Protein: EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

Gene: EDEM1
Organism: Homo sapiens
Interactions: 202
UniProt ID: Q92611

Gene Ontology (top 5):
GO:0004571 - mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509 - calcium ion binding
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005975 - carbohydrate metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

654620

CALX
Calnexin

5

4

Small-scale

0.709

High

1268026

SE1L1
Protein sel-1 homolog 1

5

4

Small-scale

0.702

High

1267981

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

4

High-throughput

0.618

High

1268005

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

4

High-throughput

0.618

High

1268031

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

1

4

High-throughput

0.618

High

423311

PDIA1
Protein disulfide-isomerase

2

11

High-throughput

0.611

High

1268028

UBQL2
Ubiquilin-2

2

2

High-throughput

0.611

High

968888

NAAA
N-acylethanolamine-hydrolyzing acid amidase

3

2

High-throughput

0.609

High

1114511

ZACN
Ligand-gated cation channel ZACN

3

3

High-throughput

0.609

High

344219

A1AT
Alpha-1-antitrypsin

2

1

Small-scale

0.584

High

538335

ENPL
Endoplasmin

2

2

Small-scale

0.584

High

1034504

OS9
Protein OS-9

2

4

Small-scale

0.584

High

1220441

DJC10
DnaJ homolog subfamily C member 10

2

14

Small-scale

0.584

High

1268018

DJB12
DnaJ homolog subfamily B member 12

2

5

Small-scale

0.584

High

1268021

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

2

2

Small-scale

0.584

High

1268025

DJB11
DnaJ homolog subfamily B member 11

2

1

Small-scale

0.584

High

1165523

LYZL1
Lysozyme-like protein 1

2

3

High-throughput

0.574

High

1190771

LYZL2
Lysozyme-like protein 2

2

3

High-throughput

0.574

High

1268022

MTCH1
Mitochondrial carrier homolog 1

2

1

High-throughput

0.574

High

1036770

SQSTM
Sequestosome-1

2

0

Small-scale

0.559

High

1268038

UB2J1
Ubiquitin-conjugating enzyme E2 J1

2

0

Small-scale

0.559

High

885382

LOXL3
Lysyl oxidase homolog 3

2

1

High-throughput

0.558

High

795222

SSRA
Translocon-associated protein subunit alpha

1

1

Small-scale

0.515

High

131025

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.513

High

234840

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.513

High

1114045

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

1

0

High-throughput

0.513

High

1161896

NCEH1
Neutral cholesterol ester hydrolase 1

1

0

High-throughput

0.513

High

1236407

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.513

High

1268002

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.513

High

389482

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

2

High-throughput

0.489

High

798547

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

3

High-throughput

0.489

High

1125844

NMS
Neuromedin-S

1

1

High-throughput

0.489

High

1139336

CDCP2
CUB domain-containing protein 2

1

1

High-throughput

0.489

High

1267988

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

1

High-throughput

0.489

High

1267994

LCFC1
Sperm-egg fusion protein LLCFC1

1

1

High-throughput

0.489

High

116700

UBXN8
UBX domain-containing protein 8

1

3

High-throughput

0.479

High

128606

DNM1L
Dynamin-1-like protein

1

1

High-throughput

0.479

High

213610

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

3

High-throughput

0.479

High

266218

ERLN1
Erlin-1

1

3

High-throughput

0.479

High

299959

ERLN2
Erlin-2

1

3

High-throughput

0.479

High

304859

MFN2
Mitofusin-2

1

1

High-throughput

0.479

High

305186

UBE4B
Ubiquitin conjugation factor E4 B

1

2

High-throughput

0.479

High

338781

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

390422

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.479

High

396777

S10A8
Protein S100-A8

1

1

High-throughput

0.479

High

416485

S10A9
Protein S100-A9

1

1

High-throughput

0.479

High

426854

ASGR2
Asialoglycoprotein receptor 2

1

4

Small-scale

0.479

High

432119

HS90A
Heat shock protein HSP 90-alpha

1

2

High-throughput

0.479

