Protein: CCNA2
Cyclin-A2 (Cyclin-A) (Cyclin A)

Gene: CCNA2
Organism: Homo sapiens
Interactions: 158
UniProt ID: P20248

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0001939 - female pronucleus
GO:0001940 - male pronucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

590125

CDK2
Cyclin-dependent kinase 2

51

20

Small-scale

0.996

High

590142

CDN1B
Cyclin-dependent kinase inhibitor 1B

17

15

Small-scale

0.987

High

414732

CDK1
Cyclin-dependent kinase 1

18

20

Small-scale

0.987

High

590139

CDN1A
Cyclin-dependent kinase inhibitor 1

15

15

Small-scale

0.983

High

590218

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

5

16

High-throughput

0.932

High

590146

CDN1C
Cyclin-dependent kinase inhibitor 1C

5

15

Small-scale

0.927

High

590149

CDK7
Cyclin-dependent kinase 7

5

20

Small-scale

0.924

High

590162

CDK3
Cyclin-dependent kinase 3

4

20

High-throughput

0.903

High

590164

CDK5
Cyclin-dependent kinase 5

4

20

High-throughput

0.903

High

585400

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

3

5

High-throughput

0.861

High

590160

CCNA1
Cyclin-A1

3

5

High-throughput

0.861

High

590241

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

2

20

High-throughput

0.811

High

590171

CDC20
Cell division cycle protein 20 homolog

19

20

Small-scale

0.767

High

590175

SKP2
S-phase kinase-associated protein 2

14

3

Small-scale

0.760

High

590235

FZR1
Fizzy-related protein homolog

10

20

Small-scale

0.756

High

515330

CDK4
Cyclin-dependent kinase 4

2

20

Small-scale

0.754

High

590224

CDT1
DNA replication factor Cdt1

7

2

Small-scale

0.751

High

590156

CKS1
Cyclin-dependent kinases regulatory subunit 1

8

20

Small-scale

0.749

High

590128

RBL1
Retinoblastoma-like protein 1

8

7

Small-scale

0.748

High

414164

RB
Retinoblastoma-associated protein

8

7

Small-scale

0.747

High

590167

H11
Histone H1.1

7

7

Small-scale

0.743

High

590177

ORC1
Origin recognition complex subunit 1

6

7

Small-scale

0.736

High

590169

RBL2
Retinoblastoma-like protein 2

6

7

Small-scale

0.732

High

590240

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

6

1

Small-scale

0.730

High

590166

E2F1
Transcription factor E2F1

5

9

Small-scale

0.720

High

517044

PCNA
Proliferating cell nuclear antigen

5

1

Small-scale

0.714

High

590135

CKS2
Cyclin-dependent kinases regulatory subunit 2

5

20

Small-scale

0.714

High

590170

EP300
Histone acetyltransferase p300

4

6

Small-scale

0.694

High

590180

CUL1
Cullin-1

4

3

Small-scale

0.694

High

590168

KPCT
Protein kinase C theta type

1

3

High-throughput

0.691

High

590181

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

20

High-throughput

0.691

High

590203

CCNQ
Cyclin-Q

1

4

High-throughput

0.691

High

267119

GEMI
Geminin

4

0

High-throughput

0.670

High

590192

MDEAS
Mitotic deacetylase-associated SANT domain protein

4

0

High-throughput

0.670

High

590222

SCAPE
S phase cyclin A-associated protein in the endoplasmic reticulum

4

0

High-throughput

0.670

High

590223

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

4

0

High-throughput

0.670

High

434939

SP1
Transcription factor Sp1

3

2

Small-scale

0.667

High

590219

CDC6
Cell division control protein 6 homolog

3

7

Small-scale

0.667

High

232637

TBCD4
TBC1 domain family member 4

3

1

High-throughput

0.667

High

590159

SKP1
S-phase kinase-associated protein 1

3

3

Small-scale

0.667

High

590197

TICRR
Treslin

3

3

High-throughput

0.667

High

590210

CBP
CREB-binding protein

3

4

High-throughput

0.667

High

590133

AKT1
RAC-alpha serine/threonine-protein kinase

1

3

Small-scale

0.665

High

590237

PHF8
Histone lysine demethylase PHF8

4

0

Small-scale

0.664

High

590233

APC4
Anaphase-promoting complex subunit 4

3

2

Small-scale

0.640

High

590205

HELB
DNA helicase B

3

0

High-throughput

0.638

High

590138

BRCA1
Breast cancer type 1 susceptibility protein

3

1

Small-scale

0.635

High

590121

CCNA2
Cyclin-A2

1

3

Small-scale

0.618

High

590134

AKT2
RAC-beta serine/threonine-protein kinase

1

3

Small-scale

0.618

High

590150

CDK9
Cyclin-dependent kinase 9

1

20

High-throughput

