Protein: KLF4
Krueppel-like factor 4 (Epithelial zinc finger protein EZF) (Gut-enriched krueppel-like factor)

Gene: KLF4
Organism: Homo sapiens
Interactions: 162
UniProt ID: O43474

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000791 - euchromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

204106

SP1
Transcription factor Sp1

2

18

Small-scale

0.768

High

204134

PLK1
Serine/threonine-protein kinase PLK1

1

3

Small-scale

0.724

High

204170

EP300
Histone acetyltransferase p300

5

20

Small-scale

0.707

High

160267

AURKA
Aurora kinase A

1

4

High-throughput

0.691

High

204206

HDAC2
Histone deacetylase 2

3

20

Small-scale

0.667

High

204209

CBP
CREB-binding protein

3

20

Small-scale

0.667

High

204220

ZFR
Zinc finger RNA-binding protein

1

7

High-throughput

0.646

High

204103

ESR1
Estrogen receptor

3

20

High-throughput

0.633

High

204097

ZEB2
Zinc finger E-box-binding homeobox 2

1

17

High-throughput

0.618

High

204112

ZEP1
Zinc finger protein 40

1

20

High-throughput

0.618

High

204113

EGR1
Early growth response protein 1

1

17

Small-scale

0.618

High

204167

KPCD
Protein kinase C delta type

1

5

Small-scale

0.618

High

204204

ZN516
Zinc finger protein 516

1

19

High-throughput

0.618

High

204221

KLF6
Krueppel-like factor 6

1

19

Small-scale

0.618

High

204238

ZN281
Zinc finger protein 281

1

18

High-throughput

0.618

High

204175

CTBP1
C-terminal-binding protein 1

2

12

Small-scale

0.612

High

159788

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

4

High-throughput

0.606

High

204099

HSF2B
Heat shock factor 2-binding protein

2

2

High-throughput

0.606

High

204111

GYS1
Glycogen [starch] synthase, muscle

2

1

High-throughput

0.606

High

204136

PAX9
Paired box protein Pax-9

2

3

High-throughput

0.606

High

204169

TLE5
TLE family member 5

2

13

High-throughput

0.606

High

204213

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

17

High-throughput

0.606

High

183043

KDM6A
Lysine-specific demethylase 6A

2

13

Small-scale

0.584

High

204110

CADH1
Cadherin-1

2

2

Small-scale

0.584

High

204181

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

4

Small-scale

0.578

High

204119

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.561

High

204133

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

11

Small-scale

0.561

High

204190

U17L2
Ubiquitin carboxyl-terminal hydrolase 17

1

9

Small-scale

0.561

High

204194

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

12

Small-scale

0.561

High

204212

KAT5
Histone acetyltransferase KAT5

1

6

Small-scale

0.561

High

204185

ZN750
Zinc finger protein 750

1

0

Small-scale

0.549

High

204201

BAALC
Brain and acute leukemia cytoplasmic protein

1

0

Small-scale

0.549

High

204107

ANDR
Androgen receptor

1

20

High-throughput

0.534

High

204104

A4
Amyloid-beta precursor protein

1

19

High-throughput

0.501

High

204128

YAP1
Transcriptional coactivator YAP1

1

18

Small-scale

0.501

High

204176

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.501

High

204199

SETD7
Histone-lysine N-methyltransferase SETD7

1

4

Small-scale

0.501

High

204243

FBX7
F-box only protein 7

1

1

High-throughput

0.501

High

127945

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

11

High-throughput

0.500

High

133244

NOP56
Nucleolar protein 56

1

5

High-throughput

0.500

High

204101

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

19

High-throughput

0.500

High

204102

MBD3
Methyl-CpG-binding domain protein 3

1

1

Small-scale

0.500

High

204105

LA
Lupus La protein

1

11

High-throughput

0.500

High

204109

PABP1
Polyadenylate-binding protein 1

1

2

High-throughput

0.500

High

204117

RS19
Small ribosomal subunit protein eS19

1

3

High-throughput

0.500

High

204120

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.500

High

204123

NOP2
Probable 28S rRNA

1

11

High-throughput

0.500

High

204125

RL27A
Large ribosomal subunit protein uL15

1

8

High-throughput

0.500

High

204126

RS5
Small ribosomal subunit protein uS7

1

10

High-throughput

0.500

High

204127

RS10
Small ribosomal subunit protein eS10

1

7

High-throughput

0.500

High

204129

RL14
Large ribosomal subunit protein eL14

1

3

High-throughput

0.500

High

204130

RT29
Small ribosomal subunit protein mS29

1

3

High-throughput

0.500

High

204139

RS3A
Small ribosomal subunit protein eS1

1

2

