Protein: TPP1
Tripeptidyl-peptidase 1 (TPP-1) (EC 3.4.14.9) (Cell growth-inhibiting gene 1 protein) (Lysosomal pepstatin-insensitive protease) (LPIC) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase I) (TPP-I)

Gene: TPP1
Organism: Homo sapiens
Interactions: 72
UniProt ID: O14773

Gene Ontology (top 5):
GO:0004175 - endopeptidase activity
GO:0004252 - serine-type endopeptidase activity
GO:0005764 - lysosome
GO:0005794 - Golgi apparatus
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

154617

RPTOR
Regulatory-associated protein of mTOR

2

1

High-throughput

0.628

High

153965

TERT
Telomerase reverse transcriptase

2

0

Small-scale

0.619

High

135543

NDKM
Nucleoside diphosphate kinase, mitochondrial

2

0

High-throughput

0.602

High

154627

OMA1
Metalloendopeptidase OMA1, mitochondrial

2

0

High-throughput

0.602

High

154587

GDC
Solute carrier family 25 member 16

2

1

High-throughput

0.574

High

154583

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

154639

POTE1
Protection of telomeres protein 1

2

1

Small-scale

0.570

High

154578

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

154630

TINF2
TERF1-interacting nuclear factor 2

1

0

Small-scale

0.537

High

154642

NALP2
NACHT, LRR and PYD domains-containing protein 2

1

1

High-throughput

0.536

High

154614

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.517

High

154596

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

1

High-throughput

0.515

High

154589

CALX
Calnexin

1

0

High-throughput

0.513

High

154608

GRDN
Girdin

1

0

High-throughput

0.513

High

154613

PKN3
Serine/threonine-protein kinase N3

1

0

High-throughput

0.513

High

154615

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

124998

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.493

High

154618

ZBT38
Zinc finger and BTB domain-containing protein 38

1

0

High-throughput

0.493

High

154626

RN183
E3 ubiquitin-protein ligase RNF183

1

0

High-throughput

0.493

High

154628

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.493

High

154580

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

154581

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

154592

BASI
Basigin

1

0

High-throughput

0.458

High

154598

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

154604

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

154605

CUL7
Cullin-7

1

0

High-throughput

0.458

High

154616

TM192
Transmembrane protein 192

1

0

High-throughput

0.458

High

154621

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

154623

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

Small-scale

0.458

High

154633

XRN2
5'-3' exoribonuclease 2

1

0

Small-scale

0.458

High

154637

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

154640

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

Small-scale

0.458

High

154643

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

154591

C2TA
MHC class II transactivator

1

1

Small-scale

0.437

High

154622

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

154584

ANGI
Angiogenin

1

0

High-throughput

0.426

High

154585

PRIO
Major prion protein

1

0

High-throughput

0.426

High

154586

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

154595

HD
Huntingtin

1

0

High-throughput

0.426

High

154603

TAGL
Transgelin

1

0

High-throughput

0.426

High

154611

ZN746
Zinc finger protein 746

1

0

High-throughput

0.426

High

154607

CTC1
CST complex subunit CTC1

2

0

Small-scale

0.335

High

154634

STN1
CST complex subunit STN1

2

0

Small-scale

0.335

High

154606

TOM20
Mitochondrial import receptor subunit TOM20 homolog

2

0

High-throughput

0.318

High

154582

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.298

High

154588

ELK1
ETS domain-containing protein Elk-1

2

0

High-throughput

0.298

High

154629

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

154579

TSN2
Tetraspanin-2

1

0

High-throughput

0.279

Low

154597

DGKG
Diacylglycerol kinase gamma

1

0

High-throughput

0.279

Low

154610

KMCP1
Kidney mitochondrial carrier protein 1

1

0

High-throughput

0.279

Low

154620

DHB8
(3R)-3-hydroxyacyl-CoA dehydrogenase

1

0

High-throughput

0.279

Low

154624

POP5
Ribonuclease P/MRP protein subunit POP5

1

0

High-throughput

0.279

Low

154625

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.279

Low

154632

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

154609

CEP55
Centrosomal protein of 55 kDa

1

0

High-throughput

0.268

Low

154612

FBX42
F-box only protein 42

1

0

High-throughput

0.268

Low

154631

TRAF4
TNF receptor-associated factor 4

1

0

High-throughput

0.268

Low

154638

CISH
Cytokine-inducible SH2-containing protein

1

0

High-throughput

0.268

Low

154641

ASB6
Ankyrin repeat and SOCS box protein 6

1

0

High-throughput

0.268

Low

154644

FBXL4
F-box/LRR-repeat protein 4

1

0

High-throughput

0.268

Low

154577

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.261

Low

100260

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

154590

MPIP3
M-phase inducer phosphatase 3

1

0

High-throughput

0.249

Low

154593

BRCA1
Breast cancer type 1 susceptibility protein

1

0

Small-scale

0.249

Low

154594

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

154601

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.249

Low

154602

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

154619

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

154635

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

154636

MAGF1
Melanoma-associated antigen F1

1

0

Small-scale

0.249

Low

154600

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low

154599

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024