0.618

High

590163

CDK6
Cyclin-dependent kinase 6

1

20

Small-scale

0.618

High

590185

CDK10
Cyclin-dependent kinase 10

1

20

High-throughput

0.618

High

590239

AKT3
RAC-gamma serine/threonine-protein kinase

1

3

Small-scale

0.618

High

590178

ORC2
Origin recognition complex subunit 2

2

3

Small-scale

0.611

High

558984

H15
Histone H1.5

2

7

Small-scale

0.602

High

590127

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

3

Small-scale

0.595

High

590225

PKHG2
Pleckstrin homology domain-containing family G member 2

2

0

High-throughput

0.585

High

590130

CDC27
Cell division cycle protein 27 homolog

2

8

Small-scale

0.584

High

175821

P73
Tumor protein p73

1

3

Small-scale

0.578

High

590140

FEN1
Flap endonuclease 1

1

6

Small-scale

0.578

High

590211

KAT2B
Histone acetyltransferase KAT2B

1

4

Small-scale

0.578

High

590216

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

1

Small-scale

0.578

High

590207

MIPT3
TRAF3-interacting protein 1

2

2

High-throughput

0.576

High

590190

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.575

High

456086

DPOLA
DNA polymerase alpha catalytic subunit

1

2

Small-scale

0.561

High

590136

CTNB1
Catenin beta-1

1

5

Small-scale

0.561

High

590199

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

4

Small-scale

0.561

High

590184

SLBP
Histone RNA hairpin-binding protein

2

0

Small-scale

0.559

High

590176

CENPR
Centromere protein R

1

0

Small-scale

0.549

High

259697

PDCD6
Programmed cell death protein 6

1

1

High-throughput

0.536

High

403082

LA
Lupus La protein

1

2

High-throughput

0.536

High

590151

FXR1
RNA-binding protein FXR1

1

1

High-throughput

0.536

High

590182

TFDP1
Transcription factor Dp-1

1

4

High-throughput

0.536

High

590183

TFDP2
Transcription factor Dp-2

1

4

High-throughput

0.536

High

590188

E2F4
Transcription factor E2F4

1

9

High-throughput

0.536

High

590196

CSN6
COP9 signalosome complex subunit 6

1

6

High-throughput

0.536

High

590208

US6NL
USP6 N-terminal-like protein

1

1

High-throughput

0.536

High

590209

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.536

High

590212

CSN5
COP9 signalosome complex subunit 5

1

6

High-throughput

0.536

High

590141

MAGAB
Melanoma-associated antigen 11

1

0

Small-scale

0.529

High

590144

TSC2
Tuberin

1

1

Small-scale

0.515

High

304423

REC8
Meiotic recombination protein REC8 homolog

1

0

High-throughput

0.513

High

331371

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

1

0

High-throughput

0.513

High

363717

ALBU
Albumin

1

0

High-throughput

0.513

High

364523

TRFE
Serotransferrin

1

0

High-throughput

0.513

High

590122

IL10
Interleukin-10

1

0

High-throughput

0.513

High

590145

TAF6
Transcription initiation factor TFIID subunit 6

1

0

High-throughput

0.513

High

590148

ASCL1
Achaete-scute homolog 1

1

0

High-throughput

0.513

High

590161

CYC
Cytochrome c

1

0

High-throughput

0.513

High

590186

TAF11
Transcription initiation factor TFIID subunit 11

1

0

High-throughput

0.513

High

590187

TAF7
Transcription initiation factor TFIID subunit 7

1

0

High-throughput

0.513

High

590201

P3H2
Prolyl 3-hydroxylase 2

1

0

High-throughput

0.513

High

590206

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.513

High

590213

ENTR1
Endosome-associated-trafficking regulator 1

1

0

High-throughput

0.513

High

590220

CITE1
Cbp/p300-interacting transactivator 1

1

0

High-throughput

0.513

High

590221

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.513

High

590229

CRIPT
Cysteine-rich PDZ-binding protein

1

0

High-throughput

0.513

High

590234

INTU
Protein inturned

1

0

High-throughput

0.513

High

209661

PRC1
Protein regulator of cytokinesis 1

1

2

Small-scale

0.501

High

236879

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

6

Small-scale

0.501

High

386079

P53
Cellular tumor antigen p53

1

3

Small-scale

0.501

High

590123

NFYA
Nuclear transcription factor Y subunit alpha

1

1

Small-scale

0.501

High

590129

ARI4A
AT-rich interactive domain-containing protein 4A

1

1

Small-scale

0.501

High

590152

BRCA2
Breast cancer type 2 susceptibility protein

