Protein: LX12B
Arachidonate 12-lipoxygenase, 12R-type (12R-LOX) (12R-lipoxygenase) (EC 1.13.11.-) (Epidermis-type lipoxygenase 12)

Gene: LX12B, ALOX12B
Organism: Homo sapiens
Interactions: 99
UniProt ID: O75342

Gene Ontology (top 5):
GO:0004052 - arachidonate 12(S)-lipoxygenase activity
GO:0005506 - iron ion binding
GO:0005829 - cytosol
GO:0006497 - protein lipidation
GO:0006665 - sphingolipid metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

259882

LOXE3
Hydroperoxide isomerase ALOXE3

1

3

Small-scale

0.618

High

259854

DPPA4
Developmental pluripotency-associated protein 4

3

1

High-throughput

0.609

High

259876

GMCL1
Germ cell-less protein-like 1

3

1

High-throughput

0.609

High

259819

FRIH
Ferritin heavy chain

2

0

High-throughput

0.602

High

259885

GPT
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

2

0

High-throughput

0.602

High

217414

AIRE
Autoimmune regulator

2

1

High-throughput

0.574

High

259812

TOX4
TOX high mobility group box family member 4

2

1

High-throughput

0.574

High

259818

ANF
Natriuretic peptides A

2

1

High-throughput

0.574

High

259848

ZIC1
Zinc finger protein ZIC 1

2

2

High-throughput

0.574

High

259849

CCD27
Coiled-coil domain-containing protein 27

2

1

High-throughput

0.574

High

259893

TB22B
TBC1 domain family member 22B

2

1

High-throughput

0.574

High

259810

B3GL1
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

2

1

High-throughput

0.558

High

259824

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.536

High

259825

VAV
Proto-oncogene vav

1

1

High-throughput

0.536

High

259834

PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

1

2

High-throughput

0.536

High

259842

UBE3A
Ubiquitin-protein ligase E3A

1

1

High-throughput

0.536

High

259860

AROS
Active regulator of SIRT1

1

1

High-throughput

0.536

High

259868

THAP4
Peroxynitrite isomerase THAP4

1

1

High-throughput

0.536

High

259891

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.536

High

259900

RN115
E3 ubiquitin-protein ligase RNF115

1

3

High-throughput

0.536

High

259815

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.513

High

259816

ADH1G
Alcohol dehydrogenase 1C

1

0

High-throughput

0.513

High

259826

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

259830

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

0

High-throughput

0.513

High

259835

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

259837

CF298
Cilia- and flagella-associated protein 298

1

0

High-throughput

0.513

High

259839

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.513

High

259841

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

259862

PLCZ1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

1

0

High-throughput

0.513

High

259865

UB2J2
Ubiquitin-conjugating enzyme E2 J2

1

0

High-throughput

0.513

High

259875

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.513

High

259881

5NT1A
Cytosolic 5'-nucleotidase 1A

1

0

High-throughput

0.513

High

200798

ZSC12
Zinc finger and SCAN domain-containing protein 12

2

1

High-throughput

0.504

High

259820

IFNA4
Interferon alpha-4

1

1

High-throughput

0.489

High

259831

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.489

High

259844

ZN154
Zinc finger protein 154

1

1

High-throughput

0.489

High

259859

ZC3C1
Zinc finger C3HC-type protein 1

1

1

High-throughput

0.489

High

259861

SFR1
Swi5-dependent recombination DNA repair protein 1 homolog

1

1

High-throughput

0.489

High

259866

FNDC5
Fibronectin type III domain-containing protein 5

1

1

High-throughput

0.489

High

259869

SIA8A
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

1

1

High-throughput

0.489

High

259872

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

1

High-throughput

0.489

High

259873

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.489

High

259879

SH23A
SH2 domain-containing protein 3A

1

9

High-throughput

0.489

High

259887

HES4
Transcription factor HES-4

1

1

High-throughput

0.489

High

259888

GALT9
Polypeptide N-acetylgalactosaminyltransferase 9

1

1

High-throughput

0.489

High

259896

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

1

1

High-throughput

0.489

High

259897

PHF11
PHD finger protein 11

1

1

High-throughput

0.489

High

209525

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

259817

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

259847

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

259870

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

259832

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

259889

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

259828

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

3

High-throughput

0.445

High

259853

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

259840

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

Small-scale

0.437

High

259884

RNF38
E3 ubiquitin-protein ligase RNF38

1

5

Small-scale

0.437

High

259814

GPAN1
G patch domain and ankyrin repeat-containing protein 1

3

0

High-throughput

0.347

High

259846

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

3

0

High-throughput

0.347

High

259874

MITOK
Mitochondrial potassium channel

3

0

High-throughput

0.347

High

259863

CC103
Coiled-coil domain-containing protein 103

2

0

High-throughput

0.328

High

128690

RTCA
RNA 3'-terminal phosphate cyclase

1

0

High-throughput

0.279

Low

209297

TSN6
Tetraspanin-6

1

0

High-throughput

0.279

Low

215789

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

0

High-throughput

0.279

Low

259809

E2F6
Transcription factor E2F6

1

0

High-throughput

0.279

Low

259811

RENR
Renin receptor

1

0

High-throughput

0.279

Low

259813

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.279

Low

259822

NMB
Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]

1

0

High-throughput

0.279

Low

259823

ADT3
ADP/ATP translocase 3

1

0

High-throughput

0.279

Low

259827

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

0

High-throughput

0.279

Low

259829

CCNC
Cyclin-C

1

0

High-throughput

0.279

Low

259833

ASCL1
Achaete-scute homolog 1

1

0

High-throughput

0.279

Low

259836

DSCR6
Protein ripply3

1

0

High-throughput

0.279

Low

259838

ANTR2
Anthrax toxin receptor 2

1

0

High-throughput

0.279

Low

259843

GABPA
GA-binding protein alpha chain

1

0

High-throughput

0.279

Low

259845

MMRN1
Multimerin-1

1

0

High-throughput

0.279

Low

259850

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

259851

DNAL1
Dynein axonemal light chain 1

1

0

High-throughput

0.279

Low

259852

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

High-throughput

0.279

Low

259855

APTX
Aprataxin

1

0

High-throughput

0.279

Low

259856

ZN550
Zinc finger protein 550

1

0

High-throughput

0.279

Low

259857

MOGT3
2-acylglycerol O-acyltransferase 3

1

0

High-throughput

0.279

Low

259858

BPHL
Valacyclovir hydrolase

1

0

High-throughput

0.279

Low

259864

D106A
Beta-defensin 106

1

0

High-throughput

0.279

Low

259867

CRGN
Gamma-crystallin N

1

0

High-throughput

0.279

Low

259871

PIGT
GPI transamidase component PIG-T

1

0

High-throughput

0.279

Low

259877

CABS1
Calcium-binding and spermatid-specific protein 1

1

0

High-throughput

0.279

Low

259878

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.279

Low

259880

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.279

Low

259886

COE2
Transcription factor COE2

1

0

High-throughput

0.279

Low

259890

TSSP
Thymus-specific serine protease

1

0

High-throughput

0.279

Low

259892

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.279

Low

259895

THA10
THAP domain-containing protein 10

1

0

High-throughput

0.279

Low

259898

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.279

Low

259899

FCF1
rRNA-processing protein FCF1 homolog

1

0

High-throughput

0.279

Low

100311

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

259821

CFAH
Complement factor H

1

0

Small-scale

0.249

Low

259883

DDX24
ATP-dependent RNA helicase DDX24

1

0

High-throughput

0.249

Low

259894

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024