Protein: PAK2
Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)]

Gene: PAK2
Organism: Homo sapiens
Interactions: 179
UniProt ID: Q13177

Gene Ontology (top 5):
GO:0002223 - stimulatory C-type lectin receptor signaling pathway
GO:0003300 - cardiac muscle hypertrophy
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

893958

CDC42
Cell division control protein 42 homolog

12

20

Small-scale

0.980

High

1026910

ARHG6
Rho guanine nucleotide exchange factor 6

9

16

Small-scale

0.973

High

1026904

ARHG7
Rho guanine nucleotide exchange factor 7

7

19

Small-scale

0.970

High

1026945

RHOJ
Rho-related GTP-binding protein RhoJ

7

20

High-throughput

0.968

High

925245

RAC1
Ras-related C3 botulinum toxin substrate 1

7

20

Small-scale

0.965

High

1026898

PAK2
Serine/threonine-protein kinase PAK 2

5

18

Small-scale

0.931

High

1026957

GIT1
ARF GTPase-activating protein GIT1

5

13

Small-scale

0.922

High

1026149

PAK1
Serine/threonine-protein kinase PAK 1

5

19

High-throughput

0.919

High

1026943

FSD1
Fibronectin type III and SPRY domain-containing protein 1

3

18

High-throughput

0.861

High

1026952

PLK2
Serine/threonine-protein kinase PLK2

3

17

High-throughput

0.861

High

1026906

GIT2
ARF GTPase-activating protein GIT2

3

12

High-throughput

0.855

High

374158

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

20

Small-scale

0.818

High

1026925

RHOU
Rho-related GTP-binding protein RhoU

2

20

High-throughput

0.789

High

545351

RAC2
Ras-related C3 botulinum toxin substrate 2

2

20

Small-scale

0.768

High

227338

PRKN
E3 ubiquitin-protein ligase parkin

2

14

High-throughput

0.754

High

915646

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

442822

HCK
Tyrosine-protein kinase HCK

1

18

Small-scale

0.747

High

522955

SRC
Proto-oncogene tyrosine-protein kinase Src

1

19

Small-scale

0.747

High

209045

NCK2
Cytoplasmic protein NCK2

6

20

High-throughput

0.736

High

863767

LIMK1
LIM domain kinase 1

1

20

Small-scale

0.735

High

337457

ABL1
Tyrosine-protein kinase ABL1

1

18

Small-scale

0.724

High

557677

NCK1
SH2/SH3 adapter protein NCK1

5

20

Small-scale

0.716

High

542873

BRAF
Serine/threonine-protein kinase B-raf

1

17

High-throughput

0.698

High

974063

DYST
Dystonin

1

11

High-throughput

0.698

High

678553

MK04
Mitogen-activated protein kinase 4

1

7

High-throughput

0.691

High

834938

RGS4
Regulator of G-protein signaling 4

1

2

High-throughput

0.691

High

872434

EPHA5
Ephrin type-A receptor 5

1

16

High-throughput

0.691

High

235500

VINEX
Vinexin

3

20

Small-scale

0.689

High

234071

O10H3
Olfactory receptor 10H3

3

1

High-throughput

0.667

High

818004

SOX2
Transcription factor SOX-2

3

8

High-throughput

0.667

High

411702

LCK
Tyrosine-protein kinase Lck

1

18

Small-scale

0.647

High

501106

MLRV
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

1

5

Small-scale

0.647

High

728603

PPM1A
Protein phosphatase 1A

1

11

Small-scale

0.647

High

992572

ACK1
Activated CDC42 kinase 1

1

20

Small-scale

0.647

High

1026915

MYLK
Myosin light chain kinase, smooth muscle

1

3

Small-scale

0.647

High

1026949

FBX28
F-box only protein 28

4

1

High-throughput

0.643

High

823382

PAXI
Paxillin

3

12

High-throughput

0.633

High

346682

MYC
Myc proto-oncogene protein

2

4

Small-scale

0.629

High

238960

LPXN
Leupaxin

2

7

High-throughput

0.628

High

361864

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

7

High-throughput

0.628

High

400062

ICAM1
Intercellular adhesion molecule 1

2

3

High-throughput

0.628

High

1026905

SCRIB
Protein scribble homolog

2

5

High-throughput

0.628

High

1026932

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

2

High-throughput

0.628

High

1026934

KIFA3
Kinesin-associated protein 3

2

5

High-throughput

0.628

High

338361

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

350133

RASK
GTPase KRas

1

12

High-throughput

0.618

High

384764

NTRK1
High affinity nerve growth factor receptor

1

13

High-throughput

0.618

High

412169

FYN
Tyrosine-protein kinase Fyn

1

18

Small-scale

0.618

High

433338

YES
Tyrosine-protein kinase Yes

1

18

Small-scale

0.618

High

433740

LYN
Tyrosine-protein kinase Lyn

1

19

Small-scale

0.618

High

436282

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

507976

FGFR1
Fibroblast growth factor receptor 1

1

11

High-throughput

0.618

High

564507

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

607955

FGFR4
Fibroblast growth factor receptor 4

1

11

High-throughput

0.618

High

796560

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

835716

GSK3B
Glycogen synthase kinase-3 beta

1

18

High-throughput

0.618

High

892346

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

897884

