Protein: TNFL6
Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand) (APTL) (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]

Gene: TNFL6, FASLG
Organism: Homo sapiens
Interactions: 101
UniProt ID: P48023

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005102 - signaling receptor binding
GO:0005123 - death receptor binding
GO:0005125 - cytokine activity
GO:0005164 - tumor necrosis factor receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

632214

TNR6
Tumor necrosis factor receptor superfamily member 6

7

20

Small-scale

0.965

High

313618

TNF6B
Tumor necrosis factor receptor superfamily member 6B

4

20

Small-scale

0.878

High

815680

CASP8
Caspase-8

7

13

Small-scale

0.739

High

584344

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

20

Small-scale

0.737

High

815677

FADD
FAS-associated death domain protein

6

16

Small-scale

0.726

High

815702

SNX33
Sorting nexin-33

5

2

Small-scale

0.723

High

557638

NCK1
SH2/SH3 adapter protein NCK1

4

14

Small-scale

0.697

High

412082

FYN
Tyrosine-protein kinase Fyn

4

12

Small-scale

0.692

High

815719

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

3

7

Small-scale

0.675

High

815720

SNX9
Sorting nexin-9

3

2

Small-scale

0.670

High

815710

E2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1

3

1

High-throughput

0.667

High

209004

NCK2
Cytoplasmic protein NCK2

3

14

Small-scale

0.658

High

224705

KALRN
Kalirin

1

1

Small-scale

0.647

High

362932

FINC
Fibronectin

1

1

Small-scale

0.647

High

815664

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

8

Small-scale

0.647

High

283171

RGS20
Regulator of G-protein signaling 20

3

0

High-throughput

0.646

High

815708

FNBP1
Formin-binding protein 1

2

10

Small-scale

0.641

High

815667

ANM2
Protein arginine N-methyltransferase 2

3

0

High-throughput

0.638

High

815699

MSPD2
Motile sperm domain-containing protein 2

3

0

High-throughput

0.638

High

815671

GRB2
Growth factor receptor-bound protein 2

2

14

Small-scale

0.629

High

433642

LYN
Tyrosine-protein kinase Lyn

2

12

Small-scale

0.613

High

207781

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

2

9

Small-scale

0.612

High

815712

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

2

10

Small-scale

0.612

High

815718

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

2

8

Small-scale

0.612

High

815696

P3H3
Prolyl 3-hydroxylase 3

3

1

High-throughput

0.609

High

815679

KT33B
Keratin, type I cuticular Ha3-II

2

5

High-throughput

0.606

High

815681

SC23A
Protein transport protein Sec23A

2

1

High-throughput

0.606

High

815707

SNX18
Sorting nexin-18

2

2

Small-scale

0.601

High

253328

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

2

3

Small-scale

0.595

High

815714

ITSN2
Intersectin-2

2

1

Small-scale

0.594

High

67006

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.580

High

815685

ECM1
Extracellular matrix protein 1

2

0

High-throughput

0.580

High

815688

TENS2
Tensin-2

2

0

High-throughput

0.580

High

815674

ITK
Tyrosine-protein kinase ITK/TSK

1

12

Small-scale

0.578

High

154325

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

20

Small-scale

0.575

High

815692

NT2NA
Notch homolog 2 N-terminal-like protein A

1

2

High-throughput

0.573

High

546973

EZRI
Ezrin

2

1

Small-scale

0.571

High

815704

CASPA
Caspase-10

2

13

Small-scale

0.571

High

815683

TRIP6
Thyroid receptor-interacting protein 6

1

0

High-throughput

0.549

High

815682

CIP4
Cdc42-interacting protein 4

1

11

Small-scale

0.534

High

433285

YES
Tyrosine-protein kinase Yes

1

12

Small-scale

0.527

High

442792

HCK
Tyrosine-protein kinase HCK

1

12

Small-scale

0.527

High

522855

SRC
Proto-oncogene tyrosine-protein kinase Src

1

12

Small-scale

0.527

High

815694

SRGP1
SLIT-ROBO Rho GTPase-activating protein 1

1

3

Small-scale

0.527

High

815705

OSTF1
Osteoclast-stimulating factor 1

1

5

Small-scale

0.527

High

815689

K1C40
Keratin, type I cytoskeletal 40

1

4

High-throughput

0.523

High

815693

TMC6
Transmembrane channel-like protein 6

1

0

High-throughput

0.513

High

63549

