Protein: MCK1
Protein kinase MCK1 (EC 2.7.12.1) (Meiosis and centromere regulatory kinase)

Gene: MCK1
Organism: Saccharomyces cerevisiae S288C
Interactions: 209
UniProt ID: P21965

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0004713 - protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

602619

MPIP
M-phase inducer phosphatase

2

5

Small-scale

0.768

High

602613

MCK1
Protein kinase MCK1

2

17

Small-scale

0.757

High

365793

HSP82
ATP-dependent molecular chaperone HSP82

2

14

High-throughput

0.754

High

543200

HSC82
ATP-dependent molecular chaperone HSC82

2

14

High-throughput

0.754

High

602656

NNK1
Nitrogen network kinase 1

1

11

High-throughput

0.691

High

602731

NOP15
Ribosome biogenesis protein 15

1

9

High-throughput

0.691

High

602738

CDC14
Tyrosine-protein phosphatase CDC14

1

3

High-throughput

0.691

High

602615

RAD53
Serine/threonine-protein kinase RAD53

1

9

Small-scale

0.680

High

597112

ACE2
Metallothionein expression activator

1

8

High-throughput

0.647

High

602629

KCC1
Calcium/calmodulin-dependent protein kinase I

1

7

High-throughput

0.647

High

602631

CDC15
Cell division control protein 15

1

20

High-throughput

0.647

High

602651

HSL1
Probable serine/threonine-protein kinase HSL1

1

8

Small-scale

0.647

High

602654

PP2C1
Protein phosphatase 2C homolog 1

1

8

High-throughput

0.647

High

602657

KKQ8
Probable serine/threonine-protein kinase KKQ8

1

19

High-throughput

0.647

High

602703

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.647

High

602719

PCL10
PHO85 cyclin-10

1

8

High-throughput

0.647

High

602727

FPK1
Flippase kinase 1

1

20

High-throughput

0.647

High

602736

CRZ1
Transcriptional regulator CRZ1

1

2

High-throughput

0.647

High

602783

CMR3
Zinc finger protein CRM3

1

1

High-throughput

0.647

High

602671

KSP1
Serine/threonine-protein kinase KSP1

1

20

High-throughput

0.646

High

447779

CDC6
Cell division control protein 6

2

4

Small-scale

0.636

High

602621

CG22
G2/mitotic-specific cyclin-2

1

20

Small-scale

0.618

High

602623

SIS1
Protein SIS1

1

4

High-throughput

0.618

High

602733

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.618

High

602767

RGA2
Rho-type GTPase-activating protein 2

2

10

High-throughput

0.611

High

587288

UBR1
E3 ubiquitin-protein ligase UBR1

1

2

Small-scale

0.598

High

602635

BMH1
Protein BMH1

2

5

High-throughput

0.594

High

602792

PEX11
Peroxisomal membrane protein PMP27

2

0

High-throughput

0.587

High

602647

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

2

0

Small-scale

0.579

High

602760

RRP5
rRNA biogenesis protein RRP5

1

4

High-throughput

0.579

High

602778

CWC2
Pre-mRNA-splicing factor CWC2

1

5

High-throughput

0.579

High

340019

KPYK1
Pyruvate kinase 1

1

4

Small-scale

0.573

High

500300

GPA2
Guanine nucleotide-binding protein alpha-2 subunit

1

1

Small-scale

0.561

High

493203

HSP72
Heat shock protein SSA2

2

9

High-throughput

0.552

High

602702

ECO1
N-acetyltransferase ECO1

1

0

Small-scale

0.545

High

602755

MYO5
Myosin-5

1

17

High-throughput

0.541

High

389686

CDC25
Cell division control protein 25

1

3

High-throughput

0.536

High

602617

URE2
Transcriptional regulator URE2

1

1

High-throughput

0.536

High

602649

PMD1
Negative regulator of sporulation PMD1

1

2

High-throughput

0.536

High

602692

SLM1
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1

1

2

High-throughput

0.536

High

602713

ASK10
Activator of SKN7 protein 10

1

2

High-throughput

0.536

High

602717

MDS3
Negative regulator of sporulation MDS3

1

2

High-throughput

0.536

High

602747

YE11B
Transposon Ty1-ER1 Gag-Pol polyprotein

1

8

High-throughput

0.536

High

602762

RGC1
Regulator of the glycerol channel 1

1

2

High-throughput

0.536

High

602772

TRM3
tRNA

1

1

High-throughput

0.536

High

602775

LAM6
Membrane-anchored lipid-binding protein LAM6

1

2

High-throughput

0.536

High

602785

PSH1
RING finger protein PSH1

1

3

High-throughput

0.536

High

602787

YB21A
Transposon Ty2-B Gag polyprotein

1

12

High-throughput

0.536

High

602614

SNF2
Transcription regulatory protein SNF2

1

6

High-throughput

0.515

High

602722

MCY1
Putative mitochondrial cysteine synthase

1

1

High-throughput

0.515

High

602723

RSC1
Chromatin structure-remodeling complex subunit RSC1

1

7

High-throughput

0.515

High

602662

SEA4
SEH-associated protein 4

1

0

High-throughput

0.513

High

602672

NPR3
Nitrogen permease regulator 3

1

0

High-throughput

0.513

High

602676

UME6
Transcriptional regulatory protein UME6

1

1

Small-scale

0.508

High

426421

SYSC
Serine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.501

High

482612

YE11A
Transposon Ty1-ER1 Gag polyprotein

1

11

High-throughput

0.501

High

560900

EF3A
Elongation factor 3A

1

2

High-throughput

0.501

High

562318

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

3

High-throughput

0.501

High

602616

