Protein: CLK2
Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2)

Gene: CLK2
Organism: Homo sapiens
Interactions: 206
UniProt ID: P49760

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

833850

CLK3
Dual specificity protein kinase CLK3

8

17

High-throughput

0.975

High

833929

SNIP1
Smad nuclear-interacting protein 1

8

2

High-throughput

0.975

High

441956

RU17
U1 small nuclear ribonucleoprotein 70 kDa

5

17

High-throughput

0.935

High

833691

CLK1
Dual specificity protein kinase CLK1

5

18

High-throughput

0.927

High

833849

CLK2
Dual specificity protein kinase CLK2

5

16

Small-scale

0.924

High

833880

RBM39
RNA-binding protein 39

4

20

High-throughput

0.909

High

833886

U2AFM
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

4

4

High-throughput

0.904

High

833884

RNPS1
RNA-binding protein with serine-rich domain 1

4

15

High-throughput

0.895

High

833932

ZN398
Zinc finger protein 398

3

5

High-throughput

0.871

High

266941

SRS10
Serine/arginine-rich splicing factor 10

3

20

Small-scale

0.866

High

833957

SRSF8
Serine/arginine-rich splicing factor 8

3

14

High-throughput

0.863

High

833877

TRA2A
Transformer-2 protein homolog alpha

3

19

High-throughput

0.861

High

833865

SRSF3
Serine/arginine-rich splicing factor 3

3

20

High-throughput

0.858

High

833863

SRPK2
SRSF protein kinase 2

2

18

High-throughput

0.817

High

833924

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

2

8

High-throughput

0.817

High

833876

PRP4K
Serine/threonine-protein kinase PRP4 homolog

2

18

High-throughput

0.811

High

833881

ZN638
Zinc finger protein 638

2

11

High-throughput

0.811

High

833938

SRS12
Serine/arginine-rich splicing factor 12

2

20

High-throughput

0.811

High

833962

REPI1
Replication initiator 1

2

2

High-throughput

0.811

High

833870

SRSF1
Serine/arginine-rich splicing factor 1

2

20

Small-scale

0.799

High

431655

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.789

High

282576

RNF8
E3 ubiquitin-protein ligase RNF8

2

12

High-throughput

0.783

High

833854

ZN136
Zinc finger protein 136

2

6

High-throughput

0.783

High

833921

ZN440
Zinc finger protein 440

2

6

High-throughput

0.783

High

833926

ZN491
Zinc finger protein 491

2

6

High-throughput

0.783

High

833947

ZN837
Zinc finger protein 837

2

2

High-throughput

0.783

High

833948

ZN764
Zinc finger protein 764

2

4

High-throughput

0.783

High

833952

ZN558
Zinc finger protein 558

2

4

High-throughput

0.783

High

833953

ZN317
Zinc finger protein 317

2

2

High-throughput

0.783

High

833970

ZN436
Zinc finger protein 436

2

2

High-throughput

0.783

High

833974

ZN768
Zinc finger protein 768

2

1

High-throughput

0.783

High

833999

ZSC21
Zinc finger and SCAN domain-containing protein 21

2

1

High-throughput

0.783

High

681740

AKT1
RAC-alpha serine/threonine-protein kinase

1

8

Small-scale

0.747

High

161797

ZN263
Zinc finger protein 263

1

3

High-throughput

0.740

High

833866

U2AF1
Splicing factor U2AF 35 kDa subunit

1

3

High-throughput

0.740

High

833893

ZN394
Zinc finger protein 394

1

5

High-throughput

0.740

High

833934

ZN473
Zinc finger protein 473

1

2

High-throughput

0.740

High

833960

RSRP1
Arginine/serine-rich protein 1

6

1

High-throughput

0.738

High

833874

ELAV2
ELAV-like protein 2

2

15

High-throughput

0.726

High

833946

RMXL1
RNA binding motif protein, X-linked-like-1

2

20

High-throughput

0.726

High

833951

YTDC1
YTH domain-containing protein 1

5

6

High-throughput

0.725

High

833980

BCLF1
Bcl-2-associated transcription factor 1

4

18

High-throughput

0.704

High

833911

RBBP6
E3 ubiquitin-protein ligase RBBP6

4

10

High-throughput

0.699

High

833972

PININ
Pinin

4

3

High-throughput

0.699

High

833990

ACINU
Apoptotic chromatin condensation inducer in the nucleus

4

17

High-throughput

0.699

High

833922

CLASR
CLK4-associating serine/arginine rich protein

4

9

High-throughput

0.698

High

236723

CCNT1
Cyclin-T1

1

20

High-throughput

0.691

High

241281

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

20

High-throughput

0.691

High

432604

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

20

High-throughput

0.691

High

