Protein: PIAS2
E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)

Gene: PIAS2
Organism: Homo sapiens
Interactions: 174
UniProt ID: O75928

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006351 - DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

278258

UBC9
SUMO-conjugating enzyme UBC9

10

14

Small-scale

0.976

High

278256

SUMO1
Small ubiquitin-related modifier 1

8

20

Small-scale

0.972

High

278253

SUMO2
Small ubiquitin-related modifier 2

5

20

Small-scale

0.926

High

278250

SUMO3
Small ubiquitin-related modifier 3

3

20

Small-scale

0.841

High

278198

PIAS2
E3 SUMO-protein ligase PIAS2

2

9

Small-scale

0.800

High

278297

Q7KZS0
SUMO-conjugating enzyme UBC9

2

14

High-throughput

0.789

High

278208

P53
Cellular tumor antigen p53

5

10

Small-scale

0.714

High

278273

TRAF2
TNF receptor-associated factor 2

3

6

Small-scale

0.672

High

278235

CBS
Cystathionine beta-synthase

3

2

High-throughput

0.667

High

102147

SUMO5
Small ubiquitin-related modifier 5

1

20

High-throughput

0.665

High

278232

PML
Protein PML

3

7

Small-scale

0.664

High

278216

GFAP
Glial fibrillary acidic protein

4

7

High-throughput

0.647

High

278259

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

1

High-throughput

0.647

High

278314

TSR2
Pre-rRNA-processing protein TSR2 homolog

3

0

High-throughput

0.646

High

278202

MYC
Myc proto-oncogene protein

3

10

Small-scale

0.646

High

278305

NAV2
Neuron navigator 2

2

8

High-throughput

0.646

High

278203

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

3

9

High-throughput

0.642

High

278213

ANDR
Androgen receptor

2

20

Small-scale

0.622

High

278306

PIAS4
E3 SUMO-protein ligase PIAS4

1

9

High-throughput

0.621

High

212334

AAKB2
5'-AMP-activated protein kinase subunit beta-2

2

0

High-throughput

0.618

High

278214

PCNA
Proliferating cell nuclear antigen

1

3

Small-scale

0.618

High

278199

CCDB1
Cyclin-D1-binding protein 1

2

0

High-throughput

0.613

High

129520

TRAF5
TNF receptor-associated factor 5

2

11

High-throughput

0.606

High

241251

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

2

2

High-throughput

0.606

High

269585

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

2

1

High-throughput

0.606

High

278219

ATF2
Cyclic AMP-dependent transcription factor ATF-2

2

5

High-throughput

0.606

High

278221

CREB1
Cyclic AMP-responsive element-binding protein 1

2

2

High-throughput

0.606

High

278222

DESM
Desmin

2

7

High-throughput

0.606

High

278223

MX1
Interferon-induced GTP-binding protein Mx1

2

3

High-throughput

0.606

High

278226

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

2

1

High-throughput

0.606

High

278237

SOX5
Transcription factor SOX-5

2

11

High-throughput

0.606

High

278269

MTG8
Protein CBFA2T1

2

1

High-throughput

0.606

High

278274

TRAF3
TNF receptor-associated factor 3

2

9

High-throughput

0.606

High

278277

IKZF1
DNA-binding protein Ikaros

2

2

High-throughput

0.606

High

278281

DMC1
Meiotic recombination protein DMC1/LIM15 homolog

2

3

High-throughput

0.606

High

278293

GRHL2
Grainyhead-like protein 2 homolog

2

1

High-throughput

0.606

High

278294

HMBX1
Homeobox-containing protein 1

2

1

High-throughput

0.606

High

278302

TRI50
E3 ubiquitin-protein ligase TRIM50

2

7

High-throughput

0.606

High

278310

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

2

1

High-throughput

0.606

High

278321

ZFP42
Zinc finger protein 42 homolog

2

2

High-throughput

0.606

High

278331

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

2

2

High-throughput

0.606

High

278339

HM20A
High mobility group protein 20A

2

5

High-throughput

0.606

High

278341

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

2

6

High-throughput

0.606

High

278345

HMGX4
HMG domain-containing protein 4

2

8

High-throughput

0.606

High

278346

MLX
Max-like protein X

2

9

High-throughput

0.606

High

278225

LMNB1
Lamin-B1

2

10

High-throughput

0.600

High

278207

GCR
Glucocorticoid receptor

2

20

Small-scale

0.595

High

278347

GT2D1
General transcription factor II-I repeat domain-containing protein 1

2

3

Small-scale

0.594

High

278266

FLI1
Friend leukemia integration 1 transcription factor

1

14

Small-scale

0.586

High

278323

RUFY1
RUN and FYVE domain-containing protein 1

1

3

High-throughput

0.586

High

278212

PARP1
Poly [ADP-ribose] polymerase 1

2

3

Small-scale

0.584

High

278251

KLF3
Krueppel-like factor 3

2

2

High-throughput

0.584

High

278211

TY3H
Tyrosine 3-monooxygenase

2

0

High-throughput

0.580

High

278246

RFX2
DNA-binding protein RFX2

2

0

High-throughput

