Protein: ROCK1
Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK)

Gene: ROCK1
Organism: Homo sapiens
Interactions: 130
UniProt ID: Q13464

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000281 - mitotic cytokinesis
GO:0001726 - ruffle
GO:0001837 - epithelial to mesenchymal transition
GO:0003180 - aortic valve morphogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

900444

RHOA
Transforming protein RhoA

7

20

Small-scale

0.966

High

254476

ROCK2
Rho-associated protein kinase 2

3

17

High-throughput

0.861

High

915655

RHOB
Rho-related GTP-binding protein RhoB

3

20

Small-scale

0.834

High

863822

LIMK2
LIM domain kinase 2

2

8

Small-scale

0.812

High

348647

RASN
GTPase NRas

2

20

High-throughput

0.754

High

349292

RASH
GTPase HRas

2

20

High-throughput

0.754

High

350143

RASK
GTPase KRas

2

20

High-throughput

0.754

High

436290

RHOC
Rho-related GTP-binding protein RhoC

2

20

Small-scale

0.754

High

498269

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

2

High-throughput

0.737

High

592236

RAB5A
Ras-related protein Rab-5A

2

9

High-throughput

0.737

High

950974

RHOG
Rho-related GTP-binding protein RhoG

2

20

Small-scale

0.737

High

180542

MAGB4
Melanoma-associated antigen B4

4

4

High-throughput

0.705

High

804235

NOTC1
Neurogenic locus notch homolog protein 1

1

5

High-throughput

0.691

High

1035177

TENS2
Tensin-2

1

6

High-throughput

0.691

High

1035188

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

4

High-throughput

0.691

High

1027872

MYBPH
Myosin-binding protein H

1

7

Small-scale

0.648

High

158465

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

16

Small-scale

0.647

High

673396

MPIP1
M-phase inducer phosphatase 1

1

1

Small-scale

0.647

High

901148

RND3
Rho-related GTP-binding protein RhoE

1

20

Small-scale

0.647

High

1035166

ROCK1
Rho-associated protein kinase 1

1

17

Small-scale

0.647

High

726031

ADDB
Beta-adducin

2

5

High-throughput

0.628

High

1035191

ANR49
Ankyrin repeat domain-containing protein 49

1

4

High-throughput

0.618

High

120420

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

297616

RHBT1
Rho-related BTB domain-containing protein 1

1

20

Small-scale

0.618

High

384789

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

433749

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

453335

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

16

High-throughput

0.618

High

507982

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

545358

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

564514

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

591838

RAB4A
Ras-related protein Rab-4A

1

9

High-throughput

0.618

High

665595

EPHB2
Ephrin type-B receptor 2

1

10

High-throughput

0.618

High

779363

CCNF
Cyclin-F

1

3

High-throughput

0.618

High

793302

MUC18
Cell surface glycoprotein MUC18

1

11

High-throughput

0.618

High

876374

AFAD
Afadin

1

20

High-throughput

0.618

High

892353

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

893975

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

895066

RAB2A
Ras-related protein Rab-2A

1

9

High-throughput

0.618

High

925253

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1035173

RAB35
Ras-related protein Rab-35

1

9

High-throughput

0.618

High

1035174

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1035176

CDKN3
Cyclin-dependent kinase inhibitor 3

1

2

Small-scale

0.618

High

1035181

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.618

High

1035198

CDK15
Cyclin-dependent kinase 15

1

8

High-throughput

0.618

High

1035206

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1035207

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.618

High

1035208

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1035212

ANLN
Anillin

1

2

High-throughput

0.618

High

507004

LAMP1
Lysosome-associated membrane glycoprotein 1

2

7

High-throughput

0.584

High

438138

HS90B
Heat shock protein HSP 90-beta

1

20

Small-scale

0.575

High

582272

NUCL
Nucleolin

1

10

Small-scale

0.575

High

1035167

GAB1
GRB2-associated-binding protein 1

1

6

Small-scale

0.575

High

638282

RBTN2
Rhombotin-2

1

4

High-throughput

0.573

High

1035203

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.573

High

657830

ELK4
ETS domain-containing protein Elk-4

2

1

High-throughput

0.571

High

823386

PAXI
Paxillin

2

7

High-throughput

0.571

High

1035200

TS101
Tumor susceptibility gene 101 protein

1

0

Small-scale

0.549

High

524912

XRCC5
X-ray repair cross-complementing protein 5

1

3

High-throughput

0.536

High

728911

AHR
Aryl hydrocarbon receptor

1

4

High-throughput

0.536

High

801510

KPB2
Phosphorylase b kinase regulatory subunit alpha, liver isoform

1

1

High-throughput

0.536

High

827193

ARRB1
Beta-arrestin-1

1

3

High-throughput

0.536

High

902902

DCAF7
DDB1- and CUL4-associated factor 7

1

14

High-throughput

0.536

High

949087

HTRA3
Serine protease HTRA3

1

3

High-throughput

0.536

High

