Protein: AXIN1
Axin-1 (Axis inhibition protein 1) (hAxin)

Gene: AXIN1
Organism: Homo sapiens
Interactions: 176
UniProt ID: O15169

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0001701 - in utero embryonic development
GO:0001934 - positive regulation of protein phosphorylation
GO:0002039 - p53 binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

170623

GSK3B
Glycogen synthase kinase-3 beta

46

8

Small-scale

0.996

High

170610

CTNB1
Catenin beta-1

31

7

Small-scale

0.992

High

170604

APC
Adenomatous polyposis coli protein

13

11

Small-scale

0.980

High

170622

GSK3A
Glycogen synthase kinase-3 alpha

12

7

Small-scale

0.979

High

150775

DVL2
Segment polarity protein dishevelled homolog DVL-2

7

15

Small-scale

0.956

High

170738

FBW1A
F-box/WD repeat-containing protein 1A

7

4

Small-scale

0.952

High

170579

AXIN1
Axin-1

6

7

Small-scale

0.948

High

170647

M3K1
Mitogen-activated protein kinase kinase kinase 1

5

9

Small-scale

0.902

High

170619

KC1E
Casein kinase I isoform epsilon

4

7

Small-scale

0.884

High

170588

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

4

6

Small-scale

0.882

High

170616

KC1A
Casein kinase I isoform alpha

4

4

Small-scale

0.860

High

170691

DVL3
Segment polarity protein dishevelled homolog DVL-3

3

16

Small-scale

0.847

High

170736

FBW1B
F-box/WD repeat-containing protein 11

3

4

Small-scale

0.847

High

150651

DVL1
Segment polarity protein dishevelled homolog DVL-1

3

17

Small-scale

0.827

High

170718

HIPK2
Homeodomain-interacting protein kinase 2

3

4

Small-scale

0.827

High

170598

PLAK
Junction plakoglobin

2

8

High-throughput

0.817

High

170721

WDR26
WD repeat-containing protein 26

2

4

Small-scale

0.773

High

170717

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

2

6

Small-scale

0.768

High

170585

LRP6
Low-density lipoprotein receptor-related protein 6

8

5

Small-scale

0.746

High

170739

AXIN2
Axin-2

2

7

Small-scale

0.737

High

170629

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

20

Small-scale

0.724

High

170664

AMER1
APC membrane recruitment protein 1

4

1

Small-scale

0.698

High

161587

GAK
Cyclin-G-associated kinase

1

1

High-throughput

0.698

High

170701

SCYL1
N-terminal kinase-like protein

1

2

High-throughput

0.698

High

170617

KC1D
Casein kinase I isoform delta

1

3

High-throughput

0.691

High

170745

WSB1
WD repeat and SOCS box-containing protein 1

1

0

Small-scale

0.687

High

170658

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

3

2

Small-scale

0.681

High

170632

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

4

6

Small-scale

0.678

High

170591

P53
Cellular tumor antigen p53

3

1

Small-scale

0.675

High

170693

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

3

4

Small-scale

0.667

High

170723

SMUF1
E3 ubiquitin-protein ligase SMURF1

2

1

Small-scale

0.653

High

170639

CALD1
Caldesmon

3

4

High-throughput

0.650

High

170583

LRP5
Low-density lipoprotein receptor-related protein 5

3

5

Small-scale

0.640

High

170682

SIAH1
E3 ubiquitin-protein ligase SIAH1

2

2

Small-scale

0.640

High

170651

ASPP2
Apoptosis-stimulating of p53 protein 2

1

11

High-throughput

0.621

High

170644

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

1

High-throughput

0.618

High

170740

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

6

Small-scale

0.618

High

170746

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

10

Small-scale

0.618

High

170688

TSC1
Hamartin

2

4

Small-scale

0.614

High

170615

YAP1
Transcriptional coactivator YAP1

2

5

Small-scale

0.611

High

170706

ANM1
Protein arginine N-methyltransferase 1

1

4

Small-scale

0.602

High

170698

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.602

High

167307

SMAD7
Mothers against decapentaplegic homolog 7

2

6

Small-scale

0.601

High

170675

RN111
E3 ubiquitin-protein ligase Arkadia

2

3

Small-scale

0.586

High

170741

STRAP
Serine-threonine kinase receptor-associated protein

1

0

Small-scale

0.586

High

170607

PML
Protein PML

1

4

Small-scale

0.578

High

170668

RNF43
E3 ubiquitin-protein ligase RNF43

2

0

Small-scale

0.576

High

170590

MYC
Myc proto-oncogene protein

1

0

Small-scale

0.571

High

170594

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

5

Small-scale

0.571

High

170727

GID8
Glucose-induced degradation protein 8 homolog

2

3

Small-scale

0.571

High

170612

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

1

High-throughput

0.568

High

170654

DPYL1
Dihydropyrimidinase-related protein 1

1

1

High-throughput

0.568

High

170722

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

1

Small-scale

0.561

High

170621

