Protein: PPP5
Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT)

Gene: PPP5, PPP5C
Organism: Homo sapiens
Interactions: 151
UniProt ID: P53041

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0000278 - mitotic cell cycle
GO:0003723 - RNA binding
GO:0004721 - phosphoprotein phosphatase activity
GO:0004722 - protein serine/threonine phosphatase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

684549

STIP1
Stress-induced-phosphoprotein 1

2

9

Small-scale

0.820

High

431681

HS90A
Heat shock protein HSP 90-alpha

14

12

Small-scale

0.763

High

438021

HS90B
Heat shock protein HSP 90-beta

7

13

Small-scale

0.753

High

858625

TEBP
Prostaglandin E synthase 3

5

3

Small-scale

0.722

High

858629

CDC37
Hsp90 co-chaperone Cdc37

4

2

Small-scale

0.702

High

496621

TAU
Microtubule-associated protein tau

4

20

Small-scale

0.694

High

858599

LIMK2
LIM domain kinase 2

1

1

High-throughput

0.691

High

672044

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

20

Small-scale

0.665

High

174743

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

11

High-throughput

0.647

High

672793

CDC27
Cell division cycle protein 27 homolog

1

7

Small-scale

0.647

High

858598

PPP5
Serine/threonine-protein phosphatase 5

1

14

Small-scale

0.646

High

151745

IRS4
Insulin receptor substrate 4

2

3

High-throughput

0.635

High

858681

CHRD1
Cysteine and histidine-rich domain-containing protein 1

2

3

High-throughput

0.633

High

858634

RAB41
Ras-related protein Rab-41

2

1

High-throughput

0.628

High

858605

ACTB
Actin, cytoplasmic 1

1

15

Small-scale

0.618

High

858611

ACTG
Actin, cytoplasmic 2

1

15

Small-scale

0.618

High

858613

P2R3A
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

1

7

Small-scale

0.618

High

858619

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

4

High-throughput

0.618

High

858631

CRY2
Cryptochrome-2

2

7

Small-scale

0.614

High

338171

EGFR
Epidermal growth factor receptor

2

13

Small-scale

0.608

High

823195

DPOD2
DNA polymerase delta subunit 2

2

0

High-throughput

0.602

High

369237

ESR1
Estrogen receptor

1

20

Small-scale

0.594

High

858672

DISC1
Disrupted in schizophrenia 1 protein

2

1

High-throughput

0.590

High

226943

PRKN
E3 ubiquitin-protein ligase parkin

2

19

High-throughput

0.584

High

841584

CDK9
Cyclin-dependent kinase 9

1

20

High-throughput

0.565

High

771849

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.561

High

822226

KC1D
Casein kinase I isoform delta

1

7

Small-scale

0.561

High

858612

GNA12
Guanine nucleotide-binding protein subunit alpha-12

1

3

Small-scale

0.561

High

858646

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

6

Small-scale

0.561

High

858663

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

20

Small-scale

0.561

High

653208

PYR1
Multifunctional protein CAD

1

7

High-throughput

0.554

High

858635

NOL9
Polynucleotide 5'-hydroxyl-kinase NOL9

1

1

High-throughput

0.554

High

858668

AGO3
Protein argonaute-3

1

6

High-throughput

0.554

High

858682

AGO1
Protein argonaute-1

1

5

High-throughput

0.554

High

858685

NUDC
Nuclear migration protein nudC

1

4

High-throughput

0.554

High

858615

TP53B
TP53-binding protein 1

1

16

Small-scale

0.552

High

858657

ESR2
Estrogen receptor beta

1

20

Small-scale

0.552

High

858600

XPO2
Exportin-2

1

2

High-throughput

0.541

High

858623

SIM2
Single-minded homolog 2

1

8

High-throughput

0.541

High

858674

BRWD1
Bromodomain and WD repeat-containing protein 1

1

9

High-throughput

0.541

High

272074

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

8

High-throughput

0.536

High

314270

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

1

High-throughput

0.536

High

319151

BRD1
Bromodomain-containing protein 1

1

3

High-throughput

0.536

High

323654

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.536

High

503738

HSP7C
Heat shock cognate 71 kDa protein

1

14

Small-scale

0.536

High

564043

HSP76
Heat shock 70 kDa protein 6

1

16

High-throughput

0.536

High

609656

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