0.580

High

278267

ZBT16
Zinc finger and BTB domain-containing protein 16

2

0

High-throughput

0.580

High

278283

SC23A
Protein transport protein Sec23A

2

0

High-throughput

0.580

High

278316

EXOS8
Exosome complex component RRP43

2

0

High-throughput

0.580

High

278320

ZC3HA
Zinc finger CCCH domain-containing protein 10

2

0

High-throughput

0.580

High

278330

SPNDC
Spindlin interactor and repressor of chromatin-binding protein

2

0

High-throughput

0.580

High

278342

ZN319
Zinc finger protein 319

2

0

High-throughput

0.580

High

278344

CGBP1
CGG triplet repeat-binding protein 1

2

0

High-throughput

0.580

High

278352

UBQL1
Ubiquilin-1

2

0

High-throughput

0.580

High

278355

NDK7
Nucleoside diphosphate kinase homolog 7

2

0

High-throughput

0.580

High

278245

MK08
Mitogen-activated protein kinase 8

1

1

Small-scale

0.573

High

278356

DNM3A
DNA

1

2

Small-scale

0.573

High

278200

ZBED1
E3 SUMO-protein ligase ZBED1

1

2

High-throughput

0.573

High

278224

MX2
Interferon-induced GTP-binding protein Mx2

1

3

High-throughput

0.573

High

278308

CCHCR
Coiled-coil alpha-helical rod protein 1

1

2

High-throughput

0.573

High

278317

ZBT8A
Zinc finger and BTB domain-containing protein 8A

1

4

High-throughput

0.573

High

278285

MK14
Mitogen-activated protein kinase 14

1

1

Small-scale

0.561

High

278299

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

Small-scale

0.561

High

278350

RCOR1
REST corepressor 1

1

1

Small-scale

0.561

High

278240

TXLNA
Alpha-taxilin

2

2

High-throughput

0.553

High

278242

PERI
Peripherin

2

7

High-throughput

0.553

High

278268

DEUP1
Deuterosome assembly protein 1

2

3

High-throughput

0.553

High

278303

HOME1
Homer protein homolog 1

2

2

High-throughput

0.553

High

278332

KIFC3
Kinesin-like protein KIFC3

2

1

High-throughput

0.553

High

278349

HOOK1
Protein Hook homolog 1

2

2

High-throughput

0.553

High

278217

TRI27
Zinc finger protein RFP

1

7

Small-scale

0.552

High

278324

PARK7
Parkinson disease protein 7

1

0

Small-scale

0.549

High

278238

TRI23
E3 ubiquitin-protein ligase TRIM23

1

0

High-throughput

0.549

High

278218

GLNA
Glutamine synthetase

1

2

High-throughput

0.541

High

278262

GTF2I
General transcription factor II-I

1

3

High-throughput

0.541

High

278272

SRBP2
Sterol regulatory element-binding protein 2

1

13

High-throughput

0.541

High

278276

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.541

High

278209

JUN
Transcription factor Jun

1

6

Small-scale

0.536

High

278236

MSX2
Homeobox protein MSX-2

1

4

Small-scale

0.527

High

278348

MBD1
Methyl-CpG-binding domain protein 1

1

2

Small-scale

0.527

High

278271

GOGA2
Golgin subfamily A member 2

1

3

High-throughput

0.523

High

278319

ACY3
N-acyl-aromatic-L-amino acid amidohydrolase

1

1

High-throughput

0.523

High

278201

ADA
Adenosine deaminase

1

0

High-throughput

0.518

High

278289

Q59GP6
Polyhomeotic-like protein 1 variant

1

4

High-throughput

0.515

High

278336

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.508

High

208762

SNAI2
Zinc finger protein SNAI2

1

3

Small-scale

0.501

High

252893

MITF
Microphthalmia-associated transcription factor

1

6

Small-scale

0.501

High

278206

ESR1
Estrogen receptor

1

20

Small-scale

0.501

High

278210

PRGR
Progesterone receptor

1

20

Small-scale

0.501

High

278264

SMAD3
Mothers against decapentaplegic homolog 3

1

16

Small-scale

0.501

High

278278

SMAD4
Mothers against decapentaplegic homolog 4

1

16

Small-scale

0.501

High

278280

HIC1
Hypermethylated in cancer 1 protein

1

1

Small-scale

0.501

High

278292

PLAG1
Zinc finger protein PLAG1

1

6

Small-scale

0.501

High

278307

SNIP1
Smad nuclear-interacting protein 1

1

3

Small-scale

0.501

High

278312

ESR2
Estrogen receptor beta

1

20

Small-scale

0.501

High

278351

PLAL1
Zinc finger protein PLAGL1

1

6

Small-scale

0.501

High

278301

TCAM2
TIR domain-containing adapter molecule 2

1

1

High-throughput

0.494

High

199075

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

8

Small-scale

0.481

High

278233

AKT1
RAC-alpha serine/threonine-protein kinase

1

4

Small-scale

0.481

High

278263

PHC1
Polyhomeotic-like protein 1

1

4

High-throughput

0.481

High

278296

PAXI1
PAX-interacting protein 1

1

4

High-throughput

0.481

High

278304

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

8

Small-scale

0.481

High

278313

CBP
CREB-binding protein

1

8

Small-scale

0.481

High

278315

TRI63
E3 ubiquitin-protein ligase TRIM63

1

16

High-throughput

0.481

High

278333

TRI55
Tripartite motif-containing protein 55

1

