Protein: BUB3
Mitotic checkpoint protein BUB3

Gene: BUB3
Organism: Homo sapiens
Interactions: 227
UniProt ID: O43684

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0007094 - mitotic spindle assembly checkpoint signaling
GO:0008608 - attachment of spindle microtubules to kinetochore

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

211084

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

32

16

Small-scale

0.994

High

211164

CDC20
Cell division cycle protein 20 homolog

14

19

Small-scale

0.979

High

210957

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

10

13

Small-scale

0.978

High

211275

APC4
Anaphase-promoting complex subunit 4

8

1

Small-scale

0.960

High

211169

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

4

5

Small-scale

0.878

High

211152

ACTA
Actin, aortic smooth muscle

2

9

High-throughput

0.811

High

211150

WDR5
WD repeat-containing protein 5

2

19

High-throughput

0.789

High

211190

EZH2
Histone-lysine N-methyltransferase EZH2

2

20

High-throughput

0.754

High

210420

ZN207
BUB3-interacting and GLEBS motif-containing protein ZNF207

8

14

Small-scale

0.751

High

211124

CDC27
Cell division cycle protein 27 homolog

8

9

Small-scale

0.747

High

211193

RBBP7
Histone-binding protein RBBP7

1

20

Small-scale

0.724

High

211093

UBR5
E3 ubiquitin-protein ligase UBR5

5

8

Small-scale

0.713

High

211156

TCPB
T-complex protein 1 subunit beta

4

20

High-throughput

0.699

High

211139

DYN2
Dynamin-2

1

4

High-throughput

0.691

High

211174

SNW1
SNW domain-containing protein 1

1

4

High-throughput

0.691

High

211133

TCPE
T-complex protein 1 subunit epsilon

3

20

High-throughput

0.675

High

211141

TCPD
T-complex protein 1 subunit delta

3

20

High-throughput

0.675

High

211219

PHIP
PH-interacting protein

2

20

Small-scale

0.675

High

211236

TCPH
T-complex protein 1 subunit eta

3

20

High-throughput

0.667

High

211239

BTBDA
BTB/POZ domain-containing protein 10

3

1

High-throughput

0.667

High

211143

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

10

High-throughput

0.665

High

211224

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

14

High-throughput

0.665

High

211273

CDC23
Cell division cycle protein 23 homolog

3

10

High-throughput

0.662

High

211099

MYC
Myc proto-oncogene protein

3

20

High-throughput

0.640

High

211082

ZC3H1
Zinc finger C3H1 domain-containing protein

4

1

High-throughput

0.638

High

211118

TCPA
T-complex protein 1 subunit alpha

2

20

High-throughput

0.628

High

211129

TCPZ
T-complex protein 1 subunit zeta

2

20

High-throughput

0.628

High

211135

TCPG
T-complex protein 1 subunit gamma

2

20

High-throughput

0.628

High

211140

TCPQ
T-complex protein 1 subunit theta

2

20

High-throughput

0.628

High

211216

KNL1
Kinetochore scaffold 1

2

2

High-throughput

0.628

High

211220

TCPW
T-complex protein 1 subunit zeta-2

2

20

High-throughput

0.628

High

211147

ATX1
Ataxin-1

2

2

High-throughput

0.621

High

211196

ACTBL
Beta-actin-like protein 2

1

8

High-throughput

0.618

High

148170

CTRO
Citron Rho-interacting kinase

1

7

High-throughput

0.618

High

150778

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

4

High-throughput

0.618

High

152559

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.618

High

165604

SET1A
Histone-lysine N-methyltransferase SETD1A

1

20

High-throughput

0.618

High

183044

KDM6A
Lysine-specific demethylase 6A

1

15

High-throughput

0.618

High

211136

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

5

High-throughput

0.618

High

211151

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

8

High-throughput

0.618

High

211161

KMT2A
Histone-lysine N-methyltransferase 2A

1

20

High-throughput

0.618

High

211179

BOP1
Ribosome biogenesis protein BOP1

1

19

Small-scale

0.618

High

211182

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.618

High

211184

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

7

High-throughput

0.618

High

211187

RBBP5
Retinoblastoma-binding protein 5

1

19

High-throughput

0.618

High

211192

DDB1
DNA damage-binding protein 1

1

9

Small-scale

0.618

High

211200

PRP8
Pre-mRNA-processing-splicing factor 8

1

6

High-throughput

0.618

High

211213

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.618

High

211241

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

8

High-throughput

0.618

High

211256

ANLN
Anillin

1

3

High-throughput

0.618

High

211260

NLE1
Notchless protein homolog 1

1

18

High-throughput

0.618

High

211262

DTL
Denticleless protein homolog

1

16

