Protein: LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-)

Gene: LRRK2
Organism: Mus musculus
Interactions: 91
UniProt ID: Q5S006

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000287 - magnesium ion binding
GO:0001933 - negative regulation of protein phosphorylation
GO:0001934 - positive regulation of protein phosphorylation
GO:0003779 - actin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1130105

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

5

19

Small-scale

0.927

High

432426

HS90A
Heat shock protein HSP 90-alpha

2

17

Small-scale

0.754

High

897015

ARP2
Actin-related protein 2

2

10

Small-scale

0.737

High

760448

DYN1
Dynamin-1

2

7

Small-scale

0.712

High

892172

ACTB
Actin, cytoplasmic 1

2

10

Small-scale

0.712

High

193182

AXIN1
Axin-1

1

3

Small-scale

0.691

High

1130142

GSK3B
Glycogen synthase kinase-3 beta

1

18

Small-scale

0.691

High

933123

1433T
14-3-3 protein theta

4

20

Small-scale

0.687

High

397214

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

8

Small-scale

0.647

High

1125648

TAOK1
Serine/threonine-protein kinase TAO1

1

11

Small-scale

0.647

High

679425

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

5

Small-scale

0.646

High

1130115

DNM1L
Dynamin-1-like protein

3

8

Small-scale

0.643

High

140005

RGS2
Regulator of G-protein signaling 2

1

3

Small-scale

0.618

High

829605

CDK5
Cyclin-dependent kinase 5

1

10

Small-scale

0.618

High

886052

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

20

Small-scale

0.618

High

892724

CDC42
Cell division control protein 42 homolog

1

9

Small-scale

0.618

High

925792

RAC1
Ras-related C3 botulinum toxin substrate 1

1

9

Small-scale

0.618

High

1112938

PAK6
Serine/threonine-protein kinase PAK 6

1

9

Small-scale

0.618

High

1130108

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

20

Small-scale

0.618

High

1130110

CDC37
Hsp90 co-chaperone Cdc37

1

6

Small-scale

0.618

High

1130111

FADD
FAS-associated death domain protein

1

5

Small-scale

0.618

High

1130119

RAB7L
Ras-related protein Rab-7L1

1

14

Small-scale

0.618

High

1130134

ARHG7
Rho guanine nucleotide exchange factor 7

1

3

Small-scale

0.618

High

905338

1433G
14-3-3 protein gamma [Cleaved into: 14-3-3 protein gamma, N-terminally processed]

