Protein: LDLR
Low-density lipoprotein receptor (LDL receptor)

Gene: LDLR
Organism: Homo sapiens
Interactions: 105
UniProt ID: P01130

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0001618 - virus receptor activity
GO:0001920 - negative regulation of receptor recycling
GO:0002020 - protease binding
GO:0005041 - low-density lipoprotein particle receptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

351090

PCSK9
Proprotein convertase subtilisin/kexin type 9

5

1

Small-scale

0.924

High

351054

AMRP
Alpha-2-macroglobulin receptor-associated protein

4

10

Small-scale

0.906

High

351079

DLK2
Protein delta homolog 2

2

5

High-throughput

0.811

High

351082

EGFL6
Epidermal growth factor-like protein 6

2

13

High-throughput

0.811

High

351034

APOH
Beta-2-glycoprotein 1

1

6

Small-scale

0.716

High

351092

MYLIP
E3 ubiquitin-protein ligase MYLIP

5

3

Small-scale

0.713

High

158886

NCTR3
Natural cytotoxicity triggering receptor 3

1

2

High-throughput

0.691

High

351038

CATG
Cathepsin G

1

15

High-throughput

0.691

High

351098

TMPSD
Transmembrane protease serine 13

1

9

High-throughput

0.691

High

351119

ST14
Suppressor of tumorigenicity 14 protein

1

7

High-throughput

0.691

High

351032

LDLR
Low-density lipoprotein receptor

1

9

Small-scale

0.647

High

351109

GINM1
Glycoprotein integral membrane protein 1

3

0

High-throughput

0.638

High

351033

APOE
Apolipoprotein E

2

7

Small-scale

0.635

High

135834

WNT7A
Protein Wnt-7a

2

13

High-throughput

0.628

High

351058

FCGRN
IgG receptor FcRn large subunit p51

2

5

High-throughput

0.628

High

351081

TAFA3
Chemokine-like protein TAFA-3

2

8

High-throughput

0.628

High

351049

CMA1
Chymase

1

17

High-throughput

0.618

High

351091

NET5
Netrin-5

1

20

High-throughput

0.618

High

351104

KLK15
Kallikrein-15

1

13

High-throughput

0.618

High

351117

KLK5
Kallikrein-5

1

12

High-throughput

0.618

High

351043

PRG2
Bone marrow proteoglycan

3

5

High-throughput

0.609

High

351089

ZFP41
Zinc finger protein 41 homolog

3

17

High-throughput

0.609

High

351111

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

3

4

High-throughput

0.609

High

351115

UST
Uronyl 2-sulfotransferase

2

0

High-throughput

0.602

High

351041

BIP
Endoplasmic reticulum chaperone BiP

2

3

Small-scale

0.584

High

351066

TLE5
TLE family member 5

2

0

High-throughput

0.580

High

351103

IF3M
Translation initiation factor IF-3, mitochondrial

2

0

High-throughput

0.580

High

351074

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

2

2

High-throughput

0.574

High

351106

ZN408
Zinc finger protein 408

2

11

High-throughput

0.574

High

351113

MGT4C
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

2

2

High-throughput

0.574

High

351116

PRG3
Proteoglycan 3

2

5

High-throughput

0.574

High

351048

RAB5A
Ras-related protein Rab-5A

2

8

High-throughput

0.571

High

351053

PDIA3
Protein disulfide-isomerase A3

1

6

Small-scale

0.561

High

351069

SNX17
Sorting nexin-17

1

4

Small-scale

0.561

High

351080

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.553

High

269114

DAB1
Disabled homolog 1

2

20

Small-scale

0.542

High

351050

MAP4
Microtubule-associated protein 4

1

2

High-throughput

0.541

High

351036

APOB
Apolipoprotein B-100

1

2

Small-scale

0.536

High

156773

FFAR1
Free fatty acid receptor 1

1

2

High-throughput

0.536

High

318334

ECEL1
Endothelin-converting enzyme-like 1

1

1

High-throughput

0.536

High

351039

LEG1
Galectin-1

1

10

High-throughput

0.536

High

351052

CD1B
T-cell surface glycoprotein CD1b

1

6

High-throughput

0.536

High

351055

TIMP3
Metalloproteinase inhibitor 3

1

4

High-throughput

0.536

High

351057

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

2

High-throughput

0.536

High

351059

WNT3A
Protein Wnt-3a

1

13

High-throughput

0.536

High

351064

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

3

High-throughput

0.536

High

351075

FSTL4
Follistatin-related protein 4

1

5

High-throughput

0.536

High

351083

DJC10
DnaJ homolog subfamily C member 10

1

7

High-throughput

0.536

High

351085

