Protein: JAK1
Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1)

Gene: JAK1
Organism: Homo sapiens
Interactions: 222
UniProt ID: P23458

Gene Ontology (top 5):
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005131 - growth hormone receptor binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

616755

STAT1
Signal transducer and activator of transcription 1-alpha/beta

10

20

Small-scale

0.976

High

616802

PTN11
Tyrosine-protein phosphatase non-receptor type 11

5

20

Small-scale

0.919

High

181799

SOCS1
Suppressor of cytokine signaling 1

5

20

Small-scale

0.912

High

616754

STAT3
Signal transducer and activator of transcription 3

5

20

Small-scale

0.912

High

616753

IL6RB
Interleukin-6 receptor subunit beta

4

20

Small-scale

0.907

High

616737

JAK1
Tyrosine-protein kinase JAK1

4

19

Small-scale

0.888

High

147392

SOCS3
Suppressor of cytokine signaling 3

3

20

Small-scale

0.866

High

616750

TGFR2
TGF-beta receptor type-2

3

20

High-throughput

0.861

High

616749

IRS1
Insulin receptor substrate 1

3

20

Small-scale

0.834

High

277005

STAM2
Signal transducing adapter molecule 2

2

20

Small-scale

0.812

High

616859

OSMR
Oncostatin-M-specific receptor subunit beta

2

20

High-throughput

0.802

High

616770

JAK3
Tyrosine-protein kinase JAK3

2

19

Small-scale

0.789

High

616783

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.780

High

238357

JAK2
Tyrosine-protein kinase JAK2

2

19

Small-scale

0.768

High

616739

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

20

Small-scale

0.768

High

337939

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.754

High

585403

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

2

20

Small-scale

0.754

High

616892

IRS2
Insulin receptor substrate 2

2

20

Small-scale

0.754

High

540444

IL2RB
Interleukin-2 receptor subunit beta

9

20

Small-scale

0.749

High

616757

STA5A
Signal transducer and activator of transcription 5A

1

20

Small-scale

0.740

High

616854

LRIQ1
Leucine-rich repeat and IQ domain-containing protein 1

2

20

High-throughput

0.726

High

616768

STA5B
Signal transducer and activator of transcription 5B

1

20

Small-scale

0.713

High

546433

INGR1
Interferon gamma receptor 1

4

18

Small-scale

0.700

High

616738

IL4RA
Interleukin-4 receptor subunit alpha

4

20

Small-scale

0.700

High

537717

INSRR
Insulin receptor-related protein

1

20

High-throughput

0.691

High

616786

KC1G2
Casein kinase I isoform gamma-2

1

20

High-throughput

0.691

High

616816

AMHR2
Anti-Muellerian hormone type-2 receptor

1

20

High-throughput

0.691

High

616820

KIF24
Kinesin-like protein KIF24

1

20

High-throughput

0.691

High

616762

LPAR6
Lysophosphatidic acid receptor 6

3

20

High-throughput

0.667

High

616806

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

20

High-throughput

0.665

High

337349

ABL1
Tyrosine-protein kinase ABL1

1

19

Small-scale

0.647

High

383610

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

435539

IGF1R
Insulin-like growth factor 1 receptor

1

20

Small-scale

0.647

High

616756

STAT6
Signal transducer and activator of transcription 6

1

20

Small-scale

0.647

High

616804

GAB1
GRB2-associated-binding protein 1

1

20

Small-scale

0.647

High

616813

SHB
SH2 domain-containing adapter protein B

1

20

Small-scale

0.647

High

616860

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

20

Small-scale

0.647

High

616765

INAR2
Interferon alpha/beta receptor 2

3

0

Small-scale

0.646

High

584315

TNR1A
Tumor necrosis factor receptor superfamily member 1A

3

20

Small-scale

0.646

High

616833

INLR1
Interferon lambda receptor 1

2

15

Small-scale

0.644

High

616746

IL3RB
Cytokine receptor common subunit beta

3

20

Small-scale

0.640

High

380088

MAS
Proto-oncogene Mas

2

20

High-throughput

0.628

High

527297

LAMP2
Lysosome-associated membrane glycoprotein 2

2

12

High-throughput

0.628

High

616748

APJ
Apelin receptor

2

18

High-throughput

0.628

High

616811

I13R2
Interleukin-13 receptor subunit alpha-2

2

20

High-throughput

0.628

High

616843

HAVR2
Hepatitis A virus cellular receptor 2

2

5

High-throughput

0.628

High

616889

LAMP3
Lysosome-associated membrane glycoprotein 3

2

12

High-throughput

0.628

High

616785

RACK1
Small ribosomal subunit protein RACK1

2

12

Small-scale

0.624

High

565998

INAR1
Interferon alpha/beta receptor 1

2

20

Small-scale

0.619

High

325629

LATS1
Serine/threonine-protein kinase LATS1

