Protein: MK07
Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5)

Gene: MK07, MAPK7
Organism: Homo sapiens
Interactions: 142
UniProt ID: Q13164

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0004674 - protein serine/threonine kinase activity
GO:0004707 - MAP kinase activity
GO:0004857 - enzyme inhibitor activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1026805

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

7

20

Small-scale

0.974

High

1026845

MK07
Mitogen-activated protein kinase 7

3

19

Small-scale

0.861

High

1026893

M3K2
Mitogen-activated protein kinase kinase kinase 2

2

18

Small-scale

0.789

High

563707

ZKSC1
Zinc finger protein with KRAB and SCAN domains 1

2

2

High-throughput

0.783

High

438129

HS90B
Heat shock protein HSP 90-beta

2

20

Small-scale

0.754

High

1026856

CDC37
Hsp90 co-chaperone Cdc37

2

9

Small-scale

0.754

High

983824

KPCZ
Protein kinase C zeta type

1

20

Small-scale

0.740

High

498265

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

5

High-throughput

0.737

High

658922

MK01
Mitogen-activated protein kinase 1

2

18

High-throughput

0.737

High

681424

DNJA1
DnaJ homolog subfamily A member 1

2

9

High-throughput

0.737

High

929843

ACTG
Actin, cytoplasmic 2

2

8

High-throughput

0.737

High

1026860

ACTBL
Beta-actin-like protein 2

2

8

High-throughput

0.737

High

1026886

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

2

20

High-throughput

0.737

High

374157

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

Small-scale

0.724

High

116999

SGK1
Serine/threonine-protein kinase Sgk1

1

20

Small-scale

0.709

High

446612

SNRPA
U1 small nuclear ribonucleoprotein A

1

10

High-throughput

0.691

High

901662

PFD3
Prefoldin subunit 3

4

1

High-throughput

0.691

High

1026883

PFD4
Prefoldin subunit 4

4

1

High-throughput

0.691

High

171614

PFD6
Prefoldin subunit 6

4

0

High-throughput

0.661

High

245969

PFD1
Prefoldin subunit 1

4

0

High-throughput

0.661

High

1026873

PFD5
Prefoldin subunit 5

4

0

High-throughput

0.661

High

1026888

PFD2
Prefoldin subunit 2

4

0

High-throughput

0.661

High

135933

UBE2C
Ubiquitin-conjugating enzyme E2 C

3

3

High-throughput

0.654

High

668645

PML
Protein PML

2

10

Small-scale

0.653

High

987215

MEF2C
Myocyte-specific enhancer factor 2C

2

16

Small-scale

0.633

High

384763

NTRK1
High affinity nerve growth factor receptor

1

18

High-throughput

0.618

High

431807

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

538216

ENPL
Endoplasmin

1

20

Small-scale

0.618

High

566379

KPCA
Protein kinase C alpha type

1

14

High-throughput

0.618

High

891741

ACTB
Actin, cytoplasmic 1

1

8

Small-scale

0.618

High

1026846

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

8

High-throughput

0.618

High

1026864

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.618

High

1026879

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

20

Small-scale

0.618

High

1026880

PKHA4
Pleckstrin homology domain-containing family A member 4

1

10

High-throughput

0.618

High

968776

MEF2A
Myocyte-specific enhancer factor 2A

2

16

Small-scale

0.614

High

381959

G3P
Glyceraldehyde-3-phosphate dehydrogenase

2

5

Small-scale

0.611

High

1026854

CCDC6
Coiled-coil domain-containing protein 6

2

7

High-throughput

0.606

High

394646

A4
Amyloid-beta precursor protein

2

2

High-throughput

0.602

High

909511

1433E
14-3-3 protein epsilon

2

7

Small-scale

0.586

High

683315

1433B
14-3-3 protein beta/alpha

1

20

Small-scale

0.586

High

1026851

MEF2D
Myocyte-specific enhancer factor 2D

1

16

Small-scale

0.586

High

323727

BAG2
BAG family molecular chaperone regulator 2

2

0

High-throughput

0.585

High

568646

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

18

High-throughput

0.575

High

225873