15

High-throughput

0.536

High

616689

KS6B1
Ribosomal protein S6 kinase beta-1

1

14

High-throughput

0.536

High

646745

1433T
14-3-3 protein theta

1

15

High-throughput

0.536

High

655282

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

6

High-throughput

0.536

High

683220

1433B
14-3-3 protein beta/alpha

1

15

High-throughput

0.536

High

794369

GRK6
G protein-coupled receptor kinase 6

1

16

High-throughput

0.536

High

812812

PA24A
Cytosolic phospholipase A2

1

1

High-throughput

0.536

High

843122

TCPD
T-complex protein 1 subunit delta

1

18

Small-scale

0.536

High

848331

IRAK1
Interleukin-1 receptor-associated kinase 1

1

2

High-throughput

0.536

High

858608

GRB2
Growth factor receptor-bound protein 2

1

10

High-throughput

0.536

High

858610

RACK1
Small ribosomal subunit protein RACK1

1

8

High-throughput

0.536

High

858614

CDK18
Cyclin-dependent kinase 18

1

14

High-throughput

0.536

High

858616

FLII
Protein flightless-1 homolog

1

20

High-throughput

0.536

High

858618

ILK
Integrin-linked protein kinase

1

5

High-throughput

0.536

High

858622

CDK13
Cyclin-dependent kinase 13

1

18

High-throughput

0.536

High

858626

RBBP5
Retinoblastoma-binding protein 5

1

5

High-throughput

0.536

High

858628

DDB1
DNA damage-binding protein 1

1

5

High-throughput

0.536

High

858630

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

8

High-throughput

0.536

High

858636

PRP8
Pre-mRNA-processing-splicing factor 8

1

2

High-throughput

0.536

High

858637

KSR2
Kinase suppressor of Ras 2

1

20

High-throughput

0.536

High

858638

DEFI8
Differentially expressed in FDCP 8 homolog

1

3

High-throughput

0.536

High

858639

GADL1
Acidic amino acid decarboxylase GADL1

1

3

High-throughput

0.536

High

858642

UBP45
Ubiquitin carboxyl-terminal hydrolase 45

1

4

High-throughput

0.536

High

858643

CD37L
Hsp90 co-chaperone Cdc37-like 1

1

1

High-throughput

0.536

High

858653

FA83F
Protein FAM83F

1

1

High-throughput

0.536

High

858655

MK15
Mitogen-activated protein kinase 15

1

11

High-throughput

0.536

High

858661

TSSK2
Testis-specific serine/threonine-protein kinase 2

1

11

High-throughput

0.536

High

858662

PSKH2
Serine/threonine-protein kinase H2

1

19

High-throughput

0.536

High

858664

LRRC1
Leucine-rich repeat-containing protein 1

1

20

High-throughput

0.536

High

858671

DYRK4
Dual specificity tyrosine-phosphorylation-regulated kinase 4

1

14

High-throughput

0.536

High

858673

LATS2
Serine/threonine-protein kinase LATS2

1

16

High-throughput

0.536

High

858676

CNTLN
Centlein

1

15

High-throughput

0.536

High

858686

SGT1
Protein SGT1 homolog

1

11

High-throughput

0.536

High

858688

MRCKB
Serine/threonine-protein kinase MRCK beta

1

16

High-throughput

0.536

High

232821

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

19

High-throughput

0.515

High

858641

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

1

5

High-throughput

0.515

High

305750

ELP1
Elongator complex protein 1

1

0

High-throughput

0.513

High

858669

ELP3
Elongator complex protein 3

1

0

High-throughput

0.513

High

858679

ABCF2
ATP-binding cassette sub-family F member 2

1

0

High-throughput

0.513

High

201277

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

9

High-throughput

0.508

High

394382

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.501

High

858624

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

3

Small-scale

0.501

High

858651

CDK20
Cyclin-dependent kinase 20

1

11

Small-scale

0.501

High

830315

KC1E
Casein kinase I isoform epsilon

1

20

Small-scale

0.500

High

858627

CRY1
Cryptochrome-1

1

7

Small-scale

0.500

High

858670

FSCN3
Fascin-3

1

1

High-throughput

0.489

High

858678

HACD3
Very-long-chain

1

3

High-throughput

0.489

High

858683

INTU
Protein inturned

1

1

High-throughput

0.489

High

278760

DNJC8
DnaJ homolog subfamily C member 8

1

1

High-throughput

0.479

High

294567

RECQ4
ATP-dependent DNA helicase Q4

1

11

High-throughput

0.479

High

377203

GCR
Glucocorticoid receptor

1

20

Small-scale

