Protein: PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)]

Gene: PUR6, PAICS
Organism: Homo sapiens
Interactions: 193
UniProt ID: P22234

Gene Ontology (top 5):
GO:0004638 - phosphoribosylaminoimidazole carboxylase activity
GO:0004639 - phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

606360

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

6

6

High-throughput

0.951

High

606385

FXR2
RNA-binding protein FXR2

3

1

High-throughput

0.681

High

606459

LNX1
E3 ubiquitin-protein ligase LNX

3

1

High-throughput

0.667

High

606484

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

3

3

Small-scale

0.633

High

226523

PRKN
E3 ubiquitin-protein ligase parkin

3

0

High-throughput

0.613

High

606440

NUD18
8-oxo-dGDP phosphatase NUDT18

2

0

High-throughput

0.613

High

606418

CUL3
Cullin-3

2

1

High-throughput

0.611

High

606507

ARIP4
Helicase ARIP4

2

1

High-throughput

0.606

High

606379

YAP1
Transcriptional coactivator YAP1

2

2

High-throughput

0.584

High

606405

RNF4
E3 ubiquitin-protein ligase RNF4

2

0

High-throughput

0.580

High

606428

CDC37
Hsp90 co-chaperone Cdc37

2

0

High-throughput

0.580

High

606497

ZMYM2
Zinc finger MYM-type protein 2

2

0

High-throughput

0.580

High

606394

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

2

3

Small-scale

0.571

High

606478

SH3G3
Endophilin-A3

2

1

High-throughput

0.571

High

606487

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

2

3

Small-scale

0.571

High

345929

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.559

High

606366

SHC1
SHC-transforming protein 1

2

0

High-throughput

0.547

High

606456

DOCK8
Dedicator of cytokinesis protein 8

2

0

High-throughput

0.547

High

606384

FXR1
RNA-binding protein FXR1

1

1

High-throughput

0.541

High

606505

PHOCN
MOB-like protein phocein

1

1

High-throughput

0.541

High

606485

NIF3L
NIF3-like protein 1

1

0

High-throughput

0.536

High

537594

NCF1
Neutrophil cytosol factor 1

1

2

High-throughput

0.536

High

606374

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

1

High-throughput

0.536

High

606396

ARP2
Actin-related protein 2

1

1

High-throughput

0.536

High

606409

KPCZ
Protein kinase C zeta type

1

1

High-throughput

0.536

High

606426

MYLK
Myosin light chain kinase, smooth muscle

1

1

High-throughput

0.536

High

606449

MYLK4
Myosin light chain kinase family member 4

1

1

High-throughput

0.536

High

606470

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

0

High-throughput

0.528

High

606389

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.518

High

606390

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

0

High-throughput

0.518

High

606410

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.518

High

606457

CEP76
Centrosomal protein of 76 kDa

1

0

High-throughput

0.518

High

455087

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.515

High

606508

TRAF6
TNF receptor-associated factor 6

1

2

High-throughput

0.515

High

87417

C9JJ79
Paired immunoglobin like type 2 receptor alpha

1

1

High-throughput

0.515

High

606443

Q7KZS0
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.515

High

128440

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

164100

ARHGA
Rho guanine nucleotide exchange factor 10

1

0

High-throughput

0.513

High

201215

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

362817

FINC
Fibronectin

1

0

High-throughput

0.513

High

606368

1433B
14-3-3 protein beta/alpha

1

0

High-throughput

0.513

High

606375

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

606387

AP2S1
AP-2 complex subunit sigma

1

0

High-throughput

0.513

High

606400

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

0

High-throughput

0.513

High

606424

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.513

High

606429

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

1

0

High-throughput

0.513

High

606458

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.513

High

606460

NEK7
Serine/threonine-protein kinase Nek7

1

0

High-throughput

0.513

High

606474

DNJC2
DnaJ homolog subfamily C member 2

1

0

High-throughput

0.513

High

606510

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.513

High

606407

UBE3A
Ubiquitin-protein ligase E3A

1

1

Small-scale

0.501

High

505549

EPB41
Protein 4.1

1

0

High-throughput

0.493

High

606361

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.493

High

606378

PRS6B
26S proteasome regulatory subunit 6B

1

0

High-throughput

0.493

High

606386

DGKE
Diacylglycerol kinase epsilon

1

0

High-throughput

0.493

High

606392

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.493

High

606402

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

0

High-throughput

0.493

High

606403

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.481

High

606501

PILRA
Paired immunoglobulin-like type 2 receptor alpha

1

1

High-throughput

0.481

High

116968

SGK1
Serine/threonine-protein kinase Sgk1

1

1

High-throughput

0.479

High

569185

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

606377

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

606412

TP4A2
Protein tyrosine phosphatase type IVA 2

1

1

High-throughput

0.479

High

606417

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

606419

CUL4A
Cullin-4A

1

1

High-throughput

0.479

High

606420

CDK13
Cyclin-dependent kinase 13

1

1

High-throughput

0.479

High

606427

CRY1
Cryptochrome-1

1

1

High-throughput

0.479

High

606430

ANR55
Ankyrin repeat domain-containing protein 55

1

2

High-throughput

0.479

High

606431

CRY2
Cryptochrome-2

1

1

High-throughput

0.479

High

606434

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.479

High

606441

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

606448

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.479

High

606453

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

606464

TP4A1
Protein tyrosine phosphatase type IVA 1

1

1

High-throughput

0.479

High

606476

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

606480

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

606481

MLP3C
Microtubule-associated proteins 1A/1B light chain 3C

1

3

Small-scale

0.479

High

606486

WWTR1
WW domain-containing transcription regulator protein 1

1

2

High-throughput

0.479

High

606489

Q9H4D1
Protein kinase

1

1

High-throughput

0.479

High

606490

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

606498

TRM7
tRNA

1

1

High-throughput

0.479

High

606503

FND3A
Fibronectin type-III domain-containing protein 3A

1

1

High-throughput

0.479

High

331210

CHK2
Serine/threonine-protein kinase Chk2

1

0

Small-scale

0.464

High

119165

LEG9
Galectin-9

1

0

High-throughput

0.458

High

122496

MEN1
Menin

1

0

High-throughput

0.458

High

165930

PER2
Period circadian protein homolog 2

1

0

Small-scale

0.458

High

241967

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

294365

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

298153

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

302901

