Protein: PPM1A
Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (Protein phosphatase IA)

Gene: PPM1A
Organism: Homo sapiens
Interactions: 135
UniProt ID: P35813

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000287 - magnesium ion binding
GO:0004722 - protein serine/threonine phosphatase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

273383

PPM1B
Protein phosphatase 1B

3

2

High-throughput

0.861

High

728613

MK14
Mitogen-activated protein kinase 14

2

12

Small-scale

0.812

High

658816

MK01
Mitogen-activated protein kinase 1

1

12

Small-scale

0.749

High

330884

PAK4
Serine/threonine-protein kinase PAK 4

1

10

High-throughput

0.691

High

566309

KPCA
Protein kinase C alpha type

1

1

Small-scale

0.647

High

728588

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

9

Small-scale

0.647

High

728595

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

11

Small-scale

0.647

High

728601

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

11

Small-scale

0.647

High

728602

PAK1
Serine/threonine-protein kinase PAK 1

1

14

Small-scale

0.647

High

728603

PAK2
Serine/threonine-protein kinase PAK 2

1

11

Small-scale

0.647

High

728622

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

4

Small-scale

0.647

High

728677

MRCKB
Serine/threonine-protein kinase MRCK beta

1

6

Small-scale

0.647

High

176395

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

3

0

High-throughput

0.638

High

323514

CER1
Cerberus

3

0

High-throughput

0.638

High

728663

GDF3
Growth/differentiation factor 3

3

0

High-throughput

0.638

High

255296

HIP1R
Huntingtin-interacting protein 1-related protein

2

1

High-throughput

0.628

High

728615

CERKL
Ceramide kinase-like protein

2

1

High-throughput

0.628

High

728633

FXL14
F-box/LRR-repeat protein 14

2

1

High-throughput

0.628

High

728655

PLK3
Serine/threonine-protein kinase PLK3

1

17

Small-scale

0.621

High

408569

KPCB
Protein kinase C beta type

1

1

Small-scale

0.618

High

728592

CDK9
Cyclin-dependent kinase 9

1

10

Small-scale

0.618

High

388268

HSPB1
Heat shock protein beta-1

2

0

High-throughput

0.605

High

728653

BSSP4
Brain-specific serine protease 4

3

1

High-throughput

0.604

High

728587

AL3B1
Aldehyde dehydrogenase family 3 member B1

2

0

High-throughput

0.602

High

728589

SYQ
Glutamine--tRNA ligase

2

0

High-throughput

0.602

High

728629

UBE3D
E3 ubiquitin-protein ligase E3D

2

0

High-throughput

0.602

High

728666

HAOX2
2-Hydroxyacid oxidase 2

2

0

High-throughput

0.602

High

206899

CHSTA
Carbohydrate sulfotransferase 10

2

0

High-throughput

0.585

High

728669

RTEL1
Regulator of telomere elongation helicase 1

2

0

High-throughput

0.585

High

728640

TRI52
E3 ubiquitin-protein ligase TRIM52

2

2

Small-scale

0.584

High

338040

EGFR
Epidermal growth factor receptor

1

10

High-throughput

0.582

High

435562

IGF1R
Insulin-like growth factor 1 receptor

1

7

High-throughput

0.582

High

728657

ZDH11
Palmitoyltransferase ZDHHC11

2

1

High-throughput

0.574

High

175648

TRI18
E3 ubiquitin-protein ligase Midline-1

1

2

Small-scale

0.561

High

728611

SMAD2
Mothers against decapentaplegic homolog 2

1

2

Small-scale

0.561

High

728656

RANB3
Ran-binding protein 3

1

0

Small-scale

0.554

High

496446

TAU
Microtubule-associated protein tau

2

1

High-throughput

0.552

High

728593

CAV2
Caveolin-2

2

0

High-throughput

0.547

High

383653

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

11

High-throughput

0.541

High

601473

FGFR2
Fibroblast growth factor receptor 2

1

9

High-throughput

0.541

High

601827

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

12

High-throughput

0.541

High

611384

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

2

High-throughput

0.541

High

728586

VGFR2
Vascular endothelial growth factor receptor 2

1

6

High-throughput

0.541

High

728600

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

11

High-throughput

0.541

High

728604

PTK7
Inactive tyrosine-protein kinase 7

1

4

High-throughput

0.541

High

728610

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

10

High-throughput

0.541

High

728626

LMTK1
Serine/threonine-protein kinase LMTK1

1

11

High-throughput

0.541

High

728631

LMTK2
Serine/threonine-protein kinase LMTK2

1

15

High-throughput

0.541

High

728673

ALK
ALK tyrosine kinase receptor

1

8

High-throughput

0.541

High

336394

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

601152

VDAC1
Voltage-dependent anion-selective channel protein 1

1

1

High-throughput

0.536

High

646686

1433T
14-3-3 protein theta

1

2

High-throughput

0.536

High

685816

ARRB2
Beta-arrestin-2

1

3

High-throughput

0.536

High

725721

SOAT1
Sterol O-acyltransferase 1

1

2

High-throughput

0.536

High

726501

TIMP3
Metalloproteinase inhibitor 3

1

1

High-throughput

0.536

High

728590

ARRB1
Beta-arrestin-1

1

3

High-throughput

0.536

High

728598

1433Z
14-3-3 protein zeta/delta

1

2

High-throughput

0.536

High

728606

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

1

High-throughput

0.536

High

728625

HSDL2
Hydroxysteroid dehydrogenase-like protein 2

1

1

High-throughput

0.536

High

728638

GCN1
Stalled ribosome sensor GCN1

1

2

High-throughput

0.536

High

728646

RB40C
Ras-related protein Rab-40C

1

1

High-throughput

0.536

High

728650

RSLBB
Ras-like protein family member 11B

1

1

High-throughput

0.536

High

728658

ARP5
Actin-related protein 5

1

2

High-throughput

0.536

High

728661

CABP2
Calcium-binding protein 2

