog C

3

1

High-throughput

0.609

High

1182914

BT2A1
Butyrophilin subfamily 2 member A1

3

4

High-throughput

0.609

High

1291488

TSN17
Tetraspanin-17

3

3

High-throughput

0.609

High

1295778

RN170
E3 ubiquitin-protein ligase RNF170

2

0

High-throughput

0.602

High

977425

KCNC4
Potassium voltage-gated channel subfamily C member 4

2

1

High-throughput

0.574

High

1103173

KLH40
Kelch-like protein 40

2

2

High-throughput

0.574

High

1166906

DLK2
Protein delta homolog 2

2

2

High-throughput

0.574

High

1199495

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

2

3

High-throughput

0.574

High

1239078

I17RC
Interleukin-17 receptor C

2

2

High-throughput

0.574

High

1308850

KCNS3
Potassium voltage-gated channel subfamily S member 3

2

1

High-throughput

0.574

High

1344941

I17RB
Interleukin-17 receptor B

2

1

High-throughput

0.574

High

1346331

PCDGG
Protocadherin gamma-B4

2

5

High-throughput

0.574

High

1346339

PCDA3
Protocadherin alpha-3

2

4

High-throughput

0.574

High

283254

RGS20
Regulator of G-protein signaling 20

2

1

High-throughput

0.558

High

1086137

AMHR2
Anti-Muellerian hormone type-2 receptor

1

2

High-throughput

0.536

High

1243485

ACV1C
Activin receptor type-1C

1

2

High-throughput

0.536

High

1332118

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

1

High-throughput

0.536

High

1335620

RXFP1
Relaxin receptor 1

1

3

High-throughput

0.536

High

1346333

CIA2B
Cytosolic iron-sulfur assembly component 2B

2

1

Small-scale

0.521

High

283047

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

0

High-throughput

0.517

High

172250

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.489

High

253917

LRP3
Low-density lipoprotein receptor-related protein 3

1

1

High-throughput

0.489

High

326239

TSN15
Tetraspanin-15

1

3

High-throughput

0.489

High

537773

INSRR
Insulin receptor-related protein

1

2

High-throughput

0.489

High

583927

CD53
Leukocyte surface antigen CD53

1

3

High-throughput

0.489

High

796187

MAGA9
Melanoma-associated antigen 9

1

2

High-throughput

0.489

High

876203

PAR2
Proteinase-activated receptor 2

1

1

High-throughput

0.489

High

884430

TMPS3
Transmembrane protease serine 3

1

3

High-throughput

0.489

High

1053827

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

1

High-throughput

0.489

High

1125384

UROL1
Uromodulin-like 1

1

1

High-throughput

0.489

High

1166465

BTNL3
Butyrophilin-like protein 3

1

4

High-throughput

0.489

High

1283300

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.489

High

1290947

I17RA
Interleukin-17 receptor A

1

1

High-throughput

0.489

High

1292724

ZDH12
Palmitoyltransferase ZDHHC12

1

1

High-throughput

0.489

High

1315159

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

1

High-throughput

0.489

High

1328454

PCDC1
Protocadherin alpha-C1

1

6

High-throughput

0.489

High

1346329

EVA1B
Protein eva-1 homolog B

1

1

High-throughput

0.489

High

1346332

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

1

High-throughput

0.489

High

1346334

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

1

High-throughput

0.489

High

1346335

PCDB3
Protocadherin beta-3

1

5

High-throughput

0.489

High

1346336

PCDGL
Protocadherin gamma-C4

1

6

High-throughput

0.489

High

1346337

PCDGH
Protocadherin gamma-B5

1

5

High-throughput

0.489

High

1346338

PCDG5
Protocadherin gamma-A5

1

5

High-throughput

0.489

High

1319267

LNP
Endoplasmic reticulum junction formation protein lunapark

1

1

High-throughput

0.479

High

164008

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

4

High-throughput

0.437

High

200351

LRRT2
Leucine-rich repeat transmembrane neuronal protein 2

1

3

High-throughput

0.437

High

206043

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

390568

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.437

High

391206

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.437

High

545647

RAC2
Ras-related C3 botulinum toxin substrate 2

1

14

High-throughput

0.437

High

632421

TNR6
Tumor necrosis factor receptor superfamily member 6

1

1

High-throughput

0.437

