Protein: FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]

Gene: FKBP4
Organism: Homo sapiens
Interactions: 228
UniProt ID: Q02790

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003755 - peptidyl-prolyl cis-trans isomerase activity
GO:0005524 - ATP binding
GO:0005525 - GTP binding
GO:0005528 - FK506 binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

431755

HS90A
Heat shock protein HSP 90-alpha

12

20

Small-scale

0.982

High

438089

HS90B
Heat shock protein HSP 90-beta

4

20

Small-scale

0.904

High

338303

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.785

High

684646

STIP1
Stress-induced-phosphoprotein 1

2

18

Small-scale

0.768

High

384676

NTRK1
High affinity nerve growth factor receptor

2

20

High-throughput

0.754

High

972563

GLMN
Glomulin

9

3

Small-scale

0.754

High

969070

KPCE
Protein kinase C epsilon type

2

7

High-throughput

0.737

High

972523

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

8

High-throughput

0.737

High

972520

H90B4
Putative heat shock protein HSP 90-beta 4

2

20

High-throughput

0.712

High

972521

HS905
Putative heat shock protein HSP 90-alpha A5

2

20

High-throughput

0.712

High

377261

GCR
Glucocorticoid receptor

5

20

Small-scale

0.705

High

153115

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

20

High-throughput

0.691

High

158449

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

18

High-throughput

0.691

High

201309

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

7

High-throughput

0.691

High

515269

KPSH1
Serine/threonine-protein kinase H1

1

14

High-throughput

0.691

High

609664

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

20

High-throughput

0.691

High

794379

GRK6
G protein-coupled receptor kinase 6

1

20

High-throughput

0.691

High

848348

IRAK1
Interleukin-1 receptor-associated kinase 1

1

5

High-throughput

0.691

High

863819

LIMK2
LIM domain kinase 2

1

10

High-throughput

0.691

High

972496

KPCZ
Protein kinase C zeta type

1

14

High-throughput

0.691

High

972503

ILK
Integrin-linked protein kinase

1

11

High-throughput

0.691

High

972513

MYLK
Myosin light chain kinase, smooth muscle

1

6

High-throughput

0.691

High

972514

STK11
Serine/threonine-protein kinase STK11

1

4

High-throughput

0.691

High

972540

ST32C
Serine/threonine-protein kinase 32C

1

18

High-throughput

0.691

High

972545

MYLK4
Myosin light chain kinase family member 4

1

17

High-throughput

0.691

High

972554

MK15
Mitogen-activated protein kinase 15

1

12

High-throughput

0.691

High

972555

NEK7
Serine/threonine-protein kinase Nek7

1

14

High-throughput

0.691

High

972568

TSSK2
Testis-specific serine/threonine-protein kinase 2

1

13

High-throughput

0.691

High

972569

PSKH2
Serine/threonine-protein kinase H2

1

18

High-throughput

0.691

High

972577

TSSK1
Testis-specific serine/threonine-protein kinase 1

1

16

High-throughput

0.691

High

972579

KPCD2
Serine/threonine-protein kinase D2

1

13

High-throughput

0.691

High

972591

DYRK4
Dual specificity tyrosine-phosphorylation-regulated kinase 4

1

15

High-throughput

0.691

High

227216

PRKN
E3 ubiquitin-protein ligase parkin

4

7

High-throughput

0.686

High

972509

TEBP
Prostaglandin E synthase 3

3

10

Small-scale

0.667

High

972616

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

15

High-throughput

0.665

High

174814

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

17

High-throughput

0.647

High

426954

FES
Tyrosine-protein kinase Fes/Fps

1

17

Small-scale

0.647

High

487347

ANDR
Androgen receptor

3

20

Small-scale

0.646

High

496884

TAU
Microtubule-associated protein tau

2

8

Small-scale

0.639

High

331261

CHK2
Serine/threonine-protein kinase Chk2

1

14

Small-scale

0.625

High

314307

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

2

4

Small-scale

0.619

High

156638

PPE2
Serine/threonine-protein phosphatase with EF-hands 2

1

5

High-throughput

0.618

High

318111

DIRA3
GTP-binding protein Di-Ras3

1

1

High-throughput

0.618

High

374083

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

17

High-throughput

0.618

High

411681

LCK
Tyrosine-protein kinase Lck

1

11

High-throughput

0.618

High

488688

ARAF
Serine/threonine-protein kinase A-Raf

1

17

High-throughput

0.618

High

625378

CDK2
Cyclin-dependent kinase 2

1

8

High-throughput

0.618

High

835676

GSK3B
Glycogen synthase kinase-3 beta

1

11

High-throughput

0.618

High

960271

CDK5
Cyclin-dependent kinase 5

1

9

Small-scale

0.618

High

972497

M3K12
Mitogen-activated protein kinase kinase kinase 12

1

16

Small-scale

0.618

High

972498

IFT88