1

2

Small-scale

0.501

High

590153

RD23A
UV excision repair protein RAD23 homolog A

1

3

Small-scale

0.501

High

590154

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

1

Small-scale

0.501

High

590172

CAF1A
Chromatin assembly factor 1 subunit A

1

1

Small-scale

0.501

High

590232

HERC5
E3 ISG15--protein ligase HERC5

1

2

Small-scale

0.501

High

590217

UIMC1
BRCA1-A complex subunit RAP80

1

0

High-throughput

0.493

High

590215

DTBP1
Dysbindin

1

0

High-throughput

0.486

High

200496

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

Small-scale

0.479

High

208242

DCX
Neuronal migration protein doublecortin

1

1

Small-scale

0.479

High

243921

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.479

High

272488

OFD1
Centriole and centriolar satellite protein OFD1

1

2

High-throughput

0.479

High

380557

K2C1
Keratin, type II cytoskeletal 1

1

1

Small-scale

0.479

High

522765

SRC
Proto-oncogene tyrosine-protein kinase Src

1

1

Small-scale

0.479

High

551924

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

580199

CADH2
Cadherin-2

1

3

Small-scale

0.479

High

590124

GATA2
Endothelial transcription factor GATA-2

1

1

Small-scale

0.479

High

590126

NFYB
Nuclear transcription factor Y subunit beta

1

1

Small-scale

0.479

High

590131

MPIP1
M-phase inducer phosphatase 1

1

8

High-throughput

0.479

High

590132

MPIP2
M-phase inducer phosphatase 2

1

8

Small-scale

0.479

High

590137

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

590155

PSA6
Proteasome subunit alpha type-6

1

2

Small-scale

0.479

High

590157

RS14
Small ribosomal subunit protein uS11

1

1

Small-scale

0.479

High

590158

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

590174

TIF1B
Transcription intermediary factor 1-beta

1

5

Small-scale

0.479

High

590179

BIRC2
Baculoviral IAP repeat-containing protein 2

1

4

Small-scale

0.479

High

590194

U17L2
Ubiquitin carboxyl-terminal hydrolase 17

1

2

Small-scale

0.479

High

590195

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

590204

FBXL6
F-box/LRR-repeat protein 6

1

4

Small-scale

0.479

High

590226

BIRC6
Baculoviral IAP repeat-containing protein 6

1

4

Small-scale

0.479

High

590227

APC11
Anaphase-promoting complex subunit 11

1

2

Small-scale

0.479

High

590231

UBQL2
Ubiquilin-2

1

2

High-throughput

0.479

High

590236

TRI33
E3 ubiquitin-protein ligase TRIM33

1

5

Small-scale

0.479

High

590238

EXO1
Exonuclease 1

1

6

Small-scale

0.479

High

590165

FANCC
Fanconi anemia group C protein

1

0

Small-scale

0.460

High

590143

PA24A
Cytosolic phospholipase A2

1

0

Small-scale

0.458

High

590147

MRE11
Double-strand break repair protein MRE11

1

0

Small-scale

0.458

High

590191

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

590198

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

590228

DTL
Denticleless protein homolog

1

0

Small-scale

0.458

High

590230

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

0

Small-scale

0.458

High

590202

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

Small-scale

0.438

High

590200

ZCH18
Zinc finger CCCH domain-containing protein 18

1

2

High-throughput

0.437

High

563387

ZNF20
Zinc finger protein 20

1

0

High-throughput

0.426

High

91475

E7ERS3
Zinc finger CCCH-type containing 18

1

1

High-throughput

0.407

High

353495

IGKC
Immunoglobulin kappa constant

1

2

High-throughput

0.407

High

353636

IGHG1
Immunoglobulin heavy constant gamma 1

1

2

High-throughput

0.407

High

353758

IGHG2
Immunoglobulin heavy constant gamma 2

1

2

High-throughput

0.407

High

590173

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

Small-scale

0.391

High

454075

GIP
Gastric inhibitory polypeptide

2

0

High-throughput

0.328

High

590189

SMTL2
Smoothelin-like protein 2

2

0

High-throughput

0.328

High

590214

MTBP
Mdm2-binding protein

2

0

High-throughput

0.318

High

344160

A1AT
Alpha-1-antitrypsin

1

0

High-throughput

0.279

Low

363563

TTHY
Transthyretin

1

0

High-throughput

0.279

Low

590193

TXD11
Thioredoxin domain-containing protein 11

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024