High

502386

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.479

High

504492

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

531924

PDIA4
Protein disulfide-isomerase A4

1

10

Small-scale

0.479

High

614401

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

2

Small-scale

0.479

High

653677

CALR
Calreticulin

1

4

High-throughput

0.479

High

763063

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

2

High-throughput

0.479

High

787535

MTOR
Serine/threonine-protein kinase mTOR

1

1

High-throughput

0.479

High

809945

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

4

High-throughput

0.479

High

825491

LMAN1
Protein ERGIC-53

1

1

High-throughput

0.479

High

913327

PRS10
26S proteasome regulatory subunit 10B

1

1

High-throughput

0.479

High

942429

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

1

2

High-throughput

0.479

High

1028087

DNJC3
DnaJ homolog subfamily C member 3

1

6

High-throughput

0.479

High

1048949

UBE4A
Ubiquitin conjugation factor E4 A

1

2

High-throughput

0.479

High

1052720

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

3

High-throughput

0.479

High

1074300

SHH
Sonic hedgehog protein

1

2

Small-scale

0.479

High

1103064

ATG2A
Autophagy-related protein 2 homolog A

1

2

High-throughput

0.479

High

1104069

P3H1
Prolyl 3-hydroxylase 1

1

1

Small-scale

0.479

High

1139414

ECM29
Proteasome adapter and scaffold protein ECM29

1

2

High-throughput

0.479

High

1156111

RHBD2
Rhomboid domain-containing protein 2

1

2

High-throughput

0.479

High

1174915

TMUB2
Transmembrane and ubiquitin-like domain-containing protein 2

1

1

High-throughput

0.479

High

1198640

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

2

High-throughput

0.479

High

1253105

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

2

High-throughput

0.479

High

1253641

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

4

High-throughput

0.479

High

1255634

RBCC1
RB1-inducible coiled-coil protein 1

1

1

High-throughput

0.479

High

1256007

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.479

High

1259699

RN139
E3 ubiquitin-protein ligase RNF139

1

2

High-throughput

0.479

High

1267582

UBXN4
UBX domain-containing protein 4

1

3

High-throughput

0.479

High

1267985

ATG2B
Autophagy-related protein 2 homolog B

1

2

High-throughput

0.479

High

1267986

FAF2
FAS-associated factor 2

1

3

High-throughput

0.479

High

1267987

ERLEC
Endoplasmic reticulum lectin 1

1

4

High-throughput

0.479

High

1267995

VP13A
Intermembrane lipid transfer protein VPS13A

1

3

High-throughput

0.479

High

1268001

ERP44
Endoplasmic reticulum resident protein 44

1

12

High-throughput

0.479

High

1268004

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

1

High-throughput

0.479

High

1268012

ZFYV1
Zinc finger FYVE domain-containing protein 1

1

2

High-throughput

0.479

High

1268016

FBX6
F-box only protein 6

1

2

High-throughput

0.479

High

1268020

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

4

High-throughput

0.479

High

1268024

DNJB9
DnaJ homolog subfamily B member 9

1

7

High-throughput

0.479

High

1268029

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

1

High-throughput

0.479

High

1268032

AMFR
E3 ubiquitin-protein ligase AMFR

1

3

High-throughput

0.479

High

1268033

UBQL1
Ubiquilin-1

1

1

High-throughput

0.479

High

1268035

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

High-throughput

0.479

High

1268036

FAF1
FAS-associated factor 1

1

3

High-throughput

0.479

High

1268042

HYOU1
Hypoxia up-regulated protein 1

1

6

High-throughput

0.479

High

1268045

TX264
Testis-expressed protein 264

1

1

High-throughput

0.479

High

1183801

5MP2
eIF5-mimic protein 2

1

1

High-throughput

0.470

High

152444

EI24
Etoposide-induced protein 2.4 homolog

1

0

High-throughput

0.458

High

167991

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

281794

WFS1
Wolframin

1

0

High-throughput

0.458

High

387213

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

395356

