Protein: ATF4
Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (Tax-responsive enhancer element-binding protein 67) (TaxREB67)

Gene: ATF4
Organism: Homo sapiens
Interactions: 102
UniProt ID: P18848

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

579249

CEBPG
CCAAT/enhancer-binding protein gamma

6

17

High-throughput

0.949

High

579169

ATF3
Cyclic AMP-dependent transcription factor ATF-3

3

15

Small-scale

0.879

High

401393

JUN
Transcription factor Jun

3

13

Small-scale

0.873

High

579266

NF2L2
Nuclear factor erythroid 2-related factor 2

3

9

Small-scale

0.866

High

345319

FOS
Protein c-Fos

3

12

Small-scale

0.840

High

579296

ZHANG
CREB/ATF bZIP transcription factor

3

0

Small-scale

0.826

High

579273

JDP2
Jun dimerization protein 2

2

14

High-throughput

0.783

High

265112

MAF
Transcription factor Maf

2

1

High-throughput

0.778

High

579246

CEBPA
CCAAT/enhancer-binding protein alpha

2

12

High-throughput

0.778

High

579267

BATF
Basic leucine zipper transcriptional factor ATF-like

2

12

High-throughput

0.778

High

548220

FOSL1
Fos-related antigen 1

2

14

Small-scale

0.768

High

569157

CEBPB
CCAAT/enhancer-binding protein beta

2

15

High-throughput

0.768

High

579247

CEBPD
CCAAT/enhancer-binding protein delta

2

16

Small-scale

0.768

High

566720

JUNB
Transcription factor JunB

2

8

High-throughput

0.767

High

579306

FBW1A
F-box/WD repeat-containing protein 1A

13

3

Small-scale

0.763

High

579283

TRIB3
Tribbles homolog 3

8

2

Small-scale

0.758

High

579238

ATF4
Cyclic AMP-dependent transcription factor ATF-4

2

0

Small-scale

0.738

High

579261

GPS2
G protein pathway suppressor 2

5

1

High-throughput

0.726

High

579259

EP300
Histone acetyltransferase p300

5

2

Small-scale

0.718

High

579286

CC106
Coiled-coil domain-containing protein 106

6

0

High-throughput

0.708

High

154924

NDC80
Kinetochore protein NDC80 homolog

5

0

High-throughput

0.691

High

579244

DDIT3
DNA damage-inducible transcript 3 protein

4

1

Small-scale

0.687

High

579304

FBW1B
F-box/WD repeat-containing protein 11

4

3

Small-scale

0.680

High

320657

LDOC1
Protein LDOC1

4

0

High-throughput

0.676

High

579274

CBP
CREB-binding protein

3

3

Small-scale

0.658

High

216665

CREB3
Cyclic AMP-responsive element-binding protein 3

1

7

High-throughput

0.647

High

547697

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

5

High-throughput

0.647

High

579263

NF2L1
Endoplasmic reticulum membrane sensor NFE2L1

1

8

High-throughput

0.647

High

579265

CEBPE
CCAAT/enhancer-binding protein epsilon

1

15

High-throughput

0.647

High

579268

NFE2
Transcription factor NF-E2 45 kDa subunit

1

8

High-throughput

0.647

High

579272

BATF2
Basic leucine zipper transcriptional factor ATF-like 2

1

3

High-throughput

0.647

High

579294

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

1

14

High-throughput

0.647

High

579308

NF2L3
Nuclear factor erythroid 2-related factor 3

1

5

High-throughput

0.647

High

579310

MAFB
Transcription factor MafB

1

8

High-throughput

0.647

High

579275

GOGA1
Golgin subfamily A member 1

3

0

High-throughput

0.646

High

579278

GCC1
GRIP and coiled-coil domain-containing protein 1

3

0

High-throughput

0.646

High

579291

EGLN3
Prolyl hydroxylase EGLN3

2

2

Small-scale

0.619

High

579121

ATF1
Cyclic AMP-dependent transcription factor ATF-1

1

4

Small-scale

0.618

High

363562

TTHY
Transthyretin

3

1

High-throughput

0.608

High

579255

MDM2
E3 ubiquitin-protein ligase Mdm2

2

0

Small-scale

0.598

High

579295

DISC1
Disrupted in schizophrenia 1 protein

2

1

Small-scale

0.590

High

579257

REL
Proto-oncogene c-Rel

1

0

Small-scale

0.586

High

579284

HAUS7
HAUS augmin-like complex subunit 7

2

0

High-throughput

0.582

High

58215

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

2

0

High-throughput

0.580

High

579270

SAPC2
Suppressor APC domain-containing protein 2

2

0

High-throughput

0.580

High

579282

NP1L5
Nucleosome assembly protein 1-like 5

2

0

High-throughput

0.580

High

579287

AP1M1
AP-1 complex subunit mu-1

2

0

High-throughput

0.580

High

579309

CEP83
Centrosomal protein of 83 kDa

2

0

High-throughput

