Protein: LDHB
L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46)

Gene: LDHB
Organism: Homo sapiens
Interactions: 218
UniProt ID: P07195

Gene Ontology (top 5):
GO:0004459 - L-lactate dehydrogenase activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

334105

LDHA
L-lactate dehydrogenase A chain

14

11

High-throughput

0.985

High

421945

LDHB
L-lactate dehydrogenase B chain

6

11

Small-scale

0.939

High

421947

LDHC
L-lactate dehydrogenase C chain

3

11

High-throughput

0.867

High

226275

PRKN
E3 ubiquitin-protein ligase parkin

4

14

High-throughput

0.686

High

422017

CUL3
Cullin-3

2

3

High-throughput

0.611

High

132714

SDCB1
Syntenin-1

2

3

High-throughput

0.606

High

421957

CFTR
Cystic fibrosis transmembrane conductance regulator

2

5

High-throughput

0.601

High

421966

VCAM1
Vascular cell adhesion protein 1

2

2

High-throughput

0.601

High

422003

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

1

Small-scale

0.595

High

385928

P53
Cellular tumor antigen p53

2

3

High-throughput

0.584

High

422051

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

4

High-throughput

0.584

High

422093

ACE2
Angiotensin-converting enzyme 2

2

1

Small-scale

0.584

High

421973

CTNB1
Catenin beta-1

2

0

Small-scale

0.576

High

421997

PEX5
Peroxisomal targeting signal 1 receptor

1

3

High-throughput

0.573

High

422064

DOCK8
Dedicator of cytokinesis protein 8

2

3

High-throughput

0.571

High

421999

TERF1
Telomeric repeat-binding factor 1

1

2

High-throughput

0.568

High

422032

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.550

High

128404

DNM1L
Dynamin-1-like protein

1

2

High-throughput

0.536

High

336307

SODC
Superoxide dismutase [Cu-Zn]