A4
Amyloid-beta precursor protein

1

0

Small-scale

0.458

High

427911

CAN1
Calpain-1 catalytic subunit

1

0

High-throughput

0.458

High

452254

HMOX1
Heme oxygenase 1

1

0

High-throughput

0.458

High

589224

ANXA7
Annexin A7

1

0

High-throughput

0.458

High

791820

HD
Huntingtin

1

0

High-throughput

0.458

High

848915

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.458

High

875171

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

882783

STX17
Syntaxin-17

1

0

High-throughput

0.458

High

890309

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

1054172

BECN1
Beclin-1

1

0

High-throughput

0.458

High

1119211

MBRL
Membralin

1

0

High-throughput

0.458

High

1150152

ATLA3
Atlastin-3

1

0

High-throughput

0.458

High

1184841

GET4
Golgi to ER traffic protein 4 homolog

1

0

High-throughput

0.458

High

1188337

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

1199376

LYRIC
Protein LYRIC

1

0

High-throughput

0.458

High

1218611

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

0

High-throughput

0.458

High

1251694

NPL4
Nuclear protein localization protein 4 homolog

1

0

High-throughput

0.458

High

1257005

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

0

High-throughput

0.458

High

1267983

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.458

High

1267984

VTI1A
Vesicle transport through interaction with t-SNAREs homolog 1A

1

0

High-throughput

0.458

High

1267991

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.458

High

1267997

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1267999

RNF5
E3 ubiquitin-protein ligase RNF5

1

0

High-throughput

0.458

High

1268000

SELS
Selenoprotein S

1

0

Small-scale

0.458

High

1268006

DERL2
Derlin-2

1

0

High-throughput

0.458

High

1268009

ANKZ1
tRNA endonuclease ANKZF1

1

0

High-throughput

0.458

High

1268010

RN121
E3 ubiquitin ligase RNF121

1

0

High-throughput

0.458

High

1268039

FBX7
F-box only protein 7

1

0

High-throughput

0.458

High

1268044

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

0

High-throughput

0.458

High

129322

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

1

High-throughput

0.437

High

205772

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.437

High

311737

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

2

High-throughput

0.437

High

426790

ASGR1
Asialoglycoprotein receptor 1

1

4

Small-scale

0.437

High

435868

OPSD
Rhodopsin

1

2

Small-scale

0.437

High

444766

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

1

High-throughput

0.437

High

507159

LAMP1
Lysosome-associated membrane glycoprotein 1

1

1

High-throughput

0.437

High

527675

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.437

High

817719

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

2

High-throughput

0.437

High

960905

CLH1
Clathrin heavy chain 1

1

1

High-throughput

0.437

High

979961

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

1

High-throughput

0.437

High

992180

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

1

High-throughput

0.437

High

998931

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.437

High

1025184

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

2

High-throughput

0.437

High

1031575

ATM
Serine-protein kinase ATM

1

1

High-throughput

0.437

High

1035192

ROCK1
Rho-associated protein kinase 1

1

1

High-throughput

0.437

High

1036527

MTM1
Myotubularin

1

1

High-throughput

0.437

High

1040941

MTMR3
Myotubularin-related protein 3

1

1

High-throughput

0.437

High

1078042

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

2

High-throughput

0.437

High

1146236

MAP1S
Microtubule-associated protein 1S

1

1

High-throughput

0.437

High

1218392

MFN1
Mitofusin-1

1

1

High-throughput

0.437

High

1224688

WDFY3
WD repeat and FYVE domain-containing protein 3

1

1

High-throughput

0.437

High

1230004

RPTOR
Regulatory-associated protein of mTOR

1

2

High-throughput

0.437

High

1267506

TSC1
Hamartin

1

1

High-throughput

0.437

High