RAP1B
Ras-related protein Rap-1b

1

20

High-throughput

0.618

High

900433

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

950964

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1026911

KIF14
Kinesin-like protein KIF14

1

10

High-throughput

0.618

High

1026914

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1026916

MK14
Mitogen-activated protein kinase 14

1

14

Small-scale

0.618

High

1026918

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

7

High-throughput

0.618

High

1026923

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.618

High

1026939

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.618

High

1026946

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1026947

TLR9
Toll-like receptor 9

1

2

Small-scale

0.618

High

1026951

ABI2
Abl interactor 2

2

20

High-throughput

0.606

High

1026907

SRC8
Src substrate cortactin

2

17

Small-scale

0.602

High

968135

OCRL
Inositol polyphosphate 5-phosphatase OCRL

2

0

High-throughput

0.602

High

876941

CASP7
Caspase-7

1

6

Small-scale

0.578

High

81635

B7Z6G2
cDNA FLJ56152, highly similar to Rho guanine nucleotide exchange factor 7

1

19

High-throughput

0.575

High

1026903

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

20

High-throughput

0.575

High

1026936

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

Small-scale

0.561

High

496951

TAU
Microtubule-associated protein tau

2

12

High-throughput

0.552

High

998640

EP300
Histone acetyltransferase p300

1

7

High-throughput

0.541

High

158097

TX1B3
Tax1-binding protein 3

1

13

High-throughput

0.536

High

262806

CISY
Citrate synthase, mitochondrial

1

2

High-throughput

0.536

High

597732

VATC1
V-type proton ATPase subunit C 1

1

1

High-throughput

0.536

High

871553

HSP72
Heat shock-related 70 kDa protein 2

1

9

High-throughput

0.536

High

873538

SNAA
Alpha-soluble NSF attachment protein

1

1

High-throughput

0.536

High

877260

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

5

High-throughput

0.536

High

904516

1433G
14-3-3 protein gamma

1

20

High-throughput

0.536

High

928086

SUMO1
Small ubiquitin-related modifier 1

1

3

High-throughput

0.536

High

928894

SKP1
S-phase kinase-associated protein 1

1

3

High-throughput

0.536

High

1026912

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.536

High

1026913

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

11

High-throughput

0.536

High

1026926

SETX
Probable helicase senataxin

1

3

High-throughput

0.536

High

1026938

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

7

High-throughput

0.536

High

1026942

BUD13
BUD13 homolog

1

3

High-throughput

0.536

High

1026931

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

20

Small-scale

0.528

High

298975

SRBS2
Sorbin and SH3 domain-containing protein 2

1

20

Small-scale

0.515

High

502047

BIP
Endoplasmic reticulum chaperone BiP

1

14

Small-scale

0.515

High

627253

MCM3
DNA replication licensing factor MCM3

1

6

High-throughput

0.515

High

725152

MYH10
Myosin-10

1

20

High-throughput

0.515

High

924538

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.515

High

1026944

SRBS1
Sorbin and SH3 domain-containing protein 1

1

20

Small-scale

0.515

High

951860

SERF2
Small EDRK-rich factor 2

1

0

High-throughput

0.513

High

1026917

ECM1
Extracellular matrix protein 1

1

0

High-throughput

0.513

High

174843

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

10

High-throughput

0.501

High

394647

A4
Amyloid-beta precursor protein

1

9

High-throughput

0.501

High

719472

MERL
Merlin

1

6

Small-scale

0.501

High

788189

CASP3
Caspase-3

1

6

Small-scale

0.501

High

844338

GRAM
Granzyme M

1

4

Small-scale

0.501

High

917204

H4
Histone H4

1

5

Small-scale

0.501

High

1026933

DOCK2
Dedicator of cytokinesis protein 2

1

2

Small-scale

0.501

High

1026953

ABI3
ABI gene family member 3

1

16

Small-scale

0.501

High

1026920

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.489

High

1026950

CARF
CDKN2A-interacting protein

1

1

High-throughput

0.489

High

152960

RIOK3
Serine/threonine-protein kinase RIO3

1

3

High-throughput

0.481

High

123581

PGRC1
Membrane-associated progesterone receptor component 1

1

1

High-throughput

0.479

High

244376

BRD4
Bromodomain-containing protein 4

1

6

High-throughput

0.479

High

322559

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.479

High

416977

IF4E
Eukaryotic translation initiation factor 4E

1

1

High-throughput

0.479

High

423217

PDIA1
Protein disulfide-isomerase

1

2

High-throughput

0.479

High

427547

ANXA2
Annexin A2

1

7

High-throughput

0.479

High

521904

CADH1
Cadherin-1

1

6

High-throughput

0.479

High

552625

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

