Protein: MPK1
Mitogen-activated protein kinase mpk-1 (EC 2.7.11.24) (MAP kinase sur-1)

Gene: MPK1, mpk-1
Organism: Caenorhabditis elegans
Interactions: 93
UniProt ID: P39745

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001556 - oocyte maturation
GO:0004674 - protein serine/threonine kinase activity
GO:0004707 - MAP kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

764290

MEK2
Dual specificity mitogen-activated protein kinase kinase mek-2

4

20

Small-scale

0.889

High

764297

UNC98
Zinc finger protein unc-98

3

1

High-throughput

0.862

High

105089

G5ECD7
cGMP-dependent protein kinase interacting domain-containing protein

3

7

High-throughput

0.847

High

248150

KCC2D
Calcium/calmodulin-dependent protein kinase type II

3

10

High-throughput

0.847

High

764298

Q19467
Arf-GAP domain-containing protein

3

7

High-throughput

0.847

High

764322

DNJ10
DnaJ homolog dnj-10

2

8

High-throughput

0.743

High

764289

MLRH
Myosin regulatory light chain

1

5

High-throughput

0.698

High

764313

KS6A1
Putative ribosomal protein S6 kinase alpha-1

1

20

High-throughput

0.698

High

764292

SPDL1
Spindly-like protein spdl-1

5

0

High-throughput

0.682

High

82886

B9WRT8
C3H1-type domain-containing protein

4

1

Small-scale

0.676

High

764288

NHR69
Nuclear hormone receptor family member nhr-69

3

13

High-throughput

0.668

High

764295

Q18318
RRM domain-containing protein

2

7

High-throughput

0.665

High

106802

NFYA1
Nuclear transcription factor Y subunit nfya-1

3

9

High-throughput

0.656

High

109635

H2KYX3
FERM domain-containing protein

3

4

High-throughput

0.656

High

183748

FIGL1
Fidgetin-like protein 1

3

4

High-throughput

0.656

High

764284

IFA1
Intermediate filament protein ifa-1

3

3

High-throughput

0.656

High

764306

IFC2
Intermediate filament protein ifc-2

3

7

High-throughput

0.656

High

764291

GLD1
Female germline-specific tumor suppressor gld-1

3

1

Small-scale

0.651

High

110173

GCK1
Germinal center kinase 1

1

11

Small-scale

0.647

High

764329

GSK3
Glycogen synthase kinase-3

1

14

Small-scale

0.647

High

110492

H2L2C3
Rap-GAP domain-containing protein

3

4

High-throughput

0.639

High

711922

ESS2
Splicing factor ESS-2

3

0

High-throughput

0.628

High

764301

HUTH1
Histidine ammonia-lyase

3

0

High-throughput

0.628

High

764296

RSP6
Probable splicing factor, arginine/serine-rich 6

1

9

High-throughput

0.621

High

711354

PLK1
Serine/threonine-protein kinase plk-1

1

16

High-throughput

0.618

High

764323

MBK1
Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1

1

16

High-throughput

0.618

High

764318

Q564V2
Lateral Signaling Target

4

1

High-throughput

0.616

High

764320

Q86G90
Nuclear Pore complex Protein

2

5

High-throughput

0.613

High

764333

DHYS
Deoxyhypusine synthase

2

3

High-throughput

0.613

High

137629

IFA2
Intermediate filament protein ifa-2

3

3

High-throughput

0.599

High

137581

O02289
C3H1-type domain-containing protein

2

1

High-throughput

0.596

High

137400

O02174
C3H1-type domain-containing protein

2

1

High-throughput

0.595

High

587388

VINC
Vinculin

2

0

High-throughput

0.587

High

764319

Q5FC73
Uncharacterized protein

3

1

High-throughput

0.583

High

764287

P91820
Lateral Signaling Target

3

1

High-throughput

0.580

High

764310

LMN1
Lamin-1

2

3

High-throughput

0.576

High

764299

SAS5
Spindle assembly abnormal protein 5

2

0

High-throughput

0.551

High

764321

GLS1
Germline survival defective-1

2

0

High-throughput

0.551

High

219826

NHR64
Nuclear hormone receptor family member nhr-64

1

13

High-throughput

0.541

High

764285

CSN5
COP9 signalosome complex subunit 5

1

4

High-throughput

0.541

High

764317

Q23463
Tr-type G domain-containing protein

2

4

High-throughput

0.526

High

248039

O62216
Regulator of microtubule dynamics protein 1

1

0

High-throughput

0.518

High

764314

Q21829
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.518

High

764316

YGH1
Uncharacterized protein T27F2.1

1

0

High-throughput

0.518

High

136896

CPB3
