Protein: UBE2K
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)

Gene: UBE2K
Organism: Homo sapiens
Interactions: 151
UniProt ID: P61086

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

475551

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

21

20

Small-scale

0.989

High

896344

RN138
E3 ubiquitin-protein ligase RNF138

10

20

Small-scale

0.980

High

607041

UBA1
Ubiquitin-like modifier-activating enzyme 1

9

20

Small-scale

0.971

High

896364

RNF5
E3 ubiquitin-protein ligase RNF5

5

20

High-throughput

0.931

High

896297

UBC9
SUMO-conjugating enzyme UBC9

5

15

Small-scale

0.919

High

896336

DTX3
Probable E3 ubiquitin-protein ligase DTX3

4

20

High-throughput

0.904

High

749302

BRCA1
Breast cancer type 1 susceptibility protein

4

20

Small-scale

0.901

High

896302

RING1
E3 ubiquitin-protein ligase RING1

4

20

High-throughput

0.892

High

896370

TRIM5
Tripartite motif-containing protein 5

4

20

High-throughput

0.892

High

896398

TRI35
E3 ubiquitin-protein ligase TRIM35

4

20

High-throughput

0.892

High

896300

MDM2
E3 ubiquitin-protein ligase Mdm2

4

15

Small-scale

0.885

High

896353

RN185
E3 ubiquitin-protein ligase RNF185

4

20

Small-scale

0.885

High

896360

RING2
E3 ubiquitin-protein ligase RING2

3

20

Small-scale

0.872

High

896325

RN111
E3 ubiquitin-protein ligase Arkadia

3

20

High-throughput

0.849

High

896377

RN167
E3 ubiquitin-protein ligase RNF167

3

20

Small-scale

0.849

High

896388

APC11
Anaphase-promoting complex subunit 11

3

20

Small-scale

0.845

High

175659

TRI18
E3 ubiquitin-protein ligase Midline-1

3

20

High-throughput

0.845

High

896304

MKRN3
Probable E3 ubiquitin-protein ligase makorin-3

2

18

High-throughput

0.783

High

896330

TRI50
E3 ubiquitin-protein ligase TRIM50

2

20

High-throughput

0.783

High

896339

DTX3L
E3 ubiquitin-protein ligase DTX3L

2

20

High-throughput

0.783

High

896346

RN166
E3 ubiquitin-protein ligase RNF166

2

20

High-throughput

0.783

High

896349

BIRC7
Baculoviral IAP repeat-containing protein 7

2

20

High-throughput

0.783

High

896365

TRAIP
E3 ubiquitin-protein ligase TRAIP

2

9

High-throughput

0.783

High

896367

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

2

20

High-throughput

0.783

High

896371

TRIM2
Tripartite motif-containing protein 2

2

20

High-throughput

0.783

High

896374

RNF32
RING finger protein 32

2

1

High-throughput

0.783

High

896376

RNF41
E3 ubiquitin-protein ligase NRDP1

2

20

High-throughput

0.783

High

896394

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

20

High-throughput

0.783

High

896396

CBLC
E3 ubiquitin-protein ligase CBL-C

2

20

High-throughput

0.783

High

896402

RN114
E3 ubiquitin-protein ligase RNF114

2

20

High-throughput

0.783

High

896355

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

20

Small-scale

0.778

High

896359

NED4L
E3 ubiquitin-protein ligase NEDD4-like

2

20

Small-scale

0.778

High

896385

RNF12
E3 ubiquitin-protein ligase RLIM

2

20

Small-scale

0.778

High

896352

RN125
E3 ubiquitin-protein ligase RNF125

2

20

High-throughput

0.768

High

474976

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

20

Small-scale

0.768

High

791441

HD
Huntingtin

6

2

Small-scale

0.732

High

896381

TRI39
E3 ubiquitin-protein ligase TRIM39

5

20

High-throughput

0.721

High

536773

TRI27
Zinc finger protein RFP

5

20

High-throughput

0.720

High

896378

MARH7
E3 ubiquitin-protein ligase MARCHF7

5

20

Small-scale

0.710

High

896296

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

20

High-throughput

0.691

High

896369

TRI31
E3 ubiquitin-protein ligase TRIM31

4

20

High-throughput

0.691

High

896389

BFAR
Bifunctional apoptosis regulator

4

20

High-throughput

0.691

High

896333

SIAH1
E3 ubiquitin-protein ligase SIAH1

3

20

High-throughput

0.680

High

896324

DUSTY
Dual serine/threonine and tyrosine protein kinase

1

3

High-throughput

0.665

High

896294

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

4

High-throughput

0.665

High

896312

NEDD8
NEDD8

1

15

High-throughput

0.665

High

896319

Q6PIA0
Baculoviral IAP repeat-containing 8

