Protein: ACTN2
Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)

Gene: ACTN2
Organism: Homo sapiens
Interactions: 138
UniProt ID: P35609

Gene Ontology (top 5):
GO:0005178 - integrin binding
GO:0005509 - calcium ion binding
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005576 - extracellular region
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

725681

TITIN
Titin

5

19

Small-scale

0.929

High

725624

ACTN2
Alpha-actinin-2

5

13

Small-scale

0.923

High

725674

MILK2
MICAL-like protein 2

4

15

High-throughput

0.901

High

608262

KCNA5
Potassium voltage-gated channel subfamily A member 5

3

2

Small-scale

0.884

High

725702

MYOZ2
Myozenin-2

3

6

High-throughput

0.881

High

667664

NOS3
Nitric oxide synthase 3

2

2

Small-scale

0.762

High

725648

ACTN3
Alpha-actinin-3

1

13

Small-scale

0.747

High

521485

ACTN1
Alpha-actinin-1

1

13

High-throughput

0.740

High

725638

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

7

High-throughput

0.740

High

608218

KCNA4
Potassium voltage-gated channel subfamily A member 4

1

2

Small-scale

0.713

High

725695

KCNN2
Small conductance calcium-activated potassium channel protein 2

1

2

Small-scale

0.713

High

725701

MYOZ1
Myozenin-1

1

6

Small-scale

0.713

High

725662

PDLI3
PDZ and LIM domain protein 3

4

20

High-throughput

0.710

High

339227

MOS
Proto-oncogene serine/threonine-protein kinase mos

1

0

High-throughput

0.702

High

725658

SP17
Sperm surface protein Sp17

1

0

High-throughput

0.702

High

725635

MYOM2
Myomesin-2

1

16

High-throughput

0.698

High

725653

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

3

High-throughput

0.698

High

725655

MYPC2
Myosin-binding protein C, fast-type

1

14

High-throughput

0.698

High

725693

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

19

High-throughput

0.698

High

326478

SNAI1
Zinc finger protein SNAI1

4

4

High-throughput

0.698

High

117257

PDLI1
PDZ and LIM domain protein 1

4

20

Small-scale

0.695

High

617250

SP100
Nuclear autoantigen Sp-100

3

5

High-throughput

0.683

High

725676

SAXO1
Stabilizer of axonemal microtubules 1

3

0

High-throughput

0.654

High

725715

TENN
Tenascin-N

1

8

Small-scale

0.647

High

725656

RTP5
Receptor-transporting protein 5

4

1

High-throughput

0.637

High

725706

DISC1
Disrupted in schizophrenia 1 protein

2

4

Small-scale

0.628

High

725666

MAST2
Microtubule-associated serine/threonine-protein kinase 2

1

1

High-throughput

0.625

High

725632

CSRP3
Cysteine and glycine-rich protein 3

2

15

Small-scale

0.624

High

427855

CAN1
Calpain-1 catalytic subunit

1

2

Small-scale

0.621

High

725645

CAC1D
Voltage-dependent L-type calcium channel subunit alpha-1D

1

3

Small-scale

0.621

High

725643

DLG4
Disks large homolog 4

2

13

Small-scale

0.619

High

148463

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.618

High

725685

IGSF8
Immunoglobulin superfamily member 8

1

10

High-throughput

0.618

High

68630

CMA1B
Ciliary microtubule associated protein 1B

2

1

High-throughput

0.606

High

637340

PSA1
Proteasome subunit alpha type-1

2

1

High-throughput

0.606

High

725700

SYP2L
Synaptopodin 2-like protein

2

20

High-throughput

0.606

High

725661

ZC21C
Zinc finger C2HC domain-containing protein 1C

3

1

High-throughput

0.597

High

725642

TBA4A
Tubulin alpha-4A chain

1

2

High-throughput

0.590

High

725665

FXL22
F-box and leucine-rich protein 22

1

1

Small-scale

0.586

High

725637

ACTB
Actin, cytoplasmic 1

1

11

Small-scale

0.584

High

725684

BAD
Bcl2-associated agonist of cell death

2

0

High-throughput

0.580

High

725687