1267989

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

3

High-throughput

0.437

High

1267993

VPS39
Vam6/Vps39-like protein

1

1

High-throughput

0.437

High

1268019

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

1

High-throughput

0.437

High

1268023

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

1

High-throughput

0.437

High

1268027

TBK1
Serine/threonine-protein kinase TBK1

1

1

High-throughput

0.437

High

82347

B9A025
Lysyl oxidase homolog

1

1

High-throughput

0.407

High

1120528

MPPE1
Metallophosphoesterase 1

2

0

High-throughput

0.328

High

1268034

SUFU
Suppressor of fused homolog

2

0

High-throughput

0.328

High

198163

MSH5
MutS protein homolog 5

1

0

High-throughput

0.279

Low

380400

CD3D
T-cell surface glycoprotein CD3 delta chain

1

0

High-throughput

0.279

Low

1109058

CHD9
Chromodomain-helicase-DNA-binding protein 9

1

0

High-throughput

0.279

Low

1219299

PHF6
PHD finger protein 6

1

0

High-throughput

0.279

Low

1219572

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.279

Low

1235206

M4A15
Membrane-spanning 4-domains subfamily A member 15

1

0

High-throughput

0.279

Low

1241704

GALT6
Polypeptide N-acetylgalactosaminyltransferase 6

1

0

High-throughput

0.279

Low

1245387

OR1M1
Olfactory receptor 1M1

1

0

High-throughput

0.279

Low

1257052

PNISR
Arginine/serine-rich protein PNISR

1

0

High-throughput

0.279

Low

1267982

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

0

High-throughput

0.279

Low

1268008

XYLT2
Xylosyltransferase 2

1

0

High-throughput

0.279

Low

1268041

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

0

High-throughput

0.279

Low

124031

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.249

Low

796863

NAMPT
Nicotinamide phosphoribosyltransferase

1

0

High-throughput

0.249

Low

835091

TSC2
Tuberin

1

0

High-throughput

0.249

Low

835911

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.249

Low

845128

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.249

Low

882043

BACE1
Beta-secretase 1

1

0

High-throughput

0.249

Low

885136

SESN2
Sestrin-2

1

0

High-throughput

0.249

Low

995095

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.249

Low

1058262

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

0

High-throughput

0.249

Low

1135101

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.249

Low

1146683

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.249

Low

1153243

RAB12
Ras-related protein Rab-12

1

0

High-throughput

0.249

Low

1162626

LARP1
La-related protein 1

1

0

High-throughput

0.249

Low

1184612

RRAGA
Ras-related GTP-binding protein A

1

0

High-throughput

0.249

Low

1201820

VPS36
Vacuolar protein-sorting-associated protein 36

1

0

High-throughput

0.249

Low

1267947

TBCD5
TBC1 domain family member 5

1

0

High-throughput

0.249

Low

1267990

CHMP6
Charged multivesicular body protein 6

1

0

High-throughput

0.249

Low

1267992

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

High-throughput

0.249

Low

1267996

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.249

Low

1267998

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.249

Low

1268003

WAC
WW domain-containing adapter protein with coiled-coil

1

0

High-throughput

0.249

Low

1268007

MCLN1
Mucolipin-1

1

0

High-throughput

0.249

Low

1268013

EPG5
Ectopic P granules protein 5 homolog

1

0

High-throughput

0.249

Low

1268014

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

0

High-throughput

0.249

Low

1268015

WDR6
tRNA

1

0

High-throughput

0.249

Low

1268017

ATG3
Ubiquitin-like-conjugating enzyme ATG3

1

0

High-throughput

0.249

Low

1268030

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

0

High-throughput

0.249

Low

1268037

SHLB1
Endophilin-B1

1

0

High-throughput

0.249

Low

1268040

WIPI4
WD repeat domain phosphoinositide-interacting protein 4

1

0

High-throughput

0.249

Low

1268043

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.249

Low

1268011

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024