1

20

High-throughput

0.618

High

373690

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

Small-scale

0.618

High

384277

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

411296

INSR
Insulin receptor

1

20

Small-scale

0.618

High

500945

GHR
Growth hormone receptor

1

20

Small-scale

0.618

High

562506

IL7RA
Interleukin-7 receptor subunit alpha

1

3

High-throughput

0.618

High

562625

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

20

Small-scale

0.618

High

566287

KPCA
Protein kinase C alpha type

1

20

Small-scale

0.618

High

580930

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

20

Small-scale

0.618

High

616741

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

19

Small-scale

0.618

High

616758

TEC
Tyrosine-protein kinase Tec

1

20

Small-scale

0.618

High

616759

ABL2
Tyrosine-protein kinase ABL2

1

19

Small-scale

0.618

High

616771

STAT2
Signal transducer and activator of transcription 2

1

20

Small-scale

0.618

High

616781

1433E
14-3-3 protein epsilon

1

13

Small-scale

0.618

High

616797

TAGL
Transgelin

1

13

Small-scale

0.618

High

616799

KPCZ
Protein kinase C zeta type

1

20

High-throughput

0.618

High

616803

BTK
Tyrosine-protein kinase BTK

1

19

Small-scale

0.618

High

616810

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.618

High

616824

I27RA
Interleukin-27 receptor subunit alpha

1

20

Small-scale

0.618

High

616826

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

616858

CSF3R
Granulocyte colony-stimulating factor receptor

1

20

Small-scale

0.618

High

616805

I10R1
Interleukin-10 receptor subunit alpha

2

15

Small-scale

0.613

High

616763

S15A1
Solute carrier family 15 member 1

2

0

High-throughput

0.602

High

412015

FYN
Tyrosine-protein kinase Fyn

1

20

High-throughput

0.590

High

616792

MDM2
E3 ubiquitin-protein ligase Mdm2

2

7

Small-scale

0.584

High

616884

ZRAN1
Ubiquitin thioesterase ZRANB1

2

6

High-throughput

0.584

High

609176

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.575

High

616867

MANS1
MANSC domain-containing protein 1

2

2

High-throughput

0.574

High

616742

PEBP1
Phosphatidylethanolamine-binding protein 1

2

1

High-throughput

0.571

High

616822

ELP2
Elongator complex protein 2

1

12

Small-scale

0.561

High

616888

CHIP
E3 ubiquitin-protein ligase CHIP

1

16

Small-scale

0.561

High

616743

AGTR1
Type-1 angiotensin II receptor

1

18

High-throughput

0.541

High

616772

TTC3
E3 ubiquitin-protein ligase TTC3

1

18

High-throughput

0.541

High

126567

P2Y10
Putative P2Y purinoceptor 10

1

20

High-throughput

0.536

High

156791

FFAR1
Free fatty acid receptor 1

1

20

High-throughput

0.536

High

171933

GP182
G-protein coupled receptor 182

1

20

High-throughput

0.536

High

253936

ADA11
Disintegrin and metalloproteinase domain-containing protein 11

1

20

High-throughput

0.536

High

380737

S100B
Protein S100-B

1

9

High-throughput

0.536

High

551609

DESP
Desmoplakin

1

20

High-throughput

0.536

High

616760

EAA3
Excitatory amino acid transporter 3

1

6

High-throughput

0.536

High

616766

PTH2R
Parathyroid hormone 2 receptor

1

10

High-throughput

0.536

High

616777

CXCR4
C-X-C chemokine receptor type 4

1

18

High-throughput

0.536

High

616787

X3CL1
Fractalkine

1

2

High-throughput

0.536

High

616789

DLK1
Protein delta homolog 1

1

14

High-throughput

0.536

High

616791

EFNB1
Ephrin-B1

1

7

High-throughput

0.536

High

616794

CD83
CD83 antigen

1

2

High-throughput

0.536

High

616795

IL5RA
Interleukin-5 receptor subunit alpha

1

20

Small-scale

0.536

High

616800

VMAT2
Synaptic vesicular amine transporter

1

2

High-throughput

0.536

High

616808

KCNC3
Potassium voltage-gated channel subfamily C member 3

1

14

High-throughput

0.536

High

616818

FILA2
Filaggrin-2

1

10

High-throughput

0.536

High

616825

I20RB
Interleukin-20 receptor subunit beta

1

15

High-throughput

0.536

High

616828

BT2A1
Butyrophilin subfamily 2 member A1

1

14

High-throughput

0.536

High

616837

RN149
E3 ubiquitin-protein ligase RNF149

1

12

High-throughput

0.536

High

616838

ARRD4
Arrestin domain-containing protein 4

1

9

High-throughput

0.536

High

616840

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

2

High-throughput

0.536

High

616848

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

6

High-throughput

0.536

High

616852

MRAP2
Melanocortin-2 receptor accessory protein 2

1

3