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

4

High-throughput

0.501

High

602620

SSD1
Protein SSD1

1

1

High-throughput

0.501

High

602622

PTP1
Tyrosine-protein phosphatase 1

1

4

High-throughput

0.501

High

602630

GYS2
Glycogen [starch] synthase isoform 2

1

3

High-throughput

0.501

High

602633

KIP2
Kinesin-like protein KIP2

1

7

Small-scale

0.501

High

602636

MCM2
DNA replication licensing factor MCM2

1

7

High-throughput

0.501

High

602640

MLF3
Protein MLF3

1

2

High-throughput

0.501

High

602648

PAH1
Phosphatidic acid phosphohydrolase 1

1

2

High-throughput

0.501

High

602659

ADCS
Aminodeoxychorismate synthase

1

4

High-throughput

0.501

High

602663

NCL1
Multisite-specific tRNA:(cytosine-C(5))-methyltransferase

1

1

High-throughput

0.501

High

602684

UBP9
Ubiquitin carboxyl-terminal hydrolase 9

1

4

High-throughput

0.501

High

602685

EDC3
Enhancer of mRNA-decapping protein 3

1

2

High-throughput

0.501

High

602690

VHS2
Protein VHS2

1

2

High-throughput

0.501

High

602693

SYA
Alanine--tRNA ligase, mitochondrial

1

3

High-throughput

0.501

High

602694

YAP4
AP-1-like transcription factor YAP4

1

1

High-throughput

0.501

High

602696

YRB1
Ran-specific GTPase-activating protein 1

1

4

High-throughput

0.501

High

602698

GZF3
Protein GZF3

1

4

High-throughput

0.501

High

602700

GCN20
Protein GCN20

1

1

High-throughput

0.501

High

602701

ROG3
Protein ROG3

1

3

High-throughput

0.501

High

602704

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

3

High-throughput

0.501

High

602706

ALY2
Arrestin-related trafficking adapter 3

1

4

High-throughput

0.501

High

602732

NIS1
Protein NIS1

1

1

High-throughput

0.501

High

602734

AQR1
Probable transporter AQR1

1

2

High-throughput

0.501

High

602741

RNT1
Ribonuclease 3

1

3

High-throughput

0.501

High

602745

NHP10
Non-histone protein 10

1

5

High-throughput

0.501

High

602751

YAP6
AP-1-like transcription factor YAP6

1

1

High-throughput

0.501

High

602758

YM11A
Transposon Ty1-ML1 Gag polyprotein

1

11

High-throughput

0.501

High

602770

BDF2
Bromodomain-containing factor 2

1

5

High-throughput

0.501

High

602773

RIX7
Ribosome biogenesis ATPase RIX7

1

5

High-throughput

0.501

High

602789

TRM13
tRNA:m(4)X modification enzyme TRM13

1

1

High-throughput

0.501

High

602790

YN11A
Transposon Ty1-NL1 Gag polyprotein

1

11

High-throughput

0.501

High

602793

YG12A
Transposon Ty1-GR2 Gag polyprotein

1

11

High-throughput

0.501

High

602794

CMR1
DNA damage-binding protein CMR1

1

3

High-throughput

0.501

High

602653

BMH2
Protein BMH2

1

5

High-throughput

0.500

High

602624

PRTD
Saccharolysin

1

0

High-throughput

0.493

High

535977

CHS2
Chitin synthase 2

1

1

High-throughput

0.489

High

602655

MNR2
Manganese resistance protein MNR2

1

1

High-throughput

0.489

High

602691

PRM5
Pheromone-regulated membrane protein 5

1

1

High-throughput

0.489

High

602711

IML1
Vacuolar membrane-associated protein IML1

1

1

High-throughput

0.489

High

602716

SEH1
Nucleoporin SEH1

1

6

High-throughput

0.489

High

602735

YNF8
Vacuolar membrane protein YNL058C

1

1

High-throughput

0.489

High

602750

WDR59
Maintenance of telomere capping protein 5

1

7

High-throughput

0.489

High

602757

SEC13
Protein transport protein SEC13

1

4

High-throughput

0.489

High

602776

ALR1
Magnesium transporter ALR1

1

1

High-throughput

0.489

High

602777

RTC1
Restriction of telomere capping protein 1

1

9

High-throughput

0.489

High

411216

LEU1
2-isopropylmalate synthase

1

0

High-throughput

0.480

High

546506

AMPD
AMP deaminase

1

0

High-throughput

0.480

High

593275

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.480

High

602626

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

Small-scale

0.480

High

602632

FUN19
SWIRM domain-containing protein FUN19

1

0

High-throughput

0.480

High

602652

SLD2
DNA replication regulator SLD2

1

0

Small-scale

0.480

High

602660

SOL2
6-phosphogluconolactonase-like protein 2

1

0

High-throughput

0.480

High

602677

CAT8
Regulatory protein CAT8

1

0

High-throughput

0.480

High

602681

MTW1
Kinetochore-associated protein MTW1

1

0

High-throughput

0.480

High

602687

PPN2
Zinc-dependent endopolyphosphatase

1

0

High-throughput

0.480

High

602688

PP4R3
Serine/threonine-protein phosphatase 4 regulatory subunit 3

1

0

High-throughput

0.480

High

602709

DPOD3
DNA polymerase delta subunit 3

1

0

High-throughput

0.480

High

602710

EFM3
Protein-lysine N-methyltransferase EFM3

1

0

High-throughput

0.480

High

602712

YJ9I
Uncharacterized protein YJR141W

1

0

High-throughput

0.480

High

602721

EFM5
Protein-lysine N-methyltransferase EFM5

1

0

High-throughput

0.480

High

602724

YG36
Uncharacterized protein YGR126W

1

0

High-throughput

0.480

High

602725

REXO1
RNA exonuclease 1

1

0

High-throughput

0.480

High

602728

DUS1
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]

