Protein: PUR8
Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase)

Gene: PUR8, ADSL
Organism: Homo sapiens
Interactions: 118
UniProt ID: P30566

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0004018 - N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
GO:0005829 - cytosol
GO:0006164 - purine nucleotide biosynthetic process
GO:0006167 - AMP biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

674991

KLH20
Kelch-like protein 20

2

1

High-throughput

0.611

High

674992

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

3

High-throughput

0.601

High

226625

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

674962

TEKT4
Tektin-4

2

1

High-throughput

0.558

High

674985

TEKT2
Tektin-2

2

1

High-throughput

0.558

High

674966

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

257925

DNJB6
DnaJ homolog subfamily B member 6

1

1

High-throughput

0.536

High

674967

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

1

High-throughput

0.536

High

674937

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.518

High

674936

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

2

High-throughput

0.515

High

456307

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

1

0

High-throughput

0.513

High

664045

T2EB
Transcription initiation factor IIE subunit beta

1

0

High-throughput

0.513

High

674923

ST1A2
Sulfotransferase 1A2

1

0

High-throughput

0.513

High

674929

MTPN
Myotrophin

1

0

High-throughput

0.513

High

674957

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

674978

E41L5
Band 4.1-like protein 5

1

0

High-throughput

0.513

High

674994

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.513

High

174650

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

674934

REL
Proto-oncogene c-Rel

1

3

High-throughput

0.481

High

475383

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.479

High

501736

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.479

High

503518

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

674924

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

2

High-throughput

0.479

High

674932

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

High-throughput

0.479

High

674933

1433Z
14-3-3 protein zeta/delta

1

2

High-throughput

0.479

High

674935

TP4A2
Protein tyrosine phosphatase type IVA 2

1

2

High-throughput

0.479

High

674938

SBP1
Methanethiol oxidase

1

1

High-throughput

0.479

High

674939

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

674942

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

674958

COP1
E3 ubiquitin-protein ligase COP1

1

3

High-throughput

0.479

High

674965

ARMC5
Armadillo repeat-containing protein 5

1

1

High-throughput

0.479

High

674970

ACON
Aconitate hydratase, mitochondrial

1

1

High-throughput

0.479

High

674981

MTMR4
Myotubularin-related protein 4

1

1

High-throughput

0.479

High

674983

SYLC
Leucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

674984

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

674987

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

1

High-throughput

0.479

High

674988

MTMR7
Myotubularin-related protein 7

1

1

High-throughput

0.479

High

149558

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.458

High

272495

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

302482

CE152
Centrosomal protein of 152 kDa

1

0

High-throughput

0.458

High

304793

MFN2
Mitofusin-2

1

0

High-throughput

0.458

High

318929

CEP43
Centrosomal protein 43

1

0

High-throughput

0.458

High

320497

OXSR1
Serine/threonine-protein kinase OSR1

1

0

High-throughput

0.458

High

322233

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

346031

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

384343

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

422602

GPX1
Glutathione peroxidase 1

1

0

High-throughput

0.458

High

623720

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

0

High-throughput

0.458

High

649041

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

0

High-throughput

0.458

High

674293

PURA2
Adenylosuccinate synthetase isozyme 2

1

0

High-throughput

0.458

High

674915

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

674919

YAP1
Transcriptional coactivator YAP1

1

0

High-throughput

0.458

High

674921

PAXI
Paxillin

1

0

High-throughput

0.458

High

674926

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

674927

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

674928

HDAC4
Histone deacetylase 4

1

0

High-throughput

0.458

High

674931

RS15A
Small ribosomal subunit protein uS8

1

0

High-throughput

0.458

High

674943

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.458

High

674946

TENS2
Tensin-2

1

0

High-throughput

0.458

High

674947

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.458

High

674954

YAF2
YY1-associated factor 2

1

0

High-throughput

0.458

High

674960

FBF1
Fas-binding factor 1

1

0

High-throughput

0.458

High

674969

CEP89
Centrosomal protein of 89 kDa

1

0

High-throughput

0.458

High

674977

CENPJ
Centromere protein J

1

0

High-throughput

0.458

High

674989

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.458

High

528625

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

587436

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

3

High-throughput

0.445

High

205092

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

552029

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

669771

ODPAT
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial

1

1

High-throughput

0.437

High

674949

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

674959

DCA11
DDB1- and CUL4-associated factor 11

1

1

High-throughput

0.437

High

674963

TP4A1
Protein tyrosine phosphatase type IVA 1

1

2

High-throughput

0.437

High

674968

RPGR1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

1

1

High-throughput

0.437

High

674973

GCP60
Golgi resident protein GCP60

1

1

High-throughput

0.437

High

674974

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

401486

JUN
Transcription factor Jun

1

2

High-throughput

0.407

High

674953

CMTD1
Catechol O-methyltransferase domain-containing protein 1

2

0

High-throughput

0.318

High

674920

CCN3
CCN family member 3

1

0

High-throughput

0.282

High

203278

FIBP
Acidic fibroblast growth factor intracellular-binding protein

1

0

High-throughput

0.279

Low

361829

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

0

High-throughput

0.279

Low

674918

MAGA9
Melanoma-associated antigen 9

1

0

High-throughput

0.279

Low

674940

KRR1
KRR1 small subunit processome component homolog

1

0

High-throughput

0.279

Low

674956

F133A
Protein FAM133A

1

0

High-throughput

0.279

Low

674961

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.279

Low

674971

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.279

Low

674972

DERL2
Derlin-2

1

0

High-throughput

0.279

Low

674975

PAAT
ATPase PAAT

1

0

High-throughput

0.279

Low

674980

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

High-throughput

0.279

Low

674990

NTNG1
Netrin-G1

1

0

High-throughput

0.279

Low

674993

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

674986

EPDR1
Mammalian ependymin-related protein 1

1

0

High-throughput

0.269

Low

100526

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

230954

CE104
Centrosomal protein of 104 kDa

1

0

High-throughput

0.249

Low

262377

TULP3
Tubby-related protein 3

1

0

High-throughput

0.249

Low

282310

NEBL
Nebulette

1

0

High-throughput

0.249

Low

318578

EYA4
Eyes absent homolog 4

1

0

High-throughput

0.249

Low

351279

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.249

Low

444675

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

0

High-throughput

0.249

Low

650456

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

674916

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

674917

BMR1A
Bone morphogenetic protein receptor type-1A

1

0

High-throughput

0.249

Low

674922

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.249

Low

674925

TXTP
Tricarboxylate transport protein, mitochondrial

1

0

High-throughput

0.249

Low

674930

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

674941

CUL4A
Cullin-4A

1

0

High-throughput

0.249

Low

674944

ANR55
Ankyrin repeat domain-containing protein 55

1

0

High-throughput

0.249

Low

674945

BSPRY
B box and SPRY domain-containing protein

1

0

High-throughput

0.249

Low

674950

CE128
Centrosomal protein of 128 kDa

1

0

High-throughput

0.249

Low

674951

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

674952

MAVS
Mitochondrial antiviral-signaling protein

1

0

High-throughput

0.249

Low

674955

CNTRB
Centrobin

1

0

High-throughput

0.249

Low

674964

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.249

Low

674976

SFXN1
Sideroflexin-1

1

0

High-throughput

0.249

Low

674979

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.249

Low

674982

SEP10
Septin-10

1

0

High-throughput

0.249

Low

674995

MTCH2
Mitochondrial carrier homolog 2

1

0

High-throughput

0.249

Low

674948

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024