Small-scale

0.618

High

211280

FZR1
Fizzy-related protein homolog

1

19

High-throughput

0.618

High

211281

KMT2B
Histone-lysine N-methyltransferase 2B

1

20

High-throughput

0.618

High

211283

SET1B
Histone-lysine N-methyltransferase SETD1B

1

20

High-throughput

0.618

High

211286

TRRAP
Transformation/transcription domain-associated protein

1

9

High-throughput

0.618

High

211176

CUL3
Cullin-3

2

20

High-throughput

0.611

High

211206

KCD20
BTB/POZ domain-containing protein KCTD20

3

1

High-throughput

0.609

High

211211

NKAP
NF-kappa-B-activating protein

2

0

Small-scale

0.605

High

211227

APC16
Anaphase-promoting complex subunit 16

2

0

High-throughput

0.585

High

122385

MEN1
Menin

2

4

High-throughput

0.584

High

211081

PRKN
E3 ubiquitin-protein ligase parkin

2

18

High-throughput

0.584

High

211109

PARP1
Poly [ADP-ribose] polymerase 1

2

6

Small-scale

0.584

High

211123

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

6

High-throughput

0.584

High

211127

RFA3
Replication protein A 14 kDa subunit

2

3

High-throughput

0.584

High

211128

BRCA1
Breast cancer type 1 susceptibility protein

2

7

High-throughput

0.584

High

211163

EP300
Histone acetyltransferase p300

2

15

High-throughput

0.584

High

211199

PKHA7
Pleckstrin homology domain-containing family A member 7

1

17

High-throughput

0.575

High

207754

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

3

High-throughput

0.573

High

211105

JUN
Transcription factor Jun

2

15

High-throughput

0.571

High

211100

FINC
Fibronectin

1

6

High-throughput

0.553

High

211201

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.553

High

211249

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.553

High

211111

TAU
Microtubule-associated protein tau

2

15

High-throughput

0.552

High

211085

EXOC3
Exocyst complex component 3

1

1

High-throughput

0.541

High

211112

THA
Thyroid hormone receptor alpha

1

11

High-throughput

0.541

High

211149

RL37A
Large ribosomal subunit protein eL43

1

2

High-throughput

0.541

High

211235

CPNE1
Copine-1

1

1

High-throughput

0.541

High

128368

DNM1L
Dynamin-1-like protein

1

4

High-throughput

0.536

High

201133

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

High-throughput

0.536

High

211110

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

12

High-throughput

0.536

High

211173

HDAC1
Histone deacetylase 1

1

10

Small-scale

0.536

High

211186

RNPS1
RNA-binding protein with serine-rich domain 1

1

11

High-throughput

0.536

High

211218

RIN3
Ras and Rab interactor 3

1

6

High-throughput

0.536

High

211222

HDAC2
Histone deacetylase 2

1

10

Small-scale

0.536

High

211223

CSN5
COP9 signalosome complex subunit 5

1

9

High-throughput

0.536

High

211231

CDC5L
Cell division cycle 5-like protein

1

12

High-throughput

0.536

High

211233

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.536

High

211268

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

16

High-throughput

0.536

High

211088

WBP4
WW domain-binding protein 4

1

7

High-throughput

0.527

High

211119

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.521

High

211203

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.517

High

211157

SMAD3
Mothers against decapentaplegic homolog 3

1

5

Small-scale

0.515

High

211189

SMAD2
Mothers against decapentaplegic homolog 2

1

5

Small-scale

0.515

High

211255

LZTL1
Leucine zipper transcription factor-like protein 1

1

0

High-throughput

0.513

High

211259

INT7
Integrator complex subunit 7

1

0

High-throughput

0.513

High

211144

DYLT3
Dynein light chain Tctex-type 3

1

4

Small-scale

0.501

High

211148

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

5

High-throughput

0.501

High

211198

RAIN
Ras-interacting protein 1

1

7

High-throughput

0.489

High

211208

ST32C
Serine/threonine-protein kinase 32C

1

3

High-throughput

0.489

High

211097

CHK2
Serine/threonine-protein kinase Chk2

1

4

Small-scale

0.484

High

211121

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

1

High-throughput

0.481

High

211244

REXO4
RNA exonuclease 4

1

2

High-throughput

0.481

High

211284

SGT1
Protein SGT1 homolog

1

5

High-throughput

0.481

High

125026

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

4

High-throughput

0.479

High

130651

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

6

Small-scale

0.479

High

132061

PESC
Pescadillo homolog

1

1

Small-scale

0.479

High

149493

COPE
Coatomer subunit epsilon

1

2

High-throughput

0.479

High

162232

XPO1
Exportin-1

1

12