1

0

High-throughput

0.480

High

602730

SWT21
Protein SWT21

1

0

High-throughput

0.480

High

602744

ADD37
Alpha1-proteinase inhibitor-degradation deficient protein 37

1

0

High-throughput

0.480

High

602756

MGR3
Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR3

1

0

High-throughput

0.480

High

602759

SML1
Ribonucleotide reductase inhibitor protein SML1

1

0

High-throughput

0.480

High

602768

UBX5
UBX domain-containing protein 5

1

0

High-throughput

0.480

High

602769

SSK1
Osmolarity two-component system protein SSK1

1

0

High-throughput

0.480

High

602779

KAD6
Adenylate kinase isoenzyme 6 homolog FAP7

1

0

High-throughput

0.480

High

602781

SAS10
Something about silencing protein 10

1

0

High-throughput

0.480

High

602786

USB1
U6 snRNA phosphodiesterase 1

1

0

High-throughput

0.480

High

602791

MPC70
Sporulation-specific protein 21

1

0

High-throughput

0.480

High

406787

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

602627

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.479

High

602634

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

602639

HS104
Heat shock protein 104

1

2

High-throughput

0.479

High

602729

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.479

High

602748

YE12B
Transposon Ty1-ER2 Gag-Pol polyprotein

1

9

High-throughput

0.479

High

602752

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.479

High

602754

PDS5
Sister chromatid cohesion protein PDS5

1

1

High-throughput

0.479

High

602763

IMB1
Importin subunit beta-1

1

6

High-throughput

0.479

High

602771

SUB2
ATP-dependent RNA helicase SUB2

1

8

High-throughput

0.479

High

602784

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

602695

HUL4
Probable E3 ubiquitin-protein ligase HUL4

1

4

High-throughput

0.470

High

524167

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

602743

ESP1
Separin

1

0

High-throughput

0.458

High

602753

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

602764

NEJ1
Non-homologous end-joining protein 1

1

0

Small-scale

0.458

High

602765

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

602766

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

563920

SEC2
Rab guanine nucleotide exchange factor SEC2

1

1

High-throughput

0.457

High

602618

MBR1
Mitochondrial biogenesis regulation protein 1

1

1

High-throughput

0.457

High

602628

YCZ0
Uncharacterized protein YCR100C

1

1

High-throughput

0.457

High

602638

RM09
Large ribosomal subunit protein uL3m

1

1

High-throughput

0.457

High

602641

YMC1
Mitochondrial glycine transporter YMC1

1

4

High-throughput

0.457

High

602642

CDC11
Cell division control protein 11

1

2

High-throughput

0.457

High

602643

EUG1
Protein disulfide-isomerase EUG1

1

6

High-throughput

0.457

High

602661

AP2A
AP-2 complex subunit alpha

1

5

High-throughput

0.457

High

602664

QDR3
Quinidine resistance protein 3

1

2

High-throughput

0.457

High

602666

AIM3
Altered inheritance of mitochondria protein 3

1

7

High-throughput

0.457

High

602668

UBX7
UBX domain-containing protein 7

1

5

High-throughput

0.457

High

602670

GLO3
ADP-ribosylation factor GTPase-activating protein GLO3

1

9

High-throughput

0.457

High

602675

GGC1
Mitochondrial GTP/GDP carrier protein 1

1

6

High-throughput

0.457

High

602680

ERP2
Protein ERP2

1

4

High-throughput

0.457

High

602682

HPH2
Protein HPH2

1

1

High-throughput

0.457

High

602689

VPS27
Vacuolar protein sorting-associated protein 27

