Protein: EIF3C
Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110)

Gene: EIF3C
Organism: Homo sapiens
Interactions: 211
UniProt ID: Q99613

Gene Ontology (top 5):
GO:0001732 - formation of cytoplasmic translation initiation complex
GO:0003723 - RNA binding
GO:0003743 - translation initiation factor activity
GO:0005829 - cytosol
GO:0005852 - eukaryotic translation initiation factor 3 complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

124931

EIF3F
Eukaryotic translation initiation factor 3 subunit F

8

6

Small-scale

0.968

High

177076

EIF3H
Eukaryotic translation initiation factor 3 subunit H

8

7

Small-scale

0.967

High

888428

EIF3E
Eukaryotic translation initiation factor 3 subunit E

8

4

Small-scale

0.965

High

1049629

EIF3A
Eukaryotic translation initiation factor 3 subunit A

7

5

Small-scale

0.960

High

1184145

EIF3M
Eukaryotic translation initiation factor 3 subunit M

6

3

Small-scale

0.944

High

176844

EIF3D
Eukaryotic translation initiation factor 3 subunit D

6

2

Small-scale

0.939

High

1305035

EIF3L
Eukaryotic translation initiation factor 3 subunit L

4

2

Small-scale

0.899

High

1305028

EIF3K
Eukaryotic translation initiation factor 3 subunit K

4

1

Small-scale

0.893

High

783588

EIF1
Eukaryotic translation initiation factor 1

2

3

Small-scale

0.777

High

122077

PSD12
26S proteasome non-ATPase regulatory subunit 12

2

0

High-throughput

0.770

High

275929

EIF3G
Eukaryotic translation initiation factor 3 subunit G

8

4

Small-scale

0.751

High

879327

EIF3B
Eukaryotic translation initiation factor 3 subunit B

6

7

Small-scale

0.735

High

1032144

EIF3I
Eukaryotic translation initiation factor 3 subunit I

5

3

High-throughput

0.718

High

78320

EIFCL
Eukaryotic translation initiation factor 3 subunit C-like protein

1

1

High-throughput

0.691

High

319983

HERC2
E3 ubiquitin-protein ligase HERC2

4

1

Small-scale

0.683

High

892881

IF4A1
Eukaryotic initiation factor 4A-I

3

3

High-throughput

0.667

High

934419

CSK21
Casein kinase II subunit alpha

3

9

High-throughput

0.667

High

979972

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

3

2

Small-scale

0.640

High

134181

DDX3X
ATP-dependent RNA helicase DDX3X

2

2

Small-scale

0.634

High

968210

OCRL
Inositol polyphosphate 5-phosphatase OCRL

2

1

High-throughput

0.628

High

586937

CSK22
Casein kinase II subunit alpha'