0.580

High

579239

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

Small-scale

0.561

High

579281

EGLN2
Prolyl hydroxylase EGLN2

1

2

Small-scale

0.552

High

579300

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

4

Small-scale

0.552

High

320258

SNP29
Synaptosomal-associated protein 29

2

0

Small-scale

0.551

High

170250

TIF1A
Transcription intermediary factor 1-alpha

1

1

High-throughput

0.541

High

579292

NEK6
Serine/threonine-protein kinase Nek6

1

0

Small-scale

0.526

High

153079

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

0

High-throughput

0.518

High

579241

LMNB1
Lamin-B1

1

0

High-throughput

0.518

High

579248

HXK3
Hexokinase-3

1

0

High-throughput

0.518

High

579280

PTCD3
Small ribosomal subunit protein mS39

1

0

High-throughput

0.518

High

579290

ASB7
Ankyrin repeat and SOCS box protein 7

1

0

High-throughput

0.518

High

579298

ZN226
Zinc finger protein 226

1

0

High-throughput

0.518

High

579305

TF2AY
TFIIA-alpha and beta-like factor

1

0

High-throughput

0.518

High

579276

KAT2B
Histone acetyltransferase KAT2B

1

1

Small-scale

0.501

High

263513

PR40A
Pre-mRNA-processing factor 40 homolog A

1

0

High-throughput

0.493

High

579250

CASP6
Caspase-6

1

0

High-throughput

0.493

High

579297

EXOC1
Exocyst complex component 1

1

0

High-throughput

0.493

High

579307

SHLB1
Endophilin-B1

1

0

High-throughput

0.493

High

579243

IKBA
NF-kappa-B inhibitor alpha

1

0

Small-scale

0.486

High

579301

ZN212
Zinc finger protein 212

1

0

Small-scale

0.486

High

394085

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

534054

T2FB
General transcription factor IIF subunit 2

1

0

Small-scale

0.480

High

579240

TBP
TATA-box-binding protein

1

0

Small-scale

0.480

High

579254

TF2B
Transcription initiation factor IIB

1

0

Small-scale

0.480

High

579293

SRA1
Steroid receptor RNA activator 1

1

0

Small-scale

0.480

High

579303

DNM3L
DNA

1

0

Small-scale

0.480

High

200084

DAPK3
Death-associated protein kinase 3

1

3

Small-scale

0.479

High

277379

GABR2
Gamma-aminobutyric acid type B receptor subunit 2

1

4

Small-scale

0.479

High

575255

EGR1
Early growth response protein 1

1

1

High-throughput

0.479

High

579264

ABRX2
BRISC complex subunit Abraxas 2

1

2

Small-scale

0.479

High

579302

DAPK2
Death-associated protein kinase 2

1

3

Small-scale

0.479

High

579242

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.460

High

579252

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.460

High

579279

REPS1
RalBP1-associated Eps domain-containing protein 1

1

0

High-throughput

0.460

High

579285

TREX2
Three prime repair exonuclease 2

1

0

High-throughput

0.460

High

438908

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

0

Small-scale

0.458

High

579245

SOX2
Transcription factor SOX-2

1

0

Small-scale

0.458

High

579251

IL2
Interleukin-2

1

0

Small-scale

0.458

High

579253

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

579256

PO5F1
POU domain, class 5, transcription factor 1

1

0

Small-scale

0.458

High

579288

EIF2A
Eukaryotic translation initiation factor 2A

1

0

Small-scale

0.458

High

579289

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

0

Small-scale

0.458

High

3291

A0A0S2Z507
Beta-transducin repeat containing isoform 3

1

3

High-throughput

0.417

High

81591

B7Z3H4
Beta-transducin repeat containing E3 ubiquitin protein ligase

1

3

High-throughput

0.417

High

579262

BFSP2
Phakinin

6

0

High-throughput

0.386

High

579269

TBC25
TBC1 domain family member 25

2

0

High-throughput

0.319

High

234739

MPZL2
Myelin protein zero-like protein 2

1

0

High-throughput

0.282

High

579277

APH1A
Gamma-secretase subunit APH-1A

1

0

High-throughput

0.282

High

579271

KTN1
Kinectin

1

0

High-throughput

0.269

Low

527288

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.268

Low

579260

GOG8D
Putative golgin subfamily A member 8D

1

0

High-throughput

0.268

Low

579299

NLGN3
Neuroligin-3

1

0

Small-scale

0.265

Low

579258

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.251

Low


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Last updated: 15 Jul 2024