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

725667

CDC73
Parafibromin

1

3

Small-scale

0.573

High

215838

ANGL7
Angiopoietin-related protein 7

1

1

High-throughput

0.573

High

725639

H4
Histone H4

1

1

High-throughput

0.573

High

725641

RACK1
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.573

High

310910

SNAPN
SNARE-associated protein Snapin

1

3

High-throughput

0.568

High

371373

ANGI
Angiogenin

1

0

Small-scale

0.561

High

197591

ADA12
Disintegrin and metalloproteinase domain-containing protein 12

1

1

Small-scale

0.561

High

271040

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

4

High-throughput

0.553

High

656944

5HT1B
5-hydroxytryptamine receptor 1B

2

1

High-throughput

0.553

High

725668

NKAP1
Uncharacterized protein NKAPD1

2

2

High-throughput

0.553

High

277784

RGS9
Regulator of G-protein signaling 9

1

5

Small-scale

0.552

High

725672

NRAP
Nebulin-related-anchoring protein

1

8

Small-scale

0.550

High

645789

CD27
CD27 antigen

1

0

High-throughput

0.549

High

666441

RABP2
Cellular retinoic acid-binding protein 2

1

0

High-throughput

0.549

High

675608

GSTT1
Glutathione S-transferase theta-1

1

0

High-throughput

0.549

High

725628

SYQ
Glutamine--tRNA ligase

1

0

High-throughput

0.549

High

725630

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.549

High

725644

CRADD
Death domain-containing protein CRADD

1

0

High-throughput

0.549

High

725669

GOGA7
Golgin subfamily A member 7

1

0

High-throughput

0.549

High

725694

TOLIP
Toll-interacting protein

1

0

High-throughput

0.549

High

277823

DYSF
Dysferlin

1

0

High-throughput

0.543

High

262380

TULP3
Tubby-related protein 3

1

1

High-throughput

0.541

High

388265

HSPB1
Heat shock protein beta-1

1

8

High-throughput

0.541

High

725631

TSC2
Tuberin

1

1

High-throughput

0.541

High

725633

FXR1
RNA-binding protein FXR1

1

4

High-throughput

0.541

High

725682

TSC1
Hamartin

1

19

High-throughput

0.541

High

725709

MYOTI
Myotilin

1

13

High-throughput

0.541

High

528678

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.536

High

725711

HSPB8
Heat shock protein beta-8

1

8

High-throughput

0.536

High

725690

ERBIN
Erbin

1

5

Small-scale

0.527

High

725675

KATL2
Katanin p60 ATPase-containing subunit A-like 2

1

7

High-throughput

0.523

High

725679

DYT2B
Dynein light chain Tctex-type protein 2B

1

2

High-throughput

0.523

High

725680

CLC4D
C-type lectin domain family 4 member D

1

7

High-throughput

0.523

High

725626

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.518

High

725712

DP13A
DCC-interacting protein 13-alpha

1

0

High-throughput

0.518

High

725660

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.515

High

607600

NDKB
Nucleoside diphosphate kinase B

1

0

High-throughput

0.513

High

173940

ATX7
Ataxin-7

1

6

High-throughput

0.508

High

725625

COIL
Coilin

1

2

High-throughput

0.508

High

725692

ATX2
Ataxin-2

1

6

High-throughput

0.508

High

725691

NEB2
Neurabin-2

1

20

Small-scale

0.501

High

725714

SYNP2
Synaptopodin-2

1

20

Small-scale

0.501

High

725634

SMCA2
Probable global transcription activator SNF2L2

1

2

High-throughput

0.494

High

725689

ARX
Homeobox protein ARX

1

3

High-throughput

0.494

High

725698

AKTIP
AKT-interacting protein

1

1

High-throughput

0.494

High

725708

ZN446
Zinc finger protein 446

1

2

High-throughput

0.494

High

725710

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

1

High-throughput

0.494

High

725636

SUMO3
Small ubiquitin-related modifier 3

1

7

High-throughput

0.489

High

225350

MED14
Mediator of RNA polymerase II transcription subunit 14