2

8

High-throughput

0.611

High

983222

UBE3A
Ubiquitin-protein ligase E3A

2

1

Small-scale

0.611

High

1064064

TNIP1
TNFAIP3-interacting protein 1

2

2

High-throughput

0.611

High

418579

NPM
Nucleophosmin

2

0

High-throughput

0.602

High

1085482

MK06
Mitogen-activated protein kinase 6

2

2

High-throughput

0.594

High

893594

SEM1
26S proteasome complex subunit SEM1

1

0

Small-scale

0.586

High

1085897

IF16
Gamma-interferon-inducible protein 16

2

0

High-throughput

0.585

High

1051905

IF4A2
Eukaryotic initiation factor 4A-II

2

3

High-throughput

0.584

High

370279

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

592455

RAB5A
Ras-related protein Rab-5A

2

1

High-throughput

0.571

High

276053

EIF3J
Eukaryotic translation initiation factor 3 subunit J

2

0

Small-scale

0.559

High

255191

ATG13
Autophagy-related protein 13

1

1

High-throughput

0.536

High

417021

IF4E
Eukaryotic translation initiation factor 4E

1

1

High-throughput

0.536

High

545896

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

1

High-throughput

0.536

High

654042

MAP4
Microtubule-associated protein 4

1

3

High-throughput

0.536

High

718133

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.536

High

780767

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

4

High-throughput

0.536

High

801334

KI67
Proliferation marker protein Ki-67

1

3

High-throughput

0.536

High

841000

MAP2
Methionine aminopeptidase 2

1

1

High-throughput

0.536

High

873870

IF5
Eukaryotic translation initiation factor 5

1

3

High-throughput

0.536

High

911487

RS11
Small ribosomal subunit protein uS17

1

1

High-throughput

0.536

High

929628

RACK1
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.536

High

1030436

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.536

High

1062387

CND2
Condensin complex subunit 2

1

1

High-throughput

0.536

High

1127680

PRC2B
Protein PRRC2B

1

6

High-throughput

0.536

High

1203332

GPBP1
Vasculin

1

1

High-throughput

0.536

High

1263514

PSPC1
Paraspeckle component 1

1

1

High-throughput

0.536

High

1305010

RBM42
RNA-binding protein 42

1

2

High-throughput

0.536

High

1305020

GPBL1
Vasculin-like protein 1

1

1

High-throughput

0.536

High

1305031

G3BP2
Ras GTPase-activating protein-binding protein 2

1

2

High-throughput

0.536

High

1305036

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.536

High

1161005

AAGAB
Alpha- and gamma-adaptin-binding protein p34

1

0

High-throughput

0.518

High

779972

CCNF
Cyclin-F

1

1

High-throughput

0.515

High

1305037

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

2

High-throughput

0.515

High

283590

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.513

High

447993

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

649687

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

806133

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

813700

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

828880

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

890368

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.513

High

908105

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

993284

ACTN3
Alpha-actinin-3

1

0

High-throughput

0.513

High

1075533

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.513

High

1221893

DDX60
Probable ATP-dependent RNA helicase DDX60

1

0

High-throughput

0.513

High

1268884

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.513

High

1304409

DNJC2
DnaJ homolog subfamily C member 2

1

0

High-throughput

0.513

High

1305030

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

850704

KS6A3
Ribosomal protein S6 kinase alpha-3

1

7

High-throughput

0.508

High

316974

KLF8
Krueppel-like factor 8

1

1

High-throughput

0.500

High

814112

IF1AX
Eukaryotic translation initiation factor 1A, X-chromosomal

1

0

Small-scale

0.494

High

1243368

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.489

High

1305022

ENY2
Transcription and mRNA export factor ENY2

1

1

High-throughput

0.489

High

1305038

EMC9
ER membrane protein complex subunit 9

1

1

High-throughput

0.489

High

171438

SMAD9
Mothers against decapentaplegic homolog 9

1

0

High-throughput

0.486

High

125667

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

High-throughput

0.479

High

163181

XPO1
Exportin-1

1

3

High-throughput

0.479

High

203406

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

2

High-throughput

0.479

High

228467

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

323043

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

455795

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

596810

CD11B
Cyclin-dependent kinase 11B

1

6

High-throughput

0.479

High

616727

KS6B1
Ribosomal protein S6 kinase beta-1

1

6

Small-scale

0.479

High

618699

IF4B
Eukaryotic translation initiation factor 4B

1

1

Small-scale

0.479

High

625574

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.479

High

668933

PML
Protein PML

1

2

High-throughput

0.479

High

787550

MTOR
Serine/threonine-protein kinase mTOR

1

1

Small-scale

0.479

High

807813

MAP1B
Microtubule-associated protein 1B

1

2

High-throughput

0.479

High

835965

GSK3B
Glycogen synthase kinase-3 beta

1

3

High-throughput

0.479

High

850166

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

2

High-throughput

0.479

High

870882

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.479

High

886180

H2B1D
Histone H2B type 1-D

1

2

High-throughput

0.479

High

893132

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

909001

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

918636

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.479

High

931812

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.479

High

944906

RED1
Double-stranded RNA-specific editase 1

1

2

High-throughput

0.479

High

974663

MECOM
Histone-lysine N-methyltransferase MECOM

1

1

High-throughput

0.479

High

999011

EP300
Histone acetyltransferase p300

1

4

High-throughput

0.479

High

1018657

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.479

High

1025924

TADBP
TAR DNA-binding protein 43

1

1

High-throughput

0.479

High

1029786

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

1038224

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

1

High-throughput

0.479

High

1042365

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1054530

RBM39
RNA-binding protein 39

1

1

High-throughput

0.479

High

1058280

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

3

Small-scale

0.479

High

1071687

KS6A2
Ribosomal protein S6 kinase alpha-2

1

7

High-throughput

0.479

High

1116483

LARP7
La-related protein 7

1

1

High-throughput

0.479

High

1146768

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

1199676

ZN598
E3 ubiquitin-protein ligase ZNF598

1

1

High-throughput

0.479

High

1201619

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.479

High

1230029

RPTOR
Regulatory-associated protein of mTOR

1

1

Small-scale

0.479

High

1243549

CSK23
Casein kinase II subunit alpha 3

1

9