Intraflagellar transport protein 88 homolog

1

15

High-throughput

0.618

High

972508

CUL7
Cullin-7

1

3

High-throughput

0.618

High

972518

DDR2
Discoidin domain-containing receptor 2

1

19

High-throughput

0.618

High

972530

Q6PK50
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

972531

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.618

High

972538

NEK8
Serine/threonine-protein kinase Nek8

1

16

High-throughput

0.618

High

972562

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

10

High-throughput

0.618

High

972578

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

15

High-throughput

0.618

High

972586

Q9H4D1
Protein kinase

1

15

High-throughput

0.618

High

972609

AGO2
Protein argonaute-2

2

14

Small-scale

0.611

High

972572

MGME1
Mitochondrial genome maintenance exonuclease 1

2

0

High-throughput

0.602

High

416611

S10A6
Protein S100-A6

1

10

Small-scale

0.597

High

369442

ESR1
Estrogen receptor

2

20

Small-scale

0.595

High

961057

HSF1
Heat shock factor protein 1

2

3

Small-scale

0.595

High

972505

SQSTM
Sequestosome-1

2

5

Small-scale

0.595

High

779269

CCNF
Cyclin-F

2

4

High-throughput

0.584

High

972559

AKAP1
A-kinase anchor protein 1, mitochondrial

2

6

High-throughput

0.584

High

388387

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.582

High

111936

K9JA46
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.575

High

883489

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

15

High-throughput

0.575

High

972532

NEK10
Serine/threonine-protein kinase Nek10

1

13

High-throughput

0.575

High

166694

CE290
Centrosomal protein of 290 kDa

2

7

High-throughput

0.571

High

581686

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.571

High

924488

GRB2
Growth factor receptor-bound protein 2

2

10

High-throughput

0.571

High

742233

SYUA
Alpha-synuclein

2

2

Small-scale

0.563

High

615212

S10A1
Protein S100-A1

1

10

Small-scale

0.561

High

972516

CDC37
Hsp90 co-chaperone Cdc37

1

11

High-throughput

0.554

High

661236

S10A2
Protein S100-A2

1

10

Small-scale

0.545

High

128842

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

7

High-throughput

0.536

High

198247

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

1

High-throughput

0.536

High

206828

FOXO3
Forkhead box protein O3

1

3

High-throughput

0.536

High

232852

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

10

High-throughput

0.536

High

301376

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

7

High-throughput

0.536

High

306120

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

3

High-throughput

0.536

High

871002

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

2

High-throughput

0.536

High

972535

CD37L
Hsp90 co-chaperone Cdc37-like 1

1

11

High-throughput

0.536

High

972544

STX12
Syntaxin-12

1

4

High-throughput

0.536

High

972584

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

3

High-throughput

0.536

High

972588

CYBP
Calcyclin-binding protein

1

3

High-throughput

0.536

High

972604

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

2

High-throughput

0.536

High

972605

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

6

High-throughput

0.536

High

972607

LSM7
U6 snRNA-associated Sm-like protein LSm7

1

1

High-throughput

0.536

High

972614

SGT1
Protein SGT1 homolog

1

19

High-throughput

0.536

High

972617

SAR1B
Small COPII coat GTPase SAR1B

1

2

High-throughput

0.536

High

972510

IRF4
Interferon regulatory factor 4

1

3

Small-scale

0.529

High

972542

LCA5
Lebercilin

2

7

High-throughput

0.521

High

972601

SAE1
SUMO-activating enzyme subunit 1

1

2

High-throughput

0.515

High

259439

NIPS2
Protein NipSnap homolog 2

1

0

High-throughput

0.513

High

972517

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.513

High

972553

PHOP1
Phosphoethanolamine/phosphocholine phosphatase

1

0

High-throughput

0.513

High

972574

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.513

High

972576

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.513

High

972592

SHLB2
Endophilin-B2

1

0

High-throughput

0.513

High

156667

PAHX
Phytanoyl-CoA dioxygenase, peroxisomal

1

0

Small-scale

0.504

High

714190

HSP74
Heat shock 70 kDa protein 4

1

18

Small-scale

0.501

High

972575

PTSS2
Phosphatidylserine synthase 2

1

1

High-throughput

0.489

High

972599

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.486

High

73118

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

12

High-throughput

0.479

High

119334

LEG9
Galectin-9

1

1

High-throughput

0.479

High

148062

