Protein: NELFA
Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein)

Gene: NELFA
Organism: Homo sapiens
Interactions: 86
UniProt ID: Q9H3P2

Gene Ontology (top 5):
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0016604 - nuclear body

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1220576

NELFD
Negative elongation factor C/D

10

1

Small-scale

0.760

High

577781

NELFE
Negative elongation factor E

7

1

Small-scale

0.753

High

1263167

NELFB
Negative elongation factor B

6

1

Small-scale

0.737

High

124081

SPT5H
Transcription elongation factor SPT5

3

4

Small-scale

0.662

High

583577

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

1

Small-scale

0.628

High

758131

SMBP2
DNA-binding protein SMUBP-2

2

1

High-throughput

0.628

High

1330250

MCM9
DNA helicase MCM9

2

4

High-throughput

0.628

High

625037

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

1

Small-scale

0.624

High

677001

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

3

High-throughput

0.611

High

209167

NCK2
Cytoplasmic protein NCK2

2

13

High-throughput

0.606

High

960121

CDK3
Cyclin-dependent kinase 3

2

3

High-throughput

0.606

High

1285190

SH3K1
SH3 domain-containing kinase-binding protein 1

2

11

High-throughput

0.606

High

1292483

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

2

1

High-throughput

0.606

High

244930

BRD4
Bromodomain-containing protein 4

2

3

High-throughput

0.584

High

776397

MLH1
DNA mismatch repair protein Mlh1

2

0

High-throughput

0.580

High

1038057

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

0

High-throughput

0.580

High

1216712

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

1

High-throughput

0.573

High

853983

NCBP2
Nuclear cap-binding protein subunit 2

2

4

High-throughput

0.571

High

387504

P53
Cellular tumor antigen p53

1

5

High-throughput

0.536

High

683705

1433B
14-3-3 protein beta/alpha

1

16

High-throughput

0.536

High

738882

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

1

High-throughput

0.536

High

813746

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

854468

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

1

High-throughput

0.536

High

927518

1433Z
14-3-3 protein zeta/delta

1

16

High-throughput

0.536

High

930996

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

1

High-throughput

0.536

High

996894

SSRP1
FACT complex subunit SSRP1

1

4

High-throughput

0.536

High

1330249

PICK1
PRKCA-binding protein

1

1

High-throughput

0.536

High

723103

OPRM
Mu-type opioid receptor

1

2

High-throughput

0.532

High

831685

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.527

High

571213

EGLN
Endoglin

1

0

High-throughput

0.513

High

583796

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.513

High

611337

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

0

High-throughput

0.513

High

854364

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.513

High

864986

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.513

High

897627

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.513

High

983075

ICA69
Islet cell autoantigen 1

1

0

High-throughput

0.513

High

998183

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.513

High

1286588

INT12
Integrator complex subunit 12

1

0

High-throughput

0.513

High

1310369

PYM1
Partner of Y14 and mago

1

0

High-throughput

0.513

High

1330255

AGO2
Protein argonaute-2

1

0

High-throughput

0.513

High

395750

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

362488

C1QA
Complement C1q subcomponent subunit A

1

4

High-throughput

0.489

High

125708

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

6

High-throughput

0.479

High

210277

PRC1
Protein regulator of cytokinesis 1

1

2

High-throughput

0.479

High

228681

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

347880

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.479

High

470157

H2AZ
Histone H2A.Z

1

7

High-throughput

0.479

High

487761

ANDR
Androgen receptor

1

14

High-throughput

0.479

High

553693

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

652230

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

668977

PML
Protein PML

1

3

High-throughput

0.479

High

721428

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

918683

H2B1C
Histone H2B type 1-C/E/F/G/I

1

9

High-throughput

0.479

High

932375

ACTC
Actin, alpha cardiac muscle 1

1

2

High-throughput

0.479

High

992929

SRSF1
Serine/arginine-rich splicing factor 1

1

2

High-throughput

0.479

High

1075179

TCEA2
Transcription elongation factor A protein 2

1

1

High-throughput

0.479

High

1123393

BRDT
Bromodomain testis-specific protein

1

6

High-throughput

0.479

High

1222574

SLX4
Structure-specific endonuclease subunit SLX4

1

4

High-throughput

0.479

High

1269602

ESR2
Estrogen receptor beta

1

14

High-throughput

0.479

High

1270440

HDAC2
Histone deacetylase 2

1

6

High-throughput

0.479

High

1270924

KAT6A
Histone acetyltransferase KAT6A

1

3

High-throughput

0.479

High

1330024

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

1

Small-scale

0.479

High

1330254

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1330256

ASF1A
Histone chaperone ASF1A

1

3

High-throughput

0.479

High

246614

MCE1
mRNA-capping enzyme

1

0

High-throughput

0.458

High

750468

COIL
Coilin

1

0

High-throughput

0.458

High

1330251

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

87267

C9J2Y9
DNA-directed RNA polymerase subunit beta

1

3

High-throughput

0.445

High

497592

TAU
Microtubule-associated protein tau

1

10

High-throughput

0.445

High

1116544

LARP7
La-related protein 7

1

2

Small-scale

0.445

High

385512

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.437

High

1171690

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1330253

HECW2
E3 ubiquitin-protein ligase HECW2

1

6

High-throughput

0.437

High

893603

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.426

High

1203383

PRSR2
Proline and serine-rich protein 2

2

0

High-throughput

0.328

High

1305625

FEZ1
Fasciculation and elongation protein zeta-1

2

0

High-throughput

0.328

High

1330252

TMOD4
Tropomodulin-4

2

0

High-throughput

0.328

High

1224039

PRR22
Proline-rich protein 22

2

0

High-throughput

0.304

High

1205230

XYLT1
Xylosyltransferase 1

1

0

High-throughput

0.279

Low

1245547

ATLA2
Atlastin-2

1

0

High-throughput

0.279

Low

1292594

RUSF1
RUS family member 1

1

0

High-throughput

0.279

Low

1311849

SPXN
Spexin

1

0

High-throughput

0.279

Low

393345

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.249

Low

714772

TRY3
Trypsin-3

1

0

High-throughput

0.249

Low

1173045

SEML
Putative protein SEM1, isoform 2

1

0

High-throughput

0.249

Low

1237353

UBR7
Putative E3 ubiquitin-protein ligase UBR7

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024