Protein: HXK2
Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase)

Gene: HXK2, HK2
Organism: Homo sapiens
Interactions: 96
UniProt ID: P52789

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0001678 - intracellular glucose homeostasis
GO:0002931 - response to ischemia
GO:0004340 - glucokinase activity
GO:0004396 - hexokinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

583304

HXK1
Hexokinase-1

2

12

High-throughput

0.811

High

856198

HXK3
Hexokinase-3

2

12

High-throughput

0.811

High

856257

UBQL1
Ubiquilin-1

2

4

High-throughput

0.646

High

226936

PRKN
E3 ubiquitin-protein ligase parkin

3

4

Small-scale

0.640

High

601184

VDAC1
Voltage-dependent anion-selective channel protein 1

2

6

Small-scale

0.611

High

856207

CUL3
Cullin-3

2

3

High-throughput

0.571

High

856210

TOM20
Mitochondrial import receptor subunit TOM20 homolog

2

1

High-throughput

0.571

High

417207

ENOA
Alpha-enolase

1

5

High-throughput

0.541

High

856246

UBQL4
Ubiquilin-4

1

4

High-throughput

0.541

High

431679

HS90A
Heat shock protein HSP 90-alpha

1

7

High-throughput

0.536

High

856208

IRF3
Interferon regulatory factor 3

1

3

High-throughput

0.536

High

856224

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

856229

IRF7
Interferon regulatory factor 7

1

3

High-throughput

0.536

High

856235

FOXB1
Forkhead box protein B1

1

6

High-throughput

0.536

High

856256

FBX2
F-box only protein 2

1

1

High-throughput

0.536

High

856259

VDAC3
Voltage-dependent anion-selective channel protein 3

1

6

High-throughput

0.536

High

856243

TIGAR
Fructose-2,6-bisphosphatase TIGAR

1

4

Small-scale

0.534

High

796364

MAGAC
Melanoma-associated antigen 12

1

3

High-throughput

0.523

High

795515

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

0

High-throughput

0.513

High

856248

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.513

High

856250

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

0

High-throughput

0.513

High

270772

FOXH1
Forkhead box protein H1

1

5

High-throughput

0.489

High

297165

IPO13
Importin-13

1

1

High-throughput

0.489

High

830727

ARL4D
ADP-ribosylation factor-like protein 4D

1

4

High-throughput

0.489

High

856200

FOXL2
Forkhead box protein L2

1

6

High-throughput

0.489

High

856204

FOXL1
Forkhead box protein L1

1

6

High-throughput

0.489

High

856212

INF2
Inverted formin-2

1

1

High-throughput

0.489

High

856219

LYPD4
Ly6/PLAUR domain-containing protein 4

1

1

High-throughput

0.489

High

856222

FOXI2
Forkhead box protein I2

1

6

High-throughput

0.489

High

856258

DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1

1

High-throughput

0.489

High

157550

MGST3
Glutathione S-transferase 3, mitochondrial

1

1

High-throughput

0.479

High

322366

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

338168

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

384540

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

455249

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

538788

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

1

High-throughput

0.479

High

779071

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

856202

KPCE
Protein kinase C epsilon type

1

1

Small-scale

0.479

High

856203

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

856214

MIDN
Midnolin

1

1

High-throughput

0.479

High

856218

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

856225

MIRO2
Mitochondrial Rho GTPase 2

1

8

High-throughput

0.479

High

856226

S15A3
Solute carrier family 15 member 3

1

3

High-throughput

0.479

High

856228

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.479

High

856234

COX14
Cytochrome c oxidase assembly protein COX14

1

1

High-throughput

0.479

High

856242

TRI36
E3 ubiquitin-protein ligase TRIM36

1

4

Small-scale

0.479

High

856244

PXMP2
Peroxisomal membrane protein 2

1

1

High-throughput

0.479

High

856245

FBX6
F-box only protein 6

1

1

High-throughput

0.479

High

856247

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

1

High-throughput

0.479

High

856249

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

5

High-throughput

0.479

High

856251

OCAD1
OCIA domain-containing protein 1

1

1

High-throughput

0.479

High

856253

MTCH1
Mitochondrial carrier homolog 1

1

3

High-throughput

0.479

High

856254

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

856255

TES
Testin

1

1

High-throughput

0.479

High

856262

FIS1
Mitochondrial fission 1 protein

1

1

High-throughput

0.479

High

856263

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

856264

MTCH2
Mitochondrial carrier homolog 2

1

3

High-throughput

0.479

High

130468

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

258420

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

530523

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

749268

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

856206

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

856209

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

856211

TWST1
Twist-related protein 1

1

0

Small-scale

0.458

High

856213

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

856215

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.458

High

856230

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

856231

OPTN
Optineurin

1

0

High-throughput

0.458

High

856236

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

856241

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

856252

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

856201

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.457

High

581566

VCAM1
Vascular cell adhesion protein 1

1

1

High-throughput

0.445

High

856216

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

856238

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

856260

ITM2B
Integral membrane protein 2B

1

2

High-throughput

0.445

High

346297

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.437

High

552300

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

650742

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

720036

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

795723

MAGA3
Melanoma-associated antigen 3

1

3

Small-scale

0.437

High

856205

RFA4
Replication protein A 30 kDa subunit

1

2

High-throughput

0.437

High

856217

MARH8
E3 ubiquitin-protein ligase MARCHF8

1

1

Small-scale

0.437

High

856223

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

856240

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

99577

F5H1C8
Solute carrier family 15 member 3

1

3

High-throughput

0.407

High

856221

CLC4G
C-type lectin domain family 4 member G

1

1

Small-scale

0.407

High

204543

PROM1
Prominin-1

1

0

Small-scale

0.292

High

856232

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

856233

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.279

Low

856239

SEM4C
Semaphorin-4C

1

0

High-throughput

0.279

Low

856199

CTBP2
C-terminal-binding protein 2

1

0

High-throughput

0.249

Low

856220

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

856237

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.249

Low

856261

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

856227

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024