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

14

High-throughput

0.479

High

232111

KDM1A
Lysine-specific histone demethylase 1A

1

3

High-throughput

0.479

High

244309

BRD4
Bromodomain-containing protein 4

1

6

High-throughput

0.479

High

256886

NPHP4
Nephrocystin-4

1

2

High-throughput

0.479

High

272540

OFD1
Centriole and centriolar satellite protein OFD1

1

8

High-throughput

0.479

High

278789

DNJC8
DnaJ homolog subfamily C member 8

1

20

High-throughput

0.479

High

304822

MFN2
Mitofusin-2

1

3

High-throughput

0.479

High

346569

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.479

High

386563

P53
Cellular tumor antigen p53

1

6

Small-scale

0.479

High

409053

K2C8
Keratin, type II cytoskeletal 8

1

1

High-throughput

0.479

High

414489

PRGR
Progesterone receptor

1

20

Small-scale

0.479

High

428150

TBB5
Tubulin beta chain

1

7

High-throughput

0.479

High

437634

MCR
Mineralocorticoid receptor

1

20

Small-scale

0.479

High

503930

HSP7C
Heat shock cognate 71 kDa protein

1

14

High-throughput

0.479

High

552534

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

569619

CEBPB
CCAAT/enhancer-binding protein beta

1

7

High-throughput

0.479

High

575725

VINC
Vinculin

1

3

High-throughput

0.479

High

583463

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.479

High

641199

DNMT1
DNA

1

1

Small-scale

0.479

High

651000

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

714822

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

2

High-throughput

0.479

High

717008

CTNB1
Catenin beta-1

1

5

High-throughput

0.479

High

720269

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

749394

BRCA1
Breast cancer type 1 susceptibility protein

1

5

High-throughput

0.479

High

817946

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

825391

LMAN1
Protein ERGIC-53

1

2

High-throughput

0.479

High

827916

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

High-throughput

0.479

High

832386

MCM2
DNA replication licensing factor MCM2

1

14

High-throughput

0.479

High

874840

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.479

High

880900

IF6
Eukaryotic translation initiation factor 6

1

1

High-throughput

0.479

High

886387

NAL11
NACHT, LRR and PYD domains-containing protein 11

1

7

High-throughput

0.479

High

896041

UBC12
NEDD8-conjugating enzyme Ubc12

1

2

High-throughput

0.479

High

896872

ARP2
Actin-related protein 2

1

5

High-throughput

0.479

High

897036

ACTZ
Alpha-centractin

1

4

High-throughput

0.479

High

908401

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

912863

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

921535

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

14

High-throughput

0.479

High

926947

1433Z
14-3-3 protein zeta/delta

1

6

High-throughput

0.479

High

933409

TBA4A
Tubulin alpha-4A chain

1

13

High-throughput

0.479

High

967118

EWS
RNA-binding protein EWS

1

7

High-throughput

0.479

High

972499

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

10

High-throughput

0.479

High

972500

TIF1B
Transcription intermediary factor 1-beta

1

9

High-throughput

0.479

High

972502

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

11

High-throughput

0.479

High

972504

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

972507

NBR1
Next to BRCA1 gene 1 protein

1

2

High-throughput

0.479

High

972511

STIL
SCL-interrupting locus protein

1

1

High-throughput

0.479

High

972515

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.479

High

972519

GLE1
mRNA export factor GLE1

1

7

High-throughput

0.479

High

972522

DCAF6
DDB1- and CUL4-associated factor 6

1

15

High-throughput

0.479

High

972524

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

972525

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

972527

DHX57
Putative ATP-dependent RNA helicase DHX57

1

6

High-throughput

0.479

High

972528

CDC73
Parafibromin

1

1

High-throughput

0.479

High

972529

PRP8
Pre-mRNA-processing-splicing factor 8

1

2

High-throughput

0.479

High

972533

MOB3C
MOB kinase activator 3C

1

4

High-throughput

0.479

High

972541

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

972543

DYR2
Dihydrofolate reductase 2, mitochondrial

1

3

High-throughput

0.479

High

972546

NUDC3
NudC domain-containing protein 3

1

7

High-throughput

0.479

High

972548

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

2

High-throughput

0.479

High

972549

WDTC1
WD and tetratricopeptide repeats protein 1

1

19

High-throughput

0.479

High

972550

POC1A
POC1 centriolar protein homolog A

1

13

High-throughput

