Protein: PRAME
Melanoma antigen preferentially expressed in tumors (Opa-interacting protein 4) (OIP-4) (Preferentially expressed antigen of melanoma)

Gene: PRAME
Organism: Homo sapiens
Interactions: 103
UniProt ID: P78395

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

943713

CUL2
Cullin-2

7

15

Small-scale

0.754

High

943717

ELOB
Elongin-B

4

3

Small-scale

0.708

High

943716

ELOC
Elongin-C

3

3

Small-scale

0.688

High

943727

ZN562
Zinc finger protein 562

3

2

High-throughput

0.667

High

943742

IFT81
Intraflagellar transport protein 81 homolog

3

12

High-throughput

0.667

High

921215

RBX1
E3 ubiquitin-protein ligase RBX1

2

4

Small-scale

0.639

High

943754

TGT
Queuine tRNA-ribosyltransferase catalytic subunit 1

3

0

High-throughput

0.638

High

943711

FOXD4
Forkhead box protein D4

2

3

High-throughput

0.628

High

897231

CSN2
COP9 signalosome complex subunit 2

2

1

High-throughput

0.611

High

943753

LST8
Target of rapamycin complex subunit LST8

2

3

High-throughput

0.611

High

669334

EF1D
Elongation factor 1-delta

2

0

High-throughput

0.602

High

824697

NPY2R
Neuropeptide Y receptor type 2

2

0

High-throughput

0.602

High

943740

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

2

0

High-throughput

0.602

High

943745

AZIN2
Antizyme inhibitor 2

2

0

High-throughput

0.602

High

943762

FSCN3
Fascin-3

2

0

High-throughput

0.602

High

943715

LAGE3
EKC/KEOPS complex subunit LAGE3

2

0

Small-scale

0.585

High

943757

NOL11
Nucleolar protein 11

2

0

High-throughput

0.585

High

943761

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

2

0

Small-scale

0.585

High

487939

RARA
Retinoic acid receptor alpha

1

5

Small-scale

0.573

High

171972

GP182
G-protein coupled receptor 182

1

3

High-throughput

0.536

High

341433

FA12
Coagulation factor XII

1

1

High-throughput

0.536

High

917100

H4
Histone H4

1

1

Small-scale

0.536

High

943710

FOXF2
Forkhead box protein F2

1

3

High-throughput

0.536

High

943724

FX4L6
Forkhead box protein D4-like 6

1

3

High-throughput

0.536

High

943726

POTEE
POTE ankyrin domain family member E

1

4

High-throughput

0.536

High

943729

CSN6
COP9 signalosome complex subunit 6

1

2

High-throughput

0.536

High

943732

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

2

High-throughput

0.536

High

943733

P2RY8
P2Y purinoceptor 8

1

4

High-throughput

0.536

High

943739

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

High-throughput

0.536

High

943748

WDR90
WD repeat-containing protein 90

1

2

High-throughput

0.536

High

943760

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

2

High-throughput

0.536

High

943768

CSN3
COP9 signalosome complex subunit 3

1

3

High-throughput

0.536

High

943769

GPR55
G-protein coupled receptor 55

1

6

High-throughput

0.536

High

245679

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

454694

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

943737

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

High-throughput

0.513

High

943743

XPF
DNA repair endonuclease XPF

1

0

High-throughput

0.513

High

943756

HEAT1
HEAT repeat-containing protein 1

1

0

High-throughput

0.513

High

943763

AP5S1
AP-5 complex subunit sigma-1

1

0

High-throughput

0.513

High

943766

RDH8
Retinol dehydrogenase 8

1

0

High-throughput

0.513

High

943767

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.513

High

943772

AMMR1
Nuclear protein AMMECR1

1

0

High-throughput

0.513

High

475613

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

Small-scale

0.501

High

943714

KRT81
Keratin, type II cuticular Hb1

1

8

High-throughput

0.489

High

943731

WDR86
WD repeat-containing protein 86

1

5

High-throughput

0.489

High

943773

NPTN
Neuroplastin

1

3

High-throughput

0.489

High

836138

STK19
Inactive serine/threonine-protein kinase 19

1

0

Small-scale

0.486

High

943755

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.481

High

943758

ZN408
Zinc finger protein 408

1

1

High-throughput

0.481

High

943771

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

