Protein: PUR9
Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)]

Gene: PUR9, ATIC
Organism: Homo sapiens
Interactions: 91
UniProt ID: P31939

Gene Ontology (top 5):
GO:0003360 - brainstem development
GO:0003937 - IMP cyclohydrolase activity
GO:0004643 - phosphoribosylaminoimidazolecarboxamide formyltransferase activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

338006

EGFR
Epidermal growth factor receptor

2

3

Small-scale

0.608

High

226640

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

625162

CDK2
Cyclin-dependent kinase 2

2

0

High-throughput

0.559

High

682497

KPCE
Protein kinase C epsilon type

2

0

High-throughput

0.547

High

682498

CAV1
Caveolin-1

2

0

High-throughput

0.547

High

682534

SHOC2
Leucine-rich repeat protein SHOC-2

2

0

High-throughput

0.547

High

411314

INSR
Insulin receptor

1

3

Small-scale

0.536

High

682483

ARL3
ADP-ribosylation factor-like protein 3

1

1

High-throughput

0.536

High

682507

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.536

High

682511

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.536

High

682537

SAR1B
Small COPII coat GTPase SAR1B

1

1

High-throughput

0.536

High

682491

RBM11
Splicing regulator RBM11

1

0

High-throughput

0.518

High

397805

ISG15
Ubiquitin-like protein ISG15

1

1

High-throughput

0.515

High

201239

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

386179

P53
Cellular tumor antigen p53

1

0

High-throughput

0.513

High

682493

ARP2
Actin-related protein 2

1

0

High-throughput

0.513

High

682504

MYLK
Myosin light chain kinase, smooth muscle

1

0

High-throughput

0.513

High

682526

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

161969

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

0

High-throughput

0.493

High

207772

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

0

High-throughput

0.493

High

607594

NDKB
Nucleoside diphosphate kinase B

1

0

High-throughput

0.493

High

646129

STOM
Stomatin

1

0

High-throughput

0.493

High

682495

ELF3
ETS-related transcription factor Elf-3

1

0

High-throughput

0.493

High

682500

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.493

High

682519

CMBL
Carboxymethylenebutenolidase homolog

1

0

High-throughput

0.493

High

682535

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

0

High-throughput

0.493

High

682487

MTR1A
Melatonin receptor type 1A

1

0

High-throughput

0.486

High

174658

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

148441

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

160404

AURKA
Aurora kinase A

1

2

High-throughput

0.479

High

384354

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

525849

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

569268

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

616745

JAK1
Tyrosine-protein kinase JAK1

1

1

High-throughput

0.479

High

682489

GSK3A
Glycogen synthase kinase-3 alpha

1

2

High-throughput

0.479

High

682490

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.479

High

682496

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

682516

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.479

High

682533

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.479

High

209705

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

373770

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

429832

CATL1
Procathepsin L

1

0

High-throughput

0.458

High

503529

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

521750

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

682481

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

682485

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

682486

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

682492

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

682494

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

682499

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

682501

CUL7
Cullin-7

1

0

High-throughput

0.458

High

682510

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

682512

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

682514

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

682517

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

682518

KAT6A
Histone acetyltransferase KAT6A

1

0

Small-scale

0.458

High

682522

NECD
Necdin

1

0

High-throughput

0.458

High

682523

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

682525

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

682528

MYO10
Unconventional myosin-X

1

0

Small-scale

0.458

High

682531

HDAC6
Histone deacetylase 6

1

0

High-throughput

0.458

High

682532

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

682536

TRAF6
TNF receptor-associated factor 6

1

0

High-throughput

0.458

High

682503

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.437

High

496411

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

682506

NF2L2
Nuclear factor erythroid 2-related factor 2

1

0

High-throughput

0.426

High

682520

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

682527

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

682488

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

682524

SH3G3
Endophilin-A3

2

0

High-throughput

0.298

High

446517

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.269

Low

682521

RADIL
Ras-associating and dilute domain-containing protein

1

0

High-throughput

0.269

Low

100532

APRIO
Alternative prion protein

1

0

Small-scale

0.251

Low

682484

SPB5
Serpin B5

1

0

Small-scale

0.251

Low

244002

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

329419

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

344945

CYTN
Cystatin-SN

1

0

Small-scale

0.249

Low

346046

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

552040

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

615518

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.249

Low

641633

U2AF2
Splicing factor U2AF 65 kDa subunit

1

0

High-throughput

0.249

Low

650469

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

682482

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

682502

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

682505

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

682508

FBX43
F-box only protein 43

1

0

Small-scale

0.249

Low

682509

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.249

Low

682513

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

682515

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

682529

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.249

Low

682530

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024