446542

SNRPA
U1 small nuclear ribonucleoprotein A

1

20

High-throughput

0.691

High

516416

PABP1
Polyadenylate-binding protein 1

1

10

High-throughput

0.691

High

563804

ZNF30
Zinc finger protein 30

1

1

High-throughput

0.691

High

641666

U2AF2
Splicing factor U2AF 65 kDa subunit

1

20

High-throughput

0.691

High

821938

KC1A
Casein kinase I isoform alpha

1

6

High-throughput

0.691

High

833851

RGS3
Regulator of G-protein signaling 3

1

3

High-throughput

0.691

High

833852

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

10

High-throughput

0.691

High

833857

TRA2B
Transformer-2 protein homolog beta

1

20

High-throughput

0.691

High

833860

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.691

High

833861

CSK21
Casein kinase II subunit alpha

1

16

High-throughput

0.691

High

833869

SRS11
Serine/arginine-rich splicing factor 11

1

9

High-throughput

0.691

High

833871

SRSF4
Serine/arginine-rich splicing factor 4

1

20

High-throughput

0.691

High

833873

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

4

High-throughput

0.691

High

833875

SRSF6
Serine/arginine-rich splicing factor 6

1

20

High-throughput

0.691

High

833885

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

19

High-throughput

0.691

High

833887

SRSF7
Serine/arginine-rich splicing factor 7

1

20

High-throughput

0.691

High

833888

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

14

High-throughput

0.691

High

833891

LARP7
La-related protein 7

1

20

High-throughput

0.691

High

833912

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

9

High-throughput

0.691

High

833940

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

18

High-throughput

0.691

High

833945

PABP5
Polyadenylate-binding protein 5

1

12

High-throughput

0.691

High

833992

SRPK3
SRSF protein kinase 3

1

17

High-throughput

0.691

High

833998

RBM7
RNA-binding protein 7

1

16

High-throughput

0.691

High

833918

SRRM1
Serine/arginine repetitive matrix protein 1

3

20

High-throughput

0.685

High

833928

PPHLN
Periphilin-1

3

2

High-throughput

0.675

High

833967

SETD2
Histone-lysine N-methyltransferase SETD2

3

6

High-throughput

0.675

High

833971

WDR33
pre-mRNA 3' end processing protein WDR33

3

13

High-throughput

0.675

High

833855

PSME3
Proteasome activator complex subunit 3

3

2

High-throughput

0.667

High

833996

TR150
Thyroid hormone receptor-associated protein 3

3

20

High-throughput

0.667

High

833997

LC7L2
Putative RNA-binding protein Luc7-like 2

3

6

High-throughput

0.667

High

88031

D3DU92
RNA-binding protein with serine-rich domain 1

1

15

High-throughput

0.665

High

833977

LUC7L
Putative RNA-binding protein Luc7-like 1

5

5

High-throughput

0.656

High

833983

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.656

High

833930

LNX1
E3 ubiquitin-protein ligase LNX

5

8

High-throughput

0.654

High

833969

UBL5
Ubiquitin-like protein 5

1

3

Small-scale

0.647

High

833981

LUZP4
Leucine zipper protein 4

3

0

High-throughput

0.646

High

833902

ZCHC8
Zinc finger CCHC domain-containing protein 8

3

0

High-throughput

0.646

High

536759

TRI27
Zinc finger protein RFP

2

4

High-throughput

0.644

High

833927

PR38A
Pre-mRNA-splicing factor 38A

2

1

High-throughput

0.633

High

172837

CASC3
Protein CASC3

2

6

High-throughput

0.628

High

204634

E41L2
Band 4.1-like protein 2

2

5

High-throughput

0.628

High

577604

SON
Protein SON

2

17

High-throughput

0.628

High

673776

NKTR
NK-tumor recognition protein

2

6

High-throughput

0.628

High

814617

CDX1
Homeobox protein CDX-1

2

6

High-throughput

0.628

High

833903

RSBNL
Lysine-specific demethylase RSBN1L

2

1

High-throughput

0.628

High

833904

ZC3HE
Zinc finger CCCH domain-containing protein 14

2

1

High-throughput

0.628

High

833914

ZCH18
Zinc finger CCCH domain-containing protein 18

2

20

High-throughput

0.628

High

833964

SRRT
Serrate RNA effector molecule homolog

2

2

High-throughput

0.628

High

833975

NCOA5
Nuclear receptor coactivator 5

2

1

High-throughput

0.628

High

833989

GPTC8
G patch domain-containing protein 8

2

11

High-throughput

0.628

High

833993

SRRM2
Serine/arginine repetitive matrix protein 2