1

20

High-throughput

0.665

High

896341

DDI1
Protein DDI1 homolog 1

1

6

High-throughput

0.662

High

896301

REL
Proto-oncogene c-Rel

2

7

High-throughput

0.651

High

125301

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

20

Small-scale

0.647

High

227031

PRKN
E3 ubiquitin-protein ligase parkin

1

20

Small-scale

0.647

High

896305

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

13

Small-scale

0.647

High

896315

RN213
E3 ubiquitin-protein ligase RNF213

1

3

Small-scale

0.647

High

896337

PJA1
E3 ubiquitin-protein ligase Praja-1

1

20

Small-scale

0.647

High

896345

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

Small-scale

0.647

High

896351

RNF31
E3 ubiquitin-protein ligase RNF31

1

20

Small-scale

0.647

High

896372

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

20

Small-scale

0.647

High

896379

RC3H2
Roquin-2

1

10

Small-scale

0.647

High

896380

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

20

Small-scale

0.647

High

896395

AMFR
E3 ubiquitin-protein ligase AMFR

1

20

Small-scale

0.647

High

896397

FZR1
Fizzy-related protein homolog

1

7

Small-scale

0.647

High

896338

MIPO1
Mirror-image polydactyly gene 1 protein

3

0

High-throughput

0.646

High

896400

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

High-throughput

0.630

High

896382

DBLOH
Diablo IAP-binding mitochondrial protein

2

1

Small-scale

0.629

High

896334

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

High-throughput

0.622

High

301048

RNF37
RING finger protein 37

1

7

High-throughput

0.621

High

842098

R144A
E3 ubiquitin-protein ligase RNF144A

1

20

High-throughput

0.621

High

896299

RNF4
E3 ubiquitin-protein ligase RNF4

1

20

High-throughput

0.621

High

896320

TRAF7
E3 ubiquitin-protein ligase TRAF7

1

10

High-throughput

0.621

High

896321

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

8

High-throughput

0.621

High

896328

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

9

High-throughput

0.621

High

896331

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

20

High-throughput

0.621

High

896357

BIRC8
Baculoviral IAP repeat-containing protein 8

1

20

High-throughput

0.621

High

896358

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

10

High-throughput

0.621

High

896366

TRI34
E3 ubiquitin-protein ligase TRIM34

1

20

High-throughput

0.621

High

896373

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

18

High-throughput

0.621

High

896295

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

20

High-throughput

0.618

High

896306

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

7

High-throughput

0.618

High

896326

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

896393

HERC5
E3 ISG15--protein ligase HERC5

1

20

Small-scale

0.618

High

131822

KRIT1
Krev interaction trapped protein 1

2

4

High-throughput

0.606

High

132806

SDCB1
Syntenin-1

2

3

High-throughput

0.606

High

624419

CCNC
Cyclin-C

2

4

High-throughput

0.606

High

896329

MARH3
E3 ubiquitin-protein ligase MARCHF3

2

20

High-throughput

0.606

High

896335

RN182
E3 ubiquitin-protein ligase RNF182

2

20

High-throughput

0.606

High

896348

TRI43
Tripartite motif-containing protein 43

2

20

High-throughput

0.606

High

896383

PICK1
PRKCA-binding protein

2

2

High-throughput

0.606

High

771864

VHL
von Hippel-Lindau disease tumor suppressor

2

4

High-throughput

0.601

High

896375

VPS11
Vacuolar protein sorting-associated protein 11 homolog

1

4

High-throughput

0.594

High

896403

NUB1
NEDD8 ultimate buster 1

1

0

Small-scale

0.589

High

484883

ZTRF1
Zinc finger TRAF-type-containing protein 1

2

20

High-throughput

0.584

High

641363

PAX6
Paired box protein Pax-6

2

0

High-throughput

0.580

High

896307

EXOS7
Exosome complex component RRP42

2

0

High-throughput

0.580

High

896310

TSN
Translin

2

0

High-throughput

0.580

High

896350

RN183
E3 ubiquitin-protein ligase RNF183

2

0

High-throughput

0.580

High

896314

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.575

High

896387

ARL15
ADP-ribosylation factor-like protein 15