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

2

9

High-throughput

0.571

High

240571

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

2

1

High-throughput

0.571

High

241518

H2B1K
Histone H2B type 1-K

2

11

High-throughput

0.571

High

316636

ACSL3
Fatty acid CoA ligase Acsl3

2

2

High-throughput

0.571

High

381182

TBB4A
Tubulin beta-4A chain

2

8

High-throughput

0.571

High

388411

HSPB1
Heat shock protein beta-1

2

4

High-throughput

0.571

High

393182

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

2

7

High-throughput

0.571

High

397368

ADT2
ADP/ATP translocase 2

2

9

High-throughput

0.571

High

504011

HSP7C
Heat shock cognate 71 kDa protein

2

8

High-throughput

0.571

High

515851

PRPS2
Ribose-phosphate pyrophosphokinase 2

2

9

High-throughput

0.571

High

518334

ADT3
ADP/ATP translocase 3

2

11

High-throughput

0.571

High

561563

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

2

6

High-throughput

0.571

High

653242

PYR1
Multifunctional protein CAD

2

9

High-throughput

0.571

High

676666

AL1B1
Aldehyde dehydrogenase X, mitochondrial

2

3

High-throughput

0.571

High

883013

H2BFS
Histone H2B type F-S

2

11

High-throughput

0.571

High

886098

H2B1D
Histone H2B type 1-D

2

11

High-throughput

0.571

High

893340

PRPS1
Ribose-phosphate pyrophosphokinase 1

2

9

High-throughput

0.571

High

933189

TBA1B
Tubulin alpha-1B chain

2

8

High-throughput

0.571

High

933782

TBB4B
Tubulin beta-4B chain

2

8

High-throughput

0.571

High

966062

LAT1
Large neutral amino acids transporter small subunit 1

2

2

High-throughput

0.571

High

1026847

TBB2A
Tubulin beta-2A chain

2

8

High-throughput

0.571

High

1026848

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

2

9

High-throughput

0.571

High

1026852

IMB1
Importin subunit beta-1

2

4

High-throughput

0.571

High

1026858

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

2

1

High-throughput

0.571

High

1026862

H2B2F
Histone H2B type 2-F

2

11

High-throughput

0.571

High

1026868

H2B1H
Histone H2B type 1-H

2

11

High-throughput

0.571

High

1026871

IPO9
Importin-9

2

7

High-throughput

0.571

High

1026874

H2B1N
Histone H2B type 1-N

2

11

High-throughput

0.571

High

1026875

H2B1M
Histone H2B type 1-M

2

11

High-throughput

0.571

High

1026876

H2B1L
Histone H2B type 1-L

2

11

High-throughput

0.571

High

1026885

ATD3A
ATPase family AAA domain-containing protein 3A

2

8

High-throughput

0.571

High

1026887

LIMA1
LIM domain and actin-binding protein 1

2

4

High-throughput

0.571

High

1026889

MYO5B
Unconventional myosin-Vb

2

4

High-throughput

0.571

High

1026890

COR1C
Coronin-1C

2

2

High-throughput

0.571

High

1026891

RUVB2
RuvB-like 2

2

7

High-throughput

0.571

High

1026892

RUVB1
RuvB-like 1

2

7

High-throughput

0.571

High

1026897

NS1BP
Influenza virus NS1A-binding protein

2

2

High-throughput

0.571

High

542010

ETS1
Protein C-ets-1

1

19

Small-scale

0.561

High

567039

CXA1
Gap junction alpha-1 protein

1

3

Small-scale

0.561

High

1026853

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

20

Small-scale

0.561

High

1026855

NF2L2
Nuclear factor erythroid 2-related factor 2

1

20

Small-scale

0.561

High

437345

4F2
Amino acid transporter heavy chain SLC3A2

2

0

High-throughput

0.547

High

966532

OTUD4
OTU domain-containing protein 4

2

0

High-throughput

0.547

High

976171

PTPS
6-pyruvoyl tetrahydrobiopterin synthase

2

0

High-throughput

0.547

High

1026872

MMS19
MMS19 nucleotide excision repair protein homolog

2

0

High-throughput

0.547

High

1026877

SPNDC
Spindlin interactor and repressor of chromatin-binding protein

2

0

High-throughput

0.547

High

265865

NR1I2
Nuclear receptor subfamily 1 group I member 2

1

15

High-throughput

0.541

High

843643

FXR1
RNA-binding protein FXR1