1

6

High-throughput

0.457

High

602737

TMEDA
Endoplasmic reticulum vesicle protein 25

1

3

High-throughput

0.457

High

602742

YP077
Uncharacterized protein YPL077C

1

1

High-throughput

0.457

High

602739

UBC7
Ubiquitin-conjugating enzyme E2 7

1

3

High-throughput

0.457

High

490341

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.445

High

602686

SSB2
Ribosome-associated molecular chaperone SSB2

1

11

High-throughput

0.445

High

602697

MPG1
Mannose-1-phosphate guanyltransferase

1

2

High-throughput

0.445

High

602780

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

9

High-throughput

0.445

High

602679

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

602740

MLP1
Protein MLP1

1

14

High-throughput

0.437

High

602678

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.426

High

602708

NOP9
Nucleolar protein 9

1

0

High-throughput

0.426

High

602667

YB75
Uncharacterized protein YBR225W

2

0

High-throughput

0.322

High

602637

ITR1
Myo-inositol transporter 1

1

0

High-throughput

0.279

Low

602645

KRE6
Beta-glucan synthesis-associated protein KRE6

1

0

High-throughput

0.279

Low

602669

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.279

Low

602674

PNT1
Pentamidine resistance factor, mitochondrial

1

0

High-throughput

0.279

Low

602683

NPR2
Nitrogen permease regulator 2

1

0

High-throughput

0.279

Low

602707

NET1
Nucleolar protein NET1

1

0

High-throughput

0.279

Low

602746

YM8V
Uncharacterized protein YMR295C

1

0

High-throughput

0.279

Low

602788

ATG34
Autophagy-related protein 34

1

0

High-throughput

0.279

Low

562034

RGP1
Guanine nucleotide exchange factor subunit RGP1

1

0

High-throughput

0.269

Low

602646

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.265

Low

141928

YP089
Dilute domain-containing protein YPR089W

1

0

High-throughput

0.261

Low

486128

ADH4
Alcohol dehydrogenase 4

1

0

High-throughput

0.261

Low

602625

ADH7
NADP-dependent alcohol dehydrogenase 7

1

0

High-throughput

0.261

Low

602650

GPT1
Glycerol-3-phosphate O-acyltransferase 1

1

0

High-throughput

0.261

Low

602658

AVT3
Vacuolar amino acid transporter 3

1

0

High-throughput

0.261

Low

602665

IST2
Increased sodium tolerance protein 2

1

0

High-throughput

0.261

Low

602673

IPT1
Inositolphosphotransferase 1

1

0

High-throughput

0.261

Low

602699

PRM10
Pheromone-regulated membrane protein 10

1

0

High-throughput

0.261

Low

602705

STB2
Protein STB2

1

0

High-throughput

0.261

Low

602714

YD186
Uncharacterized protein YDL186W

1

0

High-throughput

0.261

Low

602718

TPN1
Vitamin B6 transporter TPN1

1

0

High-throughput

0.261

Low

602720

MST27
Multicopy suppressor of SEC21 protein 27

1

0

High-throughput

0.261

Low

602726

SUN4
Probable secreted beta-glucosidase SUN4

1

0

High-throughput

0.261

Low

602749

YMD7
Uncharacterized protein YML037C

1

0

High-throughput

0.261

Low

602761

DFG5
Mannan endo-1,6-alpha-mannosidase DFG5

1

0

High-throughput

0.261

Low

602774

YL030
Putative uncharacterized protein YLR030W

1

0

High-throughput

0.261

Low

602782

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.261

Low

602795

VCX1
Vacuolar calcium ion transporter

1

0

High-throughput

0.261

Low

602715

SC6B1
Protein transport protein SBH1

1

0

Small-scale

0.251

Low

90175

STE2
Pheromone alpha factor receptor

1

0

High-throughput

0.249

Low

602644

ERG1
Squalene epoxidase ERG1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024