Protein: UMPS
Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (ODC) (OMPD) (EC 4.1.1.23) (OMPdecase)]

Gene: UMPS
Organism: Homo sapiens
Interactions: 76
UniProt ID: P11172

Gene Ontology (top 5):
GO:0004588 - orotate phosphoribosyltransferase activity
GO:0004590 - orotidine-5'-phosphate decarboxylase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

505696

UMPS
Uridine 5'-monophosphate synthase

1

14

Small-scale

0.692

High

505713

EPHA4
Ephrin type-A receptor 4

2

1

High-throughput

0.621

High

226357

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

327762

EPPI
Eppin

2

1

High-throughput

0.574

High

505722

CASP8
Caspase-8

1

1

High-throughput

0.541

High

505742

RBCC1
RB1-inducible coiled-coil protein 1

1

1

High-throughput

0.541

High

505703

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

High-throughput

0.536

High

505737

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

505739

SESQ1
Sesquipedalian-1

1

2

High-throughput

0.536

High

505753

CHODL
Chondrolectin

1

2

High-throughput

0.536

High

505754

KLC4
Kinesin light chain 4

1

1

High-throughput

0.536

High

505710

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

High-throughput

0.518

High

505718

RAD51
DNA repair protein RAD51 homolog 1

1

0

High-throughput

0.518

High

505735

ZN227
Zinc finger protein 227

1

0

High-throughput

0.518

High

505750

PG12A
Group XIIA secretory phospholipase A2

1

0

High-throughput

0.518

High

505757

BORG2
Cdc42 effector protein 3

1

0

High-throughput

0.518

High

349089

RASH
GTPase HRas

1

0

High-throughput

0.513

High

505697

MYH6
Myosin-6

1

0

High-throughput

0.513

High

505700

S10A4
Protein S100-A4

1

0

High-throughput

0.513

High

505708

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.513

High

505720

CUL3
Cullin-3

1

0

High-throughput

0.513

High

505749

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

174579

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

505714

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.501

High

505733

UBP50
Ubiquitin carboxyl-terminal hydrolase 50

1

0

High-throughput

0.493

High

505702

NOS3
Nitric oxide synthase 3

1

0

High-throughput

0.486

High

505712

PSN1
Presenilin-1

1

0

High-throughput

0.486

High

505732

PAXI1
PAX-interacting protein 1

1

0

High-throughput

0.486

High

505744

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

High-throughput

0.480

High

337840

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

373594

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

505699

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

505701

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

505704

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

505709

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

505711

CASP4
Caspase-4

1

1

High-throughput

0.479

High

505724

DUS7
Dual specificity protein phosphatase 7

1

5

High-throughput

0.479

High

505728

TENS3
Tensin-3

1

2

High-throughput

0.479

High

505730

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

2

High-throughput

0.479

High

505731

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

505743

SSH1
Protein phosphatase Slingshot homolog 1

1

5

High-throughput

0.479

High

505751

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

505752

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

505756

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

505716

RS29
Small ribosomal subunit protein uS14

1

0

High-throughput

0.460

High

505705

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

505715

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

505717

VIGLN
Vigilin

1

0

High-throughput

0.458

High

505719

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

505723

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

High-throughput

0.458

High

505725

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

505734

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

505745

PP14B
Protein phosphatase 1 regulatory subunit 14B

1

0

Small-scale

0.458

High

505748

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

505755

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

401310

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

505721

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.445

High

505726

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

505707

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.438

High

505706

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

505758

STYL1
Serine/threonine/tyrosine-interacting-like protein 1

1

5

High-throughput

0.437

High

371347

ANGI
Angiogenin

1

0

High-throughput

0.426

High

505698

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

505738

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

216157

CALU
Calumenin

1

0

High-throughput

0.282

High

505736

TMM25
Transmembrane protein 25

1

0

High-throughput

0.279

Low

505741

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

505746

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

505747

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.279

Low

344427

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.265

Low

100425

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

390685

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

505727

OTUD1
OTU domain-containing protein 1

1

0

High-throughput

0.249

Low

505729

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

505740

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024