2

20

High-throughput

0.628

High

833856

1433G
14-3-3 protein gamma

4

20

High-throughput

0.627

High

833923

FGRL1
Fibroblast growth factor receptor-like 1

1

9

High-throughput

0.618

High

833956

CAB45
45 kDa calcium-binding protein

1

5

High-throughput

0.618

High

437996

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

833853

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

20

High-throughput

0.618

High

792175

ECE1
Endothelin-converting enzyme 1

3

1

High-throughput

0.616

High

300081

PRP6
Pre-mRNA-processing factor 6

2

7

High-throughput

0.614

High

833908

Q7KZS0
SUMO-conjugating enzyme UBC9

2

8

High-throughput

0.611

High

833984

NXF1
Nuclear RNA export factor 1

2

2

High-throughput

0.606

High

646727

1433T
14-3-3 protein theta

3

20

Small-scale

0.593

High

683206

1433B
14-3-3 protein beta/alpha

3

20

Small-scale

0.593

High

833859

UBC9
SUMO-conjugating enzyme UBC9

2

8

High-throughput

0.584

High

383481

HSP1
Sperm protamine P1

2

0

High-throughput

0.580

High

833935

CATIN
Splicing factor Cactin

2

0

High-throughput

0.580

High

833968

ASPC1
Tether containing UBX domain for GLUT4

2

0

High-throughput

0.580

High

833907

NKAP1
Uncharacterized protein NKAPD1

2

1

High-throughput

0.574

High

833919

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

2

4

High-throughput

0.574

High

834000

TNPO3
Transportin-3

2

7

High-throughput

0.574

High

132781

SDCB1
Syntenin-1

1

6

High-throughput

0.573

High

833915

TRI50
E3 ubiquitin-protein ligase TRIM50

2

4

High-throughput

0.553

High

833944

DDT4L
DNA damage-inducible transcript 4-like protein

2

1

High-throughput

0.553

High

833963

GTPB2
GTP-binding protein 2

2

7

High-throughput

0.553

High

749232

BRCA1
Breast cancer type 1 susceptibility protein

1

11

High-throughput

0.552

High

833868

1433F
14-3-3 protein eta

2

20

High-throughput

0.549

High

127745

SAP18
Histone deacetylase complex subunit SAP18

1

3

High-throughput

0.536

High

181172

NUP42
Nucleoporin NUP42

1

1

High-throughput

0.536

High

196977

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

12

High-throughput

0.536

High

256483

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

1

High-throughput

0.536

High

308183

LC7L3
Luc7-like protein 3

1

5

High-throughput

0.536

High

317818

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

1

6

High-throughput

0.536

High

657311

ABCD3
ATP-binding cassette sub-family D member 3

1

2

High-throughput

0.536

High

786910

MTREX
Exosome RNA helicase MTR4

1

11

High-throughput

0.536

High

833889

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

15

High-throughput

0.536

High

833890

RN151
RING finger protein 151

1

15

High-throughput

0.536

High

833906

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

2

High-throughput

0.536

High

833909

MEPCE
7SK snRNA methylphosphate capping enzyme

1

3

High-throughput

0.536

High

833916

DHX40
Probable ATP-dependent RNA helicase DHX40

1

8

High-throughput

0.536

High

833941

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

11

High-throughput

0.536

High

833954

ANM1
Protein arginine N-methyltransferase 1

1

6

High-throughput

0.536

High

833955

PKP2
Plakophilin-2

1

14

High-throughput

0.536

High

833985

DAXX
Death domain-associated protein 6

1

1

High-throughput

0.536

High

833986

TRM7
tRNA

1

1

High-throughput

0.536

High

833988

PURG
Purine-rich element-binding protein gamma

1

3

High-throughput

0.536

High

573613

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

6

Small-scale

0.535

High

833894

Q53SE7
Germ cell-less homolog 1

1

3

High-throughput

0.515

High

833897

CE170
Centrosomal protein of 170 kDa

1

19

High-throughput

0.514

High

833878

EXOS2
Exosome complex component RRP4

1

0

High-throughput

0.513

High

833892

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.513

High

833982

CPSF2
Cleavage and polyadenylation specificity factor subunit 2

1

0

High-throughput

0.513

High

834001

TX264
Testis-expressed protein 264

1

0

High-throughput

0.513

High

833905

LARP1
La-related protein 1

1

16

High-throughput

0.489

High

833939

LAR4B
La-related protein 4B

1

14