High

786157

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.437

High

795304

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.437

High

839176

EMD
Emerin

1

2

High-throughput

0.437

High

845281

RAB7A
Ras-related protein Rab-7a

1

4

High-throughput

0.437

High

847683

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.437

High

890456

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.437

High

894493

CDC42
Cell division control protein 42 homolog

1

14

High-throughput

0.437

High

900962

RHOA
Transforming protein RhoA

1

15

High-throughput

0.437

High

951387

RHOG
Rho-related GTP-binding protein RhoG

1

14

High-throughput

0.437

High

990705

CKAP4
Cytoskeleton-associated protein 4

1

3

High-throughput

0.437

High

1040279

STIM1
Stromal interaction molecule 1

1

1

High-throughput

0.437

High

1168707

SYNE3
Nesprin-3

1

2

High-throughput

0.437

High

1240327

DHB11
Estradiol 17-beta-dehydrogenase 11

1

1

High-throughput

0.437

High

1284107

LRC59
Leucine-rich repeat-containing protein 59

1

2

High-throughput

0.437

High

1296090

DNJC1
DnaJ homolog subfamily C member 1

1

4

High-throughput

0.437

High

1303594

SEC62
Translocation protein SEC62

1

1

High-throughput

0.437

High

1313074

DERL1
Derlin-1

1

2

High-throughput

0.437

High

1333593

TMT1A
Thiol S-methyltransferase TMT1A

1

1

High-throughput

0.437

High

1344445

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.437

High

1346179

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.437

High

72210

B3KSW4
Regulator of G protein signaling 20

1

1

High-throughput

0.407

High

1346330

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

1

High-throughput

0.407

High

1303001

MMS19
MMS19 nucleotide excision repair protein homolog

3

0

Small-scale

0.330

High

1244896

GP156
Probable G-protein coupled receptor 156

2

0

High-throughput

0.328

High

1259439

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

2

0

High-throughput

0.328

High

1326129

NMUR2
Neuromedin-U receptor 2

2

0

High-throughput

0.328

High

1079790

EREP1
Endosomal transmembrane epsin interactor 1

2

0

High-throughput

0.318

High

179455

MPPD1
Metallophosphoesterase domain-containing protein 1

1

0

High-throughput

0.279

Low

452169

CD7
T-cell antigen CD7

1

0

High-throughput

0.279

Low

452488

PGFRB
Platelet-derived growth factor receptor beta

1

0

High-throughput

0.279

Low

685293

CEAM8
Carcinoembryonic antigen-related cell adhesion molecule 8

1

0

High-throughput

0.279

Low

771163

TPOR
Thrombopoietin receptor

1

0

High-throughput

0.279

Low

778607

PMEL
Melanocyte protein PMEL

1

0

High-throughput

0.279

Low

989655

ACHD
Acetylcholine receptor subunit delta

1

0

High-throughput

0.279

Low

1109953

SHSL1
Protein shisa-like-1

1

0

High-throughput

0.279

Low

1121959

H1BP3
HCLS1-binding protein 3

1

0

High-throughput

0.279

Low

1125145

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.279

Low

1136847

FAXC
Failed axon connections homolog

1

0

High-throughput

0.279

Low

1139687

TM268
Transmembrane protein 268

1

0

High-throughput

0.279

Low

1236247

I22R1
Interleukin-22 receptor subunit alpha-1

1

0

High-throughput

0.279

Low

1245393

OR1M1
Olfactory receptor 1M1

1

0

High-throughput

0.279

Low

1253092

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.279

Low

1261150

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.279

Low

1283165

T106A
Transmembrane protein 106A

1

0

High-throughput

0.279

Low

1298586

CEP20
Centrosomal protein 20

1

0

High-throughput

0.279

Low

1317660

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

1

0

High-throughput

0.279

Low

1342554

KCMB3
Calcium-activated potassium channel subunit beta-3

1

0

High-throughput

0.279

Low

1343098

TMM9B
Transmembrane protein 9B

1

0

High-throughput

0.279

Low

434030

LYN
Tyrosine-protein kinase Lyn

1

0

Small-scale

0.249

Low

1218526

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.249

Low

1300795

PANX1
Pannexin-1

1

0

High-throughput

0.249

Low

1315668

TMM59
Transmembrane protein 59

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024