High-throughput

0.536

High

616853

TET5A
Terminal nucleotidyltransferase 5A

1

1

High-throughput

0.536

High

616856

OPALI
Opalin

1

1

High-throughput

0.536

High

616861

CML1
Chemerin-like receptor 1

1

17

High-throughput

0.536

High

616863

SYT11
Synaptotagmin-11

1

7

High-throughput

0.536

High

616870

CRLF2
Cytokine receptor-like factor 2

1

20

High-throughput

0.536

High

616872

AGO4
Protein argonaute-4

1

2

High-throughput

0.536

High

616880

GPC5B
G-protein coupled receptor family C group 5 member B

1

6

High-throughput

0.536

High

616885

HSPB8
Heat shock protein beta-8

1

8

High-throughput

0.536

High

616886

CLC4A
C-type lectin domain family 4 member A

1

8

High-throughput

0.536

High

616887

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

19

High-throughput

0.536

High

616893

PCDA8
Protocadherin alpha-8

1

8

High-throughput

0.536

High

616895

GPR45
Probable G-protein coupled receptor 45

1

19

High-throughput

0.536

High

616897

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

3

High-throughput

0.536

High

616850

RN125
E3 ubiquitin-protein ligase RNF125

2

20

Small-scale

0.533

High

146594

SOCS2
Suppressor of cytokine signaling 2

1

20

Small-scale

0.527

High

616876

CISH
Cytokine-inducible SH2-containing protein

1

20

Small-scale

0.527

High

616751

BRCA1
Breast cancer type 1 susceptibility protein

1

13

Small-scale

0.515

High

616764

PA24A
Cytosolic phospholipase A2

1

11

Small-scale

0.515

High

616793

IL9R
Interleukin-9 receptor

1

20

Small-scale

0.515

High

616798

UPAR
Urokinase plasminogen activator surface receptor

1

4

Small-scale

0.515

High

616809

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

20

High-throughput

0.515

High

616869

IL21R
Interleukin-21 receptor

1

20

Small-scale

0.515

High

616774

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

0

High-throughput

0.513

High

616812

PDCD1
Programmed cell death protein 1

1

0

High-throughput

0.513

High

616831

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

High-throughput

0.513

High

616832

TCAM2
TIR domain-containing adapter molecule 2

1

0

High-throughput

0.513

High

616844

BSND
Barttin

1

0

High-throughput

0.513

High

616874

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.513

High

616883

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.513

High

153571

ANM5
Protein arginine N-methyltransferase 5

1

12

Small-scale

0.501

High

616747

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

20

Small-scale

0.501

High

616817

H31T
Histone H3.1t

1

4

Small-scale

0.501

High

616801

CTSL2
CTD small phosphatase-like protein 2

1

5

High-throughput

0.489

High

616839

F174A
Membrane protein FAM174A

1

1

High-throughput

0.489

High

616877

ARL15
ADP-ribosylation factor-like protein 15

1

14

High-throughput

0.489

High

616890

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

18

High-throughput

0.489

High

164351

TRI66
Tripartite motif-containing protein 66

1

20

High-throughput

0.479

High

296869

LTN1
E3 ubiquitin-protein ligase listerin

1

2

High-throughput

0.479

High

298159

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

325039

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

4

High-throughput

0.479

High

326441

SNAI1
Zinc finger protein SNAI1

1

3

High-throughput

0.479

High

352493

TNFA
Tumor necrosis factor

1

10

High-throughput

0.479

High

368993

ESR1
Estrogen receptor

1

20

High-throughput

0.479

High

386106

P53
Cellular tumor antigen p53

1

9

High-throughput

0.479

High

397780

ISG15
Ubiquitin-like protein ISG15

1

14

High-throughput

0.479

High

417940

NPM
Nucleophosmin

1

4

High-throughput

0.479

High

431543

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.479

High

436160

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

437906

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.479

High

445715

IL6RA
Interleukin-6 receptor subunit alpha

1

20

Small-scale

0.479

High

509512

UBL4A
Ubiquitin-like protein 4A

1

15

High-throughput

0.479

High

528561

CFTR
Cystic fibrosis transmembrane conductance regulator

1

7

Small-scale

0.479

High

536729

TRI27
Zinc finger protein RFP

1

16

Small-scale

0.479

High

560484

TSHR
Thyrotropin receptor

1

19

Small-scale

0.479

High

564414

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

610226

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.479

High

616740

PML
Protein PML