2

1

High-throughput

0.574

High

386415

P53
Cellular tumor antigen p53

1

7

Small-scale

0.552

High

452708

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

896363

CDC6
Cell division control protein 6 homolog

1

0

High-throughput

0.518

High

538506

CCNB1
G2/mitotic-specific cyclin-B1

1

2

Small-scale

0.515

High

727352

DEK
Protein DEK

1

1

High-throughput

0.515

High

235779

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

2

High-throughput

0.515

High

281588

WFS1
Wolframin

1

1

High-throughput

0.515

High

896303

TP53B
TP53-binding protein 1

1

4

High-throughput

0.515

High

896316

ADAL
Adenosine deaminase-like protein

1

1

High-throughput

0.515

High

896317

Q6FHY5
MEOX2 protein

1

3

High-throughput

0.515

High

896347

SPSB1
SPRY domain-containing SOCS box protein 1

1

13

High-throughput

0.515

High

896361

SPSB2
SPRY domain-containing SOCS box protein 2

1

9

High-throughput

0.515

High

896386

DDIT4
DNA damage-inducible transcript 4 protein

1

1

High-throughput

0.515

High

896401

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

1

High-throughput

0.515

High

896309

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

896311

ITSN1
Intersectin-1

1

4

High-throughput

0.508

High

296286

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

5

Small-scale

0.501

High

321881

RIGI
Antiviral innate immune response receptor RIG-I

1

4

Small-scale

0.501

High

896323

CASPC
Inactive caspase-12

1

1

Small-scale

0.501

High

896362

BARD1
BRCA1-associated RING domain protein 1

1

12

Small-scale

0.501

High

896332

ZDH17
Palmitoyltransferase ZDHHC17

1

8

High-throughput

0.494

High

174285

TELT
Telethonin

1

0

High-throughput

0.493

High

285158

DXO
Decapping and exoribonuclease protein

1

0

High-throughput

0.493

High

456531

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

0

High-throughput

0.493

High

896342

BRK1
Protein BRICK1

1

0

High-throughput

0.493

High

896343

PRUN2
Protein prune homolog 2

1

0

High-throughput

0.493

High

896356

HSFY1
Heat shock transcription factor, Y-linked

1

0

High-throughput

0.493

High

837903

MEOX2
Homeobox protein MOX-2

1

3

High-throughput

0.481

High

896390

SENP1
Sentrin-specific protease 1

1

0

Small-scale

0.480

High

244198

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.479

High

324312

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

496699

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.479

High

503799

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

532462

TCTP
Translationally-controlled tumor protein

1

5

High-throughput

0.479

High

607621

NDKB
Nucleoside diphosphate kinase B

1

1

High-throughput

0.479

High

650836

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

779133

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

896298

H31
Histone H3.1

1

4

Small-scale

0.479

High

896308

SETB1
Histone-lysine N-methyltransferase SETDB1

1

3

Small-scale

0.479

High

896384

HELLS
Lymphoid-specific helicase

1

2

Small-scale

0.479

High

896392

ZRAN1
Ubiquitin thioesterase ZRANB1

1

16

High-throughput

0.479

High

263578

PR40A
Pre-mRNA-processing factor 40 homolog A

1

20

High-throughput

0.464

High

896340

ZN384
Zinc finger protein 384

1

0

High-throughput

0.460

High

896391

NXF1
Nuclear RNA export factor 1

1

0

Small-scale

0.458

High

354395

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.437

High

896399

XCT
Cystine/glutamate transporter

1

1

Small-scale

0.437

High

831165

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

896368

TMG4
Transmembrane gamma-carboxyglutamic acid protein 4

1

0

High-throughput

0.282

High

896322

PXDC2
Plexin domain-containing protein 2

1

0

High-throughput

0.279

Low

896313

GRPL2
GLIPR1-like protein 2

1

0

High-throughput

0.268

Low

896318

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.268

Low

896327

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

0

High-throughput

0.268

Low

896354

F163A
Protein FAM163A

1

0

High-throughput

0.268

Low

100642

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024