Protein: MK01
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)

Gene: MK01, Mapk1
Organism: Mus musculus
Interactions: 82
UniProt ID: P63085

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001784 - phosphotyrosine residue binding
GO:0003690 - double-stranded DNA binding
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

926412

KSR1
Kinase suppressor of Ras 1

6

13

Small-scale

0.934

High

926416

SQSTM
Sequestosome-1

2

6

Small-scale

0.799

High

926408

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

2

9

High-throughput

0.789

High

682463

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

20

Small-scale

0.778

High

139597

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

2

20

Small-scale

0.757

High

926425

MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

2

20

Small-scale

0.757

High

926403

DUS2
Dual specificity protein phosphatase 2

1

20

Small-scale

0.724

High

926413

PEA15
Astrocytic phosphoprotein PEA-15

1

4

Small-scale

0.724

High

926432

PAXI
Paxillin

4

6

Small-scale

0.707

High

926398

TNIK
Traf2 and NCK-interacting protein kinase

1

9

High-throughput

0.691

High

926406

AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

1

5

High-throughput

0.691

High

926395

MK01
Mitogen-activated protein kinase 1

1

17

Small-scale

0.690

High

926415

PTPRR
Receptor-type tyrosine-protein phosphatase R

3

20

Small-scale

0.674

High

926414

DLG4
Disks large homolog 4

3

9

High-throughput

0.667

High

785336

ELK1
ETS domain-containing protein Elk-1

3

19

Small-scale

0.655

High

926439

DUS6
Dual specificity protein phosphatase 6

1

20

Small-scale

0.653

High

578259

KS6A3
Ribosomal protein S6 kinase alpha-3

1

20

Small-scale

0.647

High

803839

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

2

Small-scale

0.647

High

926405

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

1

2

Small-scale

0.647

High

926426

DJC27
DnaJ homolog subfamily C member 27

1

1

Small-scale

0.647

High

626855

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

3

Small-scale

0.629

High

139002

CAN2
Calpain-2 catalytic subunit

1

2

Small-scale

0.618

High

384060

ARAF
Serine/threonine-protein kinase A-Raf

1

13

Small-scale

0.618

High

432419

HS90A
Heat shock protein HSP 90-alpha

1

19

Small-scale

0.618

High

724164

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

10

Small-scale

0.618

High

857304

TIA1
Cytotoxic granule associated RNA binding protein TIA1

1

6

High-throughput

0.618

High

926397

FER
Tyrosine-protein kinase Fer

1

5

Small-scale

0.618

High

926428

VRK3
Serine/threonine-protein kinase VRK3

1

20

Small-scale

0.618

High

926438

DUS3
Dual specificity protein phosphatase 3

1

20

Small-scale

0.618

High

562975

ATF2
Cyclic AMP-dependent transcription factor ATF-2

2

16

Small-scale

0.613

High

926437

DLGP1
Disks large-associated protein 1

2

1

High-throughput

0.611

High

381380

MBP
Myelin basic protein

2

6

Small-scale

0.602

High

926402

ZEP1
Zinc finger protein 40

1

2

High-throughput

0.590

High

926410

KLF4
Krueppel-like factor 4

1

8

Small-scale

0.590

High

926444

KS6A4
Ribosomal protein S6 kinase alpha-4

1

20

High-throughput

0.590

High

926419

TRPV1
Transient receptor potential cation channel subfamily V member 1

1

0

High-throughput

0.586

High

926429

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.586

High

926423

NANOG
Homeobox protein NANOG

1

2

Small-scale

0.573

High

926434

Q99K94
Signal transducer and activator of transcription

1

5

Small-scale

0.561

High

655997

CEBPB
CCAAT/enhancer-binding protein beta

1

16

Small-scale

0.536

High

99948

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

8

High-throughput

0.536

High

723559

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

3

High-throughput

0.536

High

926422

MYOME
Myomegalin

1

3

High-throughput

0.536

High

250701

ITB5
Integrin beta-5

1

2

Small-scale

0.527

High

926433

EED
Polycomb protein EED

1

3

High-throughput

0.515

High

570287

GATA1
Erythroid transcription factor

1

4

Small-scale

0.501

High

873169

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

20

Small-scale

0.501

High

926396

4EBP2
Eukaryotic translation initiation factor 4E-binding protein 2

1

4

Small-scale

0.501

High

926411

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

4

Small-scale

0.501

High

926441

ITA2B
Integrin alpha-IIb

1

3

High-throughput

0.501

High

102949

G3X9H5
Huntingtin

1

1

High-throughput

0.479

High

139654

MAP2
Methionine aminopeptidase 2

1

2

Small-scale

0.479

High

192937

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

5

High-throughput

0.479

High

193650

PER1
Period circadian protein homolog 1

1

4

Small-scale

0.479

High

222693

PER2
Period circadian protein homolog 2

1

4

Small-scale

0.479

High

497992

TAU
Microtubule-associated protein tau

1

10

High-throughput

0.479

High

926399

CRY1
Cryptochrome-1

1

1

Small-scale

0.479

High

926400

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

3

High-throughput

0.479

High

926401

TOP2A
DNA topoisomerase 2-alpha

1

3

Small-scale

0.479

High

926404

PECA1
Platelet endothelial cell adhesion molecule

1

5

Small-scale

0.479

High

926407

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

3

High-throughput

0.479

High

926409

SRC8
Src substrate cortactin

1

3

Small-scale

0.479

High

926418

NEB2
Neurabin-2

1

7

High-throughput

0.479

High

926424

Q8BPK8
Agenet-like domain-containing protein

1

3

High-throughput

0.479

High

926440

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

1

5

Small-scale

0.479

High

926442

BLNK
B-cell linker protein

1

2

Small-scale

0.479

High

926443

CRY2
Cryptochrome-2

1

1

Small-scale

0.479

High

192710

EFNB3
Ephrin-B3

1

0

Small-scale

0.458

High

829151

PCY1A
Choline-phosphate cytidylyltransferase A

1

0

Small-scale

0.458

High

868877

ATX1
Ataxin-1

1

0

High-throughput

0.458

High

926420

FACD2
Fanconi anemia group D2 protein homolog

1

0

High-throughput

0.458

High

926435

CKLF3
CKLF-like MARVEL transmembrane domain-containing protein 3

1

0

Small-scale

0.458

High

926421

RHDF2
Inactive rhomboid protein 2

1

1

High-throughput

0.457

High

926427

CROCC
Rootletin

1

1

High-throughput

0.457

High

926430

NUP58
Nucleoporin p58/p45

1

2

High-throughput

0.457

High

926431

ZMY11
Zinc finger MYND domain-containing protein 11

1

2

High-throughput

0.457

High

729440

FMR1
Fragile X messenger ribonucleoprotein 1

1

3

High-throughput

0.445

High

926417

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.438

High

857549

HMGA2
High mobility group protein HMGI-C

1

0

High-throughput

0.426

High

926436

Q9D318
GRAM domain-containing protein

1

1

High-throughput

0.417

High

371755

CFAD
Complement factor D

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024