1

4

High-throughput

0.536

High

362694

FINC
Fibronectin

1

4

High-throughput

0.536

High

421946

CATD
Cathepsin D

1

1

High-throughput

0.536

High

421949

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

3

High-throughput

0.536

High

421952

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.536

High

421960

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

6

High-throughput

0.536

High

421970

PML
Protein PML

1

8

High-throughput

0.536

High

421971

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

3

High-throughput

0.536

High

421978

SOAT1
Sterol O-acyltransferase 1

1

2

High-throughput

0.536

High

421981

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

4

High-throughput

0.536

High

422018

CUL4B
Cullin-4B

1

3

High-throughput

0.536

High

422021

CKAP5
Cytoskeleton-associated protein 5

1

1

High-throughput

0.536

High

422065

RIN3
Ras and Rab interactor 3

1

1

High-throughput

0.536

High

422072

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.536

High

422077

REPS1
RalBP1-associated Eps domain-containing protein 1

1

1

High-throughput

0.536

High

422080

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

1

High-throughput

0.536

High

422085

PSB7
Proteasome subunit beta type-7

1

2

High-throughput

0.536

High

422111

ARHGC
Rho guanine nucleotide exchange factor 12

1

1

High-throughput

0.536

High

270558

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

0

High-throughput

0.518

High

421986

HD
Huntingtin

1

6

High-throughput

0.515

High

421963

H2AX
Histone H2AX

1

0

High-throughput

0.513

High

422069

PP4R1
Serine/threonine-protein phosphatase 4 regulatory subunit 1

1

0

High-throughput

0.513

High

174552

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

422108

POTE1
Protection of telomeres protein 1

1

1

High-throughput

0.494

High

422050

HEAT3
HEAT repeat-containing protein 3

1

2

High-throughput

0.489

High

422056

MYLK4
Myosin light chain kinase family member 4

1

6

High-throughput

0.489

High

422103

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

1

High-throughput

0.489

High

421951

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

1

Small-scale

0.481

High

422109

UBP40
Ubiquitin carboxyl-terminal hydrolase 40

1

4

Small-scale

0.481

High

119088

LEG9
Galectin-9

1

1

High-throughput

0.479

High

214036

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.479

High

279405

FLOT1
Flotillin-1

1

2

High-throughput

0.479

High

282481

RNF8
E3 ubiquitin-protein ligase RNF8

1

5

High-throughput

0.479

High

294270

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

298061

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

302793

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

314198

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

2

Small-scale

0.479

High

322081

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

326381

SNAI1
Zinc finger protein SNAI1

1

1

High-throughput

0.479

High

345704

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

359573

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

4

Small-scale

0.479

High

373532

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

Small-scale

0.479

High

384103

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

397723

ISG15
Ubiquitin-like protein ISG15

1

13

High-throughput

0.479

High

421948

VIME
Vimentin

1

1

High-throughput

0.479

High

421950

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

11

Small-scale

0.479

High

421953

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

421954

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

3

High-throughput

0.479

High

421955

UBL4A
Ubiquitin-like protein 4A

1

11

High-throughput

0.479

High

421958

ITA4
Integrin alpha-4

1

5

High-throughput

0.479

High

421961

VAV
Proto-oncogene vav

1

2

High-throughput

0.479

High

421965

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.479

High

421967

RAB4A
Ras-related protein Rab-4A

1

4

High-throughput

0.479

High

421968

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.479

High

421975

PHB1
Prohibitin 1

1

5

High-throughput

0.479

High

421977

MSX2
Homeobox protein MSX-2

1

2

High-throughput

0.479

High

421979

FUS
RNA-binding protein FUS

1

4

High-throughput

0.479

High

421980

TRI23
E3 ubiquitin-protein ligase TRIM23

1

3

High-throughput

0.479

High

421982

BRCA1
Breast cancer type 1 susceptibility protein

1

6

High-throughput

0.479

High

421983

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

421984

PERI
Peripherin

1

1

High-throughput

0.479

High

421988

RECQ1
ATP-dependent DNA helicase Q1

1

3

High-throughput

0.479

High

421989

YAP1
Transcriptional coactivator YAP1

1

5

High-throughput

0.479

High

421990

TISD
mRNA decay activator protein ZFP36L2

1

2

High-throughput

0.479

High

421991

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

421994

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

421995

GSK3B
Glycogen synthase kinase-3 beta

1

6

High-throughput

0.479

High

421998

ATX3
Ataxin-3

1

1

High-throughput

0.479

High

422000

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

High-throughput

0.479

High

422001

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

422002

RAB25
Ras-related protein Rab-25

1

4

High-throughput

0.479

High

422004

RAC3
Ras-related C3 botulinum toxin substrate 3

1

2

High-throughput

0.479

High

422006

UBC12
NEDD8-conjugating enzyme Ubc12

1

3

High-throughput

0.479

High

422007

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

422008

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

2

High-throughput

0.479

High

422009

1433Z
14-3-3 protein zeta/delta

1

5

High-throughput

0.479

High

422010

HSF1
Heat shock factor protein 1

1

4

High-throughput

0.479

High

422011

EWS
RNA-binding protein EWS

1

5

High-throughput

0.479

High

422012

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

422013

ARL16
ADP-ribosylation factor-like protein 16

1

5

High-throughput

0.479

High

422014

TFCP2
Alpha-globin transcription factor CP2

1

2

High-throughput

0.479

High

422015

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

422023

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

7

High-throughput

0.479

High

422026

TNIP1
TNFAIP3-interacting protein 1

1

5

High-throughput

0.479

High

422027

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

422028

SETB1
Histone-lysine N-methyltransferase SETDB1

1

3

Small-scale

0.479

High

422034

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

2

High-throughput

0.479

High

422035

TET5C
Terminal nucleotidyltransferase 5C

1

2

High-throughput

0.479

High

422037

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.479

High

422038

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

422040

ZN746
Zinc finger protein 746

1

1

High-throughput

0.479

High

422042

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

422043

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

422044

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

5

High-throughput

0.479

High

422045

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

422047

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

422052

SLN11
Schlafen family member 11

1

1

Small-scale

0.479

High

422053

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

422055

MF2L2
Probable guanine nucleotide exchange factor MCF2L2

1

1

High-throughput

0.479

High

422058

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

