Protein: NPC2
NPC intracellular cholesterol transporter 2 (Epididymal secretory protein E1) (Human epididymis-specific protein 1) (He1) (Niemann-Pick disease type C2 protein)

Gene: NPC2
Organism: Homo sapiens
Interactions: 46
UniProt ID: P61916

Gene Ontology (top 5):
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005764 - lysosome
GO:0005783 - endoplasmic reticulum
GO:0008203 - cholesterol metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

902274

NEGR1
Neuronal growth regulator 1

1

0

Small-scale

0.664

High

509857

PSG1
Pregnancy-specific beta-1-glycoprotein 1

1

0

High-throughput

0.656

High

902273

RRAGA
Ras-related GTP-binding protein A

3

0

High-throughput

0.638

High

341581

CFAB
Complement factor B

2

1

High-throughput

0.628

High

607626

NDKB
Nucleoside diphosphate kinase B

2

2

High-throughput

0.611

High

363582

TTHY
Transthyretin

2

0

High-throughput

0.602

High

856267

HXK3
Hexokinase-3

2

0

High-throughput

0.602

High

887020

DEF1
Neutrophil defensin 1

2

0

High-throughput

0.602

High

902276

TM11B
Transmembrane protease serine 11B

2

0

High-throughput

0.585

High

233748

NDK8
Putative nucleoside diphosphate kinase

2

2

High-throughput

0.552

High

902275

DHDDS
Dehydrodolichyl diphosphate synthase complex subunit DHDDS

1

0

Small-scale

0.549

High

902282

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

0

Small-scale

0.529

High

328257

BY55
CD160 antigen

1

0

High-throughput

0.513

High

435947

MSMB
Beta-microseminoprotein

1

0

High-throughput

0.513

High

514806

MPRI
Cation-independent mannose-6-phosphate receptor

1

0

High-throughput

0.513

High

532043

CO6
Complement component C6

1

0

High-throughput

0.513

High

614195

CAH6
Carbonic anhydrase 6

1

0

High-throughput

0.513

High

902279

PIEZ1
Piezo-type mechanosensitive ion channel component 1

1

0

High-throughput

0.513

High

902281

LCFC1
Sperm-egg fusion protein LLCFC1

1

0

High-throughput

0.513

High

902285

SIAS
Sialic acid synthase

1

0

High-throughput

0.513

High

902286

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

0

High-throughput

0.513

High

433309

YES
Tyrosine-protein kinase Yes

1

0

High-throughput

0.493

High

749309

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.481

High

167889

NPC1
NPC intracellular cholesterol transporter 1

1

0

Small-scale

0.480

High

902268

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

0

Small-scale

0.460

High

902287

ERRFI
ERBB receptor feedback inhibitor 1

1

0

Small-scale

0.460

High

544954

AMPN
Aminopeptidase N

1

0

High-throughput

0.458

High

902277

TM192
Transmembrane protein 192

1

0

High-throughput

0.458

High

902272

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.439

High

902271

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

100168

F6XY72
Histidine protein kinase NDKB

1

2

High-throughput

0.407

High

254387

LDB3
LIM domain-binding protein 3

3

0

High-throughput

0.347

High

902278

IRGQ
Immunity-related GTPase family Q protein

2

0

High-throughput

0.328

High

902283

BARD1
BRCA1-associated RING domain protein 1

1

0

High-throughput

0.288

High

170316

TIF1A
Transcription intermediary factor 1-alpha

1

0

High-throughput

0.279

Low

789615

I12R1
Interleukin-12 receptor subunit beta-1

1

0

High-throughput

0.279

Low

821539

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

842099

R144A
E3 ubiquitin-protein ligase RNF144A

1

0

High-throughput

0.279

Low

902267

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

0

High-throughput

0.279

Low

902270

EPHA7
Ephrin type-A receptor 7

1

0

High-throughput

0.279

Low

902280

TSR2
Pre-rRNA-processing protein TSR2 homolog

1

0

High-throughput

0.279

Low

836811

DNLI4
DNA ligase 4

1

0

High-throughput

0.251

Low

902269

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.251

Low

902284

ECT2
Protein ECT2

1

0

High-throughput

0.251

Low

205241

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

882212

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024