0.479

High

972551

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

972557

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

972558

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

10

High-throughput

0.479

High

972560

SYMPK
Symplekin

1

3

High-throughput

0.479

High

972561

RPGR
X-linked retinitis pigmentosa GTPase regulator

1

7

High-throughput

0.479

High

972564

FBXW7
F-box/WD repeat-containing protein 7

1

8

Small-scale

0.479

High

972565

CHM4C
Charged multivesicular body protein 4c

1

4

High-throughput

0.479

High

972567

MRP9
ATP-binding cassette sub-family C member 12

1

4

High-throughput

0.479

High

972570

NECD
Necdin

1

3

High-throughput

0.479

High

972571

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.479

High

972573

TRI56
E3 ubiquitin-protein ligase TRIM56

1

9

High-throughput

0.479

High

972580

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

15

High-throughput

0.479

High

972581

RHG39
Rho GTPase-activating protein 39

1

2

High-throughput

0.479

High

972582

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

3

High-throughput

0.479

High

972583

EGLN1
Egl nine homolog 1

1

5

Small-scale

0.479

High

972585

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

3

High-throughput

0.479

High

972587

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

972593

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

972594

DJC11
DnaJ homolog subfamily C member 11

1

20

High-throughput

0.479

High

972595

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

3

High-throughput

0.479

High

972596

MKS1
Tectonic-like complex member MKS1

1

2

High-throughput

0.479

High

972597

MTCH1
Mitochondrial carrier homolog 1

1

7

High-throughput

0.479

High

972598

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.479

High

972600

SEP10
Septin-10

1

3

High-throughput

0.479

High

972603

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

972606

ANC2
Anaphase-promoting complex subunit 2

1

8

High-throughput

0.479

High

972608

FBW1B
F-box/WD repeat-containing protein 11

1

8

High-throughput

0.479

High

972610

TRPC5
Short transient receptor potential channel 5

1

13

Small-scale

0.479

High

972612

FND3A
Fibronectin type-III domain-containing protein 3A

1

6

High-throughput

0.479

High

972615

SAM50
Sorting and assembly machinery component 50 homolog

1

3

High-throughput

0.479

High

972618

MTCH2
Mitochondrial carrier homolog 2

1

7

High-throughput

0.479

High

173573

NPHP1
Nephrocystin-1

1

0

High-throughput

0.458

High

972506

NFYC
Nuclear transcription factor Y subunit gamma

1

0

High-throughput

0.458

High

972512

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

972526

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

0

High-throughput

0.458

High

972589

ANLN
Anillin

1

0

High-throughput

0.458

High

972611

SMAG1
Protein Smaug homolog 1

1

0

High-throughput

0.458

High

378029

PRIO
Major prion protein

1

1

High-throughput

0.445

High

401869

JUN
Transcription factor Jun

1

7

High-throughput

0.445

High

968565

TAGL
Transgelin

1

4

High-throughput

0.445

High

972539

Q86SX1
Full-length cDNA 5-PRIME end of clone CS0DN005YI08 of Adult brain of Homo sapiens

1

20

High-throughput

0.445

High

972566

OTUB1
Ubiquitin thioesterase OTUB1

1

1

High-throughput

0.445

High

972619

S4R435
Small ribosomal subunit protein eS10

1

3

High-throughput

0.445

High

100690

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

225611

PCDH7
Protocadherin-7

1

1

High-throughput

0.437

High

329655

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

823170

TRPC1
Short transient receptor potential channel 1

1

13

Small-scale

0.437

High

972534

KCTD9
BTB/POZ domain-containing protein KCTD9

1

4

High-throughput

0.437

High

972536

DET1
DET1 homolog

1

3

High-throughput

0.437

High

972537

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.437

High

972590

PRDM6
Putative histone-lysine N-methyltransferase PRDM6

1

1

High-throughput

0.437

High

972602

TRPC4
Short transient receptor potential channel 4

1

11

Small-scale

0.437

High

831241

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

High-throughput

0.408

High

972556

Q8TE30
RNA-directed DNA polymerase

1

1

Small-scale

0.407

High

972552

NPB
Neuropeptide B

2

0

High-throughput

0.328

High

972547

LOXH1
Lipoxygenase homology domain-containing protein 1

1

0

High-throughput

0.269

Low

972613

TMA7
Translation machinery-associated protein 7

1

0

High-throughput

0.249

Low

972501

ZN211
Zinc finger protein 211

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024