Protein: CO1A2
Collagen alpha-2(I) chain (Alpha-2 type I collagen)

Gene: CO1A2, COL1A2
Organism: Homo sapiens
Interactions: 69
UniProt ID: P08123

Gene Ontology (top 5):
GO:0001501 - skeletal system development
GO:0001568 - blood vessel development
GO:0002020 - protease binding
GO:0005201 - extracellular matrix structural constituent
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

358452

CO1A1
Collagen alpha-1(I) chain

3

17

Small-scale

0.839

High

213453

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

4

4

High-throughput

0.644

High

436052

UBQL1
Ubiquilin-1

4

3

High-throughput

0.644

High

358629

CO3A1

1

14

High-throughput

0.618

High

271512

ERAL1
GTPase Era, mitochondrial

3

2

High-throughput

0.609

High

436037

CMKMT
Calmodulin-lysine N-methyltransferase

3

1

High-throughput

0.609

High

436051

UBQL2
Ubiquilin-2

3

3

High-throughput

0.596

High

436010

CO5A1

1

14

Small-scale

0.590

High

208508

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

2

2

High-throughput

0.574

High

436032

MESD
LRP chaperone MESD

2

1

High-throughput

0.553

High

350946

PDGFB
Platelet-derived growth factor subunit B

1

11

Small-scale

0.536

High

436026

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.536

High

436027

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.536

High

436038

YAF2
YY1-associated factor 2

1

1

High-throughput

0.536

High

436040

CBLL2
E3 ubiquitin-protein ligase CBLL2

1

2

High-throughput

0.536

High

436017

SPB5
Serpin B5

1

2

Small-scale

0.527

High

436009

RAB5A
Ras-related protein Rab-5A

1

0

High-throughput

0.513

High

436011

COMT
Catechol O-methyltransferase

1

0

High-throughput

0.513

High

372723

MMP1
Interstitial collagenase

1

17

Small-scale

0.501

High

376359

PDGFA
Platelet-derived growth factor subunit A

1

11

Small-scale

0.501

High

436001

MMP2
72 kDa type IV collagenase

1

20

Small-scale

0.501

High

436002

MMP3
Stromelysin-1

1

17

Small-scale

0.501

High

436005

MMP9
Matrix metalloproteinase-9

1

20

Small-scale

0.501

High

436008

ITA2
Integrin alpha-2

1

9

Small-scale

0.501

High

436012

MMP8
Neutrophil collagenase

1

17

Small-scale

0.501

High

436022

MMP14
Matrix metalloproteinase-14

1

17

Small-scale

0.501

High

436024

MMP15
Matrix metalloproteinase-15

1

17

Small-scale

0.501

High

436025

MMP16
Matrix metalloproteinase-16

1

17

Small-scale

0.501

High

436030

DDR1
Epithelial discoidin domain-containing receptor 1

1

7

Small-scale

0.501

High

436043

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

4

High-throughput

0.494

High

436013

PAX3
Paired box protein Pax-3

1

3

High-throughput

0.489

High

436023

R144A
E3 ubiquitin-protein ligase RNF144A

1

1

High-throughput

0.489

High

436028

FANCC
Fanconi anemia group C protein

1

1

High-throughput

0.489

High

436029

CDK18
Cyclin-dependent kinase 18

1

1

High-throughput

0.489

High

436033

TMM44
Transmembrane protein 44

1

1

High-throughput

0.489

High

380928

SHBG
Sex hormone-binding globulin

1

2

Small-scale

0.481

High

436045

MYOC
Myocilin

1

1

Small-scale

0.481

High

436018

CATK
Cathepsin K

1

0

Small-scale

0.480

High

337795

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

436016

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

1

High-throughput

0.479

High

436031

FOXO1
Forkhead box protein O1

1

1

High-throughput

0.479

High

436047

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.479

High

149818

RFXK
DNA-binding protein RFXANK

1

1

Small-scale

0.470

High

436006

HIS3
Histatin-3

1

0

Small-scale

0.458

High

436034

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.458

High

436035

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

436007

ZNF16
Zinc finger protein 16

1

1

Small-scale

0.457

High

436014

LYOX
Protein-lysine 6-oxidase

1

2

Small-scale

0.457

High

100399

APRIO
Alternative prion protein

1

6

High-throughput

0.437

High

345724

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

436003

IRF1
Interferon regulatory factor 1

1

1

Small-scale

0.437

High

436004

IRF2
Interferon regulatory factor 2

1

1

Small-scale

0.437

High

436039

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.437

High

436046

NTPCR
Cancer-related nucleoside-triphosphatase

1

1

High-throughput

0.437

High

436048

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.437

High

403574

AP2A
Transcription factor AP-2-alpha

1

4

High-throughput

0.417

High

436041

AP2C
Transcription factor AP-2 gamma

1

4

High-throughput

0.417

High

436049

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.417

High

436015

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.407

High

436036

KCIP4
Kv channel-interacting protein 4

3

0

High-throughput

0.348

High

309428

MTMR5
Myotubularin-related protein 5

2

0

High-throughput

0.318

High

124733

EIF3F
Eukaryotic translation initiation factor 3 subunit F

2

0

High-throughput

0.316

High

436044

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

2

0

High-throughput

0.316

High

307939

ZWINT
ZW10 interactor

1

0

High-throughput

0.279

Low

436050

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.279

Low

436020

RFX5
DNA-binding protein RFX5

1

0

Small-scale

0.269

Low

436042

HDAC2
Histone deacetylase 2

1

0

Small-scale

0.269

Low

436021

DNLI4
DNA ligase 4

1

0

High-throughput

0.251

Low

436019

GATA4
Transcription factor GATA-4

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024