High-throughput

0.479

High

211083

NUPR1
Nuclear protein 1

1

3

High-throughput

0.479

High

211087

BRD4
Bromodomain-containing protein 4

1

19

High-throughput

0.479

High

211089

RNF8
E3 ubiquitin-protein ligase RNF8

1

8

High-throughput

0.479

High

211090

RECQ4
ATP-dependent DNA helicase Q4

1

20

High-throughput

0.479

High

211091

ST17B
Serine/threonine-protein kinase 17B

1

4

High-throughput

0.479

High

211092

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

211094

HERC2
E3 ubiquitin-protein ligase HERC2

1

6

High-throughput

0.479

High

211095

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

15

High-throughput

0.479

High

211101

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

211104

P53
Cellular tumor antigen p53

1

6

High-throughput

0.479

High

211106

GLI1
Zinc finger protein GLI1

1

3

Small-scale

0.479

High

211107

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

8

High-throughput

0.479

High

211114

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.479

High

211116

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

211117

CEBPB
CCAAT/enhancer-binding protein beta

1

11

High-throughput

0.479

High

211120

BTF3
Transcription factor BTF3

1

2

High-throughput

0.479

High

211122

APC
Adenomatous polyposis coli protein

1

19

Small-scale

0.479

High

211125

STIP1
Stress-induced-phosphoprotein 1

1

7

High-throughput

0.479

High

211126

PHB1
Prohibitin 1

1

4

High-throughput

0.479

High

211130

GATA4
Transcription factor GATA-4

1

5

Small-scale

0.479

High

211131

MAP1B
Microtubule-associated protein 1B

1

10

High-throughput

0.479

High

211132

YAP1
Transcriptional coactivator YAP1

1

9

High-throughput

0.479

High

211134

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

11

High-throughput

0.479

High

211138

MCM2
DNA replication licensing factor MCM2

1

8

High-throughput

0.479

High

211142

HCFC1
Host cell factor 1

1

8

High-throughput

0.479

High

211145

HDGF
Hepatoma-derived growth factor

1

10

High-throughput

0.479

High

211153

H4
Histone H4

1

7

High-throughput

0.479

High

211154

YBOX1
Y-box-binding protein 1

1

4

Small-scale

0.479

High

211155

H31
Histone H3.1

1

9

High-throughput

0.479

High

211159

HSF1
Heat shock factor protein 1

1

5

High-throughput

0.479

High

211160

KIF23
Kinesin-like protein KIF23

1

9

High-throughput

0.479

High

211165

TP53B
TP53-binding protein 1

1

13

High-throughput

0.479

High

211166

FOXC1
Forkhead box protein C1

1

7

High-throughput

0.479

High

211168

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

2

High-throughput

0.479

High

211170

IKZF1
DNA-binding protein Ikaros

1

6

High-throughput

0.479

High

211171

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

211172

SQSTM
Sequestosome-1

1

4

High-throughput

0.479

High

211175

CUL2
Cullin-2

1

20

Small-scale

0.479

High

211177

CUL4A
Cullin-4A

1

20

Small-scale

0.479

High

211178

CUL4B
Cullin-4B

1

20

Small-scale

0.479

High

211181

IMB1
Importin subunit beta-1

1

9

Small-scale

0.479

High

211183

TNIP1
TNFAIP3-interacting protein 1

1

10

High-throughput

0.479

High

211185

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

211188

SF3A2
Splicing factor 3A subunit 2

1

8

High-throughput

0.479

High

211202

PAXI1
PAX-interacting protein 1

1

13

High-throughput

0.479

High

211204

KANL1
KAT8 regulatory NSL complex subunit 1

1

4

High-throughput

0.479

High

211207

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

5

High-throughput

0.479

High

211210

SLX4
Structure-specific endonuclease subunit SLX4

1

13

High-throughput

0.479

High

211212

ZBT38
Zinc finger and BTB domain-containing protein 38

1

1

Small-scale

0.479

High

211214

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

18

High-throughput

0.479

High

211221

ESR2
Estrogen receptor beta

1

16

High-throughput

0.479

High

211225

FUBP1
Far upstream element-binding protein 1

1

16

High-throughput

0.479

High

211226

CHM4C
Charged multivesicular body protein 4c

1

2

High-throughput

0.479

High

211230

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

211232

NECD
Necdin

1

9

High-throughput

0.479

High

211234

ACON
Aconitate hydratase, mitochondrial

1

1

High-throughput

0.479

High

211238

RIOK1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

211240

TRI31
E3 ubiquitin-protein ligase TRIM31

1

3

High-throughput

0.479

High

211245

WWTR1
WW domain-containing transcription regulator protein 1

1

8

High-throughput

0.479

High

211250

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

211251