High-throughput

0.479

High

1305009

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

3

High-throughput

0.479

High

1305012

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

4

High-throughput

0.479

High

1305019

PRD16
Histone-lysine N-methyltransferase PRDM16

1

1

High-throughput

0.479

High

1305021

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

1

High-throughput

0.479

High

1305034

HDAC5
Histone deacetylase 5

1

1

High-throughput

0.479

High

1305040

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.479

High

1305042

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.470

High

1305041

TACC3
Transforming acidic coiled-coil-containing protein 3

1

0

High-throughput

0.460

High

119492

LEG9
Galectin-9

1

0

High-throughput

0.458

High

122959

MEN1
Menin

1

0

High-throughput

0.458

High

224507

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

300246

PRP6
Pre-mRNA-processing factor 6

1

0

High-throughput

0.458

High

387374

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

684289

1433S
14-3-3 protein sigma

1

0

Small-scale

0.458

High

684974

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

782948

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.458

High

794093

MATR3
Matrin-3

1

0

High-throughput

0.458

High

829052

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

845196

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.458

High

1064632

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1071980

PCBP1
Poly(rC)-binding protein 1

1

0

Small-scale

0.458

High

1148749

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1184283

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1193160

SLN11
Schlafen family member 11

1

0

Small-scale

0.458

High

1200606

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1261402

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.458

High

1284026

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1289333

SPDLY
Protein Spindly

1

0

High-throughput

0.458

High

1305008

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

1305015

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

1305017

GAN
Gigaxonin

1

0

High-throughput

0.458

High

1305023

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1305024

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

1305029

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1305032

ANGE1
Protein angel homolog 1

1

0

High-throughput

0.458

High

976501

ERCC6
DNA excision repair protein ERCC-6

1

2

High-throughput

0.457

High

483266

TPC2A
Trafficking protein particle complex subunit 2

1

1

High-throughput

0.457

High

1305011

KLF16
Krueppel-like factor 16

1

1

High-throughput

0.457

High

374748

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.445

High

402384

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

497488

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

881007

IF6
Eukaryotic translation initiation factor 6

1

1

Small-scale

0.445

High

1305013

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

1

High-throughput

0.445

High

483339

TPC2B
Trafficking protein particle complex subunit 2B

1

1

High-throughput

0.439

High

719595

MERL
Merlin

1

0

Small-scale

0.438

High

1250995

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.438

High

244838

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.437

High

266419

TAD2A
Transcriptional adapter 2-alpha

1

1

High-throughput

0.437

High

295170

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.437

High

400103

ICAM1
Intercellular adhesion molecule 1

1

2

High-throughput

0.437

High

553522

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

832662

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.437

High

887932

CD81
CD81 antigen

1

1

High-throughput

0.437

High

935159

H31
Histone H3.1

1

1

High-throughput

0.437

High

1024507

CAF1A
Chromatin assembly factor 1 subunit A

1

1

Small-scale

0.437

High

1026520

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.437

High

1038246

4EBP2
Eukaryotic translation initiation factor 4E-binding protein 2

1

1

High-throughput

0.437

High

1059822

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.437

High

1116771

DUS28
Dual specificity phosphatase 28

1

1

High-throughput

0.437

High

1171388

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1281775

IGSF8
Immunoglobulin superfamily member 8

1

1

High-throughput

0.437

High

1282950

H2B1A
Histone H2B type 1-A

1

2

High-throughput

0.437

High

1300912

CIC
Protein capicua homolog

1

1

High-throughput

0.437

High

1305026

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.437

High

1305033

CD11A
Cyclin-dependent kinase 11A

1

6

High-throughput

0.437

High

532596

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.426

High

1075733

SF01
Splicing factor 1

1

0

High-throughput

0.426

High

581832

VCAM1
Vascular cell adhesion protein 1

1

1

High-throughput

0.407

High

1305016

RSPH9
Radial spoke head protein 9 homolog

2

0

High-throughput

0.318

High

1305018

PKHF2
Pleckstrin homology domain-containing family F member 2

2

0

High-throughput

0.316

High

1295574

NEUL4
Neuralized-like protein 4

2

0

High-throughput

0.313

High

234572

DSCAM
Cell adhesion molecule DSCAM

1

0

High-throughput

0.282

High

1051189

BTG3
Protein BTG3

1

0

High-throughput

0.282

High

380329

HG2A
HLA class II histocompatibility antigen gamma chain

1

0

High-throughput

0.279

Low

452860

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1024830

DUS4
Dual specificity protein phosphatase 4

1

0

High-throughput

0.279

Low

1305039

MB212
Protein mab-21-like 2

1

0

High-throughput

0.279

Low

246028

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.265

Low

674238

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.265

Low

1305027

ALKB4
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

1

0

Small-scale

0.265

Low

233605

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

303438

HEXI1
Protein HEXIM1

1

0

High-throughput

0.249

Low

347692

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

353304

CD4
T-cell surface glycoprotein CD4

1

0

Small-scale

0.249

Low

385406

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

569996

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.249

Low

652054

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

721249

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

903459

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

981916

RON
Macrophage-stimulating protein receptor

1

0

High-throughput

0.249

Low

1080270

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

1188770

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1231316

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

1239315

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

1256354

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

1305014

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

1305043

PCLO
Protein piccolo

1

0

High-throughput

0.249

Low

1305025

NUA4L
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024