TSC2
Tuberin

2

0

Small-scale

0.559

High

170692

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

2

5

Small-scale

0.552

High

170606

MK03
Mitogen-activated protein kinase 3

1

0

Small-scale

0.546

High

170584

STX11
Syntaxin-11

1

3

High-throughput

0.541

High

170586

TRI37
E3 ubiquitin-protein ligase TRIM37

1

8

High-throughput

0.541

High

170597

TRI27
Zinc finger protein RFP

1

3

High-throughput

0.541

High

170625

FXR1
RNA-binding protein FXR1

1

3

High-throughput

0.541

High

170626

FXR2
RNA-binding protein FXR2

1

3

High-throughput

0.541

High

170631

SUMO1
Small ubiquitin-related modifier 1

1

3

High-throughput

0.541

High

170641

GOGA2
Golgin subfamily A member 2

1

6

High-throughput

0.541

High

170642

TRAF2
TNF receptor-associated factor 2

1

4

High-throughput

0.541

High

170645

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

5

High-throughput

0.541

High

170660

TRIP6
Thyroid receptor-interacting protein 6

1

3

High-throughput

0.541

High

170662

CCD57
Coiled-coil domain-containing protein 57

1

5

High-throughput

0.541

High

170663

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

8

High-throughput

0.541

High

170670

K1C40
Keratin, type I cytoskeletal 40

1

3

High-throughput

0.541

High

170694

LHX4
LIM/homeobox protein Lhx4

1

4

High-throughput

0.541

High

170700

ANCHR
Abscission/NoCut checkpoint regulator

1

2

High-throughput

0.541

High

170705

MDFI
MyoD family inhibitor

1

1

High-throughput

0.541

High

170708

KR412
Keratin-associated protein 4-12

1

13

High-throughput

0.541

High

170709

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

1

High-throughput

0.541

High

170710

KRA42
Keratin-associated protein 4-2

1

12

High-throughput

0.541

High

170713

TRI15
E3 ubiquitin-protein ligase TRIM15

1

3

High-throughput

0.541

High

170716

CARD9
Caspase recruitment domain-containing protein 9

1

6

High-throughput

0.541

High

170729

TFP11
Tuftelin-interacting protein 11

1

1

High-throughput

0.541

High

170735

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

10

High-throughput

0.541

High

170690

KAT5
Histone acetyltransferase KAT5

1

0

Small-scale

0.537

High

170702

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

Small-scale

0.537

High

170744

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

0

Small-scale

0.537

High

170618

ARRB1
Beta-arrestin-1

1

1

Small-scale

0.536

High

170656

GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1

1

3

High-throughput

0.536

High

170665

RHG21
Rho GTPase-activating protein 21

1

1

High-throughput

0.536

High

170628

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

5

Small-scale

0.534

High

170731

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.529

High

170580

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

0

High-throughput

0.518

High

170633

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.518

High

170730

MYOTI
Myotilin

1

0

High-throughput

0.518

High

170599

H15
Histone H1.5

1

4

High-throughput

0.515

High

170600

H12
Histone H1.2

1

4

High-throughput

0.515

High

170667

DAB2P
Disabled homolog 2-interacting protein

1

1

Small-scale

0.515

High

170678

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

2

High-throughput

0.515

High

170609

CTNA1
Catenin alpha-1

1

0

High-throughput

0.513

High

170650

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

Small-scale

0.513

High

170661

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

170720

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

170737

PNMA2
Paraneoplastic antigen Ma2

1

0

High-throughput

0.513

High

170636

DAB2
Disabled homolog 2

1

2

Small-scale

0.501

High

170680

CARM1
Histone-arginine methyltransferase CARM1

1

4

Small-scale

0.501

High

170659

TGIF1
Homeobox protein TGIF1

1

1

Small-scale

0.500

High

170724

ZBT26
Zinc finger and BTB domain-containing protein 26

1

5

High-throughput

0.494

High

170592

H10
Histone H1.0

1

0

High-throughput

0.493

High

170602

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

0

High-throughput

0.493

High

170687

DDHD1
Phospholipase DDHD1

1

0

High-throughput

0.493

High

170725

SMYD2
N-lysine methyltransferase SMYD2

1

0

High-throughput

0.493

High

170603

TBG1
Tubulin gamma-1 chain

1

5

Small-scale

0.484

High

170605

RBTN2
Rhombotin-2

1

4

High-throughput

0.481

High

170613

ETV6
Transcription factor ETV6

1

1

High-throughput

0.481

High

170624

MEOX2
Homeobox protein MOX-2

1

5

High-throughput

0.481

High

170627

KR103
Keratin-associated protein 10-3

1

12

High-throughput

0.481

High

170655

NBR1
Next to BRCA1 gene 1 protein

1

1

High-throughput

0.481

