Protein: SPF45
Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17)

Gene: SPF45, RBM17
Organism: Homo sapiens
Interactions: 187
UniProt ID: Q96I25

Gene Ontology (top 5):
GO:0000380 - alternative mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0045292 - mRNA cis splicing, via spliceosome
GO:0071011 - precatalytic spliceosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

268825

SF3B1
Splicing factor 3B subunit 1

6

7

Small-scale

0.958

High

195517

DHX15
ATP-dependent RNA helicase DHX15

6

9

High-throughput

0.956

High

165551

SR140
U2 snRNP-associated SURP motif-containing protein

5

11

High-throughput

0.932

High

1075725

SF01
Splicing factor 1

5

11

Small-scale

0.925

High

1018852

SF3A3
Splicing factor 3A subunit 3

4

2

High-throughput

0.903

High

1073713

SF3A2
Splicing factor 3A subunit 2

4

6

Small-scale

0.895

High

1034372

SF3B2
Splicing factor 3B subunit 2

3

3

High-throughput

0.871

High

453890

RU2A
U2 small nuclear ribonucleoprotein A'

3

4

High-throughput

0.861

High

1077216

U2AFM
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

3

11

High-throughput

0.861

High

441349

RU2B
U2 small nuclear ribonucleoprotein B''

2

20

High-throughput

0.811

High

856111

RBM5
RNA-binding protein 5

2

20

High-throughput

0.811

High

1294307

LN28A
Protein lin-28 homolog A

2

6

High-throughput

0.776

High

934394

CSK21
Casein kinase II subunit alpha

1

7

High-throughput

0.735

High

1074205

SF3A1
Splicing factor 3A subunit 1

4

8

High-throughput

0.699

High

541107

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

19

High-throughput

0.691

High

616465

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.691

High

834817

RBP2
E3 SUMO-protein ligase RanBP2

1

5

High-throughput

0.691

High

942871

SRPK2
SRSF protein kinase 2

1

20

High-throughput

0.691

High

958106

RBM10
RNA-binding protein 10

1

20

High-throughput

0.691

High

994290

DHX9
ATP-dependent RNA helicase A

1

10

High-throughput

0.691

High

1073111

SF3B3
Splicing factor 3B subunit 3

1

4

High-throughput

0.691

High

1073617

SF3B4
Splicing factor 3B subunit 4

1

16

High-throughput

0.691

High

1204684

DDX42
ATP-dependent RNA helicase DDX42

1

13

High-throughput

0.691

High

1294310

DDX21
Nucleolar RNA helicase 2

1

18

High-throughput

0.691

High

1219725

CHERP
Calcium homeostasis endoplasmic reticulum protein

3

17

High-throughput

0.675

High

1255575

NEK7
Serine/threonine-protein kinase Nek7

1

3

High-throughput

0.665

High

995132

GOGA2
Golgin subfamily A member 2

5

2

High-throughput

0.657

High

1254479

CCHCR
Coiled-coil alpha-helical rod protein 1

5

6

High-throughput

0.654

High

641894

U2AF2
Splicing factor U2AF 65 kDa subunit

1

17

Small-scale

0.647

High

1219994

SUGP1
SURP and G-patch domain-containing protein 1

2

16

High-throughput

0.644

High

1077197

U2AFL
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1

2

11

High-throughput

0.637

High

911933

RUXF
Small nuclear ribonucleoprotein F

2

7

High-throughput

0.628

High

1018423

SFSWA
Splicing factor, suppressor of white-apricot homolog

2

10

High-throughput

0.628

High

1102944

QRIC1
Transcriptional regulator QRICH1

2

2

High-throughput

0.628

High

198955

RFOX2
RNA binding protein fox-1 homolog 2

1

18

High-throughput

0.621

High

851631

NEK4
Serine/threonine-protein kinase Nek4

1

3

High-throughput

0.618

High

1294319

SRPK3
SRSF protein kinase 3

1

20

High-throughput

0.618

High

163146

XPO1
Exportin-1

1

5

High-throughput

0.618

High

442400

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

20

High-throughput

0.618

High

625557

CDK2
Cyclin-dependent kinase 2

1

5

High-throughput

0.618

High

726989

FUS
RNA-binding protein FUS

1

20

High-throughput

0.618

High

1018639

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

11

High-throughput

