Protein: STAT3
Signal transducer and activator of transcription 3 (Acute-phase response factor)

Gene: STAT3
Organism: Mus musculus
Interactions: 119
UniProt ID: P42227

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

786510

STAT3
Signal transducer and activator of transcription 3

9

16

Small-scale

0.963

High

193377

SOCS3
Suppressor of cytokine signaling 3

7

20

Small-scale

0.951

High

786536

JAK2
Tyrosine-protein kinase JAK2

4

20

Small-scale

0.878

High

786537

JAK3
Tyrosine-protein kinase JAK3

2

20

Small-scale

0.776

High

786511

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.771

High

403422

SRC
Proto-oncogene tyrosine-protein kinase Src

2

15

Small-scale

0.754

High

554870

KPCE
Protein kinase C epsilon type

1

7

Small-scale

0.724

High

786519

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.691

High

729741

BTK
Tyrosine-protein kinase BTK

1

15

Small-scale

0.647

High

786571

Q99K94
Signal transducer and activator of transcription

1

17

High-throughput

0.621

High

665978

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

16

Small-scale

0.618

High

729405

VGFR3
Vascular endothelial growth factor receptor 3

1

14

Small-scale

0.618

High

786520

FER
Tyrosine-protein kinase Fer

1

17

Small-scale

0.618

High

786524

TIE2
Angiopoietin-1 receptor

1

16

Small-scale

0.618

High

786529

CDON
Cell adhesion molecule-related/down-regulated by oncogenes

1

1

Small-scale

0.618

High

786544

BOC
Brother of CDO

1

2

Small-scale

0.618

High

786581

Q9QXJ2
Signal transducer and activator of transcription

1

17

Small-scale

0.618

High

786542

MK03
Mitogen-activated protein kinase 3

2

5

Small-scale

0.602

High

786522

PRGR
Progesterone receptor

2

18

Small-scale

0.601

High

404124

JUN
Transcription factor Jun

2

7

Small-scale

0.586

High

222357

DAPK3
Death-associated protein kinase 3

1

3

Small-scale

0.586

High

345606

FOS
Protein c-Fos

2

12

Small-scale

0.584

High

786540

IL17
Interleukin-17A

2

3

Small-scale

0.584

High

786570

FOXP3
Forkhead box protein P3

2

2

Small-scale

0.584

High

621294

CRYAB
Alpha-crystallin B chain

2

4

Small-scale

0.576

High

786543

CDK6
Cyclin-dependent kinase 6

1

1

Small-scale

0.536

High

348407

MYC
Myc proto-oncogene protein

1

4

Small-scale

0.515

High

786515

CEBPG
CCAAT/enhancer-binding protein gamma

1

16

Small-scale

0.515

High

786541

IRAK1
Interleukin-1 receptor-associated kinase 1

1

2

Small-scale

0.515

High

786532

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

6

Small-scale

0.501

High

786526

PO6F1
POU domain, class 6, transcription factor 1

1

6

High-throughput

0.481

High

82730

TMF1
TATA element modulatory factor

1

3

Small-scale

0.479

High

93505

ARI1B
AT-rich interactive domain-containing protein 1B

1

1

Small-scale

0.479

High

139023

ANGP1
Angiopoietin-1

1

4

Small-scale

0.479

High

139807

NFIL3
Nuclear factor interleukin-3-regulated protein

1

8

Small-scale

0.479

High

140185

GATA2
Endothelial transcription factor GATA-2

1

3

Small-scale

0.479

High

222290

PIAS3
E3 SUMO-protein ligase PIAS3

1

4

Small-scale

0.479

High

292653

SP1
Transcription factor Sp1

1

4

Small-scale

0.479

High

378809

GRAB
Granzyme B(G,H)