High-throughput

0.489

High

833950

JPH4
Junctophilin-4

1

1

High-throughput

0.489

High

833973

E41L1
Band 4.1-like protein 1

1

7

High-throughput

0.489

High

833976

WDR6
tRNA

1

20

High-throughput

0.489

High

833991

PAI2B
Polyadenylate-binding protein-interacting protein 2B

1

1

High-throughput

0.489

High

833995

E41L3
Band 4.1-like protein 3

1

4

High-throughput

0.489

High

311795

TACC2
Transforming acidic coiled-coil-containing protein 2

1

11

High-throughput

0.481

High

833862

RBM6
RNA-binding protein 6

1

15

High-throughput

0.481

High

833898

RM02
Large ribosomal subunit protein uL2m

1

3

High-throughput

0.481

High

833913

PATL1
Protein PAT1 homolog 1

1

9

High-throughput

0.481

High

833949

GMCL1
Germ cell-less protein-like 1

1

3

High-throughput

0.481

High

267954

EED
Polycomb protein EED

1

16

High-throughput

0.479

High

319762

HERC2
E3 ubiquitin-protein ligase HERC2

1

12

High-throughput

0.479

High

659909

ERCC5
DNA excision repair protein ERCC-5

1

11

High-throughput

0.479

High

697724

TF2H1
General transcription factor IIH subunit 1

1

3

High-throughput

0.479

High

790710

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

9

High-throughput

0.479

High

823697

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.479

High

833858

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

4

High-throughput

0.479

High

833867

ENL
Protein ENL

1

13

High-throughput

0.479

High

833879

TF2H3
General transcription factor IIH subunit 3

1

2

High-throughput

0.479

High

833895

Q59FZ7
DNA-repair protein complementing XP-G cells variant

1

11

High-throughput

0.479

High

833901

Q6ICH2
Apolipoprotein B mRNA editing enzyme catalytic subunit 3D

1

4

High-throughput

0.479

High

833910

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

833920

FANCM
Fanconi anemia group M protein

1

15

Small-scale

0.479

High

833936

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

833961

HIRP3
HIRA-interacting protein 3

1

4

High-throughput

0.479

High

833978

RAD18
E3 ubiquitin-protein ligase RAD18

1

2

High-throughput

0.479

High

833987

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

70875

B2RWP4
TACC2 protein

1

14

High-throughput

0.470

High

833872

ECHP
Peroxisomal bifunctional enzyme

1

2

High-throughput

0.470

High

833937

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.460

High

833994

NIP7
60S ribosome subunit biogenesis protein NIP7 homolog

1

0

High-throughput

0.460

High

833882

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

833883

PTPA
Serine/threonine-protein phosphatase 2A activator

1

0

Small-scale

0.458

High

833925

CGAS
Cyclic GMP-AMP synthase

1

0

Small-scale

0.458

High

833959

FAP24
Fanconi anemia core complex-associated protein 24

1

0

Small-scale

0.458

High

3286

A0A0S2Z4Z6
Serine and arginine repetitive matrix 1

1

20

High-throughput

0.457

High

571359

DDX5
Probable ATP-dependent RNA helicase DDX5

1

8

High-throughput

0.445

High

717565

BMI1
Polycomb complex protein BMI-1

1

9

High-throughput

0.445

High

833896

ODFP2
Outer dense fiber protein 2

1

18

High-throughput

0.445

High

833942

ABC3D
DNA dC->dU-editing enzyme APOBEC-3D

1

4

High-throughput

0.445

High

833943

AP2M1
AP-2 complex subunit mu

1

3

High-throughput

0.439

High

833966

YTHD1
YTH domain-containing family protein 1

1

8

High-throughput

0.439

High

833979

TBA8
Tubulin alpha-8 chain

1

6

High-throughput

0.439

High

833899

TBC9B
TBC1 domain family member 9B

1

3

High-throughput

0.437

High

833900

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.437

High

833958

ATGA1
Autophagy-related protein 101

1

2

High-throughput

0.437

High

307158

KLHL2
Kelch-like protein 2

3

0

High-throughput

0.352

High

600950

MK
Midkine

2

0

High-throughput

0.328

High

833917

GPAM1
GPALPP motifs-containing protein 1

2

0

High-throughput

0.328

High

833965

RM04
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.299

High

833864

PRR3
Proline-rich protein 3

1

0

High-throughput

0.279

Low

833931

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

833933

CE192
Centrosomal protein of 192 kDa

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024