Cytoplasmic polyadenylation element-binding protein 3

1

0

Small-scale

0.504

High

185143

O18056
RNA helicase

1

5

Small-scale

0.501

High

764324

PPME1
Probable protein phosphatase methylesterase 1

1

1

High-throughput

0.494

High

764325

Q9N3Y1
PDZ GRASP-type domain-containing protein

1

6

High-throughput

0.494

High

106124

G5EDL0
ETS domain-containing protein

1

18

Small-scale

0.481

High

107584

G5EFG1
PDZ and LIM domain protein Zasp

1

6

High-throughput

0.481

High

220110

NH111
Nuclear hormone receptor family member nhr-111

1

14

High-throughput

0.481

High

764293

Q17746
ZZ-type domain-containing protein

1

6

High-throughput

0.481

High

712842

SKN1
Protein skinhead-1

1

0

Small-scale

0.480

High

108053

BRC2
DNA repair protein brc-2

1

0

High-throughput

0.460

High

248257

O62486
Nanos-type domain-containing protein

1

0

Small-scale

0.460

High

764302

CEP1
Transcription factor cep-1

1

0

Small-scale

0.460

High

764326

Q9N582
RanBP2-type domain-containing protein

1

0

High-throughput

0.460

High

283774

O76388
Biogenesis of lysosome-related organelles complex 1 subunit 1

1

0

Small-scale

0.458

High

764327

Q9TXM1
Uncharacterized protein

1

0

High-throughput

0.458

High

104567

G5EBY5
Rap-GAP domain-containing protein

1

4

High-throughput

0.457

High

109838

H2KZI3
C3H1-type domain-containing protein

1

1

High-throughput

0.457

High

764305

Q21021
Nuclear Pore complex Protein

1

5

High-throughput

0.457

High

764315

MIG5
Segment polarity protein dishevelled homolog mig-5

1

8

High-throughput

0.457

High

108202

G5EGG0
Uso1_p115_head domain-containing protein

1

1

High-throughput

0.439

High

110524

H2L2C8
Alpha-actinin, sarcomeric

1

7

High-throughput

0.439

High

183870

O16369
AP complex subunit sigma

1

2

High-throughput

0.439

High

764283

P90848
FAS1 domain-containing protein

1

3

High-throughput

0.439

High

764332

FLH1
FLYWCH transcription factor 1

1

0

High-throughput

0.438

High

105864

KLHL8
Kelch-like protein 8

1

2

High-throughput

0.417

High

764303

Q20771
Uncharacterized protein

1

1

High-throughput

0.417

High

764331

Q9XVU8
Alpha-actinin, sarcomeric

1

7

High-throughput

0.417

High

764308

Q21229
Uncharacterized protein

3

0

High-throughput

0.348

High

764330

Q9XUF2
Coiled-coil domain-containing protein 176

3

0

High-throughput

0.348

High

218148

O44150
MATH

3

0

High-throughput

0.342

High

711875

YLU3
Uncharacterized protein F10E9.3

3

0

High-throughput

0.342

High

764300

Q20330
Intermediate Filament Organize

3

0

High-throughput

0.342

High

764309

Q21234
Integrase zinc-binding domain-containing protein

3

0

High-throughput

0.342

High

86297

C0Z1Y1
LRAT domain-containing protein

3

0

High-throughput

0.333

High

109566

PICC1
PAC-1 interacting and coiled-coil domain-containing protein 1

2

0

High-throughput

0.319

High

764312

Q21648

2

0

High-throughput

0.319

High

185322

O18246
PRKCA-binding protein

2

0

High-throughput

0.300

High

184382

O17109
Methyltransf_11 domain-containing protein

1

0

High-throughput

0.282

High

764286

P91249
Nematode cuticle collagen N-terminal domain-containing protein

1

0

High-throughput

0.282

High

764304

GCDH
Probable glutaryl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.282

High

186294

O18687
Cytochrome c oxidase polypeptide VIIc

1

0

High-throughput

0.257

Low

110089

H2L025
RNA-directed RNA polymerase

1

0

High-throughput

0.251

Low

111038

I2HA96
Cat eye syndrome critical region protein 5

1

0

High-throughput

0.251

Low

247810

O61900
THUMP domain-containing protein

1

0

High-throughput

0.251

Low

764294

YTE4
Uncharacterized protein C09G1.4

1

0

High-throughput

0.251

Low

764307

Q21088
GEX Interacting protein

1

0

High-throughput

0.251

Low

764311

Q21462
WW domain-containing protein

1

0

High-throughput

0.251

Low

764328

Q9U211
EB domain-containing protein

1

0

High-throughput

0.251

Low

764334

Q9XXU2
Uncharacterized protein

1

0

High-throughput

0.251

Low


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Last updated: 15 Jul 2024