0.618

High

1046132

DX39B
Spliceosome RNA helicase DDX39B

1

13

High-throughput

0.618

High

1055452

DHX8
ATP-dependent RNA helicase DHX8

1

9

High-throughput

0.618

High

1059791

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

11

High-throughput

0.618

High

1201130

THOC4
THO complex subunit 4

1

12

High-throughput

0.618

High

1270875

KAT6A
Histone acetyltransferase KAT6A

1

12

High-throughput

0.618

High

1271164

RBP56
TATA-binding protein-associated factor 2N

1

12

High-throughput

0.618

High

1294297

DDX23
Probable ATP-dependent RNA helicase DDX23

1

14

High-throughput

0.618

High

1294318

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

5

High-throughput

0.618

High

1294299

PP12C
Protein phosphatase 1 regulatory subunit 12C

3

3

High-throughput

0.616

High

1238031

GPT11
G patch domain-containing protein 11

3

2

High-throughput

0.616

High

1294292

CDC5L
Cell division cycle 5-like protein

2

4

High-throughput

0.611

High

210202

PRC1
Protein regulator of cytokinesis 1

2

2

High-throughput

0.586

High

1056936

MDC1
Mediator of DNA damage checkpoint protein 1

2

10

Small-scale

0.584

High

253154

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

1294315

DDX41
Probable ATP-dependent RNA helicase DDX41

1

15

High-throughput

0.575

High

915476

ACTA
Actin, aortic smooth muscle

2

8

High-throughput

0.574

High

1294290

WDFY2
WD repeat and FYVE domain-containing protein 2

2

6

High-throughput

0.558

High

1223599

CC170
Coiled-coil domain-containing protein 170

2

3

High-throughput

0.553

High

149171

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.553

High

325851

LATS1
Serine/threonine-protein kinase LATS1

1

2

High-throughput

0.553

High

374696

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.553

High

1224869

FAM9B
Protein FAM9B

1

0

High-throughput

0.549

High

199805

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

2

High-throughput

0.536

High

202508

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

1

5

High-throughput

0.536

High

242540

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

1

High-throughput

0.536

High

278856

DNJC8
DnaJ homolog subfamily C member 8

1

5

High-throughput

0.536

High

281376

RL1D1
Ribosomal L1 domain-containing protein 1

1

4

High-throughput

0.536

High

550901

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.536

High

557566

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

4

High-throughput

0.536

High

759779

RS19
Small ribosomal subunit protein eS19

1

2

High-throughput

0.536

High

790514

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.536

High

801307

KI67
Proliferation marker protein Ki-67

1

11

High-throughput

0.536

High

807481

RS10
Small ribosomal subunit protein eS10

1

1

High-throughput

0.536

High

875713

MFAP1
Microfibrillar-associated protein 1

1

3

High-throughput

0.536

High

911718

RUXE
Small nuclear ribonucleoprotein E

1

2

High-throughput

0.536

High

912094

RUXG
Small nuclear ribonucleoprotein G

1

13

High-throughput

0.536

High

912356

SMD1
Small nuclear ribonucleoprotein Sm D1

1

9

High-throughput

0.536

High

912539

SMD2
Small nuclear ribonucleoprotein Sm D2

1

3

High-throughput

0.536

High

1039775

SNW1
SNW domain-containing protein 1

1

4

High-throughput

0.536

High

1042280

CUL3
Cullin-3

1

10

High-throughput

0.536

High

1149933

KDM4D
Lysine-specific demethylase 4D

1

1

High-throughput

0.536

High

1220142

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

5

High-throughput

0.536

High

1262131

PCNP
PEST proteolytic signal-containing nuclear protein

1

1

High-throughput

0.536

High

1294298

GNL3
Guanine nucleotide-binding protein-like 3

1

1

High-throughput

0.536

High

868681

ATX1
Ataxin-1

1

4

Small-scale

0.529

High

1294302

IQCN
IQ domain-containing protein N