15

High-throughput

0.481

High

278354

ZN451
E3 SUMO-protein ligase ZNF451

1

1

Small-scale

0.481

High

278247

MAPK2
MAP kinase-activated protein kinase 2

1

0

Small-scale

0.480

High

226089

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

278215

XRCC6
X-ray repair cross-complementing protein 6

1

3

High-throughput

0.479

High

278220

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

278228

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

16

Small-scale

0.479

High

278229

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

4

Small-scale

0.479

High

278230

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

278241

ETV6
Transcription factor ETV6

1

12

High-throughput

0.479

High

278243

ELK3
ETS domain-containing protein Elk-3

1

14

High-throughput

0.479

High

278244

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

1

Small-scale

0.479

High

278248

CENPA
Histone H3-like centromeric protein A

1

11

High-throughput

0.479

High

278249

PAX9
Paired box protein Pax-9

1

2

High-throughput

0.479

High

278254

H2B1C
Histone H2B type 1-C/E/F/G/I

1

5

High-throughput

0.479

High

278255

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

Small-scale

0.479

High

278257

RACK1
Small ribosomal subunit protein RACK1

1

2

Small-scale

0.479

High

278260

H31
Histone H3.1

1

11

High-throughput

0.479

High

278261

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.479

High

278265

H33
Histone H3.3

1

11

High-throughput

0.479

High

278275

RFA4
Replication protein A 30 kDa subunit

1

4

High-throughput

0.479

High

278282

STAT4
Signal transducer and activator of transcription 4

1

4

Small-scale

0.479

High

278286

SMN
Survival motor neuron protein

1

1

Small-scale

0.479

High

278295

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.479

High

278300

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

1

High-throughput

0.479

High

278309

SP7
Transcription factor Sp7

1

4

High-throughput

0.479

High

278311

TOPB1
DNA topoisomerase 2-binding protein 1

1

5

Small-scale

0.479

High

278322

CIC
Protein capicua homolog

1

10

High-throughput

0.479

High

278325

FEV
Protein FEV

1

13

High-throughput

0.479

High

278326

MNT
Max-binding protein MNT

1

8

Small-scale

0.479

High

278327

EPAS1
Endothelial PAS domain-containing protein 1

1

5

Small-scale

0.479

High

278334

IFIH1
Interferon-induced helicase C domain-containing protein 1

1

3

Small-scale

0.479

High

278343

ZMYM2
Zinc finger MYM-type protein 2

1

4

High-throughput

0.479

High

278353

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

278287

Q17R54
Synapsin III

1

3

High-throughput

0.470

High

278288

BOREA
Borealin

1

0

Small-scale

0.460

High

278231

TEAD1
Transcriptional enhancer factor TEF-1

1

0

High-throughput

0.458

High

278234

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

278239

COIL
Coilin

1

0

High-throughput

0.458

High

278329

SOSB1
SOSS complex subunit B1

1

0

Small-scale

0.458

High

131184

BIN1
Myc box-dependent-interacting protein 1

1

2

High-throughput

0.457

High

278204

APOE
Apolipoprotein E

1

2

High-throughput

0.457

High

278270

FMR1
Fragile X messenger ribonucleoprotein 1

1

2

High-throughput

0.457

High

278279

DX39B
Spliceosome RNA helicase DDX39B

1

3

Small-scale

0.457

High

278338

CHM1A
Charged multivesicular body protein 1a

1

1

High-throughput

0.457

High

164071

SYN3
Synapsin-3

1

1

High-throughput

0.439

High

100324

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

278337

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

278284

NEDD8
NEDD8

1

0

Small-scale

0.426

High

278340

CHMP5
Charged multivesicular body protein 5

1

1

High-throughput

0.417

High

224877

ZNRD2
Protein ZNRD2

2

0

High-throughput

0.316

High

259905

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

2

0

High-throughput

0.316

High

278227

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

2

0

High-throughput

0.316

High

278290

LCE1E
Late cornified envelope protein 1E

2

0

High-throughput

0.316

High

278291

LCE2C
Late cornified envelope protein 2C

2

0

High-throughput

0.316

High

278298

CE024
UPF0461 protein C5orf24

2

0

High-throughput

0.316

High

278318

EDC3
Enhancer of mRNA-decapping protein 3

2

0

High-throughput

0.316

High

278328

F118B
Protein FAM118B

2

0

High-throughput

0.316

High

278335

SPC1L
Speriolin-like protein

2

0

High-throughput

0.316

High

278205

C1QA
Complement C1q subcomponent subunit A

1

0

High-throughput

0.282

High

278252

CLD2
Claudin-2

1

0

Small-scale

0.251

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024