Protein: DPOLA
DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180)

Gene: DPOLA, POLA1
Organism: Homo sapiens
Interactions: 78
UniProt ID: P09884

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0000731 - DNA synthesis involved in DNA repair
GO:0000785 - chromatin
GO:0003677 - DNA binding
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

456118

DPOA2
DNA polymerase alpha subunit B

2

10

Small-scale

0.768

High

456101

PRI2
DNA primase large subunit

2

3

Small-scale

0.755

High

456116

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

3

High-throughput

0.691

High

456091

RFA1
Replication protein A 70 kDa DNA-binding subunit

4

2

Small-scale

0.680

High

456100

PRI1
DNA primase small subunit

3

4

Small-scale

0.662

High

456090

CDK2
Cyclin-dependent kinase 2

2

5

Small-scale

0.629

High

456136

STN1
CST complex subunit STN1

2

0

High-throughput

0.585

High

322102

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

3

High-throughput

0.584

High

456084

RFA2
Replication protein A 32 kDa subunit

2

1

High-throughput

0.584

High

456096

RFA3
Replication protein A 14 kDa subunit

2

2

High-throughput

0.584

High

456109

H31
Histone H3.1

2

7

Small-scale

0.584

High

456110

RAE1L
mRNA export factor RAE1

2

2

High-throughput

0.584

High

455010

PARP1
Poly [ADP-ribose] polymerase 1

1

4

Small-scale

0.561

High

456086

CCNA2
Cyclin-A2

1

2

Small-scale

0.561

High

456113

RAD51
DNA repair protein RAD51 homolog 1

1

1

Small-scale

0.561

High

456092

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

0

Small-scale

0.549

High

414135

RB
Retinoblastoma-associated protein

1

1

Small-scale

0.536

High

456087

BTF3
Transcription factor BTF3

1

1

High-throughput

0.536

High

456097

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

5

High-throughput

0.536

High

456098

MAGA3
Melanoma-associated antigen 3

1

1

High-throughput

0.536

High

456114

SSRP1
FACT complex subunit SSRP1

1

6

High-throughput

0.536

High

456119

SMC1A
Structural maintenance of chromosomes protein 1A

1

2

Small-scale

0.515

High

456126

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

1

0

High-throughput

0.513

High

456141

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

0

High-throughput

0.513

High

264163

CDC45
Cell division control protein 45 homolog

1

4

Small-scale

0.501

High

414693

CDK1
Cyclin-dependent kinase 1

1

5

Small-scale

0.501

High

456083

CCNB1
G2/mitotic-specific cyclin-B1

1

2

Small-scale

0.501

High

456104

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.501

High

456134

SLD5
DNA replication complex GINS protein SLD5

1

7

Small-scale

0.501

High

456132

BT3L4
Transcription factor BTF3 homolog 4

1

1

High-throughput

0.489

High

146792

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

0

Small-scale

0.480

High

456129

HELB
DNA helicase B

1

0

Small-scale

0.480

High

147478

SOCS6
Suppressor of cytokine signaling 6

1

2

High-throughput

0.479

High

226329

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

243833

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

345761

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

385961

P53
Cellular tumor antigen p53

1

1

Small-scale

0.479

High

437824

HS90B
Heat shock protein HSP 90-beta

1

5

High-throughput

0.479

High

456085

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

456089

CCNE1
G1/S-specific cyclin-E1

1

4

Small-scale

0.479

High

456094

STIP1
Stress-induced-phosphoprotein 1

1

4

High-throughput

0.479

High

456099

CDK8
Cyclin-dependent kinase 8

1

6

High-throughput

0.479

High

456102

MCM2
DNA replication licensing factor MCM2

1

8

Small-scale

0.479

High

456103

CTBP2
C-terminal-binding protein 2

1

1

High-throughput

0.479

High

456105

H4
Histone H4

1

2

Small-scale

0.479

High

456106

H2B1C
Histone H2B type 1-C/E/F/G/I

1

6

High-throughput

0.479

High

456107

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

1

Small-scale

0.479

High

456108

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.479

High

456111

H33
Histone H3.3

1

7

High-throughput

0.479

High

456117

TIF1B
Transcription intermediary factor 1-beta

1

3

High-throughput

0.479

High

456120

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

456123

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

456124

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

456125

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

456127

SKAP1
Src kinase-associated phosphoprotein 1

1

3

High-throughput

0.479

High

456128

NUP43
Nucleoporin Nup43

1

3

High-throughput

0.479

High

456131

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

3

High-throughput

0.479

High

456133

MMS19
MMS19 nucleotide excision repair protein homolog

1

3

High-throughput

0.479

High

456137

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

456138

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

456140

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

154120

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.458

High

456082

XRCC5
X-ray repair cross-complementing protein 5

1

0

Small-scale

0.458

High

456088

RAE1
Rab proteins geranylgeranyltransferase component A 1

1

0

High-throughput

0.458

High

456093

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

0

Small-scale

0.458

High

456121

AL1L2
Mitochondrial 10-formyltetrahydrofolate dehydrogenase

1

0

High-throughput

0.458

High

456122

TFDP3
Transcription factor Dp family member 3

1

0

High-throughput

0.458

High

456130

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

224672

SSX4
Protein SSX4

1

1

High-throughput

0.445

High

256935

KDM4A
Lysine-specific demethylase 4A

1

3

Small-scale

0.445

High

456095

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.445

High

282806

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

4

High-throughput

0.437

High

384146

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

456135

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

456115

TRAF3
TNF receptor-associated factor 3

1

0

High-throughput

0.426

High

100413

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

456112

RON
Macrophage-stimulating protein receptor

1

0

High-throughput

0.249

Low

456139

RBL2A
Rab-like protein 2A

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024