1

1

High-throughput

0.523

High

433447

YES
Tyrosine-protein kinase Yes

2

3

High-throughput

0.521

High

653694

CALR
Calreticulin

1

4

High-throughput

0.515

High

739234

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.515

High

117796

MYO1C
Unconventional myosin-Ic

1

0

High-throughput

0.513

High

207090

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.513

High

1235533

COMD1
COMM domain-containing protein 1

1

0

High-throughput

0.513

High

1294295

TRIR
Telomerase RNA component interacting RNase

1

0

High-throughput

0.513

High

1294312

CWC15
Spliceosome-associated protein CWC15 homolog

1

1

High-throughput

0.508

High

1294314

S30BP
SAP30-binding protein

1

3

High-throughput

0.508

High

121001

APBB1
Amyloid beta precursor protein binding family B member 1

1

2

High-throughput

0.501

High

175120

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

8

High-throughput

0.501

High

1062621

EMC2
ER membrane protein complex subunit 2

1

5

High-throughput

0.489

High

1122479

ACTBL
Beta-actin-like protein 2

1

8

High-throughput

0.489

High

1285045

ARRD3
Arrestin domain-containing protein 3

1

2

High-throughput

0.489

High

1294296

HINFP
Histone H4 transcription factor

1

2

Small-scale

0.481

High

122938

MEN1
Menin

1

1

High-throughput

0.479

High

244789

BRD4
Bromodomain-containing protein 4

1

5

High-throughput

0.479

High

308980

KI20A
Kinesin-like protein KIF20A

1

10

High-throughput

0.479

High

323004

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

12

High-throughput

0.479

High

326748

SNAI1
Zinc finger protein SNAI1

1

4

High-throughput

0.479

High

347595

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.479

High

379729

MYCN
N-myc proto-oncogene protein

1

7

High-throughput

0.479

High

487679

ANDR
Androgen receptor

1

12

High-throughput

0.479

High

504577

HSP7C
Heat shock cognate 71 kDa protein

1

7

High-throughput

0.479

High

553441

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

651960

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

717280

CTNB1
Catenin beta-1

1

2

High-throughput

0.479

High

721162

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

737977

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

1

High-throughput

0.479

High

877832

FOXA1
Hepatocyte nuclear factor 3-alpha

1

5

High-throughput

0.479

High

917747

H4
Histone H4

1

4

High-throughput

0.479

High

931792

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.479

High

935115

H31
Histone H3.1

1

4

High-throughput

0.479

High

959603

VIGLN
Vigilin

1

20

High-throughput

0.479

High

967939

PO5F1
POU domain, class 5, transcription factor 1

1

3

High-throughput

0.479

High

969922

KIF23
Kinesin-like protein KIF23

1

7

High-throughput

0.479

High

998979

EP300
Histone acetyltransferase p300

1

7

High-throughput

0.479

High

1026511

RFA4
Replication protein A 30 kDa subunit

1

8

High-throughput

0.479

High

1064034

TNIP1
TNFAIP3-interacting protein 1

1

10

High-throughput

0.479

High

1071970

PCBP1
Poly(rC)-binding protein 1

1

20

High-throughput

0.479

High

1076085

OASL
2'-5'-oligoadenylate synthase-like protein

1

3

High-throughput

0.479

High

1183751

DPPA4
Developmental pluripotency-associated protein 4

1

1

High-throughput

0.479

High

1200574

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

1201599

ZCH18
Zinc finger CCCH domain-containing protein 18

1

11

High-throughput

0.479

High

1221640

SMC5
Structural maintenance of chromosomes protein 5

1

6

High-throughput

0.479

High

1250987

SNIP1
Smad nuclear-interacting protein 1

1

3

High-throughput

0.479

High

1269360

ESR2
Estrogen receptor beta

1

12

High-throughput

0.479

High

1288238

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

10

High-throughput

0.479

High

1294291

CIC
