Protein: SYMPK
Symplekin

Gene: SYMPK
Organism: Homo sapiens
Interactions: 172
UniProt ID: Q92797

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex
GO:0005856 - cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1271068

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

2

3

Small-scale

0.834

High

1271078

CPSF2
Cleavage and polyadenylation specificity factor subunit 2

7

7

Small-scale

0.746

High

703425

CSTF2
Cleavage stimulation factor subunit 2

5

3

Small-scale

0.721

High

1271081

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

5

8

Small-scale

0.716

High

317848

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

4

2

High-throughput

0.699

High

1271059

WDR33
pre-mRNA 3' end processing protein WDR33

4

1

Small-scale

0.683

High

726338

BASI
Basigin

3

1

High-throughput

0.667

High

1271061

CSTFT
Cleavage stimulation factor subunit 2 tau variant

3

3

High-throughput

0.667

High

1271055

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

4

0

Small-scale

0.667

High

1014177

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

3

2

High-throughput

0.656

High

274120

XRP2
Protein XRP2

3

0

High-throughput

0.638

High

310332

LYPD3
Ly6/PLAUR domain-containing protein 3

3

0

High-throughput

0.638

High

1271053

KLDC3
Kelch domain-containing protein 3

3

0

High-throughput

0.638

High

1022300

CSTF3
Cleavage stimulation factor subunit 3

2

1

High-throughput

0.611

High

1084555

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

2

1

High-throughput

0.611

High

1164857

FIP1
Pre-mRNA 3'-end-processing factor FIP1

2

1

High-throughput

0.611

High

1237304

SIGL1
SIGLEC family-like protein 1

2

0

High-throughput

0.602

High

1271076

WWOX
WW domain-containing oxidoreductase

2

0

High-throughput

0.582

High

508641

TOP1
DNA topoisomerase 1

2

0

Small-scale

0.577

High

553337

RFA2
Replication protein A 32 kDa subunit

2

0

High-throughput

0.559

High

651849

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

0

High-throughput

0.559

High

668874

PML
Protein PML

2

0

High-throughput

0.559

High

684930

STIP1
Stress-induced-phosphoprotein 1

2

0

High-throughput

0.559

High

721066

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.559

High

1251877

RIN3
Ras and Rab interactor 3

2

0

High-throughput

0.551

High

1271054

TRI55
Tripartite motif-containing protein 55

1

2

High-throughput

0.541

High

563163

YBOX3
Y-box-binding protein 3

1

0

Small-scale

0.537

High

1270857

KAT6A
Histone acetyltransferase KAT6A

1

0

Small-scale

0.537

High

172157

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.536

High

180071

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

1

High-throughput

0.536

High

416671

S10A6
Protein S100-A6

1

1

High-throughput

0.536

High

446725

SNRPA
U1 small nuclear ribonucleoprotein A

1

1

High-throughput

0.536

High

877629

FOXG1
Forkhead box protein G1

1

4

High-throughput

0.536

High

1236416

SIR6
NAD-dependent protein deacylase sirtuin-6

1

1

High-throughput

0.536

High

1271050

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

1271058

SEM4C
Semaphorin-4C

1

1

High-throughput

0.536

High

1271064

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

1

1

Small-scale

0.536

High

263763

PR40A
Pre-mRNA-processing factor 40 homolog A

1

1

High-throughput

0.515

High

149898

RFXK
DNA-binding protein RFXANK

1

0

High-throughput

0.513

High

258132

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.513

High

264729

VP26A
Vacuolar protein sorting-associated protein 26A

1

0

High-throughput

0.513

High

278648

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.513

High

319019

CEP43
Centrosomal protein 43

1

0

High-throughput

0.513

High

362259

GLPA
Glycophorin-A

1

0

High-throughput

0.513

High

363246

FINC
Fibronectin

1

0

High-throughput

0.513

High

423316

PDIA1
Protein disulfide-isomerase

1

0

High-throughput

0.513

High

539081

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

574400

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

597527

GSTM3
Glutathione S-transferase Mu 3

1

0

High-throughput

0.513

High

647644

MK03
Mitogen-activated protein kinase 3

1

0

High-throughput

0.513

High

726965

FUS
RNA-binding protein FUS

1

0

High-throughput

0.513

High

856437

EFNA4
Ephrin-A4

1

0

High-throughput

0.513

High

895695

CXCR4
C-X-C chemokine receptor type 4

1

0

High-throughput

0.513

High

975459

PPARD
Peroxisome proliferator-activated receptor delta

1

0

High-throughput

0.513

High

996806

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

1039733

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

1076380

IKBB
NF-kappa-B inhibitor beta

1

0

High-throughput

0.513

High

1159690

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.513

High

1159991

KLC3
Kinesin light chain 3

1

0

High-throughput

0.513

High

1221970

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.513

High

1240899

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

1271046

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1271047

ELMO3
Engulfment and cell motility protein 3

1

0

High-throughput

0.513

High

1271049

RBM14
RNA-binding protein 14

1

0

High-throughput

0.513

High

1271056

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1271067

MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

1

0

High-throughput

0.513

High

1271083

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

0

High-throughput

0.513

High

1271090

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

961221

HSF1
Heat shock factor protein 1

1

0

Small-scale

0.504

High

843553

PAPOA
Poly(A) polymerase alpha

1

2

Small-scale

0.500

High

336568

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.493

High

527681

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.493

High

742443

SYUA
Alpha-synuclein

1

0

High-throughput

0.493

High

791824

HD
Huntingtin

1

0

High-throughput

0.493

High

877111

CASP6
Caspase-6

1

0

High-throughput

0.493

High

919196

RAN
GTP-binding nuclear protein Ran

1

0

High-throughput

0.493

High

958493

CYC
Cytochrome c

1

0

High-throughput

0.493

High

1025881

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.493

High

126470

FOXE1
Forkhead box protein E1

1

3

High-throughput

0.489

High

270823

FOXH1
Forkhead box protein H1

1

5

High-throughput

0.489

High

532182

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

1

High-throughput

0.489

High

661376

S10A2
Protein S100-A2

