HitPredict
Protein: IRS1
Insulin receptor substrate 1 (IRS-1) (pp185)

Gene: IRS1
Organism: Rattus norvegicus
Interactions: 12
UniProt ID: P35570

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0002053 - positive regulation of mesenchymal cell proliferation
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005080 - protein kinase C binding
GO:0005158 - insulin receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score		 Confidence

724631

 GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

 0.754

High

724634

 P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

7

20

Small-scale

 0.738

High

292432

 GRB14
Growth factor receptor-bound protein 14

1

20

Small-scale

 0.618

High

544792

 INSR
Insulin receptor

1

20

Small-scale

 0.618

High

724632

 JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

 0.618

High

139615

 SQSTM
Sequestosome-1

1

4

Small-scale

 0.561

High

88599

 D3ZFJ0
phosphatidylinositol-4,5-bisphosphate 3-kinase

1

9

Small-scale

 0.479

High

88771

 D3ZV15
E3 ubiquitin-protein ligase CBL

1

8

Small-scale

 0.479

High

88791

 D3ZVH5
E3 ubiquitin-protein ligase Mdm2

1

2

Small-scale

 0.479

High

724630

 PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

10

Small-scale

 0.479

High

724633

 UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related]

1

8

Small-scale

 0.479

High

724635

 PABP1
Polyadenylate-binding protein 1

1

7

Small-scale

 0.479

High

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Last updated: 15 Jul 2024