Protein: MAPK2
MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1)

Gene: MAPK2, MAPKAPK2
Organism: Homo sapiens
Interactions: 111
UniProt ID: P49137

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0002224 - toll-like receptor signaling pathway
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004683 - calmodulin-dependent protein kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

824641

MK14
Mitogen-activated protein kinase 14

19

20

Small-scale

0.991

High

824640

MK11
Mitogen-activated protein kinase 11

4

20

Small-scale

0.903

High

824615

MAPK2
MAP kinase-activated protein kinase 2

4

16

Small-scale

0.879

High

658848

MK01
Mitogen-activated protein kinase 1

4

20

Small-scale

0.878

High

681736

AKT1
RAC-alpha serine/threonine-protein kinase

2

15

Small-scale

0.834

High

824642

MAPK3
MAP kinase-activated protein kinase 3

2

17

High-throughput

0.811

High

824653

PHC2
Polyhomeotic-like protein 2

2

4

Small-scale

0.800

High

647511

MK03
Mitogen-activated protein kinase 3

2

20

Small-scale

0.767

High

388304

HSPB1
Heat shock protein beta-1

17

9

Small-scale

0.764

High

226829

PRKN
E3 ubiquitin-protein ligase parkin

2

13

High-throughput

0.754

High

824620

LIMK1
LIM domain kinase 1

1

20

Small-scale

0.735

High

824619

PLK1
Serine/threonine-protein kinase PLK1

1

19

Small-scale

0.724

High

824623

CSK2B
Casein kinase II subunit beta

1

4

Small-scale

0.713

High

824651

MAPK5
MAP kinase-activated protein kinase 5

1

16

Small-scale

0.713

High

596726

CD11B
Cyclin-dependent kinase 11B

1

10

High-throughput

0.691

High

824633

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

8

High-throughput

0.691

High

824637

DHX8
ATP-dependent RNA helicase DHX8

1

1

High-throughput

0.691

High

824638

ZN638
Zinc finger protein 638

1

1

High-throughput

0.691

High

824639

SAFB1
Scaffold attachment factor B1

1

2

High-throughput

0.691

High

824675

SLTM
SAFB-like transcription modulator

1

2

High-throughput

0.691

High

824678

CDK12
Cyclin-dependent kinase 12

1

14

High-throughput

0.691

High

824654

SREK1
Splicing regulatory glutamine/lysine-rich protein 1

1

0

High-throughput

0.656

High

516410

PABP1
Polyadenylate-binding protein 1

1

1

Small-scale

0.647

High

673374

MPIP1
M-phase inducer phosphatase 1

1

2

Small-scale

0.647

High

673456

MPIP2
M-phase inducer phosphatase 2

1

2

Small-scale

0.647

High

682149

AKT2
RAC-beta serine/threonine-protein kinase

1

15

Small-scale

0.647

High

824618

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

14

Small-scale

0.647

High

824631

ROA0
Heterogeneous nuclear ribonucleoprotein A0

1

5

Small-scale

0.647

High

148528

CTRO
Citron Rho-interacting kinase

1

10

High-throughput

0.618

High

824624

HSF1
Heat shock factor protein 1

1

1

Small-scale

0.615

High

456310

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

1

Small-scale

0.602

High

644235

TTP
mRNA decay activator protein ZFP36

2

2

Small-scale

0.602

High

824625

MDM2
E3 ubiquitin-protein ligase Mdm2

2

2

Small-scale

0.602

High

824628

TISB
mRNA decay activator protein ZFP36L1

2

2

Small-scale

0.602

High

776605

STAT3
Signal transducer and activator of transcription 3

2

3

High-throughput

0.594

High

217860

PRKY
Putative serine/threonine-protein kinase PRKY

1

12

High-throughput

0.575

High

666041

SHC1
SHC-transforming protein 1

1

6

Small-scale

0.573

High

571354

DDX5
Probable ATP-dependent RNA helicase DDX5

1

2

Small-scale

0.561

High

824622

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.536

High

263558

PR40A
Pre-mRNA-processing factor 40 homolog A

1

2

High-throughput

0.536

High

317817

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

1

1

High-throughput

0.536

High

369178

ESR1
Estrogen receptor

1

7

High-throughput

0.536

High

820847

PRC2A
Protein PRRC2A

1

3

High-throughput

0.536

High

824616

YLPM1
YLP motif-containing protein 1

1

1

High-throughput

0.536

High

824634

CUL3
Cullin-3

1

4

High-throughput

0.536

High

824645

DDX46
Probable ATP-dependent RNA helicase DDX46

1

2

High-throughput

0.536

High

824648

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

3

High-throughput

0.536

High

824656

PHF3
PHD finger protein 3

1

3

High-throughput

0.536

High

824658

CSN5
COP9 signalosome complex subunit 5

1

2

High-throughput

0.536

High

824664

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

14

High-throughput

0.536

High

824665

SCAFB
Protein SCAF11

1

1

High-throughput

0.536

High

824666

DIDO1
Death-inducer obliterator 1

1

5

High-throughput

0.536

High

824670

