Protein: CDN1B
Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1)

Gene: CDN1B, CDKN1B
Organism: Homo sapiens
Interactions: 138
UniProt ID: P46527

Gene Ontology (top 5):
GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0001890 - placenta development
GO:0001934 - positive regulation of protein phosphorylation
GO:0004860 - protein kinase inhibitor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

625207

CDK2
Cyclin-dependent kinase 2

58

20

Small-scale

0.997

High

515368

CDK4
Cyclin-dependent kinase 4

31

20

Small-scale

0.993

High

624561

CCNE1
G1/S-specific cyclin-E1

25

20

Small-scale

0.991

High

622395

CCND1
G1/S-specific cyclin-D1

20

20

Small-scale

0.988

High

590142

CCNA2
Cyclin-A2

17

15

Small-scale

0.987

High

804106

CDK5
Cyclin-dependent kinase 5

11

20

Small-scale

0.983

High

673130

CCND3
G1/S-specific cyclin-D3

12

20

Small-scale

0.981

High

414811

CDK1
Cyclin-dependent kinase 1

11

20

Small-scale

0.979

High

804103

CCNA1
Cyclin-A1

8

15

Small-scale

0.968

High

804105

CDK6
Cyclin-dependent kinase 6

8

20

Small-scale

0.967

High

673038

CCND2
G1/S-specific cyclin-D2

6

20

Small-scale

0.952

High

538492

CCNB1
G2/mitotic-specific cyclin-B1

6

15

Small-scale

0.948

High

681728

AKT1
RAC-alpha serine/threonine-protein kinase

4

8

Small-scale

0.924

High

331632

CCNE2
G1/S-specific cyclin-E2

4

20

Small-scale

0.910

High

804104

CDK3
Cyclin-dependent kinase 3

4

20

High-throughput

0.903

High

804083

CDK7
Cyclin-dependent kinase 7

3

20

Small-scale

0.861

High

303836

CCNB2
G2/mitotic-specific cyclin-B2

2

15

High-throughput

0.811

High

804107

CDK16
Cyclin-dependent kinase 16

2

20

High-throughput

0.811

High

804126

KS6A1
Ribosomal protein S6 kinase alpha-1

1

8

Small-scale

0.785

High

804120

SKP2
S-phase kinase-associated protein 2

33

7

Small-scale

0.769

High

804145

CSN5
COP9 signalosome complex subunit 5

11

2

Small-scale

0.756

High

116983

SGK1
Serine/threonine-protein kinase Sgk1

1

6

Small-scale

0.735

High

804090

CKS1
Cyclin-dependent kinases regulatory subunit 1

6

3

Small-scale

0.731

High

800718

MK08
Mitogen-activated protein kinase 8

1

15

Small-scale

0.724

High

804124

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

1

1

Small-scale

0.724

High

804131

SPDYA
Speedy protein A

5

2

Small-scale

0.716

High

646711

1433T
14-3-3 protein theta

4

8

Small-scale

0.696

High

300630

CDK14
Cyclin-dependent kinase 14

1

20

High-throughput

0.691

High

610200

CCNO
Cyclin-O

1

20

High-throughput

0.691

High

804108

CDK17
Cyclin-dependent kinase 17

1

20

High-throughput

0.691

High

804141

CCNB3
G2/mitotic-specific cyclin-B3

1

17

High-throughput

0.691

High

804123

CUL4A
Cullin-4A

4

6

Small-scale

0.676

High

804122

CUL1
Cullin-1

4

6

Small-scale

0.674

High

804117

TRAF2
TNF receptor-associated factor 2

3

6

High-throughput

0.664

High

162484

XPO1
Exportin-1

4

0

Small-scale

0.662

High

683191

1433B
14-3-3 protein beta/alpha

3

8

Small-scale

0.655

High

167497

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

10

Small-scale

0.647

High

804088

MK10
Mitogen-activated protein kinase 10

1

12

Small-scale

0.647

High

804081

UB2R1
Ubiquitin-conjugating enzyme E2 R1

3

3

Small-scale

0.639

High

804093

1433E
14-3-3 protein epsilon

3

0

Small-scale

0.636

High

804091

RHOA
Transforming protein RhoA

2

1

Small-scale

0.634

High

706790

CKS2
Cyclin-dependent kinases regulatory subunit 2

2

3

High-throughput

0.628

High

507549

PIM1
Serine/threonine-protein kinase pim-1

1

9

Small-scale

0.618

High

804096

GRB2
Growth factor receptor-bound protein 2