0.479

High

384545

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

414470

PRGR
Progesterone receptor

1

20

Small-scale

0.479

High

437629

MCR
Mineralocorticoid receptor

1

20

Small-scale

0.479

High

443415

VIME
Vimentin

1

4

Small-scale

0.479

High

487258

ANDR
Androgen receptor

1

20

Small-scale

0.479

High

552308

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

569445

CEBPB
CCAAT/enhancer-binding protein beta

1

7

High-throughput

0.479

High

650751

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.479

High

714148

HSP74
Heat shock 70 kDa protein 4

1

20

Small-scale

0.479

High

720043

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

834953

PSN2
Presenilin-2

1

1

High-throughput

0.479

High

858601

TPTE
Putative tyrosine-protein phosphatase TPTE

1

10

High-throughput

0.479

High

858603

DJB13
DnaJ homolog subfamily B member 13

1

6

High-throughput

0.479

High

858604

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

10

High-throughput

0.479

High

858606

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

858607

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

7

High-throughput

0.479

High

858609

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

2

Small-scale

0.479

High

858617

DUS8
Dual specificity protein phosphatase 8

1

9

High-throughput

0.479

High

858620

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

858621

ATR
Serine/threonine-protein kinase ATR

1

13

Small-scale

0.479

High

858645

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

19

High-throughput

0.479

High

858649

YAF2
YY1-associated factor 2

1

1

High-throughput

0.479

High

858652

WDTC1
WD and tetratricopeptide repeats protein 1

1

7

High-throughput

0.479

High

858656

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

858658

CSN5
COP9 signalosome complex subunit 5

1

5

High-throughput

0.479

High

858659

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

20

High-throughput

0.479

High

858665

Q9H4D1
Protein kinase

1

6

High-throughput

0.479

High

858666

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

858667

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

858675

DJC11
DnaJ homolog subfamily C member 11

1

8

High-throughput

0.479

High

858677

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

858680

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

159345

PLD2
Phospholipase D2

1

0

High-throughput

0.458

High

310388

EPM2A
Laforin

1

0

High-throughput

0.458

High

825363

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

858644

DET1
DET1 homolog

1

0

High-throughput

0.458

High

858654

FLCN
Folliculin

1

0

Small-scale

0.458

High

858660

FBXW5
F-box/WD repeat-containing protein 5

1

0

High-throughput

0.458

High

858684

MTMR7
Myotubularin-related protein 7

1

0

High-throughput

0.458

High

656992

5HT2A
5-hydroxytryptamine receptor 2A

1

1

Small-scale

0.457

High

91338

E5RHT1
Presenilin-2

1

1

High-throughput

0.445

High

110680

H3BSK8
RB binding protein 6, ubiquitin ligase

1

2

High-throughput

0.445

High

111935

K9JA46
Heat shock protein HSP 90-alpha

1

12

High-throughput

0.445

High

858602

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

6

High-throughput

0.445

High

858632

H90B4
Putative heat shock protein HSP 90-beta 4

1

13

High-throughput

0.445

High

858633

HS905
Putative heat shock protein HSP 90-alpha A5

1

14

High-throughput

0.445

High

858647

Q86SX1
Full-length cDNA 5-PRIME end of clone CS0DN005YI08 of Adult brain of Homo sapiens

1

11

High-throughput

0.445

High

858650

ULK2
Serine/threonine-protein kinase ULK2

1

20

High-throughput

0.445

High

858687

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

13

High-throughput

0.445

High

500755

CLUS
Clusterin

1

0

High-throughput

0.438

High

858640

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.437

High

831134

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

High-throughput

0.408

High

858648

BPHL
Valacyclovir hydrolase

2

0

High-throughput

0.318

High


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024