Protein: MINT
Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog)

Gene: MINT, SPEN
Organism: Homo sapiens
Interactions: 124
UniProt ID: Q96T58

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003677 - DNA binding
GO:0003714 - transcription corepressor activity
GO:0003723 - RNA binding
GO:0003729 - mRNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1026209

PAK1
Serine/threonine-protein kinase PAK 1

1

6

Small-scale

0.756

High

1059815

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

11

High-throughput

0.754

High

1241308

CAMKV
CaM kinase-like vesicle-associated protein

2

3

High-throughput

0.726

High

986974

SUH
Recombining binding protein suppressor of hairless

7

0

Small-scale

0.716

High

1029050

SRSF6
Serine/arginine-rich splicing factor 6

1

19

High-throughput

0.691

High

1302939

NCOR2
Nuclear receptor corepressor 2

3

12

Small-scale

0.682

High

624494

CCNC
Cyclin-C

3

8

High-throughput

0.656

High

833803

CLK1
Dual specificity protein kinase CLK1

1

18

High-throughput

0.647

High

942890

SRPK2
SRSF protein kinase 2

1

17

High-throughput

0.647

High

817734

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

2

2

High-throughput

0.628

High

841300

CDK7
Cyclin-dependent kinase 7

1

4

High-throughput

0.618

High

853964

NCBP2
Nuclear cap-binding protein subunit 2

1

19

High-throughput

0.618

High

818382

SOX2
Transcription factor SOX-2

2

10

Small-scale

0.611

High

1201616

ZCH18
Zinc finger CCCH domain-containing protein 18

2

14

High-throughput

0.611

High

1302931

WRP73
WD repeat-containing protein WRAP73

3

8

High-throughput

0.609

High

1302933

DAXX
Death domain-associated protein 6

2

0

High-throughput

0.602

High

802709

CRK
Adapter molecule crk

2

12

High-throughput

0.595

High

377624

GCR
Glucocorticoid receptor

2

20

Small-scale

0.584

High

935150

H31
Histone H3.1

2

7

High-throughput

0.584

High

1237105

TRIMM
Probable E3 ubiquitin-protein ligase TRIML2

2

2

High-throughput

0.574

High

159086

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

2

Small-scale

0.573

High

370263

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1032571

CTBP1
C-terminal-binding protein 1

1

6

Small-scale

0.561

High

1038652

HDAC1
Histone deacetylase 1

1

7

Small-scale

0.561

High

1302936

MED23
Mediator of RNA polymerase II transcription subunit 23

1

1

High-throughput

0.554

High

987458

MTG8
Protein CBFA2T1

1

1

Small-scale

0.552

High

1297360

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

0

Small-scale

0.549

High

1302922

CTIP
DNA endonuclease RBBP8

1

0

Small-scale

0.537

High

1302923

SRA1
Steroid receptor RNA activator 1

1

0

Small-scale

0.537

High

256328

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

11

High-throughput

0.536

High

314131

BAG4
BAG family molecular chaperone regulator 4

1

5

High-throughput

0.536

High

504619

HSP7C
Heat shock cognate 71 kDa protein

1

7

High-throughput

0.536

High

801326

KI67
Proliferation marker protein Ki-67

1

16

High-throughput

0.536

High

871747

HSP72
Heat shock-related 70 kDa protein 2

1

7

High-throughput

0.536

High

1050757

FHL2
Four and a half LIM domains protein 2

1

4

High-throughput

0.536

High

1200430

URP2
Fermitin family homolog 3

1

1

High-throughput

0.536

High

1232275

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

1

High-throughput

0.536

High

1302930

BCLF1
Bcl-2-associated transcription factor 1

1

8

High-throughput

0.536

High

565008

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

High-throughput

0.515

High

922678

RL10A
Large ribosomal subunit protein uL1

1

5

High-throughput

0.515

High

1302932

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.513

High

1302937

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.513

High

868703

ATX1
Ataxin-1

1

2

High-throughput

0.508

High

261572

NCOR1
Nuclear receptor corepressor 1

1

8

Small-scale

0.501

High

1294841

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

8

High-throughput

0.501

High

323982

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.489

High

1231748

AN36B
Ankyrin repeat domain-containing protein 36B

1

10

High-throughput

0.489

High

1285055

ARRD3
Arrestin domain-containing protein 3

1

5

High-throughput

0.489

High

124057

SPT5H
Transcription elongation factor SPT5

1

6

High-throughput

0.479

High

171069

TBXT
T-box transcription factor T

1

3

High-throughput

0.479

High

197809

CRX
Cone-rod homeobox protein

1

3

High-throughput

0.479

High

210221

PRC1
Protein regulator of cytokinesis 1

1

7

High-throughput

0.479

High

268238

EED
Polycomb protein EED

1

10

High-throughput

0.479

High

301987

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

High-throughput

0.479

High

316970

KLF8
Krueppel-like factor 8

1

8

High-throughput

0.479

High

323032

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

20

High-throughput

0.479

High

338874

EGFR
Epidermal growth factor receptor

1

13

High-throughput

0.479

High

347668

MYC
Myc proto-oncogene protein

1

16

High-throughput

0.479

High

387358

P53
Cellular tumor antigen p53

1

7

High-throughput