High-throughput

0.500

High

204142

RS29
Small ribosomal subunit protein uS14

1

1

High-throughput

0.500

High

204143

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.500

High

204144

RS11
Small ribosomal subunit protein uS17

1

6

High-throughput

0.500

High

204146

RS15
Small ribosomal subunit protein uS19

1

5

High-throughput

0.500

High

204147

RS24
Small ribosomal subunit protein eS24

1

2

High-throughput

0.500

High

204150

RL10A
Large ribosomal subunit protein uL1

1

6

High-throughput

0.500

High

204157

RT15
Small ribosomal subunit protein uS15m

1

3

High-throughput

0.500

High

204162

RL19
Large ribosomal subunit protein eL19

1

3

High-throughput

0.500

High

204163

RL18A
Large ribosomal subunit protein eL20

1

2

High-throughput

0.500

High

204172

ILF2
Interleukin enhancer-binding factor 2

1

7

High-throughput

0.500

High

204174

PABP4
Polyadenylate-binding protein 4

1

2

High-throughput

0.500

High

204179

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

12

High-throughput

0.500

High

204180

RRP5
Protein RRP5 homolog

1

7

High-throughput

0.500

High

204187

ZN326
DBIRD complex subunit ZNF326

1

9

High-throughput

0.500

High

204188

RRP12
RRP12-like protein

1

3

High-throughput

0.500

High

204189

LARP1
La-related protein 1

1

11

High-throughput

0.500

High

204192

DHX30
ATP-dependent RNA helicase DHX30

1

5

High-throughput

0.500

High

204193

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

5

High-throughput

0.500

High

204202

DDX1
ATP-dependent RNA helicase DDX1

1

5

High-throughput

0.500

High

204210

RENT1
Regulator of nonsense transcripts 1

1

1

High-throughput

0.500

High

204218

PTCD3
Small ribosomal subunit protein mS39

1

3

High-throughput

0.500

High

204222

DDX50
ATP-dependent RNA helicase DDX50

1

8

High-throughput

0.500

High

204223

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

11

High-throughput

0.500

High

204225

RT26
Small ribosomal subunit protein mS26

1

3

High-throughput

0.500

High

204226

MOV10
Helicase MOV-10

1

1

High-throughput

0.500

High

204227

ATD3A
ATPase family AAA domain-containing protein 3A

1

8

High-throughput

0.500

High

204230

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

9

High-throughput

0.500

High

204231

RM15
Large ribosomal subunit protein uL15m

1

1

High-throughput

0.500

High

204240

RT16
Small ribosomal subunit protein bS16m

1

2

High-throughput

0.500

High

204245

RT18B
Small ribosomal subunit protein mS40

1

5

High-throughput

0.500

High

204246

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

11

High-throughput

0.500

High

204141

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.479

High

204148

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.479

High

204160

RL24
Large ribosomal subunit protein eL24

1

0

High-throughput

0.479

High

204242

RTCB
RNA-splicing ligase RtcB homolog

1

0

High-throughput

0.479

High

131295

CLD5
Claudin-5

1

1

Small-scale

0.479

High

131677

BCL9
B-cell CLL/lymphoma 9 protein

1

20

High-throughput

0.479

High

146115

ARI1A
AT-rich interactive domain-containing protein 1A

1

20

High-throughput

0.479

High

152558

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.479

High

165798

KDM6B
Lysine-specific demethylase 6B

1

20

Small-scale

0.479

High

204108

BCL2
Apoptosis regulator Bcl-2

1

1

Small-scale

0.479

High

204114

ELK1
ETS domain-containing protein Elk-1

1

20

Small-scale

0.479

High

204116

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.479

High

204118

CUX1
Homeobox protein cut-like 1

1

14

High-throughput

0.479

High

204121

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

6

Small-scale

0.479

High

204122

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

13

Small-scale

0.479

High

204124

NOTC1
Neurogenic locus notch homolog protein 1

1

20

Small-scale

0.479

High

204131

SMCA2
Probable global transcription activator SNF2L2

1

19

High-throughput

0.479

High

204132

SMCA4
Transcription activator BRG1

1

19

High-throughput

0.479

High

204135

ATX3
Ataxin-3

1

1

Small-scale

0.479

High

204137

CTBP2
C-terminal-binding protein 2

1

12

Small-scale

0.479

High

204140

RL26
Large ribosomal subunit protein uL24

1

13

High-throughput

0.479

High

204145

H4
Histone H4

1

6

High-throughput

0.479

High

204161

RL36A
Large ribosomal subunit protein eL42

1

10

High-throughput

0.479

High