1

1

High-throughput

0.489

High

1021332

FOXL1
Forkhead box protein L1

1

4

High-throughput

0.489

High

1169829

FOXI2
Forkhead box protein I2

1

3

High-throughput

0.489

High

1271052

FOXB1
Forkhead box protein B1

1

5

High-throughput

0.489

High

1271057

FOXQ1
Forkhead box protein Q1

1

5

High-throughput

0.489

High

1271088

WIF1
Wnt inhibitory factor 1

1

1

High-throughput

0.489

High

1271089

NPTN
Neuroplastin

1

1

High-throughput

0.489

High

1271045

TRI63
E3 ubiquitin-protein ligase TRIM63

1

2

High-throughput

0.481

High

902697

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

930328

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.480

High

1158297

CDC73
Parafibromin

1

0

Small-scale

0.479

High

118772

AIP
AH receptor-interacting protein

1

2

High-throughput

0.479

High

300440

PCF11
Pre-mRNA cleavage complex 2 protein Pcf11

1

1

High-throughput

0.479

High

442359

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

4

High-throughput

0.479

High

486943

MYBB
Myb-related protein B

1

1

High-throughput

0.479

High

487637

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

808815

YAP1
Transcriptional coactivator YAP1

1

1

High-throughput

0.479

High

972560

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

3

High-throughput

0.479

High

1034949

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

3

High-throughput

0.479

High

1161983

GLD2
Poly(A) RNA polymerase GLD2

1

2

Small-scale

0.479

High

1171069

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1217414

NUDC3
NudC domain-containing protein 3

1

2

High-throughput

0.479

High

1261382

NUDC2
NudC domain-containing protein 2

1

2

High-throughput

0.479

High

1269277

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1271069

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

3

High-throughput

0.479

High

1271070

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

1271084

NUDC
Nuclear migration protein nudC

1

2

High-throughput

0.479

High

1271086

SGT1
Protein SGT1 homolog

1

1

High-throughput

0.479

High

122917

MEN1
Menin

1

0

High-throughput

0.458

High

149135

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

205783

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

244731

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

304273

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

High-throughput

0.458

High

347490

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

385281

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

504504

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

569926

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

617620

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

622501

CCND1
G1/S-specific cyclin-D1

1

0

High-throughput

0.458

High

875177

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

917686

H4
Histone H4

1

0

High-throughput

0.458

High

941253

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

975300

KMT2A
Histone-lysine N-methyltransferase 2A

1

0

Small-scale

0.458

High

1051747

NPAT
Protein NPAT

1

0

High-throughput

0.458

High

1055443

DHX8
ATP-dependent RNA helicase DHX8

1

0

High-throughput

0.458

High

1128997

SAMD9
Sterile alpha motif domain-containing protein 9

1

0

High-throughput

0.458

High

1140674

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

1148706

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1165812

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1191908

UBE3D
E3 ubiquitin-protein ligase E3D

1

0

High-throughput

0.458

High

1199660

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.458

High

1221615

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1222497

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.458

High

1245109

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1253522

CIP2A
Protein CIP2A

1

0

High-throughput

0.458

High

1256312

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1267056

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1271044

GLMN
Glomulin

1

0

High-throughput

0.458

High

1271051

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

High-throughput

0.458

High

1271062

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

0

High-throughput

0.458

High

1271063

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1271066

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

1271071

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1271072

KTU
Protein kintoun

1

0

High-throughput

0.458

High

1271074

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1271075

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1271077

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.458

High

1271079

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1271080

TASOR
Protein TASOR

1

0

High-throughput

0.458

High

1271082

C8AP2
CASP8-associated protein 2

1

0

High-throughput

0.458

High

1271085

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.458

High

402305

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

353978

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.426

High

1072146

PCBP2
Poly(rC)-binding protein 2

1

0

Small-scale

0.426

High

1056229

I13R2
Interleukin-13 receptor subunit alpha-2

2

0

High-throughput

0.328

High

196842

CYB5B
Cytochrome b5 type B

1

0

High-throughput

0.279

Low

263947

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.279

Low

440646

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.279

Low

833791

CLK1
Dual specificity protein kinase CLK1

1

0

High-throughput

0.279

Low

1271060

DNAI2
Dynein axonemal intermediate chain 2

1

0

High-throughput

0.279

Low

1271073

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.279

Low

413160

CCKN
Cholecystokinin

1

0

High-throughput

0.268

Low

81745

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

Small-scale

0.249

Low

101028

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

795901

MAGA6
Melanoma-associated antigen 6

1

0

High-throughput

0.249

Low

1188653

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1261325

TM171
Transmembrane protein 171

1

0

High-throughput

0.249

Low

1271065

SFR19
Splicing factor, arginine/serine-rich 19

1

0

High-throughput

0.249

Low

1271087

SALL2
Sal-like protein 2

1

0

High-throughput

0.249

Low

1169883

PKHG7
Pleckstrin homology domain-containing family G member 7

1

0

High-throughput

0.232

Low

1271048

C170L
Cep170-like protein

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024