1

2

Small-scale

0.479

High

447438

PAX1
Paired box protein Pax-1

1

2

Small-scale

0.479

High

450545

JUNB
Transcription factor JunB

1

9

Small-scale

0.479

High

546497

INGR1
Interferon gamma receptor 1

1

14

Small-scale

0.479

High

547385

IRF1
Interferon regulatory factor 1

1

20

Small-scale

0.479

High

558504

IL4RA
Interleukin-4 receptor subunit alpha

1

20

Small-scale

0.479

High

562610

GHR
Growth hormone receptor

1

20

Small-scale

0.479

High

591193

TBXT
T-box transcription factor T

1

6

Small-scale

0.479

High

603913

TAL1
T-cell acute lymphocytic leukemia protein 1 homolog

1

2

Small-scale

0.479

High

607374

GA45B
Growth arrest and DNA damage-inducible protein GADD45 beta

1

1

Small-scale

0.479

High

607520

HNF1A
Hepatocyte nuclear factor 1-alpha

1

3

Small-scale

0.479

High

626853

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

2

Small-scale

0.479

High

655993

CEBPB
CCAAT/enhancer-binding protein beta

1

13

Small-scale

0.479

High

667782

NOS2
Nitric oxide synthase, inducible

1

3

Small-scale

0.479

High

685346

SCP2
Sterol carrier protein 2

1

1

Small-scale

0.479

High

723509

HES1
Transcription factor HES-1

1

3

Small-scale

0.479

High

786512

RORG
Nuclear receptor ROR-gamma

1

14

Small-scale

0.479

High

786514

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

Small-scale

0.479

High

786517

RACK1
Small ribosomal subunit protein RACK1

1

6

Small-scale

0.479

High

786518

NCOA1
Nuclear receptor coactivator 1

1

10

Small-scale

0.479

High

786521

LDB1
LIM domain-binding protein 1

1

1

Small-scale

0.479

High

786523

LYAM3
P-selectin

1

2

Small-scale

0.479

High

786527

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

4

Small-scale

0.479

High

786528

GSK3A
Glycogen synthase kinase-3 alpha

1

4

Small-scale

0.479

High

786530

STING
Stimulator of interferon genes protein

1

4

High-throughput

0.479

High

786531

SEM3G
Semaphorin-3G

1

1

Small-scale

0.479

High

786535

I10R1
Interleukin-10 receptor subunit alpha

1

14

Small-scale

0.479

High

786538

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

6

Small-scale

0.479

High

786545

HDAC4
Histone deacetylase 4

1

12

Small-scale

0.479

High

786546

PAXI1
PAX-interacting protein 1

1

3

Small-scale

0.479

High

786547

RIGI
Antiviral innate immune response receptor RIG-I

1

1

High-throughput

0.479

High

786549

Q6ZPV5
MKIAA1235 protein

1

1

Small-scale

0.479

High

786550

ASAP2
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2

1

5

Small-scale

0.479

High

786552

IL17F
Interleukin-17F

1

3

Small-scale

0.479

High

786557

DZIP1
Cilium assembly protein DZIP1

1

3

Small-scale

0.479

High

786558

RFOX2
RNA binding protein fox-1 homolog 2

1

1

Small-scale

0.479

High

786559

GBP5
Guanylate-binding protein 5

1

2

Small-scale

0.479

High

786560

INLR1
Interferon lambda receptor 1

1

14

Small-scale

0.479

High

786562

BAG4
BAG family molecular chaperone regulator 4

1

5

Small-scale

0.479

High

786563

ZN467
Zinc finger protein 467

1

2

Small-scale

0.479

High

786565

CADM4
Cell adhesion molecule 4

1

1

Small-scale

0.479

High

786567

ELP2
Elongator complex protein 2

1

8

Small-scale

0.479

High

786568

EED
Polycomb protein EED

1

4

High-throughput

0.479

High

786576

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

1

Small-scale

0.479

High

786579

SMAD9
Mothers against decapentaplegic homolog 9

1

2

Small-scale

0.479

High

786583

GSK3B
Glycogen synthase kinase-3 beta

1

5

Small-scale

0.479

High

786584

BCL3
B-cell lymphoma 3 protein homolog

1

8

Small-scale

0.479

High

140004

RGS2
Regulator of G-protein signaling 2

1

0

Small-scale

0.458

High

351617

COLI
Pro-opiomelanocortin

1

0

Small-scale

0.458

High

578873

SDC1
Syndecan-1

1

0

Small-scale

0.458

High

786513

EFNB1
Ephrin-B1

1

0

Small-scale

0.458

High

786516

PCBP1
Poly(rC)-binding protein 1

1

0

Small-scale

0.458

High

786525

ECT2
Protein ECT2

1

0

Small-scale

0.458

High

786534

CTNA2
Catenin alpha-2

1

0

Small-scale

0.458

High

786554

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

Small-scale

0.458

High

786556

GBRA5
Gamma-aminobutyric acid receptor subunit alpha-5

1

0

Small-scale

0.458

High

786561

NAV1
Neuron navigator 1

1

0

Small-scale

0.458

High

786564

PDK1L
Serine/threonine-protein kinase PDIK1L

1

0

Small-scale

0.458

High

786566

ZNG1
Zinc-regulated GTPase metalloprotein activator 1

1

0

Small-scale

0.458

High

786569

STEA4
Metalloreductase STEAP4

1

0

Small-scale

0.458

High

786573

GGYF1
GRB10-interacting GYF protein 1

1

0

Small-scale

0.458

High

786574

QCR10
Cytochrome b-c1 complex subunit 10

1

0

Small-scale

0.458

High

786575

SRFB1
Serum response factor-binding protein 1

1

0

Small-scale

0.458

High

786577

S40A1
Solute carrier family 40 member 1

1

0

Small-scale

0.458

High

786578

RT34
Small ribosomal subunit protein mS34

1

0

Small-scale

0.458

High

786580

PORCN
Protein-serine O-palmitoleoyltransferase porcupine

1

0

Small-scale

0.458

High

192704

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.457

High

250498

STMN3
Stathmin-3

1

2

Small-scale

0.457

High

376392

K2C1
Keratin, type II cytoskeletal 1

1

1

High-throughput

0.457

High

537690

HSPB1
Heat shock protein beta-1

1

4

High-throughput

0.457

High

786533

Q5U4D4
POU domain protein

1

6

High-throughput

0.457

High

786551

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

6

High-throughput

0.457

High

222758

LAT
Linker for activation of T-cells family member 1

1

1

High-throughput

0.445

High

786553

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.438

High

786555

BANK1
B-cell scaffold protein with ankyrin repeats

1

0

High-throughput

0.438

High

786572

MLF2
Myeloid leukemia factor 2

1

0

High-throughput

0.438

High

521434

FGL2
Fibroleukin

1

4

Small-scale

0.437

High

786582

ANGL2
Angiopoietin-related protein 2

1

4

Small-scale

0.437

High

786539

TSN7
Tetraspanin-7

1

0

Small-scale

0.249

Low

786548

Q6YIY0
Gag protein

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024