204164

TF65
Transcription factor p65

1

8

Small-scale

0.479

High

204165

TLE1
Transducin-like enhancer protein 1

1

20

High-throughput

0.479

High

204168

ZO1
Tight junction protein ZO-1

1

6

Small-scale

0.479

High

204171

NFIA
Nuclear factor 1 A-type

1

17

High-throughput

0.479

High

204173

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

5

Small-scale

0.479

High

204177

CUL1
Cullin-1

1

20

Small-scale

0.479

High

204178

CUL2
Cullin-2

1

20

Small-scale

0.479

High

204182

TNIP1
TNFAIP3-interacting protein 1

1

13

High-throughput

0.479

High

204184

OCLN
Occludin

1

1

Small-scale

0.479

High

204186

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

2

High-throughput

0.479

High

204191

PAXI1
PAX-interacting protein 1

1

10

High-throughput

0.479

High

204195

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.479

High

204197

ARI1B
AT-rich interactive domain-containing protein 1B

1

20

High-throughput

0.479

High

204198

KDM2B
Lysine-specific demethylase 2B

1

10

High-throughput

0.479

High

204200

HDAC7
Histone deacetylase 7

1

20

Small-scale

0.479

High

204207

DPF1
Zinc finger protein neuro-d4

1

20

High-throughput

0.479

High

204208

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

204211

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

10

High-throughput

0.479

High

204214

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

13

Small-scale

0.479

High

204215

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

13

Small-scale

0.479

High

204232

RCOR1
REST corepressor 1

1

18

Small-scale

0.479

High

204234

HDAC5
Histone deacetylase 5

1

20

Small-scale

0.479

High

204244

TRAF6
TNF receptor-associated factor 6

1

19

Small-scale

0.479

High

204247

NCOA3
Nuclear receptor coactivator 3

1

14

High-throughput

0.479

High

204219

MY15B
Unconventional myosin-XVB

1

5

High-throughput

0.470

High

204151

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.458

High

204183

ELOB
Elongin-B

1

0

Small-scale

0.458

High

204196

FBX22
F-box only protein 22

1

0

Small-scale

0.458

High

204216

FBX32
F-box only protein 32

1

0

Small-scale

0.458

High

204233

NDRG2
Protein NDRG2

1

0

Small-scale

0.458

High

204098

RT14
Small ribosomal subunit protein uS14m

1

3

High-throughput

0.457

High

204100

RL1D1
Ribosomal L1 domain-containing protein 1

1

7

High-throughput

0.457

High

204152

RT22
Small ribosomal subunit protein mS22

1

3

High-throughput

0.457

High

204153

RT25
Small ribosomal subunit protein mS25

1

2

High-throughput

0.457

High

204154

RT35
Small ribosomal subunit protein mS35

1

4

High-throughput

0.457

High

204155

RT05
Small ribosomal subunit protein uS5m

1

7

High-throughput

0.457

High

204156

RT11
Small ribosomal subunit protein uS11m

1

3

High-throughput

0.457

High

204158

RT34
Small ribosomal subunit protein mS34

1

4

High-throughput

0.457

High

204159

RT09
Small ribosomal subunit protein uS9m

1

10

High-throughput

0.457

High

204166

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

4

High-throughput

0.457

High

204203

RT27
Small ribosomal subunit protein mS27

1

3

High-throughput

0.457

High

204205

RT31
Small ribosomal subunit protein mS31

1

3

High-throughput

0.457

High

204217

RT24
Small ribosomal subunit protein uS3m

1

2

High-throughput

0.457

High

204224

RM04
Large ribosomal subunit protein uL4m

1

2

High-throughput

0.457

High

204228

RM39
Large ribosomal subunit protein mL39

1

1

High-throughput

0.457

High

204235

RT28
Small ribosomal subunit protein bS1m

1

2

High-throughput

0.457

High

204236

RT17
Small ribosomal subunit protein uS17m

1

1

High-throughput

0.457

High

204237

RT07
Small ribosomal subunit protein uS7m

1

10

High-throughput

0.457

High

204239

RT02
Small ribosomal subunit protein uS2m

1

5

High-throughput

0.457

High

204241

RT23
Small ribosomal subunit protein mS23

1

4

High-throughput

0.457

High

204149

RS30
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

1

1

High-throughput

0.445

High

204229

GRHL1
Grainyhead-like protein 1 homolog

1

4

High-throughput

0.445

High

100285

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

204115

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

2

Small-scale

0.437

High

204138

CXCR4
C-X-C chemokine receptor type 4

1

3

Small-scale

0.437

High


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024