Protein: SYYC
Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed]

Gene: SYYC, YARS1
Organism: Homo sapiens
Interactions: 138
UniProt ID: P54577

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0003723 - RNA binding
GO:0004831 - tyrosine-tRNA ligase activity
GO:0005153 - interleukin-8 receptor binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

870624

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

9

Small-scale

0.647

High

664058

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.602

High

870688

TRIM5
Tripartite motif-containing protein 5

2

0

High-throughput

0.602

High

870629

CDC42
Cell division control protein 42 homolog

2

6

High-throughput

0.595

High

226964

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

779085

CCNF
Cyclin-F

2

0

High-throughput

0.576

High

581573

VCAM1
Vascular cell adhesion protein 1

2

1

High-throughput

0.571

High

870648

HAPR1
HUWE1-associated protein modifying stress responses 1

2

0

Small-scale

0.559

High

870702

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

1

High-throughput

0.541

High

270773

FOXH1
Forkhead box protein H1

1

4

High-throughput

0.536

High

452695

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

870627

FOXL2
Forkhead box protein L2

1

3

High-throughput

0.536

High

870636

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

1

High-throughput

0.536

High

870641

FOXL1
Forkhead box protein L1

1

3

High-throughput

0.536

High

870659

FOXI2
Forkhead box protein I2

1

3

High-throughput

0.536

High

870683

FOXB1
Forkhead box protein B1

1

4

High-throughput

0.536

High

870687

FOXQ1
Forkhead box protein Q1

1

5

High-throughput

0.536

High

455259

PARP1
Poly [ADP-ribose] polymerase 1

1

5

Small-scale

0.515

High

637231

CATS
Cathepsin S

1

2

High-throughput

0.515

High

870633

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.515

High

870699

MAGC2
Melanoma-associated antigen C2

1

2

High-throughput

0.515

High

799897

ABCG1
ATP-binding cassette sub-family G member 1

1

0

High-throughput

0.513

High

870681

SORT
Sortilin

1

0

High-throughput

0.513

High

174748

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

369246

ESR1
Estrogen receptor

1

1

Small-scale

0.501

High

127749

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.493

High

239539

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.493

High

870626

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.493

High

278002

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

High-throughput

0.493

High

563394

ZNF20
Zinc finger protein 20

1

0

High-throughput

0.493

High

870647

CBX2
Chromobox protein homolog 2

1

0

High-throughput

0.493

High

870662

ANR23
Ankyrin repeat domain-containing protein 23

1

0

High-throughput

0.493

High

870668

SLN12
Ribonuclease SLFN12

1

0

High-throughput

0.493

High

870669

TCAL8
Transcription elongation factor A protein-like 8

1

0

High-throughput

0.493

High

870673

CEP70
Centrosomal protein of 70 kDa

1

0

High-throughput

0.493

High

870680

ASB9
Ankyrin repeat and SOCS box protein 9

1

0

High-throughput

0.493

High

870685

SPAG8
Sperm-associated antigen 8

1

0

High-throughput

0.493

High

870689

GHITM
Growth hormone-inducible transmembrane protein

1

0

High-throughput

0.493

High

870705

CSN3
COP9 signalosome complex subunit 3

1

0

High-throughput

0.493

High

870640

REL
Proto-oncogene c-Rel

1

1

High-throughput

0.481

High

244168

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

308531

KI20A
Kinesin-like protein KIF20A

1

3

High-throughput

0.479

High

328783

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.479

High

362969

FINC
Fibronectin

1

1

High-throughput

0.479

High

384555

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

411653

LCK
Tyrosine-protein kinase Lck

1

1

High-throughput

0.479

High

429858

CATL1
Procathepsin L

1

2

High-throughput

0.479

High

431195

CATB
Cathepsin B

1

3

High-throughput

0.479

High

544951

AMPN
Aminopeptidase N

1

1

High-throughput

0.479

High

552328

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

569456

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

583441

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

598023

FLNA
Filamin-A

1

1

High-throughput

0.479

High

625265

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.479

High

650772

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

666564

LTK
Leukocyte tyrosine kinase receptor

1

4

High-throughput

0.479

High

737280

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.479

High

835605

GSK3B
Glycogen synthase kinase-3 beta

1

3

High-throughput

0.479

High

852413

RND2
Rho-related GTP-binding protein RhoN

1

7

High-throughput

0.479

High

870630

RHOA
Transforming protein RhoA

1

6

High-throughput

0.479

High

870631

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.479

High

870632

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

870634

H4
Histone H4

1

1

High-throughput

0.479

High

870635

RAC1
Ras-related C3 botulinum toxin substrate 1

1

6

High-throughput

0.479

High

870642

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.479

High

870643

