Protein: PUR4
Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase) (Phosphoribosylformylglycineamide amidotransferase)

Gene: PUR4, PFAS
Organism: Homo sapiens
Interactions: 88
UniProt ID: O15067

Gene Ontology (top 5):
GO:0004642 - phosphoribosylformylglycinamidine synthase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006164 - purine nucleotide biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

166451

DNJC7
DnaJ homolog subfamily C member 7

2

0

High-throughput

0.585

High

166389

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

166401

HSP7C
Heat shock cognate 71 kDa protein

2

0

High-throughput

0.559

High

166449

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

166467

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

0

High-throughput

0.513

High

166465

DUX4
Double homeobox protein 4

1

0

High-throughput

0.494

High

166402

EPB41
Protein 4.1

1

0

High-throughput

0.493

High

166404

TFE3
Transcription factor E3

1

0

High-throughput

0.493

High

166406

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.493

High

166408

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.493

High

166425

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.493

High

166450

UIMC1
BRCA1-A complex subunit RAP80

1

0

High-throughput

0.493

High

166473

TRAF6
TNF receptor-associated factor 6

1

0

High-throughput

0.493

High

166400

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

166388

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.479

High

166410

GSK3A
Glycogen synthase kinase-3 alpha

1

1

High-throughput

0.479

High

166411

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.479

High

166432

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.479

High

166442

SSH3
Protein phosphatase Slingshot homolog 3

1

1

High-throughput

0.479

High

166445

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

166454

DUS26
Dual specificity protein phosphatase 26

1

1

High-throughput

0.479

High

166458

Q9H4D1
Protein kinase

1

1

High-throughput

0.479

High

116942

SGK1
Serine/threonine-protein kinase Sgk1

1

0

High-throughput

0.458

High

166391

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

0

High-throughput

0.458

High

166392

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

0

High-throughput

0.458

High

166393

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

166394

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

166395

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

166397

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

166398

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

166399

TBB5
Tubulin beta chain

1

0

High-throughput

0.458

High

166405

RAB5A
Ras-related protein Rab-5A

1

0

High-throughput

0.458

High

166409

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

166412

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

166414

ACTB
Actin, cytoplasmic 1

1

0

High-throughput

0.458

High

166415

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

166416

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.458

High

166417

CCNA1
Cyclin-A1

1

0

High-throughput

0.458

High

166418

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

166420

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

166422

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

166423

MTM1
Myotubularin

1

0

High-throughput

0.458

High

166424

CUL3
Cullin-3

1

0

High-throughput

0.458

High

166426

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

166427

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

166428

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

166429

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

166430

CCDC6
Coiled-coil domain-containing protein 6

1

0

High-throughput

0.458

High

166431

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

166433

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

166434

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

166436

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

166437

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

166438

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

166439

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.458

High

166441

WDTC1
WD and tetratricopeptide repeats protein 1

1

0

High-throughput

0.458

High

166444

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

166446

ARMC5
Armadillo repeat-containing protein 5

1

0

High-throughput

0.458

High

166447

OPTN
Optineurin

1

0

High-throughput

0.458

High

166452

PHB2
Prohibitin-2

1

0

High-throughput

0.458

High

166453

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

166455

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

166457

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

0

High-throughput

0.458

High

166459

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

166460

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

166461

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

166463

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

166466

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

166468

FBW1B
F-box/WD repeat-containing protein 11

1

0

High-throughput

0.458

High

166471

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

0

High-throughput

0.458

High

166413

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

166419

TLE2
Transducin-like enhancer protein 2

1

1

High-throughput

0.437

High

166421

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.437

High

166462

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

1

High-throughput

0.437

High

166470

TRI33
E3 ubiquitin-protein ligase TRIM33

1

1

High-throughput

0.437

High

166396

PRIO
Major prion protein

1

0

High-throughput

0.426

High

100268

APRIO
Alternative prion protein

2

0

High-throughput

0.305

High

166390

NIPS2
Protein NipSnap homolog 2

1

0

High-throughput

0.279

Low

166448

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

166469

TF3C4
General transcription factor 3C polypeptide 4

1

0

High-throughput

0.279

Low

166464

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

0

High-throughput

0.269

Low

166403

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

166407

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

166435

DET1
DET1 homolog

1

0

High-throughput

0.249

Low

166440

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.249

Low

166443

DCA11
DDB1- and CUL4-associated factor 11

1

0

High-throughput

0.249

Low

166472

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

166456

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024