1

1

High-throughput

0.481

High

254385

LDB3
LIM domain-binding protein 3

1

15

Small-scale

0.481

High

725629

NRIP1
Nuclear receptor-interacting protein 1

1

2

High-throughput

0.481

High

725650

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

9

Small-scale

0.481

High

725671

MYPN
Myopalladin

1

18

Small-scale

0.481

High

725683

KAT2B
Histone acetyltransferase KAT2B

1

4

High-throughput

0.481

High

129708

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

6

High-throughput

0.479

High

209717

PRC1
Protein regulator of cytokinesis 1

1

11

High-throughput

0.479

High

637791

PSA3
Proteasome subunit alpha type-3

1

1

Small-scale

0.479

High

646682

1433T
14-3-3 protein theta

1

12

High-throughput

0.479

High

725627

HD
Huntingtin

1

3

Small-scale

0.479

High

725646

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

9

Small-scale

0.479

High

725649

DLG1
Disks large homolog 1

1

13

Small-scale

0.479

High

725654

SCRIB
Protein scribble homolog

1

10

Small-scale

0.479

High

725657

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

725677

ABI1
Abl interactor 1

1

5

High-throughput

0.479

High

725686

CHM4C
Charged multivesicular body protein 4c

1

15

High-throughput

0.479

High

725696

CHM4B
Charged multivesicular body protein 4b

1

15

High-throughput

0.479

High

725697

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.479

High

725699

ECT2
Protein ECT2

1

8

High-throughput

0.479

High

725703

ANLN
Anillin

1

7

High-throughput

0.479

High

111238

J3KMY6
Zinc finger C2HC-type containing 1C

1

1

High-throughput

0.470

High

725651

CENPR
Centromere protein R

1

0

High-throughput

0.460

High

725664

CNDH2
Condensin-2 complex subunit H2

1

0

High-throughput

0.460

High

725713

PSME2
Proteasome activator complex subunit 2

1

0

High-throughput

0.458

High

725659

ZYX
Zyxin

1

7

Small-scale

0.457

High

725640

1433Z
14-3-3 protein zeta/delta

1

12

High-throughput

0.445

High

725704

PDLI7
PDZ and LIM domain protein 7

1

20

High-throughput

0.445

High

265854

NR1I2
Nuclear receptor subfamily 1 group I member 2

1

7

High-throughput

0.439

High

725652

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.439

High

725688

DUX5
Double homeobox protein 5

1

7

High-throughput

0.439

High

725707

EXOC1
Exocyst complex component 1

1

0

High-throughput

0.438

High

308454

KI20A
Kinesin-like protein KIF20A

1

16

High-throughput

0.437

High

3283

A0A0S2Z4Y0
Myotilin isoform 2

1

7

High-throughput

0.417

High

215072

DUX1
Double homeobox protein 1

1

6

High-throughput

0.417

High

725717

LRP12
Low-density lipoprotein receptor-related protein 12

1

3

Small-scale

0.417

High

725663

BRM1L
Breast cancer metastasis-suppressor 1-like protein

4

0

High-throughput

0.364

High

303788

RPP14
Ribonuclease P protein subunit p14

2

0

High-throughput

0.316

High

725673

Q8IVT4
Hypothetical MGC50722

2

0

High-throughput

0.316

High

725678

CNNM3
Metal transporter CNNM3

2

0

High-throughput

0.316

High

224903

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.299

High

403478

AT5G1
ATP synthase F(0) complex subunit C1, mitochondrial

1

0

High-throughput

0.299

High

620458

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

0

High-throughput

0.299

High

725670

RM10
Large ribosomal subunit protein uL10m

1

0

High-throughput

0.299

High

725716

FA50B
Protein FAM50B

1

0

High-throughput

0.299

High

725705

ST7
Suppressor of tumorigenicity 7 protein

1

0

Small-scale

0.251

Low

725647

KDSR
3-ketodihydrosphingosine reductase

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024