422059

SLX4
Structure-specific endonuclease subunit SLX4

1

2

High-throughput

0.479

High

422060

RPTOR
Regulatory-associated protein of mTOR

1

4

High-throughput

0.479

High

422061

RHG24
Rho GTPase-activating protein 24

1

2

High-throughput

0.479

High

422066

BICD2
Protein bicaudal D homolog 2

1

3

High-throughput

0.479

High

422070

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

6

High-throughput

0.479

High

422074

EFMT3
EEF1A lysine methyltransferase 3

1

8

High-throughput

0.479

High

422076

CHM4C
Charged multivesicular body protein 4c

1

2

High-throughput

0.479

High

422081

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.479

High

422084

RUFY1
RUN and FYVE domain-containing protein 1

1

2

High-throughput

0.479

High

422086

RING2
E3 ubiquitin-protein ligase RING2

1

12

High-throughput

0.479

High

422087

NECD
Necdin

1

2

High-throughput

0.479

High

422088

ANM1
Protein arginine N-methyltransferase 1

1

6

High-throughput

0.479

High

422089

BAG1
BAG family molecular chaperone regulator 1

1

3

High-throughput

0.479

High

422090

RIOK1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

422091

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

8

High-throughput

0.479

High

422092

FACD2
Fanconi anemia group D2 protein

1

4

High-throughput

0.479

High

422094

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

422096

RHG39
Rho GTPase-activating protein 39

1

3

High-throughput

0.479

High

422098

SHRPN
Sharpin

1

2

Small-scale

0.479

High

422099

UN45A
Protein unc-45 homolog A

1

4

High-throughput

0.479

High

422100

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.479

High

422101

ECT2
Protein ECT2

1

3

High-throughput

0.479

High

422102

NMRL1
NmrA-like family domain-containing protein 1

1

3

High-throughput

0.479

High

422104

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

4

High-throughput

0.479

High

422106

ANLN
Anillin

1

1

High-throughput

0.479

High

422110

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

422112

HDAC6
Histone deacetylase 6

1

11

High-throughput

0.479

High

422113

TBK1
Serine/threonine-protein kinase TBK1

1

4

High-throughput

0.479

High

422114

UBQL2
Ubiquilin-2

1

4

High-throughput

0.479

High

422115

ANC2
Anaphase-promoting complex subunit 2

1

4

High-throughput

0.479

High

422116

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

2

High-throughput

0.479

High

422117

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

422118

FAF1
FAS-associated factor 1

1

2

High-throughput

0.479

High

422120

FBW1A
F-box/WD repeat-containing protein 1A

1

2

High-throughput

0.479

High

422121

FND3A
Fibronectin type-III domain-containing protein 3A

1

6

High-throughput

0.479

High

422124

SAR1B
Small COPII coat GTPase SAR1B

1

4

High-throughput

0.479

High

119911

AP3B1
AP-3 complex subunit beta-1

1

0

High-throughput

0.458

High

122448

MEN1
Menin

1

0

High-throughput

0.458

High

166203

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.458

High

265939

PSIP1
PC4 and SFRS1-interacting protein

1

0

High-throughput

0.458

High

364136

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

421956

CO6A3

1

0

High-throughput

0.458

High

421964

IL7RA
Interleukin-7 receptor subunit alpha

1

0

High-throughput

0.458

High

422022

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.458

High

422031

RRP12
RRP12-like protein

1

0

High-throughput

0.458

High

422057

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.458

High

422068

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

422071

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.458

High

422073

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

0

Small-scale

0.458

High

422075

F136A
Protein FAM136A

1

0

High-throughput

0.458

High

422079

VMP1
Vacuole membrane protein 1

1

0

Small-scale

0.458

High

422083

F210A
Protein FAM210A

1

0

High-throughput

0.458

High

422105

NGB
Neuroglobin

1

0

High-throughput

0.458

High

421972

CKS2
Cyclin-dependent kinases regulatory subunit 2

1

1

Small-scale

0.457

High

422005

CKS1
Cyclin-dependent kinases regulatory subunit 1

1

1

Small-scale

0.457

High

173811

MK13
Mitogen-activated protein kinase 13

1

9

Small-scale

0.445

High

421974

BMI1
Polycomb complex protein BMI-1

1

11

High-throughput

0.445

High

422016

TBB3
Tubulin beta-3 chain

1

3

High-throughput

0.445

High

422019

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.445

High

422039

PKHA7
Pleckstrin homology domain-containing family A member 7

1

11

High-throughput

0.445

High

422048

TBA1A
Tubulin alpha-1A chain

1

2

High-throughput

0.445

High

422062

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.445

High

422078

OTUB1
Ubiquitin thioesterase OTUB1

1

1

High-throughput

0.445

High

100389

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

225470

PCDH7
Protocadherin-7

1

2

High-throughput

0.437

High

243806

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.437

High

329245

AGR2
Anterior gradient protein 2 homolog

1

3

Small-scale

0.437

High

421962

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

421969

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

421976

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

421992

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

421996

DNLI4
DNA ligase 4

1

2

High-throughput

0.437

High

422024

RBM39
RNA-binding protein 39

1

4

High-throughput

0.437

High

422030

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

422046

PAXI1
PAX-interacting protein 1

1

3

High-throughput

0.437

High

422049

KCTD9
BTB/POZ domain-containing protein KCTD9

1

2

High-throughput

0.437

High

422054

ZCH18
Zinc finger CCCH domain-containing protein 18

1

2

High-throughput

0.437

High

422067

DCA11
DDB1- and CUL4-associated factor 11

1

1

High-throughput

0.437

High

422082

DOCK7
Dedicator of cytokinesis protein 7

1

3

High-throughput

0.437

High

422095

Z518B
Zinc finger protein 518B

1

1

High-throughput

0.437

High

422107

SLX9
Ribosome biogenesis protein SLX9 homolog

1

1

Small-scale

0.437

High

422122

AAR2
Protein AAR2 homolog

1

3

High-throughput

0.437

High

422123

PPME1
Protein phosphatase methylesterase 1

1

2

Small-scale

0.437

High

421985

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.426

High

422119

GLCNE
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

1

0

Small-scale

0.426

High

421993

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

High-throughput

0.408

High

320948

PTBP3
Polypyrimidine tract-binding protein 3

1

1

High-throughput

0.407

High

401269

JUN
Transcription factor Jun

1

10

High-throughput

0.407

High

421987

RAD52
DNA repair protein RAD52 homolog

1

0

Small-scale

0.279

Low

422025

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.269

Low

421959

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.249

Low

422020

PTC1
Protein patched homolog 1

1

0

Small-scale

0.249

Low

422029

TCAL1
Transcription elongation factor A protein-like 1

1

0

High-throughput

0.249

Low

422036

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.249

Low

422041

NEPRO
Nucleolus and neural progenitor protein

1

0

High-throughput

0.249

Low

422097

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

239712

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

422033

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low

422063

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024