Protein: PCSK9
Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9)

Gene: PCSK9
Organism: Homo sapiens
Interactions: 76
UniProt ID: Q8NBP7

Gene Ontology (top 5):
GO:0001822 - kidney development
GO:0001889 - liver development
GO:0001920 - negative regulation of receptor recycling
GO:0002091 - negative regulation of receptor internalization
GO:0002092 - positive regulation of receptor internalization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

351090

LDLR
Low-density lipoprotein receptor

5

1

Small-scale

0.924

High

158959

NCTR3
Natural cytotoxicity triggering receptor 3

1

3

High-throughput

0.691

High

789642

I12R1
Interleukin-12 receptor subunit beta-1

1

2

High-throughput

0.691

High

1072551

EPHA7
Ephrin type-A receptor 7

1

1

High-throughput

0.691

High

1240189

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

13

Small-scale

0.647

High

439249

MMP2
72 kDa type IV collagenase

1

4

Small-scale

0.586

High

1036298

BIRC2
Baculoviral IAP repeat-containing protein 2

1

1

Small-scale

0.578

High

372912

TRGV3
T cell receptor gamma variable 3

1

2

High-throughput

0.575

High

1220943

FA20C
Extracellular serine/threonine protein kinase FAM20C

2

0

Small-scale

0.569

High

146374

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

1

High-throughput

0.536

High

155766

GDF8
Growth/differentiation factor 8

1

3

High-throughput

0.536

High

211386

PI15
Peptidase inhibitor 15

1

3

High-throughput

0.536

High

252755

FCG3B
Low affinity immunoglobulin gamma Fc region receptor III-B

1

2

High-throughput

0.536

High

257278

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

1

1

High-throughput

0.536

High

271936

FCN3
Ficolin-3

1

3

High-throughput

0.536

High

319604

LY86
Lymphocyte antigen 86

1

2

High-throughput

0.536

High

362543

C1QB
Complement C1q subcomponent subunit B

1

4

High-throughput

0.536

High

398558

PPB1
Alkaline phosphatase, placental type

1

1

High-throughput

0.536

High

526908

TDGF1
Protein Cripto

1

2

High-throughput

0.536

High

533013

PRG2
Bone marrow proteoglycan

1

6

High-throughput

0.536

High

535663

EDN3
Endothelin-3

1

1

High-throughput

0.536

High

557199

PGFRA
Platelet-derived growth factor receptor alpha

1

2

High-throughput

0.536

High

561308

CRIS2
Cysteine-rich secretory protein 2

1

3

High-throughput

0.536

High

589602

KLK2
Kallikrein-2

1

7

High-throughput

0.536

High

606916

IDS
Iduronate 2-sulfatase

1

1

High-throughput

0.536

High

885345

INHBE
Inhibin beta E chain

1

3

High-throughput

0.536

High

964676

IL5RA
Interleukin-5 receptor subunit alpha

1

5

High-throughput

0.536

High

1044386

PTC1
Protein patched homolog 1

1

2

High-throughput

0.536

High

1154456

FSTL4
Follistatin-related protein 4

1

2

High-throughput

0.536

High

1165328

LYPD4
Ly6/PLAUR domain-containing protein 4

1

1

High-throughput

0.536

High

1165520

LYZL1
Lysozyme-like protein 1

1

1

High-throughput

0.536

High

1240080

TM87A
Transmembrane protein 87A

1

1

High-throughput

0.536

High

1240190

FIBIN
Fin bud initiation factor homolog

1

1

High-throughput

0.536

High

1240192

CA054
Uncharacterized protein C1orf54

1

2

High-throughput

0.536

High

1240193

GGH
Gamma-glutamyl hydrolase

1

2

High-throughput

0.536

High

1240194

ESPB1
Epididymal sperm-binding protein 1

1

2

High-throughput

0.536

High

1240199

SDF2L
Stromal cell-derived factor 2-like protein 1

1

3

High-throughput

0.536

High

1240200

CBLN4
Cerebellin-4

1

4

High-throughput

0.536

High

1240205

PRG3
Proteoglycan 3

1

5

High-throughput

0.536

High

1240206

ADA18
Disintegrin and metalloproteinase domain-containing protein 18

1

2

High-throughput

0.536

High

882041

BACE1
Beta-secretase 1

1

0

Small-scale

0.513

High

305275

NXPH3
Neurexophilin-3

1

0

High-throughput

0.513

High

614225

CAH6
Carbonic anhydrase 6

1

0

High-throughput

0.513

High

824949

DNSL1
Deoxyribonuclease-1-like 1

1

0

High-throughput

0.513

High

1101936

TECT1
Tectonic-1

1

0

High-throughput

0.513

High

1240191

CLC4C
C-type lectin domain family 4 member C

1

0

High-throughput

0.513

High

427622

ANXA2
Annexin A2

1

0

Small-scale

0.512

High

1240197

SC11C
Signal peptidase complex catalytic subunit SEC11C

1

0

High-throughput

0.493

High

82434

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

2

High-throughput

0.489

High

1084741

TAZ
Tafazzin

1

1

High-throughput

0.489

High

123654

PGRC1
Membrane-associated progesterone receptor component 1

1

1

Small-scale

0.479

High

161117

CLGN
Calmegin

1

2

Small-scale

0.479

High

205687

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

243500

DNJA2
DnaJ homolog subfamily A member 2

1

6

Small-scale

0.479

High

531909

PDIA4
Protein disulfide-isomerase A4

1

3

Small-scale

0.479

High

681525

DNJA1
DnaJ homolog subfamily A member 1

1

6

Small-scale

0.479

High

1020813

TRAF2
TNF receptor-associated factor 2

1

1

Small-scale

0.479

High

1070863

RCN1
Reticulocalbin-1

1

1

Small-scale

0.479

High

1220433

DJC10
DnaJ homolog subfamily C member 10

1

7

Small-scale

0.479

High

1240195

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

4

Small-scale

0.479

High

1240196

TBB6
Tubulin beta-6 chain

1

2

Small-scale

0.479

High

1240202

DJB11
DnaJ homolog subfamily B member 11

1

4

Small-scale

0.479

High

1240204

CHIP
E3 ubiquitin-protein ligase CHIP

1

4

Small-scale

0.479

High

153348

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

Small-scale

0.458

High

388605

HSPB1
Heat shock protein beta-1

1

0

Small-scale

0.458

High

806594

RL28
Large ribosomal subunit protein eL28

1

0

Small-scale

0.458

High

1240201

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

0

Small-scale

0.458

High

274583

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

3

Small-scale

0.437

High

858292

TXTP
Tricarboxylate transport protein, mitochondrial

1

4

Small-scale

0.437

High

1121310

AGK
Acylglycerol kinase, mitochondrial

1

1

Small-scale

0.437

High

1220721

MIRO1
Mitochondrial Rho GTPase 1

1

3

Small-scale

0.437

High

1240203

DIC
Mitochondrial dicarboxylate carrier

1

5

Small-scale

0.437

High

209265

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.426

High

1157068

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.279

Low

1240198

DPEP2
Dipeptidase 2

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024