Protein: SHLD2
Shieldin complex subunit 2 (Protein FAM35A) (RINN1-REV7-interacting novel NHEJ regulator 2) (Shield complex subunit 2)

Gene: SHLD2
Organism: Homo sapiens
Interactions: 50
UniProt ID: Q86V20

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0002208 - somatic diversification of immunoglobulins involved in immune response
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005694 - chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1200840

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

6

0

Small-scale

0.705

High

1200830

SHLD1
Shieldin complex subunit 1

3

1

Small-scale

0.674

High

1200828

SHLD2
Shieldin complex subunit 2

2

0

Small-scale

0.559

High

886148

H2B1D
Histone H2B type 1-D

1

0

High-throughput

0.493

High

1019010

TP53B
TP53-binding protein 1

1

0

Small-scale

0.479

High

125900

CDC7
Cell division cycle 7-related protein kinase

1

1

High-throughput

0.479

High

801908

RECQ1
ATP-dependent DNA helicase Q1

1

2

High-throughput

0.479

High

1041940

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1043437

CUL4B
Cullin-4B

1

2

High-throughput

0.479

High

1050605

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

2

High-throughput

0.479

High

1200829

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

1

High-throughput

0.479

High

1200833

CUL5
Cullin-5

1

2

High-throughput

0.479

High

151500

CHD2
Chromodomain-helicase-DNA-binding protein 2

1

0

High-throughput

0.458

High

157217

BACH1
Transcription regulator protein BACH1

1

0

High-throughput

0.458

High

264215

CDC45
Cell division control protein 45 homolog

1

0

High-throughput

0.458

High

314652

PARN
Poly(A)-specific ribonuclease PARN

1

0

High-throughput

0.458

High

387024

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

453450

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

579473

DNLI1
DNA ligase 1

1

0

High-throughput

0.458

High

781564

CETN2
Centrin-2

1

0

High-throughput

0.458

High

847838

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.458

High

960105

CDK3
Cyclin-dependent kinase 3

1

0

High-throughput

0.458

High

1046818

TF2H3
General transcription factor IIH subunit 3

1

0

High-throughput

0.458

High

1052698

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

0

High-throughput

0.458

High

1053286

FA50A
Protein FAM50A

1

0

Small-scale

0.458

High

1056589

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

0

High-throughput

0.458

High

1082261

DDB1
DNA damage-binding protein 1

1

0

High-throughput

0.458

High

1184683

MCM10
Protein MCM10 homolog

1

0

High-throughput

0.458

High

1184897

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.458

High

1200831

TF2H4
General transcription factor IIH subunit 4

1

0

High-throughput

0.458

High

1200832

XPF
DNA repair endonuclease XPF

1

0

High-throughput

0.458

High

1200834

TONSL
Tonsoku-like protein

1

0

High-throughput

0.458

High

1200836

CSN4
COP9 signalosome complex subunit 4

1

0

High-throughput

0.458

High

1200837

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

1200838

BABA1
BRISC and BRCA1-A complex member 1

1

0

High-throughput

0.458

High

1200839

PARP2
Poly [ADP-ribose] polymerase 2

1

0

High-throughput

0.458

High

523854

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.445

High

524972

XRCC5
X-ray repair cross-complementing protein 5

1

1

Small-scale

0.445

High

867609

BLM
RecQ-like DNA helicase BLM

1

2

Small-scale

0.445

High

770914

TCPZ
T-complex protein 1 subunit zeta

1

1

High-throughput

0.437

High

1035334

TOP3A
DNA topoisomerase 3-alpha

1

0

Small-scale

0.426

High

1137522

RIF1
Telomere-associated protein RIF1

1

0

Small-scale

0.426

High

1169524

SHLD3
Shieldin complex subunit 3

1

0

High-throughput

0.426

High

965248

DEF5
Defensin alpha 5

2

0

High-throughput

0.328

High

1061977

T132D
Transmembrane protein 132D

1

0

Small-scale

0.251

Low

78311

EIFCL
Eukaryotic translation initiation factor 3 subunit C-like protein

1

0

Small-scale

0.249

Low

814487

SYQ
Glutamine--tRNA ligase

1

0

High-throughput

0.249

Low

867344

DPOG1
DNA polymerase subunit gamma-1

1

0

High-throughput

0.249

Low

1200835

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024