73117

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

8

High-throughput

0.479

High

209883

PRC1
Protein regulator of cytokinesis 1

1

4

High-throughput

0.479

High

227145

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

386507

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

432650

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

3

Small-scale

0.479

High

487325

ANDR
Androgen receptor

1

6

High-throughput

0.479

High

509627

UBL4A
Ubiquitin-like protein 4A

1

4

Small-scale

0.479

High

538902

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

1

Small-scale

0.479

High

649448

RL10
Large ribosomal subunit protein uL16

1

1

Small-scale

0.479

High

682768

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

6

Small-scale

0.479

High

749367

BRCA1
Breast cancer type 1 susceptibility protein

1

6

High-throughput

0.479

High

779226

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

790745

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

2

Small-scale

0.479

High

852873

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

1

Small-scale

0.479

High

855018

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

6

Small-scale

0.479

High

943708

PRAME
Melanoma antigen preferentially expressed in tumors

1

13

Small-scale

0.479

High

943712

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

2

High-throughput

0.479

High

943719

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

Small-scale

0.479

High

943720

H31T
Histone H3.1t

1

4

Small-scale

0.479

High

943721

H2A2C
Histone H2A type 2-C

1

10

Small-scale

0.479

High

943722

H2B2E
Histone H2B type 2-E

1

6

Small-scale

0.479

High

943725

Q6PK50
Heat shock protein HSP 90-beta

1

5

High-throughput

0.479

High

943735

NUDC3
NudC domain-containing protein 3

1

2

High-throughput

0.479

High

943746

Q96BE0
Heat shock cognate 71 kDa protein

1

7

High-throughput

0.479

High

943749

PRPK
EKC/KEOPS complex subunit TP53RK

1

1

Small-scale

0.479

High

943751

AASD1
Alanyl-tRNA editing protein Aarsd1

1

2

High-throughput

0.479

High

943759

Q9HAV2
Heat shock transcription factor 1

1

1

High-throughput

0.479

High

943764

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.479

High

232097

KDM1A
Lysine-specific histone demethylase 1A

1

0

Small-scale

0.458

High

721965

RFC4
Replication factor C subunit 4

1

0

Small-scale

0.458

High

722378

RL22
Large ribosomal subunit protein eL22

1

0

Small-scale

0.458

High

798638

PRS6B
26S proteasome regulatory subunit 6B

1

0

Small-scale

0.458

High

911093

RS13
Small ribosomal subunit protein uS15

1

0

Small-scale

0.458

High

940774

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

943709

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

943736

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.458

High

943752

CC28B
Coiled-coil domain-containing protein 28B

1

0

High-throughput

0.458

High

943770

TPRKB
EKC/KEOPS complex subunit TPRKB

1

0

Small-scale

0.458

High

353922

IGHM
Immunoglobulin heavy constant mu

1

1

High-throughput

0.445

High

943718

NEDD8
NEDD8

1

2

Small-scale

0.445

High

943744

UBE2F
NEDD8-conjugating enzyme UBE2F

1

0

High-throughput

0.438

High

323685

BAG2
BAG family molecular chaperone regulator 2

1

1

Small-scale

0.437

High

943750

Q9BPW0
Serine/threonine-protein phosphatase

1

7

High-throughput

0.437

High

943765

FXL12
F-box/LRR-repeat protein 12

1

2

Small-scale

0.437

High

943728

PKHG7
Pleckstrin homology domain-containing family G member 7

1

5

High-throughput

0.407

High

272346

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.279

Low

943730

DAAM2
Disheveled-associated activator of morphogenesis 2

1

0

High-throughput

0.279

Low

943734

CQ082
Putative uncharacterized protein LINC02875

1

0

High-throughput

0.279

Low

943738

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

943741

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

943747

LOXL4
Lysyl oxidase homolog 4

1

0

High-throughput

0.279

Low

943723

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024