2

5

Small-scale

0.613

High

804082

TSC2
Tuberin

2

3

Small-scale

0.612

High

168624

IMA6
Importin subunit alpha-6

2

8

Small-scale

0.611

High

433636

LYN
Tyrosine-protein kinase Lyn

1

4

Small-scale

0.608

High

804129

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

1

High-throughput

0.606

High

804148

ZN363
RING finger and CHY zinc finger domain-containing protein 1

2

0

Small-scale

0.598

High

522849

SRC
Proto-oncogene tyrosine-protein kinase Src

1

4

Small-scale

0.598

High

804100

UBC9
SUMO-conjugating enzyme UBC9

2

5

Small-scale

0.595

High

804132

RN123
E3 ubiquitin-protein ligase RNF123

2

2

Small-scale

0.595

High

804159

ARI1
E3 ubiquitin-protein ligase ARIH1

2

3

Small-scale

0.585

High

804112

1433F
14-3-3 protein eta

2

8

Small-scale

0.584

High

708833

MCM7
DNA replication licensing factor MCM7

1

3

Small-scale

0.582

High

238381

JAK2
Tyrosine-protein kinase JAK2

1

7

Small-scale

0.578

High

804139

COP1
E3 ubiquitin-protein ligase COP1

1

2

Small-scale

0.578

High

804143

KAT2B
Histone acetyltransferase KAT2B

1

1

Small-scale

0.578

High

804158

RNF6
E3 ubiquitin-protein ligase RNF6

1

1

Small-scale

0.578

High

238643

IMA7
Importin subunit alpha-7

1

8

Small-scale

0.561

High

804086

IMA5
Importin subunit alpha-5

1

8

Small-scale

0.561

High

804113

UBE3A
Ubiquitin-protein ligase E3A

1

3

Small-scale

0.561

High

594471

PSB1
Proteasome subunit beta type-1

1

0

Small-scale

0.554

High

771811

VHL
von Hippel-Lindau disease tumor suppressor

1

2

Small-scale

0.552

High

804121

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

Small-scale

0.537

High

804136

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

Small-scale

0.537

High

804152

GNL3
Guanine nucleotide-binding protein-like 3

1

0

Small-scale

0.537

High

123875

SPT5H
Transcription elongation factor SPT5

1

1

High-throughput

0.536

High

717534

BMI1
Polycomb complex protein BMI-1

1

4

High-throughput

0.536

High

804146

ARL11
ADP-ribosylation factor-like protein 11

1

1

High-throughput

0.536

High

804150

CAB45
45 kDa calcium-binding protein

1

1

High-throughput

0.536

High

346179

MYC
Myc proto-oncogene protein

1

0

Small-scale

0.529

High

804156

NUP50
Nuclear pore complex protein Nup50

1

1

Small-scale

0.527

High

501013

IRF1
Interferon regulatory factor 1

1

0

High-throughput

0.518

High

804087

GDIR1
Rho GDP-dissociation inhibitor 1

1

0

High-throughput

0.518

High

562899

STMN1
Stathmin

1

2

Small-scale

0.515

High

153893

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

0

High-throughput

0.513

High

180830

YKT6
Synaptobrevin homolog YKT6

1

0

High-throughput

0.513

High

282041

CLPX
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial

1

0

High-throughput

0.513

High

396327

APOD
Apolipoprotein D

1

0

High-throughput

0.513

High

518966

PIP
Prolactin-inducible protein

1

0

High-throughput

0.513

High

804109

TAGL
Transgelin

1

0

High-throughput

0.513

High

804147

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

0

High-throughput

0.513

High

134849

IMA3
Importin subunit alpha-3

1

8

Small-scale

0.501

High

337390

ABL1
Tyrosine-protein kinase ABL1

1

4

Small-scale

0.501

High

433281

YES
Tyrosine-protein kinase Yes

1

4

Small-scale

0.501

High

559012

H15
Histone H1.5

1

2

Small-scale

0.501

High

804094

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

2

Small-scale

0.501

High

804097

1433Z
14-3-3 protein zeta/delta

1

8

Small-scale

0.501

High

804098

UBE2B
Ubiquitin-conjugating enzyme E2 B

1

2

Small-scale

0.501

High

804101