2

20

Small-scale

0.612

High

910249

1433E
14-3-3 protein epsilon

2

13

Small-scale

0.612

High

926794

1433Z
14-3-3 protein zeta/delta

2

20

Small-scale

0.612

High

935502

1433F
14-3-3 protein eta

2

20

Small-scale

0.612

High

1130124

1433B
14-3-3 protein beta/alpha

2

20

Small-scale

0.612

High

804018

NSF
Vesicle-fusing ATPase

2

2

Small-scale

0.584

High

435923

ENPL
Endoplasmin

1

17

High-throughput

0.575

High

929787

ACTG
Actin, cytoplasmic 2

1

10

Small-scale

0.575

High

956463

MPRIP
Myosin phosphatase Rho-interacting protein

1

11

Small-scale

0.575

High

1111864

ML12B
Myosin regulatory light chain 12B

1

16

Small-scale

0.575

High

1130112

ACTBL
Beta-actin-like protein 2

1

10

Small-scale

0.575

High

1130120

ARP3
Actin-related protein 3

1

10

Small-scale

0.575

High

1130129

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

5

Small-scale

0.575

High

1130130

RAI14
Ankycorbin

1

4

Small-scale

0.575

High

1130133

LIMA1
LIM domain and actin-binding protein 1

1

6

Small-scale

0.575

High

970134

CTNB1
Catenin beta-1

1

7

Small-scale

0.536

High

1130109

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

7

Small-scale

0.536

High

1130114

BAG5
BAG family molecular chaperone regulator 5

1

4

Small-scale

0.536

High

222644

WSB1
WD repeat and SOCS box-containing protein 1

1

9

Small-scale

0.515

High

1130140

CHIP
E3 ubiquitin-protein ligase CHIP

1

13

Small-scale

0.515

High

381385

MBP
Myelin basic protein

1

1

Small-scale

0.501

High

223164

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

3

High-throughput

0.500

High

93779

SC16A
Protein transport protein Sec16A

1

6

Small-scale

0.479

High

223033

SYUA
Alpha-synuclein

1

1

Small-scale

0.479

High

498034

TAU
Microtubule-associated protein tau

1

6

Small-scale

0.479

High

844418

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

6

Small-scale

0.479

High

1118132

HERC2
E3 ubiquitin-protein ligase HERC2

1

11

Small-scale

0.479

High

1129457

NEUL4
Neuralized-like protein 4

1

3

Small-scale

0.479

High

1130113

Q8CG29
Myosin IF

1

12

Small-scale

0.479

High

1130117

MYH9
Myosin-9

1

4

Small-scale

0.479

High

1130123

FIS1
Mitochondrial fission 1 protein

1

1

Small-scale

0.479

High

1130127

TBB4A
Tubulin beta-4A chain

1

12

Small-scale

0.479

High

1130131

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

3

Small-scale

0.479

High

1130132

VPS35
Vacuolar protein sorting-associated protein 35

1

1

Small-scale

0.479

High

558868

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

1130136

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

Small-scale

0.458

High

139564

STXB1
Syntaxin-binding protein 1

1

5

Small-scale

0.445

High

444640

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

4

Small-scale

0.445

High

447639

PDIA1
Protein disulfide-isomerase

1

11

High-throughput

0.445

High

536154

CALR
Calreticulin

1

6

High-throughput

0.445

High

588717

BIP
Endoplasmic reticulum chaperone BiP

1

13

High-throughput

0.445

High

596681

TPM3
Tropomyosin alpha-3 chain

1

7

Small-scale

0.445

High

805503

MYO1B
Unconventional myosin-Ib

1

11

Small-scale

0.445

High

812923

CAZA1
F-actin-capping protein subunit alpha-1

1

6

Small-scale

0.445

High

812944

CAZA2
F-actin-capping protein subunit alpha-2

1

6

Small-scale

0.445

High

813904

CAPZB
F-actin-capping protein subunit beta

1

3

Small-scale

0.445

High

885424

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

9

Small-scale

0.445

High

886031

TPM1
Tropomyosin alpha-1 chain

1

7

Small-scale

0.445

High

886043

TPM2
Tropomyosin beta chain

1

7

Small-scale

0.445

High

887519

ARPC4
Actin-related protein 2/3 complex subunit 4

1

2

Small-scale

0.445

High

926336

VAMP2
Vesicle-associated membrane protein 2

1

2

Small-scale

0.445

High

936346

MYO1F
Unconventional myosin-If

1

12

Small-scale

0.445

High

1130106

MYO1D
Unconventional myosin-Id

1

11

Small-scale

0.445

High

1130116

TMX1
Thioredoxin-related transmembrane protein 1

1

17

High-throughput

0.445

High

1130118

ERLN1
Erlin-1

1

4

High-throughput

0.445

High

1130121

ATP5L
ATP synthase subunit g, mitochondrial

1

1

Small-scale

0.445

High

1130122

ARPC5
Actin-related protein 2/3 complex subunit 5

1

1

Small-scale

0.445

High

1130125

ARPC2
Actin-related protein 2/3 complex subunit 2

1

1

Small-scale

0.445

High

1130126

MPC2
Mitochondrial pyruvate carrier 2

1

1

Small-scale

0.445

High

1130128

EFHD2
EF-hand domain-containing protein D2

1

20

Small-scale

0.445

High

1130135

TMOD3
Tropomodulin-3

1

4

Small-scale

0.445

High

1130137

PLEC
Plectin

1

5

Small-scale

0.445

High

1130138

DREB
Drebrin

1

4

Small-scale

0.445

High

1130139

MYO1C
Unconventional myosin-Ic

1

9

Small-scale

0.445

High

1130141

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

10

Small-scale

0.445

High

192849

STX1A
Syntaxin-1A

1

0

Small-scale

0.426

High

1130107

MYL6
Myosin light polypeptide 6

1

13

Small-scale

0.407

High


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Last updated: 15 Jul 2024