NRSN1
Neurensin-1

1

1

High-throughput

0.536

High

351093

S39A7
Zinc transporter SLC39A7

1

1

High-throughput

0.536

High

351100

WN10A
Protein Wnt-10a

1

13

High-throughput

0.536

High

351102

CXL16
C-X-C motif chemokine 16

1

1

High-throughput

0.536

High

351108

IGSF5
Immunoglobulin superfamily member 5

1

1

High-throughput

0.536

High

351112

P2RX2
P2X purinoceptor 2

1

1

High-throughput

0.536

High

351114

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

1

8

High-throughput

0.536

High

351118

LIPG
Endothelial lipase

1

6

High-throughput

0.536

High

351087

SH2D3
SH2 domain-containing protein 3C

2

4

High-throughput

0.521

High

351076

BRID5
BRICHOS domain-containing protein 5

1

0

High-throughput

0.513

High

351096

T106A
Transmembrane protein 106A

1

0

High-throughput

0.513

High

351097

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

0

High-throughput

0.513

High

351046

CD36
Platelet glycoprotein 4

1

1

Small-scale

0.501

High

351065

DAB2
Disabled homolog 2

1

20

Small-scale

0.501

High

351073

ARH
Low density lipoprotein receptor adapter protein 1

1

20

Small-scale

0.501

High

351094

CBP
CREB-binding protein

1

2

Small-scale

0.490

High

211341

PI15
Peptidase inhibitor 15

1

5

High-throughput

0.489

High

312825

CCN6
Cellular communication network factor 6

1

5

High-throughput

0.489

High

351044

EDN3
Endothelin-3

1

3

High-throughput

0.489

High

351060

DEF1
Neutrophil defensin 1

1

2

High-throughput

0.489

High

351071

DB136
Defensin beta 136

1

1

High-throughput

0.489

High

351072

FX4L6
Forkhead box protein D4-like 6

1

6

High-throughput

0.489

High

351077

LYZL1
Lysozyme-like protein 1

1

3

High-throughput

0.489

High

351078

IGFL3
Insulin growth factor-like family member 3

1

6

High-throughput

0.489

High

351086

TAFA2
Chemokine-like protein TAFA-2

1

8

High-throughput

0.489

High

351088

DB123
Beta-defensin 123

1

3

High-throughput

0.489

High

351105

GREM2
Gremlin-2

1

2

High-throughput

0.489

High

351035

PLF4
Platelet factor 4

1

0

Small-scale

0.480

High

204899

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.479

High

271013

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

3

Small-scale

0.479

High

351037

MMP2
72 kDa type IV collagenase

1

3

Small-scale

0.479

High

351042

PDIA4
Protein disulfide-isomerase A4

1

6

Small-scale

0.479

High

351045

ENPL
Endoplasmin

1

1

Small-scale

0.479

High

351047

VGFR1
Vascular endothelial growth factor receptor 1

1

3

Small-scale

0.479

High

351051

CALX
Calnexin

1

4

Small-scale

0.479

High

351068

CUL3
Cullin-3

1

11

High-throughput

0.479

High

351062

H4
Histone H4

1

0

High-throughput

0.458

High

351070

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.458

High

351084

TM192
Transmembrane protein 192

1

0

High-throughput

0.458

High

351099

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.458

High

326001

TSN15
Tetraspanin-15

1

3

High-throughput

0.445

High

351061

TSN5
Tetraspanin-5

1

3

High-throughput

0.445

High

301513

TRI37
E3 ubiquitin-protein ligase TRIM37

1

6

High-throughput

0.437

High

319101

BRD1
Bromodomain-containing protein 1

1

3

High-throughput

0.437

High

351056

CEBPD
CCAAT/enhancer-binding protein delta

1

1

Small-scale

0.437

High

351063

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.437

High

351095

FGF11
Fibroblast growth factor 11

1

2

High-throughput

0.437

High

351107

FBX6
F-box only protein 6

1

7

High-throughput

0.437

High

239685

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.426

High

351040

GOG8G
Putative golgin subfamily A member 8G

1

3

High-throughput

0.407

High

276071

CBR3
Carbonyl reductase [NADPH] 3

1

0

High-throughput

0.279

Low

351067

MFAP5
Microfibrillar-associated protein 5

1

0

High-throughput

0.279

Low

351101

KTBL1
KATNB1-like protein 1

1

0

High-throughput

0.279

Low

100364

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

351110

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

351120

AP1M2
AP-1 complex subunit mu-2

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024