Protein capicua homolog

1

11

High-throughput

0.479

High

1294293

BARD1
BRCA1-associated RING domain protein 1

1

6

High-throughput

0.479

High

1294294

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

1294300

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

5

High-throughput

0.479

High

1294305

ECT2
Protein ECT2

1

5

High-throughput

0.479

High

1294306

NANOG
Homeobox protein NANOG

1

2

High-throughput

0.479

High

1294308

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

3

High-throughput

0.479

High

1294313

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1294317

FZR1
Fizzy-related protein homolog

1

11

High-throughput

0.479

High

1294320

TRRAP
Transformation/transcription domain-associated protein

1

2

High-throughput

0.479

High

557488

PECA1
Platelet endothelial cell adhesion molecule

1

6

High-throughput

0.470

High

1291099

CDCA5
Sororin

1

0

High-throughput

0.458

High

1294311

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1147698

TENS3
Tensin-3

1

1

High-throughput

0.457

High

402355

JUN
Transcription factor Jun

1

7

High-throughput

0.445

High

718106

BMI1
Polycomb complex protein BMI-1

1

7

High-throughput

0.445

High

963665

E2F1
Transcription factor E2F1

1

3

High-throughput

0.445

High

125651

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

3

High-throughput

0.437

High

228359

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.437

High

255990

OBSL1
Obscurin-like protein 1

1

4

High-throughput

0.437

High

298720

UFL1
E3 UFM1-protein ligase 1

1

3

High-throughput

0.437

High

779920

CCNF
Cyclin-F

1

5

High-throughput

0.437

High

908967

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.437

High

932328

ACTC
Actin, alpha cardiac muscle 1

1

7

High-throughput

0.437

High

1048368

SCRB2
Lysosome membrane protein 2

1

1

High-throughput

0.437

High

1066530

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.437

High

1163797

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.437

High

1171245

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

1293907

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.437

High

1294304

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.437

High

1294316

HECD1
E3 ubiquitin-protein ligase HECTD1

1

10

High-throughput

0.437

High

1294321

MB212
Protein mab-21-like 2

1

1

High-throughput

0.437

High

1059344

CASP8
Caspase-8

1

0

High-throughput

0.426

High

831588

CEBPA
CCAAT/enhancer-binding protein alpha

1

7

High-throughput

0.408

High

92703

E9PQQ4
Heat shock cognate 71 kDa protein

1

8

High-throughput

0.407

High

1047209

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.407

High

1124590

ODFP2
Outer dense fiber protein 2

1

1

High-throughput

0.407

High

600050

SAT1
Diamine acetyltransferase 1

6

0

High-throughput

0.385

High

1120294

CEP55
Centrosomal protein of 55 kDa

4

0

High-throughput

0.364

High

1190319

COMD6
COMM domain-containing protein 6

1

0

High-throughput

0.279

Low

1204170

COMD2
COMM domain-containing protein 2

1

0

High-throughput

0.279

Low

1233925

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.279

Low

1294301

COMD4
COMM domain-containing protein 4

1

0

High-throughput

0.279

Low

281824

WFS1
Wolframin

1

0

High-throughput

0.268

Low

327144

CF047
Uncharacterized protein C6orf47

1

0

High-throughput

0.261

Low

1232899

LNX2
Ligand of Numb protein X 2

1

0

High-throughput

0.251

Low

242122

PAGE4
P antigen family member 4

1

0

High-throughput

0.249

Low

484389

SCHI1
Schwannomin-interacting protein 1

1

0

High-throughput

0.249

Low

1263209

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

0

High-throughput

0.249

Low

1294303

TOLIP
Toll-interacting protein

1

0

High-throughput

0.249

Low

1294309

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024