KANL2
KAT8 regulatory NSL complex subunit 2

1

2

High-throughput

0.479

High

211252

NMRL1
NmrA-like family domain-containing protein 1

1

1

High-throughput

0.479

High

211253

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

2

High-throughput

0.479

High

211254

BRD7
Bromodomain-containing protein 7

1

17

High-throughput

0.479

High

211257

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

211263

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

1

High-throughput

0.479

High

211265

CXXC1
CXXC-type zinc finger protein 1

1

18

High-throughput

0.479

High

211266

KANL3
KAT8 regulatory NSL complex subunit 3

1

3

High-throughput

0.479

High

211267

RERE
Arginine-glutamic acid dipeptide repeats protein

1

11

High-throughput

0.479

High

211269

HDAC6
Histone deacetylase 6

1

10

High-throughput

0.479

High

211271

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

211272

UBQL2
Ubiquilin-2

1

2

High-throughput

0.479

High

211276

TNIK
TRAF2 and NCK-interacting protein kinase

1

9

High-throughput

0.479

High

211277

IKZF3
Zinc finger protein Aiolos

1

7

High-throughput

0.479

High

211278

BAG5
BAG family molecular chaperone regulator 5

1

1

High-throughput

0.479

High

211282

FAF1
FAS-associated factor 1

1

3

High-throughput

0.479

High

211287

TRAF6
TNF receptor-associated factor 6

1

9

High-throughput

0.479

High

211288

HCFC2
Host cell factor 2

1

8

High-throughput

0.479

High

211191

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

0

Small-scale

0.458

High

211146

NCBP2
Nuclear cap-binding protein subunit 2

1

6

High-throughput

0.445

High

211162

NCBP1
Nuclear cap-binding protein subunit 1

1

1

High-throughput

0.445

High

211167

CDC16
Cell division cycle protein 16 homolog

1

10

High-throughput

0.445

High

211180

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

8

High-throughput

0.445

High

211197

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

High-throughput

0.445

High

211215

ARI1B
AT-rich interactive domain-containing protein 1B

1

13

High-throughput

0.445

High

211243

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

6

High-throughput

0.445

High

211246

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

6

High-throughput

0.445

High

211247

APC1
Anaphase-promoting complex subunit 1

1

1

High-throughput

0.445

High

211248

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

6

High-throughput

0.445

High

100292

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

146436

BHE40
Class E basic helix-loop-helix protein 40

1

3

Small-scale

0.437

High

167773

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.437

High

211098

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.437

High

211103

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

211115

ITA4
Integrin alpha-4

1

1

High-throughput

0.437

High

211158

VIGLN
Vigilin

1

20

High-throughput

0.437

High

211205

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.437

High

211209

ZCH18
Zinc finger CCCH domain-containing protein 18

1

20

High-throughput

0.437

High

211229

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.437

High

211242

ASXL3
Putative Polycomb group protein ASXL3

1

14

High-throughput

0.437

High

211261

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.437

High

211264

RN181
E3 ubiquitin-protein ligase RNF181

1

3

High-throughput

0.437

High

211270

ST17A
Serine/threonine-protein kinase 17A

1

4

High-throughput

0.437

High

211279

HECD1
E3 ubiquitin-protein ligase HECTD1

1

12

High-throughput

0.437

High

211285

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

211217

CDC26
Anaphase-promoting complex subunit CDC26

1

0

High-throughput

0.426

High

211274

APC5
Anaphase-promoting complex subunit 5

1

0

High-throughput

0.426

High

211102

ANXA1
Annexin A1

1

4

Small-scale

0.408

High

211113

TOP1
DNA topoisomerase 1

1

2

Small-scale

0.408

High

211137

CEBPA
CCAAT/enhancer-binding protein alpha

1

12

High-throughput

0.408

High

211195

NCBP3
Nuclear cap-binding protein subunit 3

1

1

High-throughput

0.407

High

211237

SH3G3
Endophilin-A3

2

0

High-throughput

0.298

High

211108

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

211194

BLTP1
Bridge-like lipid transfer protein family member 1

1

0

High-throughput

0.279

Low

211228

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

211086

PAGE4
P antigen family member 4

1

0

High-throughput

0.249

Low

211096

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

211258

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024