High

170669

LHX8
LIM/homeobox protein Lhx8

1

2

High-throughput

0.481

High

170685

HOMEZ
Homeobox and leucine zipper protein Homez

1

2

High-throughput

0.481

High

170697

CDA7L
Cell division cycle-associated 7-like protein

1

1

High-throughput

0.481

High

170699

GMCL1
Germ cell-less protein-like 1

1

4

High-throughput

0.481

High

170712

TSG10
Testis-specific gene 10 protein

1

6

High-throughput

0.481

High

170611

PPM1A
Protein phosphatase 1A

1

0

Small-scale

0.479

High

162204

XPO1
Exportin-1

1

4

High-throughput

0.479

High

170581

NCK2
Cytoplasmic protein NCK2

1

3

Small-scale

0.479

High

170582

PRC1
Protein regulator of cytokinesis 1

1

3

Small-scale

0.479

High

170587

UBR5
E3 ubiquitin-protein ligase UBR5

1

2

Small-scale

0.479

High

170593

SP1
Transcription factor Sp1

1

4

Small-scale

0.479

High

170595

SKI
Ski oncogene

1

1

Small-scale

0.479

High

170596

SKIL
Ski-like protein

1

1

Small-scale

0.479

High

170601

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

2

Small-scale

0.479

High

170614

HD
Huntingtin

1

3

Small-scale

0.479

High

170649

SQSTM
Sequestosome-1

1

4

Small-scale

0.479

High

170652

TRI29
Tripartite motif-containing protein 29

1

9

Small-scale

0.479

High

170673

TRI65
E3 ubiquitin-protein ligase TRIM65

1

5

Small-scale

0.479

High

170696

TRI11
E3 ubiquitin-protein ligase TRIM11

1

3

Small-scale

0.479

High

170711

TRI54
Tripartite motif-containing protein 54

1

9

Small-scale

0.479

High

170715

UBP44
Ubiquitin carboxyl-terminal hydrolase 44

1

1

Small-scale

0.479

High

170726

RN146
E3 ubiquitin-protein ligase RNF146

1

1

Small-scale

0.479

High

170728

DACT1
Dapper homolog 1

1

1

Small-scale

0.479

High

170732

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

170734

PUF60
Poly(U)-binding-splicing factor PUF60

1

1

High-throughput

0.479

High

170743

AMMR1
Nuclear protein AMMECR1

1

1

Small-scale

0.479

High

170681

NUTM1
NUT family member 1

1

0

High-throughput

0.460

High

170634

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

170637

CAV1
Caveolin-1

1

0

Small-scale

0.458

High

170640

FOXM1
Forkhead box protein M1

1

0

Small-scale

0.458

High

170672

LTOR1
Ragulator complex protein LAMTOR1

1

0

Small-scale

0.458

High

170679

STING
Stimulator of interferon genes protein

1

0

Small-scale

0.458

High

170704

CRBN
Protein cereblon

1

0

Small-scale

0.458

High

170733

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

0

Small-scale

0.458

High

170742

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

0

Small-scale

0.458

High

102143

SUMO5
Small ubiquitin-related modifier 5

1

3

High-throughput

0.457

High

170671

Q6FHY5
MEOX2 protein

1

5

High-throughput

0.457

High

170707

SH3G1
Endophilin-A2

1

3

High-throughput

0.457

High

170608

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

2

Small-scale

0.445

High

170630

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

1

Small-scale

0.445

High

170638

K1C17
Keratin, type I cytoskeletal 17

1

1

High-throughput

0.445

High

170643

DLG1
Disks large homolog 1

1

3

Small-scale

0.445

High

170646

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

3

Small-scale

0.445

High

170648

2A5G
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

1

2

Small-scale

0.445

High

170657

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

2

Small-scale

0.445

High

170674

RBP10
Ran-binding protein 10

1

2

Small-scale

0.445

High

170676

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

1

4

Small-scale

0.445

High

170677

MAEA
E3 ubiquitin-protein transferase MAEA

1

3

Small-scale

0.445

High

170686

NIN
Ninein

1

5

Small-scale

0.445

High

170703

RANB9
Ran-binding protein 9

1

2

Small-scale

0.445

High

170714

WWTR1
WW domain-containing transcription regulator protein 1

1

5

Small-scale

0.445

High

170684

TRI42
Tripartite motif-containing protein 42

1

10

High-throughput

0.439

High

170695

ENTR1
Endosome-associated-trafficking regulator 1

1

1

High-throughput

0.439

High

170589

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

170620

RBP2
E3 SUMO-protein ligase RanBP2

1

0

Small-scale

0.426

High

170653

TFDP1
Transcription factor Dp-1

1

0

Small-scale

0.426

High

170666

ZN318
Zinc finger protein 318

1

0

Small-scale

0.426

High

170683

PHF6
PHD finger protein 6

1

0

Small-scale

0.426

High

170689

FRAT1
Proto-oncogene FRAT1

1

0

Small-scale

0.426

High

170719

YTDC2
3'-5' RNA helicase YTHDC2

1

0

Small-scale

0.426

High

92686

E9PQ56
Poly(U)-binding-splicing factor PUF60

1

1

High-throughput

0.407

High

170635

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024