WDR33
pre-mRNA 3' end processing protein WDR33

1

1

High-throughput

0.536

High

824672

BRD9
Bromodomain-containing protein 9

1

6

High-throughput

0.536

High

824674

DDX21
Nucleolar RNA helicase 2

1

4

High-throughput

0.536

High

824679

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

1

High-throughput

0.536

High

824682

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

1

High-throughput

0.536

High

824685

PRC2C
Protein PRRC2C

1

4

High-throughput

0.536

High

181304

ARPC5
Actin-related protein 2/3 complex subunit 5

1

0

Small-scale

0.513

High

230324

ZC3H1
Zinc finger C3H1 domain-containing protein

1

0

High-throughput

0.513

High

722191

RFC1
Replication factor C subunit 1

1

0

High-throughput

0.513

High

824630

SFSWA
Splicing factor, suppressor of white-apricot homolog

1

0

High-throughput

0.513

High

824647

HDGR2
Hepatoma-derived growth factor-related protein 2

1

0

High-throughput

0.513

High

824649

CIR1
Corepressor interacting with RBPJ 1

1

0

High-throughput

0.513

High

824650

SPAS2
Spermatogenesis-associated serine-rich protein 2

1

0

High-throughput

0.513

High

824652

SUGP2
SURP and G-patch domain-containing protein 2

1

0

High-throughput

0.513

High

824661

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

High-throughput

0.513

High

824663

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

0

High-throughput

0.513

High

824669

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

0

High-throughput

0.513

High

824683

WBP11
WW domain-binding protein 11

1

0

High-throughput

0.513

High

824686

PAXB1
PAX3- and PAX7-binding protein 1

1

0

High-throughput

0.513

High

551483

TFE2
Transcription factor E2-alpha

1

1

Small-scale

0.501

High

579131

ATF1
Cyclic AMP-dependent transcription factor ATF-1

1

9

Small-scale

0.501

High

703461

LSP1
Lymphocyte-specific protein 1

1

1

Small-scale

0.501

High

824617

ETV1
ETS translocation variant 1

1

1

Small-scale

0.501

High

824636

BECN1
Beclin-1

1

1

Small-scale

0.501

High

824643

CPZIP
CapZ-interacting protein

1

1

Small-scale

0.501

High

824655

WASF1
Actin-binding protein WASF1

1

6

Small-scale

0.501

High

824680

AGO2
Protein argonaute-2

1

1

Small-scale

0.501

High

824681

CP131
Centrosomal protein of 131 kDa

1

2

Small-scale

0.501

High

824684

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

3

Small-scale

0.501

High

534289

MTDC
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase

1

1

High-throughput

0.489

High

824673

MTD2L
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial

1

1

High-throughput

0.489

High

278247

PIAS2
E3 SUMO-protein ligase PIAS2

1

0

Small-scale

0.480

High

314612

PARN
Poly(A)-specific ribonuclease PARN

1

0

Small-scale

0.480

High

824629

B2CL1
Bcl-2-like protein 1

1

0

Small-scale

0.480

High

824632

TIF1B
Transcription intermediary factor 1-beta

1

0

Small-scale

0.480

High

824677

AATF
Protein AATF

1

0

Small-scale

0.480

High

162506

XPO1
Exportin-1

1

3

High-throughput

0.479

High

203104

P52K
52 kDa repressor of the inhibitor of the protein kinase

1

1

Small-scale

0.479

High

278920

SPF30
Survival of motor neuron-related-splicing factor 30

1

1

High-throughput

0.479

High

483782

HS71B
Heat shock 70 kDa protein 1B

1

5

High-throughput

0.479

High

650643

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

824621

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

4

High-throughput

0.479

High

824627

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.479

High

824657

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

824660

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

824671

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.479

High

569061

DESM
Desmin

1

0

Small-scale

0.460

High

824659

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.458

High

824662

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

824676

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.458

High

824635

TRI29
Tripartite motif-containing protein 29

1

3

Small-scale

0.457

High

100585

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

351987

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

824644

RBM43
RNA-binding protein 43

1

0

High-throughput

0.279

Low

824646

RSRC2
Arginine/serine-rich coiled-coil protein 2

1

0

High-throughput

0.279

Low

824667

TTPAL
Alpha-tocopherol transfer protein-like

1

0

High-throughput

0.279

Low

824668

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.279

Low

824626

DEF6
Defensin-6

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024