1

3

High-throughput

0.536

High

728609

GRM3
Metabotropic glutamate receptor 3

1

0

Small-scale

0.529

High

400769

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.518

High

728605

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

2

High-throughput

0.515

High

157299

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

0

High-throughput

0.513

High

397293

ADT2
ADP/ATP translocase 2

1

0

High-throughput

0.513

High

524817

XRCC5
X-ray repair cross-complementing protein 5

1

0

High-throughput

0.513

High

728594

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

High-throughput

0.513

High

728619

TOIP1
Torsin-1A-interacting protein 1

1

0

High-throughput

0.513

High

728620

TMM31
Transmembrane protein 31

1

0

High-throughput

0.513

High

728630

SLN11
Schlafen family member 11

1

0

High-throughput

0.513

High

728632

DCP1B
mRNA-decapping enzyme 1B

1

0

High-throughput

0.513

High

728637

NEDD1
Protein NEDD1

1

0

High-throughput

0.513

High

728644

HSFY1
Heat shock transcription factor, Y-linked

1

0

High-throughput

0.513

High

728647

PIGS
GPI transamidase component PIG-S

1

0

High-throughput

0.513

High

728648

IWS1
Protein IWS1 homolog

1

0

High-throughput

0.513

High

728660

E41L5
Band 4.1-like protein 5

1

0

High-throughput

0.513

High

728665

FANCI
Fanconi anemia group I protein

1

0

High-throughput

0.513

High

728599

SMAD3
Mothers against decapentaplegic homolog 3

1

2

Small-scale

0.501

High

728608

RRP5
Protein RRP5 homolog

1

0

High-throughput

0.493

High

728642

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

1

High-throughput

0.489

High

728654

IL25
Interleukin-25

1

1

High-throughput

0.489

High

170611

AXIN1
Axin-1

1

0

Small-scale

0.479

High

241994

PAGE4
P antigen family member 4

1

1

High-throughput

0.479

High

411324

INSR
Insulin receptor

1

8

High-throughput

0.479

High

566947

CXA1
Gap junction alpha-1 protein

1

1

Small-scale

0.479

High

728597

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.479

High

728607

RBM39
RNA-binding protein 39

1

1

High-throughput

0.479

High

728612

SMAD1
Mothers against decapentaplegic homolog 1

1

2

Small-scale

0.479

High

728636

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.479

High

728641

BICD1
Protein bicaudal D homolog 1

1

1

High-throughput

0.479

High

728643

TRI47
E3 ubiquitin-protein ligase TRIM47

1

1

Small-scale

0.479

High

728651

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

1

High-throughput

0.479

High

728662

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

728664

DUS22
Dual specificity protein phosphatase 22

1

1

High-throughput

0.479

High

728671

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

728672

FBW1B
F-box/WD repeat-containing protein 11

1

2

High-throughput

0.479

High

728674

DUS12
Dual specificity protein phosphatase 12

1

1

High-throughput

0.479

High

148043

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

0

High-throughput

0.458

High

213494

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

0

Small-scale

0.458

High

552090

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

719829

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

728591

5NTC
Cytosolic purine 5'-nucleotidase

1

0

High-throughput

0.458

High

728616

SGO2
Shugoshin 2

1

0

Small-scale

0.458

High

728617

SGO1
Shugoshin 1

1

0

Small-scale

0.458

High

728623

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

728628

MOB2
MOB kinase activator 2

1

0

High-throughput

0.458

High

728645

ASB2
Ankyrin repeat and SOCS box protein 2

1

0

High-throughput

0.458

High

728649

INT14
Integrator complex subunit 14

1

0

High-throughput

0.458

High

728659

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

0

High-throughput

0.458

High

665159

EPHA2
Ephrin type-A receptor 2

1

3

High-throughput

0.457

High

377967

PRIO
Major prion protein

1

1

High-throughput

0.445

High

100549

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

728627

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

716824

CTNB1
Catenin beta-1

1

0

Small-scale

0.426

High

728639

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

0

Small-scale

0.426

High

728596

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

3

0

High-throughput

0.347

High

728618

RNS13
Probable inactive ribonuclease-like protein 13

3

0

High-throughput

0.347

High

165328

TCPR2
Tectonin beta-propeller repeat-containing protein 2

2

0

High-throughput

0.328

High

728614

MTEF2
Transcription termination factor 2, mitochondrial

2

0

High-throughput

0.328

High

728634

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

2

0

High-throughput

0.328

High

728676

INSL6
Insulin-like peptide INSL6

2

0

High-throughput

0.328

High

134726

CCL22
C-C motif chemokine 22

1

0

High-throughput

0.279

Low

307331

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.279

Low

728624

ISK14
Serine protease inhibitor Kazal-type 14

1

0

High-throughput

0.279

Low

728635

WFD11
Protein WFDC11

1

0

High-throughput

0.279

Low

728667

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

0

High-throughput

0.279

Low

728668

IL20
Interleukin-20

1

0

High-throughput

0.279

Low

728675

PA2GD
Group IID secretory phospholipase A2

1

0

High-throughput

0.279

Low

728652

LXN
Latexin

1

0

High-throughput

0.269

Low

728670

PEF1
Peflin

1

0

Small-scale

0.249

Low

728621

PRAM5
PRAME family member 5

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024