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

3

Small-scale

0.501

High

804110

H11
Histone H1.1

1

2

Small-scale

0.501

High

131399

IMA4
Importin subunit alpha-4

1

8

Small-scale

0.500

High

804157

SCML2
Sex comb on midleg-like protein 2

1

1

Small-scale

0.500

High

456523

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

0

Small-scale

0.493

High

804080

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.493

High

804142

TSC1
Hamartin

1

0

Small-scale

0.493

High

804137

BANP
Protein BANP

1

0

High-throughput

0.493

High

804155

THAP1
THAP domain-containing protein 1

1

0

High-throughput

0.493

High

804099

SKP1
S-phase kinase-associated protein 1

2

3

Small-scale

0.492

High

804095

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.480

High

804149

DCR1C
Protein artemis

1

0

Small-scale

0.480

High

804151

UBAC1
Ubiquitin-associated domain-containing protein 1

1

0

Small-scale

0.480

High

125226

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

Small-scale

0.479

High

475466

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

6

Small-scale

0.479

High

503635

HSP7C
Heat shock cognate 71 kDa protein

1

4

Small-scale

0.479

High

575322

EGR1
Early growth response protein 1

1

3

High-throughput

0.479

High

584897

RO52
E3 ubiquitin-protein ligase TRIM21

1

3

Small-scale

0.479

High

683889

1433S
14-3-3 protein sigma

1

8

Small-scale

0.479

High

804089

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

804092

1433G
14-3-3 protein gamma

1

8

Small-scale

0.479

High

804102

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

Small-scale

0.479

High

804114

ACK1
Activated CDC42 kinase 1

1

7

Small-scale

0.479

High

804115

EP300
Histone acetyltransferase p300

1

3

Small-scale

0.479

High

804116

CDC20
Cell division cycle protein 20 homolog

1

2

Small-scale

0.479

High

804118

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

Small-scale

0.479

High

804119

TIF1B
Transcription intermediary factor 1-beta

1

4

Small-scale

0.479

High

804125

CD5R1
Cyclin-dependent kinase 5 activator 1

1

1

Small-scale

0.479

High

804127

DDB1
DNA damage-binding protein 1

1

5

Small-scale

0.479

High

804128

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

3

Small-scale

0.479

High

804130

SPDYC
Speedy protein C

1

2

Small-scale

0.479

High

804133

CSN6
COP9 signalosome complex subunit 6

1

1

Small-scale

0.479

High

804135

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

1

Small-scale

0.479

High

804138

SPDE1
Speedy protein E1

1

2

Small-scale

0.479

High

804144

CELF1
CUGBP Elav-like family member 1

1

2

Small-scale

0.479

High

804154

CSN7B
COP9 signalosome complex subunit 7b

1

1

Small-scale

0.479

High

556807

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.458

High

804084

BAP31
B-cell receptor-associated protein 31

1

0

Small-scale

0.458

High

804111

PAX5
Paired box protein Pax-5

1

0

Small-scale

0.458

High

804134

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

0

Small-scale

0.458

High

804140

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

804153

TXNIP
Thioredoxin-interacting protein

1

0

Small-scale

0.458

High

804085

IMA1
Importin subunit alpha-1

1

8

Small-scale

0.445

High

377980

PRIO
Major prion protein

1

0

High-throughput

0.426

High

496521

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

264498

LRCH4
Leucine-rich repeat and calponin homology domain-containing protein 4

1

0

High-throughput

0.279

Low

586097

A1AG2
Alpha-1-acid glycoprotein 2

1

0

High-throughput

0.279

Low

100575

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024