1

3

High-throughput

0.541

High

1026850

GOGB1
Golgin subfamily B member 1

1

8

High-throughput

0.541

High

1026881

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.541

High

1026882

SH22A
SH2 domain-containing protein 2A

1

9

High-throughput

0.541

High

1026884

FGF21
Fibroblast growth factor 21

1

1

High-throughput

0.541

High

447675

ENOG
Gamma-enolase

1

2

High-throughput

0.536

High

533669

GYS1
Glycogen [starch] synthase, muscle

1

2

High-throughput

0.536

High

542304

PLAK
Junction plakoglobin

1

6

High-throughput

0.536

High

589851

TBP
TATA-box-binding protein

1

1

High-throughput

0.536

High

970764

DSG1
Desmoglein-1

1

6

High-throughput

0.536

High

1023150

FLII
Protein flightless-1 homolog

1

5

High-throughput

0.536

High

1026865

TRM1L
TRMT1-like protein

1

3

High-throughput

0.536

High

1026866

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.536

High

1026895

MYO5A
Unconventional myosin-Va

1

5

High-throughput

0.536

High

518132

ADT1
ADP/ATP translocase 1

2

9

High-throughput

0.521

High

959196

S25A3
Solute carrier family 25 member 3

2

13

High-throughput

0.521

High

1026859

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

2

1

High-throughput

0.521

High

1026867

GSLG1
Golgi apparatus protein 1

2

2

High-throughput

0.521

High

1026870

MACIR
Macrophage immunometabolism regulator

1

0

High-throughput

0.518

High

1026863

Q5TZN3
Ubiquitin-conjugating enzyme E2 C

1

3

High-throughput

0.515

High

855404

TF2AA
Transcription initiation factor IIA subunit 1

1

0

High-throughput

0.513

High

345416

FOS
Protein c-Fos

1

17

Small-scale

0.501

High

654298

CALX
Calnexin

1

1

High-throughput

0.489

High

995960

DSC1
Desmocollin-1

1

5

High-throughput

0.489

High

1026861

NOM1
Nucleolar MIF4G domain-containing protein 1

1

2

High-throughput

0.489

High

211573

ACTN4
Alpha-actinin-4

1

9

High-throughput

0.481

High

1026894

GPSM3
G-protein-signaling modulator 3

1

1

High-throughput

0.481

High

91435

E7EPN9
Proline rich coiled-coil 2C

1

10

High-throughput

0.479

High

162692

XPO1
Exportin-1

1

6

High-throughput

0.479

High

324371

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.479

High

386649

P53
Cellular tumor antigen p53

1

7

Small-scale

0.479

High

428178

TBB5
Tubulin beta chain

1

8

Small-scale

0.479

High

431315

LDHC
L-lactate dehydrogenase C chain

1

4

Small-scale

0.479

High

502046

BIP
Endoplasmic reticulum chaperone BiP

1

12

Small-scale

0.479

High

537891

KPYM
Pyruvate kinase PKM

1

5

Small-scale

0.479

High

569672

CEBPB
CCAAT/enhancer-binding protein beta

1

17

High-throughput

0.479

High

636913

ATPA
ATP synthase subunit alpha, mitochondrial

1

11

Small-scale

0.479

High

714207

HSP74
Heat shock 70 kDa protein 4

1

12

Small-scale

0.479

High

904515

1433G
14-3-3 protein gamma

1

20

Small-scale

0.479

High

926999

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.479

High

981973

1433F
14-3-3 protein eta

1

20

Small-scale

0.479

High

994074

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

7

Small-scale

0.479

High

1026857

FSCN1
Fascin

1

1

Small-scale

0.479

High

1026878

PRAX
Periaxin

1

11

High-throughput

0.479

High

1026896

PRC2C
Protein PRRC2C

1

10

High-throughput

0.479

High

918333

H2B1C
Histone H2B type 1-C/E/F/G/I

1

11

High-throughput

0.445

High

1026849

GANAB
Neutral alpha-glucosidase AB

1

1

Small-scale

0.437

High

602252

CD9
CD9 antigen

2

0

High-throughput

0.298

High

883813

TMM33
Transmembrane protein 33

2

0

High-throughput

0.298

High

1016566

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

0

High-throughput

0.298

High

1026869

ZB10P
Putative protein ZBED10P

1

0

High-throughput

0.282

High


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Last updated: 15 Jul 2024