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

318571

EYA4
Eyes absent homolog 4

1

0

High-throughput

0.458

High

354290

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

384263

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

417937

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

487132

ANDR
Androgen receptor

1

0

High-throughput

0.458

High

503433

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

521724

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

547439

FOLR1
Folate receptor alpha

1

0

High-throughput

0.458

High

606362

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

0

High-throughput

0.458

High

606363

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

606367

KCY
UMP-CMP kinase

1

0

High-throughput

0.458

High

606369

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

606370

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

606372

MSX2
Homeobox protein MSX-2

1

0

High-throughput

0.458

High

606373

FUS
RNA-binding protein FUS

1

0

High-throughput

0.458

High

606376

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

606381

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

606383

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

606388

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

606391

BID
BH3-interacting domain death agonist

1

0

Small-scale

0.458

High

606395

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

606397

RS3A
Small ribosomal subunit protein eS1

1

0

High-throughput

0.458

High

606398

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

606401

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

606404

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

606406

CCNA1
Cyclin-A1

1

0

High-throughput

0.458

High

606408

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

0

High-throughput

0.458

High

606411

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

606413

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

0

High-throughput

0.458

High

606414

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.458

High

606415

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

606416

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

606422

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

606423

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

606425

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

606435

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

606437

CDC73
Parafibromin

1

0

High-throughput

0.458

High

606438

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

0

High-throughput

0.458

High

606439

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

606444

5MP2
eIF5-mimic protein 2

1

0

High-throughput

0.458

High

606446

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

606451

RPTOR
Regulatory-associated protein of mTOR

1

0

High-throughput

0.458

High

606452

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

606454

MTMRE
Myotubularin-related protein 14

1

0

High-throughput

0.458

High

606455

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

606461

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

606462

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

606463

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

606468

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

606472

RANB9
Ran-binding protein 9

1

0

Small-scale

0.458

High

606473

RUFY1
RUN and FYVE domain-containing protein 1

1

0

High-throughput

0.458

High

606477

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

606479

TIPIN
TIMELESS-interacting protein

1

0

High-throughput

0.458

High

606482

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

606488

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

606491

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

606492

ANLN
Anillin

1

0

High-throughput

0.458

High

606493

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

606494

PHP14
14 kDa phosphohistidine phosphatase

1

0

High-throughput

0.458

High

606495

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

606496

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

606499

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

606500

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

606502

FAF1
FAS-associated factor 1

1

0

High-throughput

0.458

High

606509

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

0

High-throughput

0.458

High

173835

MK13
Mitogen-activated protein kinase 13

1

1

Small-scale

0.445

High

606393

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

606432

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

606436

PKHA7
Pleckstrin homology domain-containing family A member 7

1

2

High-throughput

0.445

High

606364

U2AF2
Splicing factor U2AF 65 kDa subunit

1

1

High-throughput

0.437

High

606442

ASXL2
Putative Polycomb group protein ASXL2

1

2

High-throughput

0.437

High

606450

ASXL1
Polycomb group protein ASXL1

1

2

High-throughput

0.437

High

606483

ASXL3
Putative Polycomb group protein ASXL3

1

2

High-throughput

0.437

High

496302

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

528549

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

581427

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.426

High

606466

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

606471

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

401419

JUN
Transcription factor Jun

1

1

High-throughput

0.407

High

606382

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.373

High

606465

LMBL2
Lethal(3)malignant brain tumor-like protein 2

2

0

High-throughput

0.337

High

278227

PIAS2
E3 SUMO-protein ligase PIAS2

2

0

High-throughput

0.316

High

606475

ZBT18
Zinc finger and BTB domain-containing protein 18

2

0

Small-scale

0.298

High

606467

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

0

High-throughput

0.282

High

606469

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

452625

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

606399

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.279

Low

205043

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

239493

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.249

Low

243933

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

329358

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

551946

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

554802

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.249

Low

606365

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

606371

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

606380

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

606421

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

606433

OTUD1
OTU domain-containing protein 1

1

0

High-throughput

0.249

Low

606445

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

606447

MGDP1
Magnesium-dependent phosphatase 1

1

0

High-throughput

0.249

Low

606504

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

606506

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024