0.479

High

438458

HS90B
Heat shock protein HSP 90-beta

1

5

High-throughput

0.479

High

553508

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

557777

NCK1
SH2/SH3 adapter protein NCK1

1

14

High-throughput

0.479

High

652037

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

655449

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

3

High-throughput

0.479

High

718128

BMI1
Polycomb complex protein BMI-1

1

13

High-throughput

0.479

High

721235

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

729684

VGFR2
Vascular endothelial growth factor receptor 2

1

3

High-throughput

0.479

High

736672

RL4
Large ribosomal subunit protein uL4

1

3

High-throughput

0.479

High

782640

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

808869

YAP1
Transcriptional coactivator YAP1

1

17

High-throughput

0.479

High

831618

CEBPA
CCAAT/enhancer-binding protein alpha

1

12

High-throughput

0.479

High

831924

CEBPD
CCAAT/enhancer-binding protein delta

1

13

Small-scale

0.479

High

917792

H4
Histone H4

1

5

High-throughput

0.479

High

918628

H2B1C
Histone H2B type 1-C/E/F/G/I

1

5

High-throughput

0.479

High

919232

RAN
GTP-binding nuclear protein Ran

1

2

High-throughput

0.479

High

924808

GRB2
Growth factor receptor-bound protein 2

1

12

High-throughput

0.479

High

952573

H33
Histone H3.3

1

7

High-throughput

0.479

High

975470

PPARD
Peroxisome proliferator-activated receptor delta

1

14

Small-scale

0.479

High

980850

TLE3
Transducin-like enhancer protein 3

1

7

High-throughput

0.479

High

1027214

CBX3
Chromobox protein homolog 3

1

1

High-throughput

0.479

High

1035995

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

1055460

DHX8
ATP-dependent RNA helicase DHX8

1

5

High-throughput

0.479

High

1060360

NFIX
Nuclear factor 1 X-type

1

6

High-throughput

0.479

High

1070759

RBBP5
Retinoblastoma-binding protein 5

1

9

High-throughput

0.479

High

1080261

EZH2
Histone-lysine N-methyltransferase EZH2

1

9

High-throughput

0.479

High

1083357

RBBP7
Histone-binding protein RBBP7

1

7

High-throughput

0.479

High

1153905

IFIX
Pyrin and HIN domain-containing protein 1

1

5

High-throughput

0.479

High

1183758

DPPA4
Developmental pluripotency-associated protein 4

1

2

High-throughput

0.479

High

1188758

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.479

High

1198269

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

4

Small-scale

0.479

High

1221669

SMC5
Structural maintenance of chromosomes protein 5

1

10

High-throughput

0.479

High

1244448

NUP43
Nucleoporin Nup43

1

9

High-throughput

0.479

High

1260881

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

1283832

FUBP1
Far upstream element-binding protein 1

1

20

High-throughput

0.479

High

1288258

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

11

High-throughput

0.479

High

1302924

ANLN
Anillin

1

9

High-throughput

0.479

High

1302925

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

5

High-throughput

0.479

High

1302926

RAD18
E3 ubiquitin-protein ligase RAD18

1

3

High-throughput

0.479

High

1302927

NLE1
Notchless protein homolog 1

1

4

High-throughput

0.479

High

1302928

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

3

High-throughput

0.479

High

1302935

NUP50
Nuclear pore complex protein Nup50

1

2

High-throughput

0.479

High

1302938

ASF1A
Histone chaperone ASF1A

1

1

High-throughput

0.479

High

856165

RIDA
2-iminobutanoate/2-iminopropanoate deaminase

1

0

High-throughput

0.460

High

1302934

SRTD1
SERTA domain-containing protein 1

1

0

High-throughput

0.460

High

523956

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

618156

COF1
Cofilin-1

1

0

High-throughput

0.458

High

1191140

I2BP2
Interferon regulatory factor 2-binding protein 2

1

0

Small-scale

0.458

High

1302929

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1057599

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

9

High-throughput

0.445

High

1302921

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.445

High

256006

OBSL1
Obscurin-like protein 1

1

8

High-throughput

0.437

High

297665

RHBT1
Rho-related BTB domain-containing protein 1

1

10

High-throughput

0.437

High

581042

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

1

High-throughput

0.437

High

928670

DYLT1
Dynein light chain Tctex-type 1

1

1

High-throughput

0.437

High

1002062

ARL16
ADP-ribosylation factor-like protein 16

1

5

High-throughput

0.437

High

1061568

CUL7
Cullin-7

1

9

High-throughput

0.437

High

781425

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.426

High

964407

RUNX1
Runt-related transcription factor 1

1

2

Small-scale

0.408

High

91307

E5RFK5
Cyclin-C

1

8

High-throughput

0.407

High

1219520

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.279

Low

1302153

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

1302940

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.279

Low

277743

PRAF3
PRA1 family protein 3

1

0

High-throughput

0.249

Low

483715

CT456
Cancer/testis antigen family 45 member A6

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024