569673

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

597502

GSTM3
Glutathione S-transferase Mu 3

1

3

High-throughput

0.479

High

617843

SAHH
Adenosylhomocysteinase

1

3

High-throughput

0.479

High

637406

PSA1
Proteasome subunit alpha type-1

1

3

High-throughput

0.479

High

637678

PSA2
Proteasome subunit alpha type-2

1

6

High-throughput

0.479

High

651098

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.479

High

652841

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

High-throughput

0.479

High

653578

CALR
Calreticulin

1

1

High-throughput

0.479

High

668646

PML
Protein PML

1

12

High-throughput

0.479

High

671651

PEBP1
Phosphatidylethanolamine-binding protein 1

1

3

High-throughput

0.479

High

791526

HD
Huntingtin

1

4

Small-scale

0.479

High

808570

YAP1
Transcriptional coactivator YAP1

1

15

High-throughput

0.479

High

873029

KAD2
Adenylate kinase 2, mitochondrial

1

3

High-throughput

0.479

High

882276

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

7

High-throughput

0.479

High

905867

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

17

Small-scale

0.479

High

906441

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

17

Small-scale

0.479

High

916170

RL23A
Large ribosomal subunit protein uL23

1

2

High-throughput

0.479

High

922817

RL32
Large ribosomal subunit protein eL32

1

1

High-throughput

0.479

High

949456

RL24
Large ribosomal subunit protein eL24

1

2

High-throughput

0.479

High

958669

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

3

High-throughput

0.479

High

979887

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

3

High-throughput

0.479

High

1016161

FOXO1
Forkhead box protein O1

1

10

High-throughput

0.479

High

1024320

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

5

High-throughput

0.479

High

1026394

RFA4
Replication protein A 30 kDa subunit

1

7

High-throughput

0.479

High

1026899

TIF1B
Transcription intermediary factor 1-beta

1

13

High-throughput

0.479

High

1026900

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

2

High-throughput

0.479

High

1026901

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

2

High-throughput

0.479

High

1026902

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

High-throughput

0.479

High

1026909

SEPT2
Septin-2

1

2

High-throughput

0.479

High

1026922

SPD2A
SH3 and PX domain-containing protein 2A

1

20

Small-scale

0.479

High

1026924

MOB3C
MOB kinase activator 3C

1

12

High-throughput

0.479

High

1026927

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.479

High

1026928

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

20

Small-scale

0.479

High

1026929

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1026935

FBX32
F-box only protein 32

1

2

High-throughput

0.479

High

1026937

OPTN
Optineurin

1

20

High-throughput

0.479

High

1026940

SCLT1
Sodium channel and clathrin linker 1

1

20

High-throughput

0.479

High

1026941

PSB7
Proteasome subunit beta type-7

1

2

High-throughput

0.479

High

1026954

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1026955

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

3

High-throughput

0.479

High

1026956

NUDC
Nuclear migration protein nudC

1

1

High-throughput

0.479

High

268981

CSDE1
Cold shock domain-containing protein E1

1

0

High-throughput

0.458

High

337229

AATM
Aspartate aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

590884

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

603158

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

High-throughput

0.458

High

623738

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

0

High-throughput

0.458

High

838632

GDIB
Rab GDP dissociation inhibitor beta

1

0

High-throughput

0.458

High

1026919

FSCN1
Fascin

1

0

High-throughput

0.458

High

1026948

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

378446

SODM
Superoxide dismutase [Mn], mitochondrial

1

1

High-throughput

0.437

High

671441

ECHM
Enoyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.437

High

720363

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

823955

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.437

High

1026908

GANAB
Neutral alpha-glucosidase AB

1

1

High-throughput

0.437

High

886278

DSCR9
Down syndrome critical region protein 9

1

1

High-throughput

0.417

High

831283

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

1026921

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

0

High-throughput

0.279

Low

1026930

FA24B
Protein FAM24B

1

0

High-throughput

0.279

Low

351692

PRL
Prolactin

1

0

Small-scale

0.261

Low


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Last updated: 15 Jul 2024