1

20

Small-scale

0.479

High

616744

IL2RG
Cytokine receptor common subunit gamma

1

20

Small-scale

0.479

High

616745

PUR9
Bifunctional purine biosynthesis protein ATIC

1

1

High-throughput

0.479

High

616752

IF4A3
Eukaryotic initiation factor 4A-III

1

11

High-throughput

0.479

High

616761

MUC18
Cell surface glycoprotein MUC18

1

20

High-throughput

0.479

High

616767

ARRB1
Beta-arrestin-1

1

6

High-throughput

0.479

High

616769

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

616773

KAD2
Adenylate kinase 2, mitochondrial

1

1

High-throughput

0.479

High

616775

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

616776

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

616779

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

616780

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

616782

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

616784

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

616788

ELF3
ETS-related transcription factor Elf-3

1

4

High-throughput

0.479

High

616790

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

616796

IFM3
Interferon-induced transmembrane protein 3

1

8

High-throughput

0.479

High

616814

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

616821

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

616823

ACD10
Acyl-CoA dehydrogenase family member 10

1

6

High-throughput

0.479

High

616827

ACD11
Acyl-CoA dehydrogenase family member 11

1

6

High-throughput

0.479

High

616829

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

616830

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

20

Small-scale

0.479

High

616834

PARP9
Protein mono-ADP-ribosyltransferase PARP9

1

11

Small-scale

0.479

High

616835

TM192
Transmembrane protein 192

1

2

High-throughput

0.479

High

616842

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

7

Small-scale

0.479

High

616845

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

616846

KAT6A
Histone acetyltransferase KAT6A

1

15

High-throughput

0.479

High

616847

FBXW7
F-box/WD repeat-containing protein 7

1

4

High-throughput

0.479

High

616849

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

1

Small-scale

0.479

High

616851

TRI11
E3 ubiquitin-protein ligase TRIM11

1

15

Small-scale

0.479

High

616855

SNX27
Sorting nexin-27

1

20

High-throughput

0.479

High

616857

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

616862

ANM1
Protein arginine N-methyltransferase 1

1

12

High-throughput

0.479

High

616864

REN3B
Regulator of nonsense transcripts 3B

1

8

High-throughput

0.479

High

616865

CHM4B
Charged multivesicular body protein 4b

1

4

High-throughput

0.479

High

616866

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

616868

KT3K
Ketosamine-3-kinase

1

1

High-throughput

0.479

High

616871

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

20

High-throughput

0.479

High

616873

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

6

High-throughput

0.479

High

616875

KIF15
Kinesin-like protein KIF15

1

12

Small-scale

0.479

High

616881

PD1L1
Programmed cell death 1 ligand 1

1

20

Small-scale

0.479

High

616891

NOC2L
Nucleolar complex protein 2 homolog

1

3

Small-scale

0.479

High

616894

UBP16
Ubiquitin carboxyl-terminal hydrolase 16

1

15

Small-scale

0.479

High

241970

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

616778

MGN
Protein mago nashi homolog

1

0

High-throughput

0.458

High

616815

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

616896

EID1
EP300-interacting inhibitor of differentiation 1

1

0

Small-scale

0.458

High

239783

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

12

High-throughput

0.445

High

496318

TAU
Microtubule-associated protein tau

1

20

High-throughput

0.445

High

616807

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

8

High-throughput

0.445

High

616879

ELOV5
Very long chain fatty acid elongase 5

1

1

High-throughput

0.437

High

508340

TOP1
DNA topoisomerase 1

1

3

Small-scale

0.408

High

616836

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

616841

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

616878

CLDN1
Claudin domain-containing protein 1

1

0

High-throughput

0.279

Low

616882

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.279

Low

100486

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

616819

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024