RIM3C
RIMS-binding protein 3C

1

1

Small-scale

0.501

High

124974

CACB4
Voltage-dependent L-type calcium channel subunit beta-4

1

1

Small-scale

0.501

High

167749

FYB1
FYN-binding protein 1

1

1

Small-scale

0.501

High

200208

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

1

3

Small-scale

0.501

High

235486

VINEX
Vinexin

1

4

Small-scale

0.501

High

269521

SKAP2
Src kinase-associated phosphoprotein 2

1

3

Small-scale

0.501

High

275179

GRAP2
GRB2-related adapter protein 2

1

14

Small-scale

0.501

High

303742

ZO3
Tight junction protein ZO-3

1

2

Small-scale

0.501

High

360624

SPTA1
Spectrin alpha chain, erythrocytic 1

1

1

Small-scale

0.501

High

411638

LCK
Tyrosine-protein kinase Lck

1

12

Small-scale

0.501

High

454807

FGR
Tyrosine-protein kinase Fgr

1

12

Small-scale

0.501

High

537608

NCF1
Neutrophil cytosol factor 1

1

8

Small-scale

0.501

High

655268

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

4

Small-scale

0.501

High

788978

TEC
Tyrosine-protein kinase Tec

1

12

Small-scale

0.501

High

802532

CRK
Adapter molecule crk

1

7

Small-scale

0.501

High

815673

BTK
Tyrosine-protein kinase BTK

1

12

Small-scale

0.501

High

815676

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

2

Small-scale

0.501

High

815678

GRAP
GRB2-related adapter protein

1

14

Small-scale

0.501

High

815684

DLG2
Disks large homolog 2

1

1

Small-scale

0.501

High

815700

ES8L3
Epidermal growth factor receptor kinase substrate 8-like protein 3

1

9

Small-scale

0.501

High

815701

SH3R2
E3 ubiquitin-protein ligase SH3RF2

1

8

Small-scale

0.501

High

815706

MPP4
MAGUK p55 subfamily member 4

1

1

Small-scale

0.501

High

815709

SH3G3
Endophilin-A3

1

4

Small-scale

0.501

High

815711

RHG09
Rho GTPase-activating protein 9

1

3

Small-scale

0.501

High

815713

SAMN1
SAM domain-containing protein SAMSN-1

1

1

Small-scale

0.501

High

815716

BI2L1
BAR/IMD domain-containing adapter protein 2-like 1

1

7

Small-scale

0.501

High

815717

MYO15
Unconventional myosin-XV

1

3

Small-scale

0.501

High

448877

MMP7
Matrilysin

1

0

Small-scale

0.480

High

815686

MIA
Melanoma-derived growth regulatory protein

1

0

Small-scale

0.480

High

815691

MACC1
Metastasis-associated in colon cancer protein 1

1

0

Small-scale

0.480

High

815698

DOCK4
Dedicator of cytokinesis protein 4

1

0

Small-scale

0.480

High

815715

SPN90
NCK-interacting protein with SH3 domain

1

0

Small-scale

0.480

High

181593

CFLAR
CASP8 and FADD-like apoptosis regulator

1

13

Small-scale

0.479

High

575325

EGR1
Early growth response protein 1

1

5

High-throughput

0.479

High

815675

EP300
Histone acetyltransferase p300

1

2

Small-scale

0.479

High

51059

SPD2B
SH3 and PX domain-containing protein 2B

1

10

Small-scale

0.457

High

815666

CACB3
Voltage-dependent L-type calcium channel subunit beta-3

1

1

Small-scale

0.457

High

815687

SPD2A
SH3 and PX domain-containing protein 2A

1

8

Small-scale

0.457

High

815690

DNMBP
Dynamin-binding protein

1

3

Small-scale

0.457

High

640063

MOES
Moesin

1

1

Small-scale

0.445

High

815668

BID
BH3-interacting domain death agonist

1

1

Small-scale

0.445

High

815670

RHOA
Transforming protein RhoA

1

1

Small-scale

0.445

High

815672

RHG04
Rho GTPase-activating protein 4

1

3

Small-scale

0.437

High

815703

SC65
Endoplasmic reticulum protein SC65

1

1

High-throughput

0.437

High

800719

MK08
Mitogen-activated protein kinase 8

1

0

Small-scale

0.426

High

815665

GDIR1
Rho GDP-dissociation inhibitor 1

1

0

Small-scale

0.426

High

3134

A0A0S2Z4D7
NCK adaptor protein 1 isoform 2

1

17

High-throughput

0.417

High

787188

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

Small-scale

0.391

High

815669

KR123
Keratin-associated protein 12-3

2

0

High-throughput

0.316

High

815695

KR111
Keratin-associated protein 11-1

2

0

High-throughput

0.316

High

815697

IHO1
Interactor of HORMAD1 protein 1

2

0

High-throughput

0.316

High

272420

TIPRL
TIP41-like protein

1

0

High-throughput

0.279

Low

282044

CLPX
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024