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

870645

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

3

High-throughput

0.479

High

870646

RBM39
RNA-binding protein 39

1

1

High-throughput

0.479

High

870649

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

870650

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

870651

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

870652

RHOH
Rho-related GTP-binding protein RhoH

1

7

High-throughput

0.479

High

870653

CCDC6
Coiled-coil domain-containing protein 6

1

1

High-throughput

0.479

High

870660

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

870661

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

870676

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

870677

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.479

High

870679

OPTN
Optineurin

1

3

High-throughput

0.479

High

870682

NECD
Necdin

1

2

High-throughput

0.479

High

870684

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

870686

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

870691

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

870692

WDR76
WD repeat-containing protein 76

1

3

High-throughput

0.479

High

870693

RHOF
Rho-related GTP-binding protein RhoF

1

8

High-throughput

0.479

High

870694

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

1

High-throughput

0.479

High

870696

ANLN
Anillin

1

2

High-throughput

0.479

High

870697

TMPS4
Transmembrane protease serine 4

1

3

High-throughput

0.479

High

870700

TRM7
tRNA

1

2

High-throughput

0.479

High

870701

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

870703

ANC2
Anaphase-promoting complex subunit 2

1

2

High-throughput

0.479

High

870706

FND3A
Fibronectin type-III domain-containing protein 3A

1

2

High-throughput

0.479

High

870707

TRAF6
TNF receptor-associated factor 6

1

2

High-throughput

0.479

High

726101

BASI
Basigin

1

1

High-throughput

0.470

High

870656

CD158
Coiled-coil domain-containing protein 158

1

1

High-throughput

0.470

High

870658

S27A4
Long-chain fatty acid transport protein 4

1

2

High-throughput

0.470

High

155308

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

326534

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

338180

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

398842

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.458

High

750194

COIL
Coilin

1

0

High-throughput

0.458

High

832262

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

870625

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

870628

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

0

High-throughput

0.458

High

870637

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

870644

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

870655

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

0

High-throughput

0.458

High

870657

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

870666

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

870670

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.458

High

870671

ANR35
Ankyrin repeat domain-containing protein 35

1

0

High-throughput

0.458

High

870678

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

870695

DCP1A
mRNA-decapping enzyme 1A

1

0

High-throughput

0.458

High

870698

DYH1
Dynein axonemal heavy chain 1

1

0

High-throughput

0.458

High

330927

PAK4
Serine/threonine-protein kinase PAK 4

1

2

High-throughput

0.445

High

401695

JUN
Transcription factor Jun

1

6

High-throughput

0.445

High

496635

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

100622

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

177850

TMPS2
Transmembrane protease serine 2

1

3

High-throughput

0.437

High

525880

IFM1
Interferon-induced transmembrane protein 1

1

3

High-throughput

0.437

High

530529

ITA4
Integrin alpha-4

1

1

High-throughput

0.437

High

648694

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.437

High

720060

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

823753

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.437

High

870638

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.437

High

870654

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

3

High-throughput

0.437

High

870663

TM11B
Transmembrane protease serine 11B

1

3

High-throughput

0.437

High

870664

RM52
Large ribosomal subunit protein mL52

1

1

High-throughput

0.437

High

870675

CLC4D
C-type lectin domain family 4 member D

1

3

High-throughput

0.437

High

870690

RHOJ
Rho-related GTP-binding protein RhoJ

1

6

High-throughput

0.437

High

870704

CLC4E
C-type lectin domain family 4 member E

1

3

High-throughput

0.437

High

870639

TAGL
Transgelin

1

0

High-throughput

0.426

High

870667

TM192
Transmembrane protein 192

1

0

High-throughput

0.279

Low

740640

HPCL1
Hippocalcin-like protein 1

1

0

High-throughput

0.268

Low

870665

Q86V28
AP-1 complex subunit gamma

1

0

High-throughput

0.268

Low

870672

PACRL
PACRG-like protein

1

0

High-throughput

0.268

Low

870674

ATLA1
Atlastin-1

1

0

High-throughput

0.268

Low

456833

FURIN
Furin

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024