1035168

SMAD4
Mothers against decapentaplegic homolog 4

1

6

High-throughput

0.536

High

1035178

KDM4D
Lysine-specific demethylase 4D

1

3

High-throughput

0.536

High

1035189

BBS1
Bardet-Biedl syndrome 1 protein

1

2

High-throughput

0.536

High

1035193

HDAC2
Histone deacetylase 2

1

10

High-throughput

0.536

High

1035194

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

1

High-throughput

0.536

High

1035205

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.536

High

1035216

I20RA
Interleukin-20 receptor subunit alpha

1

2

High-throughput

0.536

High

1035182

FRMD5
FERM domain-containing protein 5

1

7

Small-scale

0.515

High

1035195

APC16
Anaphase-promoting complex subunit 16

1

0

High-throughput

0.513

High

1035217

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.513

High

643343

HMGB2
High mobility group protein B2

1

13

Small-scale

0.508

High

1035175

SMAD2
Mothers against decapentaplegic homolog 2

1

5

High-throughput

0.508

High

788192

CASP3
Caspase-3

1

4

Small-scale

0.501

High

876943

CASP7
Caspase-7

1

4

Small-scale

0.501

High

1035199

SMAD5
Mothers against decapentaplegic homolog 5

1

5

Small-scale

0.501

High

1035210

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

4

Small-scale

0.501

High

1035196

CERS2
Ceramide synthase 2

1

2

High-throughput

0.489

High

1035213

MED17
Mediator of RNA polymerase II transcription subunit 17

1

1

High-throughput

0.489

High

1035204

TRI15
E3 ubiquitin-protein ligase TRIM15

1

8

Small-scale

0.481

High

1035214

ITSN2
Intersectin-2

1

7

High-throughput

0.481

High

296612

TPPP
Tubulin polymerization-promoting protein

1

0

Small-scale

0.480

High

1035172

MLC1
Membrane protein MLC1

1

0

Small-scale

0.480

High

124205

TAF4
Transcription initiation factor TFIID subunit 4

1

7

High-throughput

0.479

High

279540

FLOT1
Flotillin-1

1

7

High-throughput

0.479

High

298492

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

386676

P53
Cellular tumor antigen p53

1

6

High-throughput

0.479

High

455401

PARP1
Poly [ADP-ribose] polymerase 1

1

6

High-throughput

0.479

High

504029

HSP7C
Heat shock cognate 71 kDa protein

1

13

High-throughput

0.479

High

518650

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.479

High

527441

LAMP2
Lysosome-associated membrane glycoprotein 2

1

7

High-throughput

0.479

High

544969

AMPN
Aminopeptidase N

1

1

High-throughput

0.479

High

555140

CD44
CD44 antigen

1

2

Small-scale

0.479

High

618072

COF1
Cofilin-1

1

6

Small-scale

0.479

High

648749

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.479

High

714963

PROF2
Profilin-2

1

1

Small-scale

0.479

High

724810

MYH9
Myosin-9

1

5

Small-scale

0.479

High

896066

UBC12
NEDD8-conjugating enzyme Ubc12

1

3

High-throughput

0.479

High

908493

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

909524

1433E
14-3-3 protein epsilon

1

3

Small-scale

0.479

High

912888

ARF6
ADP-ribosylation factor 6

1

7

High-throughput

0.479

High

965657

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

998661

EP300
Histone acetyltransferase p300

1

14

High-throughput

0.479

High

1035169

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1035170

CUL4A
Cullin-4A

1

4

High-throughput

0.479

High

1035179

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.479

High

1035183

TM11B
Transmembrane protease serine 11B

1

8

High-throughput

0.479

High

1035185

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

6

High-throughput

0.479

High

1035197

SNX27
Sorting nexin-27

1

20

High-throughput

0.479

High

1035201

ANM1
Protein arginine N-methyltransferase 1

1

4

High-throughput

0.479

High

1035209

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

7

High-throughput

0.479

High

1035211

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

5

High-throughput

0.479

High

1035215

ZRAN1
Ubiquitin thioesterase ZRANB1

1

12

High-throughput

0.479

High

1035218

LAMP3
Lysosome-associated membrane glycoprotein 3

1

7

High-throughput

0.479

High

586034

SL9A1
Sodium/hydrogen exchanger 1

1

0

Small-scale

0.458

High

1035171

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1035202

RNZ2
Zinc phosphodiesterase ELAC protein 2

1

0

High-throughput

0.458

High

596217

NEBU
Nebulin

1

8

Small-scale

0.445

High

100732

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

244394

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.437

High

1035180

FBX42
F-box only protein 42

1

2

High-throughput

0.437

High

1035192

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.437

High

1035184

F124A
Protein FAM124A

1

0

High-throughput

0.299

High

1035186

CF206
Cilia- and flagella-associated protein 206

1

0

High-throughput

0.299

High

612011

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.279

Low

1035187

SYCE1
Synaptonemal complex central element protein 1

1

0

High-throughput

0.279

Low

1035190

NEIL3
Endonuclease 8-like 3

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024